LOCUS       NM_001136534            2775 bp    mRNA    linear   PRI 01-AUG-2024
DEFINITION  Homo sapiens transmembrane protein 233 (TMEM233), mRNA.
ACCESSION   NM_001136534 XM_001720577 XM_370707 XM_941692
VERSION     NM_001136534.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2775)
  AUTHORS   Jami,S., Deuis,J.R., Klasfauseweh,T., Cheng,X., Kurdyukov,S.,
            Chung,F., Okorokov,A.L., Li,S., Zhang,J., Cristofori-Armstrong,B.,
            Israel,M.R., Ju,R.J., Robinson,S.D., Zhao,P., Ragnarsson,L.,
            Andersson,A., Tran,P., Schendel,V., McMahon,K.L., Tran,H.N.T.,
            Chin,Y.K., Zhu,Y., Liu,J., Crawford,T., Purushothamvasan,S.,
            Habib,A.M., Andersson,D.A., Rash,L.D., Wood,J.N., Zhao,J.,
            Stehbens,S.J., Mobli,M., Leffler,A., Jiang,D., Cox,J.J.,
            Waxman,S.G., Dib-Hajj,S.D., Neely,G.G., Durek,T. and Vetter,I.
  TITLE     Pain-causing stinging nettle toxins target TMEM233 to modulate
            NaV1.7 function
  JOURNAL   Nat Commun 14 (1), 2442 (2023)
   PUBMED   37117223
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2775)
  AUTHORS   Sallman Almen,M., Bringeland,N., Fredriksson,R. and Schioth,H.B.
  TITLE     The dispanins: a novel gene family of ancient origin that contains
            14 human members
  JOURNAL   PLoS One 7 (2), e31961 (2012)
   PUBMED   22363774
REFERENCE   3  (bases 1 to 2775)
  AUTHORS   Wu,H., Wang,J., Deng,R., Xing,K., Xiong,Y., Huang,J., He,X. and
            Wang,X.
  TITLE     Benefits of random-priming: exhaustive survey of a cDNA library
            from lung tissue of a SARS patient
  JOURNAL   J Med Virol 83 (4), 574-586 (2011)
   PUBMED   21328370
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DC315309.1, GD264605.1, AC002563.1 and AA476740.1.
            
            On Nov 22, 2018 this sequence version replaced NM_001136534.2.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: DC368732.1, AK296289.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA2144120
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000426426.3/ ENSP00000403130.1
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-452               DC315309.1         127-578
            453-853             GD264605.1         1-401               c
            854-2517            AC002563.1         15184-16847
            2518-2766           AA476740.1         5-253               c
            2767-2775           AC002563.1         17097-17105
FEATURES             Location/Qualifiers
     source          1..2775
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q24.23"
     gene            1..2775
                     /gene="TMEM233"
                     /gene_synonym="DSPB2; IFITMD2"
                     /note="transmembrane protein 233"
                     /db_xref="GeneID:387890"
                     /db_xref="HGNC:HGNC:37219"
                     /db_xref="MIM:618296"
     exon            1..261
                     /gene="TMEM233"
                     /gene_synonym="DSPB2; IFITMD2"
                     /inference="alignment:Splign:2.1.0"
     CDS             76..405
                     /gene="TMEM233"
                     /gene_synonym="DSPB2; IFITMD2"
                     /note="interferon induced transmembrane protein domain
                     containing 2; interferon-induced transmembrane
                     domain-containing protein D2; dispanin subfamily B member
                     2"
                     /codon_start=1
                     /product="transmembrane protein 233"
                     /protein_id="NP_001130006.1"
                     /db_xref="CCDS:CCDS44995.1"
                     /db_xref="GeneID:387890"
                     /db_xref="HGNC:HGNC:37219"
                     /db_xref="MIM:618296"
                     /translation="MSQYAPSPDFKRALDSSPEANTEDDKTEEDVPMPKNYLWLTIVS
                     CFCPAYPINIVALVFSIMSLNSYNDGDYEGARRLGRNAKWVAIASIIIGLLIIGISCA
                     VHFTRNA"
     exon            262..398
                     /gene="TMEM233"
                     /gene_synonym="DSPB2; IFITMD2"
                     /inference="alignment:Splign:2.1.0"
     exon            399..2775
                     /gene="TMEM233"
                     /gene_synonym="DSPB2; IFITMD2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1165..1170
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TMEM233"
                     /gene_synonym="DSPB2; IFITMD2"
                     /note="hexamer: AATAAA"
     polyA_site      1185
                     /gene="TMEM233"
                     /gene_synonym="DSPB2; IFITMD2"
     regulatory      2746..2751
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TMEM233"
                     /gene_synonym="DSPB2; IFITMD2"
                     /note="hexamer: AATAAA"
     polyA_site      2775
                     /gene="TMEM233"
                     /gene_synonym="DSPB2; IFITMD2"
                     /note="major polyA site"
ORIGIN      
        1 acaagccggc ggccagagcc ccagaccaca cagaccgtgc gctcctccgc cctcccggcg
       61 ccgccggcct cgcccatgtc tcagtacgcc cctagcccgg acttcaagag ggctttggac
      121 agcagtcccg aggccaacac tgaagatgac aagaccgagg aggacgtgcc catgcccaag
      181 aactacctgt ggctcaccat cgtctcgtgt ttttgccctg cgtaccccat caacatcgtg
      241 gctttggtct tttccatcat gtctctgaac agctacaacg atggagacta cgaaggagcc
      301 aggcggcttg ggcggaatgc taagtgggta gccatcgcct ccatcatcat tggccttctc
      361 atcatcggca tttcttgtgc agttcacttc acaaggaatg cctgaggaac cagcggtcag
      421 tgggctgtga gcgtggagga tggacctcat ccacacacac cccaaaggag tttctaagga
      481 atggatcctt gacttcagac tgtgagatct tttcctccag gactctccag aggcaggtcc
      541 ctggcaaatg aacaagaaaa aaaaaaaaaa aaagtccaaa atttaggcaa tccaagctgc
      601 acagccggat cagccaaagt cattgatttg taaaaatgaa aagaaaacag aaaaaagaaa
      661 aatgaagtct cactgtctca gtttagcgaa tcccgttgtg tccactcctg tcctccagag
      721 gcgagcctca ggaaatcaca taacttttca ctgaggggat ccagggggtc tccatatagg
      781 gggagatgga ggtttctagg aagagcagca ggtgctggta tttacaatgt tgagcacaaa
      841 catttgcagc atgtttaaaa ttgtctagta gagttcaagt tgtggatttg cttttccttt
      901 tattcttata accttcagta actcctcctc tgggagtcag cactcccatg cccagagttc
      961 acccatctgg tcatcaaaca ctcaaagaag gggcttttct ggccttttgt cttgatgctt
     1021 atatttccaa ataggccccc tcccttgctt gcatccacgt tggtcaactt gaccaaaacc
     1081 tcactcttca ctcaaacagg ctctgagaat ggacttagtg gccaattcta ggtacatgag
     1141 cacttcctgt atcccagttt tgggaataaa ctggctgtat ttatagaatg tgcttttttt
     1201 ttttcaattt ctcactctct ctcctatctc tagcaagtct caggcaagat ctttgatttt
     1261 cctggatgcc acctggaaat gccacccatt gtgtttcttt tctgtcaaat gtaaaccctt
     1321 tagatgtgaa tgtactggtt taatgatgcc attattctgc ctgccagaac gcagtaaccc
     1381 agtgtctcac agagcacaag gggtgtgcca ctggtggtac acaagataat ttttaagtag
     1441 tttctaggaa caacattaag taataccaaa tcacaaagaa tgtttcccct tttctattct
     1501 tttttcatcc tgattacagc aaggaaaaag tctctgttta gtgctagcag gtcctttaca
     1561 cctttcagac actatggctc ttttcccttt ttagcaaaga aagagcaggc ctcagagtct
     1621 tctgtctaga tagaatttaa tgatattgtt ttgtgtcatg gtatttattt tatttattac
     1681 cttccattta cagcttccca cagtggggga tgtgacatat tgtttctgtt caaataaatt
     1741 aagaaaaaca agagaactca agaaaatatc aagtaattaa cacaccagat aagtatatgt
     1801 ggcaaaagtc acttcaaaga attaatgtca gaaagatggt gataatgaag caaaagaaag
     1861 gcagattatg ctggccgggc gtggtggctc acgcctgtaa tcccagcaat ttgagaggct
     1921 gagatcactt aaggtcagga gtttgagacc agcctgacca acatggtgaa actccatctc
     1981 tactaaaaat acaaaaatta gccaggcgtg gtggtgcatg cctgtaatcc cagctaatag
     2041 agaggctgag gcaggagaat cacttgaatc cagaaggcgg aggttgccgt gagctgagac
     2101 tgtgccacta cactccagcc cggggtgaca gagcaagact ccatctcaaa aaaaaaagaa
     2161 aagaaaacga aagaaaaaga aaaaagaaag gcagattatt ctaattgaat gaataagagg
     2221 ctgagagtca atacctagtt ccaacgccct tttgtttttg cagggttttt attggccact
     2281 aactagctat gcaagctgat tttaggcaag tttcatagcc tctctgtgcc taaaattcct
     2341 tcacctgcaa aatggggata agaatgcctg cctacttacc tcacagtgct gttatgagaa
     2401 ttaattgttg taatagttgt gactaaccat tggcggggag aattctaagt actataccaa
     2461 tacaaatttc agcatttttt catatactga accctagcaa aaaaaaaaaa aattctgatg
     2521 aacatcagat tcaacctgtc attttacccg gatgttgtga tgagccagca cttgtcccag
     2581 gaggacgttg aatcagggac acgaaatctc agcacacaga gattctagca tcattccaat
     2641 agattggacc ctgatttctg tttctgacat cctgtttttt gtttgtgcgt gtttgggtcc
     2701 ctggtctttt acccaaatca aatgaaaagt gttgctcaga ggcagaataa aaatggtttt
     2761 aagtaagcct gtgta
//
