LOCUS       NM_001204210            2508 bp    mRNA    linear   PRI 17-FEB-2024
DEFINITION  Homo sapiens transmembrane protein 235 (TMEM235), transcript
            variant 1, mRNA.
ACCESSION   NM_001204210
VERSION     NM_001204210.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2508)
  AUTHORS   Maher,G.J., Hilton,E.N., Urquhart,J.E., Davidson,A.E.,
            Spencer,H.L., Black,G.C. and Manson,F.D.
  TITLE     The cataract-associated protein TMEM114, and TMEM235, are
            glycosylated transmembrane proteins that are distinct from claudin
            family members
  JOURNAL   FEBS Lett 585 (14), 2187-2192 (2011)
   PUBMED   21689651
  REMARK    GeneRIF: Data demonstrate that TMEM114, and the closely related
            TMEM235, are closely related to members of the voltage dependent
            calcium channel gamma subunit family.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC087645.19, BC042066.1, BI757060.1 and BI757981.1.
            
            On Aug 14, 2020 this sequence version replaced NM_001204210.1.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            ##Evidence-Data-START##
            CDS exon combination :: BI757060.1, SRR1660805.160494.1
                                    [ECO:0000331]
            RNAseq introns       :: single sample supports all introns
                                    SAMEA2157437 [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-17                AC087645.19        110816-110832       c
            18-624              BC042066.1         1-607
            625-625             AC087645.19        110118-110118       c
            626-679             BC042066.1         609-662
            680-967             BI757060.1         1-288
            968-1339            BI757981.1         221-592
            1340-2393           BC042066.1         1104-2157
            2394-2394           AC087645.19        101252-101252       c
            2395-2508           BC042066.1         2159-2272
FEATURES             Location/Qualifiers
     source          1..2508
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q25.3"
     gene            1..2508
                     /gene="TMEM235"
                     /gene_synonym="ARGM1"
                     /note="transmembrane protein 235"
                     /db_xref="GeneID:283999"
                     /db_xref="HGNC:HGNC:27563"
                     /db_xref="MIM:620272"
     exon            1..49
                     /gene="TMEM235"
                     /gene_synonym="ARGM1"
                     /inference="alignment:Splign:2.1.0"
     exon            50..831
                     /gene="TMEM235"
                     /gene_synonym="ARGM1"
                     /inference="alignment:Splign:2.1.0"
     CDS             642..1313
                     /gene="TMEM235"
                     /gene_synonym="ARGM1"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; transmembrane protein ENSP00000364084"
                     /codon_start=1
                     /product="transmembrane protein 235 isoform 1 precursor"
                     /protein_id="NP_001191139.1"
                     /db_xref="CCDS:CCDS56046.1"
                     /db_xref="GeneID:283999"
                     /db_xref="HGNC:HGNC:27563"
                     /db_xref="MIM:620272"
                     /translation="MARLGALLLAAALGALLSFALLAAAVASDYWYILEVADAGNGSA
                     WPGRAELLSSHSGLWRICEGQNGCIPLVDPFASESLDVSTSVQHLILLHRAVIVVLPL
                     SLVLLVCGWICGLLSSLAQSVSLLLFTGCYFLLGSVLTLAGVSIYISYSHLAFAETVQ
                     QYGPQHMQGVRVSFGWSMALAWGSCALEAFSGTLLLSAAWTLSLSPPICGHLSPQQVG
                     GRGGD"
     exon            832..912
                     /gene="TMEM235"
                     /gene_synonym="ARGM1"
                     /inference="alignment:Splign:2.1.0"
     exon            913..1050
                     /gene="TMEM235"
                     /gene_synonym="ARGM1"
                     /inference="alignment:Splign:2.1.0"
     exon            1051..1300
                     /gene="TMEM235"
                     /gene_synonym="ARGM1"
                     /inference="alignment:Splign:2.1.0"
     exon            1301..2508
                     /gene="TMEM235"
                     /gene_synonym="ARGM1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2394..2399
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TMEM235"
                     /gene_synonym="ARGM1"
                     /note="hexamer: AGTAAA"
     polyA_site      2417
                     /gene="TMEM235"
                     /gene_synonym="ARGM1"
     regulatory      2476..2481
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TMEM235"
                     /gene_synonym="ARGM1"
                     /note="hexamer: CATAAA"
     polyA_site      2508
                     /gene="TMEM235"
                     /gene_synonym="ARGM1"
                     /note="major polyA site"
ORIGIN      
        1 actggcaccc cacgcctgtc ctagaaggtt ctttctgcct gttttctccc cccccgcccg
       61 gctgtggggc ccagccactg cacttcaccg gatgccgtct ggttggtcct caggactgat
      121 acagaccagg accccagggc cagcccgtgc caggctccta tgcttccagg agcacgggtg
      181 ggtggtcctg ctgcctggcc ggccatcctc ctggggtcgg tctctggccg atcctccctc
      241 ctcctctcaa gccctgcaca gcccggccag gcaggtgcat cttgtttggc tgctgaggag
      301 ccgggggttc agggaaatta aggaacgtgc ccagggaccc ggggccagcc cgtggggacg
      361 ctgggattgg agcccaagcc ccaggttcgc cgcgcggctc tcgacttcct ctcctttccc
      421 ccaggggcga gctcagcgac cgcagagagg tggggtcgat ctccctgcga ccccaggggg
      481 cccgcgaggc cagtgcgcgg gcaggagcgg ggacgtgctc agaagagccg ggcgccgccg
      541 cgcccgcccg ccccccgtcc cccggctccc ggctccgcgc gccccccgcc gcccccgggg
      601 ccctgctacc cccgacccgt cccctcccgc cggccgcccc catggcccgg ctgggcgcgc
      661 tgctcctggc cgccgccctg ggtgcactgc tcagcttcgc gctcctggcc gccgcggtcg
      721 ccagcgacta ctggtacatc ctggaggtgg cggacgccgg caatggcagc gcctggcccg
      781 ggcgcgcaga gctgctctcc tcgcactcgg ggctctggcg catctgcgaa gggcagaacg
      841 gctgcatccc gctggtcgac ccttttgcca gtgagagcct ggacgtctcc acctcggtgc
      901 agcacctcat cttgctgcac cgtgcagtca ttgtggtcct gcccctgagc ctggtccttc
      961 tcgtgtgtgg ctggatctgc ggcctgctca gctccctggc ccagagcgtg tctctgctgc
     1021 ttttcaccgg ctgctacttc ctgctgggga gtgtcctgac actggcgggg gtcagcatct
     1081 acatcagcta ctcgcacctg gcctttgcgg agacggtgca gcagtatggc ccgcagcaca
     1141 tgcagggcgt ccgcgtcagc ttcggctggt ccatggccct ggcctggggc tcctgtgcct
     1201 tggaggcatt cagcggaacc ctcctgctct cagctgcctg gaccctcagc ctgagccccc
     1261 caatctgtgg tcatctgagt ccccagcagg tgggagggag agggggagac tgaggcccag
     1321 agcggcagag ggacccaccc agatcgcctg gcgccagaga gatgccgtct caggccaagg
     1381 cctccctggc ctctgttctg tccactctcc ccgaagggca ggcttggtgg agaagaggct
     1441 gatgagaggg cccgagagcc cctccgattt gcaggggtgg ggggcaagga gctgagcgat
     1501 ccagatgtac ccctctgccc cctcccttgt tctcaagcct gctaggtact tttcactgag
     1561 cacttccggg aagagcaggc acccagatct ctgtccttgt cctggcacag gctgctgctg
     1621 cttccggccc ccgacccttc ctctctgcag caacccgggg gaggtatgcc actgtgagtg
     1681 ccctggtggg cacactgagc tggcagagat ggaagtccca gaagggtggg gtgggggtgt
     1741 catgccatgg tggaggagtt tggggccact ccttgcctgc ctcaaagggg gcctggctga
     1801 gggtgcttct tgaccacagg ggccagggct gcctagggtg gcgcagggct gggcctggag
     1861 tttgggatgc aggcttgtta aacacagggc agaaccccag gttgggaggg gctcagtttg
     1921 caggcccagg cccgcaggcc cactgctggt cccagggtga gacaggtgag aagagggatg
     1981 gccagcacac acttgagtcc ccttgggcca caaaggctgg ggcacgccca ccgttatgca
     2041 gatggacagt tgaggtggct gcaggagaag ggttcccagg gcctgtacaa cacgtggaag
     2101 cactaaacgg ccccgtttgg ggtttggggg cccttcccga gtcttgagag gtcttgagag
     2161 gtgtgctggg gaaggtggca gcctcttgta gcttgatctt cctccaccct gccccacccc
     2221 taggtctctt tattgattca aaggttaagg aagctcctgg gggcttgagg gggtggcaca
     2281 gttttggtgg ggcccagtga ggacaaatct ggggggtgag cagggcctcc tcttcctcct
     2341 ggtgtttgaa cgtttaccat tccatgtggg accattgtgc caatttgtcc ttaagtaaat
     2401 cacttgtgct gtgtgcagta taagcctttt atttttctta gaacttttca aaataggtaa
     2461 cacatgcctg tctgtcataa acagtacaaa cgtgagcaaa cactgtca
//
