LOCUS       NM_019118               1107 bp    mRNA    linear   PRI 06-APR-2024
DEFINITION  Homo sapiens transmembrane protein 234 (TMEM234), transcript
            variant 1, mRNA.
ACCESSION   NM_019118
VERSION     NM_019118.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1107)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 1107)
  AUTHORS   Rodriguez,P.Q., Oddsson,A., Ebarasi,L., He,B., Hultenby,K.,
            Wernerson,A., Betsholtz,C., Tryggvason,K. and Patrakka,J.
  TITLE     Knockdown of Tmem234 in zebrafish results in proteinuria
  JOURNAL   Am J Physiol Renal Physiol 309 (11), F955-F966 (2015)
   PUBMED   26377798
REFERENCE   3  (bases 1 to 1107)
  AUTHORS   Clark,H.F., Gurney,A.L., Abaya,E., Baker,K., Baldwin,D., Brush,J.,
            Chen,J., Chow,B., Chui,C., Crowley,C., Currell,B., Deuel,B.,
            Dowd,P., Eaton,D., Foster,J., Grimaldi,C., Gu,Q., Hass,P.E.,
            Heldens,S., Huang,A., Kim,H.S., Klimowski,L., Jin,Y., Johnson,S.,
            Lee,J., Lewis,L., Liao,D., Mark,M., Robbie,E., Sanchez,C.,
            Schoenfeld,J., Seshagiri,S., Simmons,L., Singh,J., Smith,V.,
            Stinson,J., Vagts,A., Vandlen,R., Watanabe,C., Wieand,D., Woods,K.,
            Xie,M.H., Yansura,D., Yi,S., Yu,G., Yuan,J., Zhang,M., Zhang,Z.,
            Goddard,A., Wood,W.I., Godowski,P. and Gray,A.
  TITLE     The secreted protein discovery initiative (SPDI), a large-scale
            effort to identify novel human secreted and transmembrane proteins:
            a bioinformatics assessment
  JOURNAL   Genome Res 13 (10), 2265-2270 (2003)
   PUBMED   12975309
  REMARK    Erratum:[Genome Res. 2003 Dec;13(12):2759]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK295232.1 and BC004885.2.
            
            On Jun 2, 2019 this sequence version replaced NM_019118.4.
            
            Transcript Variant: This variant (1) encodes isoform a.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC004885.2, SRR14038191.1441306.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000309777.11/ ENSP00000309792.6
            RefSeq Select criteria :: based on manual assertion, conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-28                AK295232.1         19-46
            29-1107             BC004885.2         1-1079
FEATURES             Location/Qualifiers
     source          1..1107
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p35.2"
     gene            1..1107
                     /gene="TMEM234"
                     /gene_synonym="AASL548; C1orf91; dJ622L5.7; PRO1105;
                     RP4-622L5"
                     /note="transmembrane protein 234"
                     /db_xref="GeneID:56063"
                     /db_xref="HGNC:HGNC:28837"
                     /db_xref="MIM:620289"
     exon            1..47
                     /gene="TMEM234"
                     /gene_synonym="AASL548; C1orf91; dJ622L5.7; PRO1105;
                     RP4-622L5"
                     /inference="alignment:Splign:2.1.0"
     CDS             32..454
                     /gene="TMEM234"
                     /gene_synonym="AASL548; C1orf91; dJ622L5.7; PRO1105;
                     RP4-622L5"
                     /note="isoform a precursor is encoded by transcript
                     variant 1"
                     /codon_start=1
                     /product="transmembrane protein 234 isoform a precursor"
                     /protein_id="NP_061991.3"
                     /db_xref="CCDS:CCDS356.2"
                     /db_xref="GeneID:56063"
                     /db_xref="HGNC:HGNC:28837"
                     /db_xref="MIM:620289"
                     /translation="MAASLGQVLALVLVAALWGGTQPLLKRASAGLQRVHEPTWAQQL
                     LQEMKTLFLNTEYLMPFLLNQCGSLLYYLTLASTDLTLAVPICNSLAIIFTLIVGKAL
                     GEDIGGKRAVAGMVLTVIGISLCITSSVSKTQGQQSTL"
     exon            48..199
                     /gene="TMEM234"
                     /gene_synonym="AASL548; C1orf91; dJ622L5.7; PRO1105;
                     RP4-622L5"
                     /inference="alignment:Splign:2.1.0"
     exon            200..266
                     /gene="TMEM234"
                     /gene_synonym="AASL548; C1orf91; dJ622L5.7; PRO1105;
                     RP4-622L5"
                     /inference="alignment:Splign:2.1.0"
     exon            267..359
                     /gene="TMEM234"
                     /gene_synonym="AASL548; C1orf91; dJ622L5.7; PRO1105;
                     RP4-622L5"
                     /inference="alignment:Splign:2.1.0"
     exon            360..1107
                     /gene="TMEM234"
                     /gene_synonym="AASL548; C1orf91; dJ622L5.7; PRO1105;
                     RP4-622L5"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1087..1092
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TMEM234"
                     /gene_synonym="AASL548; C1orf91; dJ622L5.7; PRO1105;
                     RP4-622L5"
                     /note="hexamer: AATAAA"
     polyA_site      1107
                     /gene="TMEM234"
                     /gene_synonym="AASL548; C1orf91; dJ622L5.7; PRO1105;
                     RP4-622L5"
                     /note="major polyA site"
ORIGIN      
        1 gttcccggaa gtagaagaca gcggcgttgc catggcggcg tctctggggc aggtgttggc
       61 tctggtgctg gtggccgctc tgtggggtgg cacgcagccg ctgctgaagc gggcctccgc
      121 cggcctgcag cgggttcatg agccgacctg ggcccagcag ttgctacagg agatgaagac
      181 cctcttcttg aatactgagt acctgatgcc ctttctcctc aaccagtgtg gatcccttct
      241 ctattacctc accttggcat cgacagatct gaccctggct gtgcccatct gtaactctct
      301 ggctatcatc ttcacactga ttgttgggaa ggcccttgga gaagatattg gtggaaaacg
      361 agcagttgct ggcatggtgc tcaccgtgat aggaatttca ctctgcatca caagctcagt
      421 gagtaagacc caggggcaac agtctaccct ttgagtgggc cgaacccact tccagctctg
      481 ctgcctccag gaagcccctg ggccatgaag tgctggcagt gagcggatgg acctagcact
      541 tcccctctct ggccttagct tcctcctctc ttatggggat aacagctacc tcatggatca
      601 caataagaga acaagagtga aagagttttg taaccttcaa gtgctgttca gctgcgggga
      661 tttagcacag gagactctac gctcaccctc agcaaccttt ctgccccagc agctctcttc
      721 ctgctaacat ctcaggctcc cagcccagcc accattactg tggcctgatc tggactatca
      781 tggtggcagg ttccatggac tgcagaactc cagctgcatg gaaagggcca gctgcagact
      841 ttgagccaga aatgcaaacg ggaggcctct gggactcagt cagagcgctt tggctgaatg
      901 aggggtggaa ccgagggaag aaggtgcgtc ggagtggcag atgcaggaaa tgagctgtct
      961 attagccttg cctgccccac ccatgaggta ggcagaaatc ctcactgcca gcccctctta
     1021 aacaggtaga gagctgtgag ccccagcccc acctgactcc agcacacctg gcgagtagta
     1081 gctgtcaata aatctatggt aaacaga
//
