LOCUS       NM_001039763            3115 bp    mRNA    linear   PRI 09-FEB-2025
DEFINITION  Homo sapiens transmembrane protein 232 (TMEM232), mRNA.
ACCESSION   NM_001039763 XM_927011 XM_931766 XM_931769 XM_931771 XM_931773
            XM_931777 XM_931781 XM_931787 XM_936744 XM_942944 XM_942949
            XM_942953 XM_942959 XM_942968 XM_942975 XM_942983
VERSION     NM_001039763.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3115)
  AUTHORS   Han,J., Cai,X., Qin,S., Zhang,Z., Wu,Y., Shi,Y., Deng,T., Chen,B.,
            Liu,L., Qian,H., Fang,W. and Xiao,F.
  TITLE     TMEM232 promotes the inflammatory response in atopic dermatitis via
            the nuclear factor-kappaB and signal transducer and activator of
            transcription 3 signalling pathways
  JOURNAL   Br J Dermatol 189 (2), 195-209 (2023)
   PUBMED   36928730
  REMARK    GeneRIF: TMEM232 promotes the inflammatory response in atopic
            dermatitis via the nuclear factor-kappaB and signal transducer and
            activator of transcription 3 signalling pathways.
            Erratum:[Br J Dermatol. 2023 Oct 25;189(5):e83-e87. doi:
            10.1093/bjd/ljad346.. PMID: 37742065]
REFERENCE   2  (bases 1 to 3115)
  AUTHORS   Zheng,J., Wu,Y.Y., Fang,W.L., Cai,X.Y., Zhang,Z.Y., Yu,C.X.,
            Zheng,X.D. and Xiao,F.L.
  TITLE     Confirming the TMEM232 gene associated with atopic dermatitis
            through targeted capture sequencing
  JOURNAL   Sci Rep 11 (1), 21830 (2021)
   PUBMED   34750414
  REMARK    GeneRIF: Confirming the TMEM232 gene associated with atopic
            dermatitis through targeted capture sequencing.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3115)
  AUTHORS   Wu,Y.Y., Tang,J.P., Liu,Q., Zheng,X.D., Fang,L., Yin,X.Y.,
            Jiang,X.Y., Zhou,F.S., Zhu,F., Liang,B., Li,Y., Zuo,X.B.,
            Zhang,X.J. and Xiao,F.L.
  TITLE     Scanning indels in the 5q22.1 region and identification of the
            TMEM232 susceptibility gene that is associated with atopic
            dermatitis in the Chinese Han population
  JOURNAL   Gene 617, 17-23 (2017)
   PUBMED   28351738
  REMARK    GeneRIF: TMEM232 is the causal gene for atopic dermatitis in
            Chinese Han population.
REFERENCE   4  (bases 1 to 3115)
  AUTHORS   Ramasamy,A., Curjuric,I., Coin,L.J., Kumar,A., McArdle,W.L.,
            Imboden,M., Leynaert,B., Kogevinas,M., Schmid-Grendelmeier,P.,
            Pekkanen,J., Wjst,M., Bircher,A.J., Sovio,U., Rochat,T.,
            Hartikainen,A.L., Balding,D.J., Jarvelin,M.R., Probst-Hensch,N.,
            Strachan,D.P. and Jarvis,D.L.
  TITLE     A genome-wide meta-analysis of genetic variants associated with
            allergic rhinitis and grass sensitization and their interaction
            with birth order
  JOURNAL   J Allergy Clin Immunol 128 (5), 996-1005 (2011)
   PUBMED   22036096
REFERENCE   5  (bases 1 to 3115)
  AUTHORS   Bailey,S.D., Xie,C., Do,R., Montpetit,A., Diaz,R., Mohan,V.,
            Keavney,B., Yusuf,S., Gerstein,H.C., Engert,J.C. and Anand,S.
  CONSRTM   DREAM investigators
  TITLE     Variation at the NFATC2 locus increases the risk of
            thiazolidinedione-induced edema in the Diabetes REduction
            Assessment with ramipril and rosiglitazone Medication (DREAM) study
  JOURNAL   Diabetes Care 33 (10), 2250-2253 (2010)
   PUBMED   20628086
  REMARK    GeneRIF: Observational study of gene-disease association,
            gene-environment interaction, and pharmacogenomic / toxicogenomic.
            (HuGE Navigator)
REFERENCE   6  (bases 1 to 3115)
  AUTHORS   Talmud,P.J., Drenos,F., Shah,S., Shah,T., Palmen,J., Verzilli,C.,
            Gaunt,T.R., Pallas,J., Lovering,R., Li,K., Casas,J.P., Sofat,R.,
            Kumari,M., Rodriguez,S., Johnson,T., Newhouse,S.J., Dominiczak,A.,
            Samani,N.J., Caulfield,M., Sever,P., Stanton,A., Shields,D.C.,
            Padmanabhan,S., Melander,O., Hastie,C., Delles,C., Ebrahim,S.,
            Marmot,M.G., Smith,G.D., Lawlor,D.A., Munroe,P.B., Day,I.N.,
            Kivimaki,M., Whittaker,J., Humphries,S.E. and Hingorani,A.D.
  CONSRTM   ASCOT investigators; NORDIL investigators; BRIGHT Consortium
  TITLE     Gene-centric association signals for lipids and apolipoproteins
            identified via the HumanCVD BeadChip
  JOURNAL   Am J Hum Genet 85 (5), 628-642 (2009)
   PUBMED   19913121
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   7  (bases 1 to 3115)
  AUTHORS   Vasan,R.S., Glazer,N.L., Felix,J.F., Lieb,W., Wild,P.S.,
            Felix,S.B., Watzinger,N., Larson,M.G., Smith,N.L., Dehghan,A.,
            Grosshennig,A., Schillert,A., Teumer,A., Schmidt,R., Kathiresan,S.,
            Lumley,T., Aulchenko,Y.S., Konig,I.R., Zeller,T., Homuth,G.,
            Struchalin,M., Aragam,J., Bis,J.C., Rivadeneira,F., Erdmann,J.,
            Schnabel,R.B., Dorr,M., Zweiker,R., Lind,L., Rodeheffer,R.J.,
            Greiser,K.H., Levy,D., Haritunians,T., Deckers,J.W., Stritzke,J.,
            Lackner,K.J., Volker,U., Ingelsson,E., Kullo,I., Haerting,J.,
            O'Donnell,C.J., Heckbert,S.R., Stricker,B.H., Ziegler,A.,
            Reffelmann,T., Redfield,M.M., Werdan,K., Mitchell,G.F., Rice,K.,
            Arnett,D.K., Hofman,A., Gottdiener,J.S., Uitterlinden,A.G.,
            Meitinger,T., Blettner,M., Friedrich,N., Wang,T.J., Psaty,B.M., van
            Duijn,C.M., Wichmann,H.E., Munzel,T.F., Kroemer,H.K.,
            Benjamin,E.J., Rotter,J.I., Witteman,J.C., Schunkert,H.,
            Schmidt,H., Volzke,H. and Blankenberg,S.
  TITLE     Genetic variants associated with cardiac structure and function: a
            meta-analysis and replication of genome-wide association data
  JOURNAL   JAMA 302 (2), 168-178 (2009)
   PUBMED   19584346
REFERENCE   8  (bases 1 to 3115)
  AUTHORS   Yang,Q., Kathiresan,S., Lin,J.P., Tofler,G.H. and O'Donnell,C.J.
  TITLE     Genome-wide association and linkage analyses of hemostatic factors
            and hematological phenotypes in the Framingham Heart Study
  JOURNAL   BMC Med Genet 8 Suppl 1 (Suppl 1), S12 (2007)
   PUBMED   17903294
  REMARK    Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BM465182.1, AK296542.1 and AC010349.7.
            
            On Nov 22, 2018 this sequence version replaced NM_001039763.3.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660809.169808.1, AK296542.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000455884.7/ ENSP00000401477.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-6                 BM465182.1         79-84
            7-2356              AK296542.1         1-2350
            2357-3115           AC010349.7         35630-36388
FEATURES             Location/Qualifiers
     source          1..3115
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q22.1"
     gene            1..3115
                     /gene="TMEM232"
                     /note="transmembrane protein 232"
                     /db_xref="GeneID:642987"
                     /db_xref="HGNC:HGNC:37270"
                     /db_xref="MIM:620143"
     exon            1..45
                     /gene="TMEM232"
                     /inference="alignment:Splign:2.1.0"
     exon            46..182
                     /gene="TMEM232"
                     /inference="alignment:Splign:2.1.0"
     CDS             58..2031
                     /gene="TMEM232"
                     /codon_start=1
                     /product="transmembrane protein 232"
                     /protein_id="NP_001034852.3"
                     /db_xref="CCDS:CCDS47253.2"
                     /db_xref="GeneID:642987"
                     /db_xref="HGNC:HGNC:37270"
                     /db_xref="MIM:620143"
                     /translation="MNMPVNKSPMINTCGGISSPYHEELWKLNFQHLSGERGHKSRPT
                     FSITKEFILRFNQTQNSKEKEELLELARKIILRCKRKLGLKTLGSGRHVHLPAAWTEV
                     IYLAQCKGEIQDESLNMLYASLDHASFDYDHLPALFFVAESVLYRLCCDASLKTYLYS
                     VEIKLAKIGYLVFLRLFIFFLHGHLESFKQHLLRLQPYLYALSFSGASYHKYPNIFSN
                     VQFILKASEIIGKRELRSESIFRPVEDKKRYENTDSDMGGYEINHLLWHCVAAWSCVQ
                     NNSPQLNNVLEHLVFHKTQLQKKCWLDSVLALLVLGEAAKLNMACLKALMDVVRDFVS
                     SIMSVQNQEESCKVDDFSWAWNVVYIYTVILAEICLYAATSDLRKTALIGFCHCKSSQ
                     KNILYLDKSVPPELKETSILSLLEYFSSKMSENCDQVVWTGYYGLVYNLVKISWELQG
                     DEEQDGLRNMIWQTLQKTKDYEEDVRIQNAINIAQAELNDPTDPFTRYSTNISSNVGE
                     EVFSKYIGWRIANTLSKLFFPPIEAHFLPLKKPSIKKDQTKYPNKKLESVKKQVLHFT
                     VREHPSVSEIPMFPYPDFFTKADKELAKIIDHHWQEELKIREKEDAICKAQELKDKKL
                     AEKNHFQEVMKKREEKLHKQTKPYELPYRKEVI"
     exon            183..294
                     /gene="TMEM232"
                     /inference="alignment:Splign:2.1.0"
     exon            295..400
                     /gene="TMEM232"
                     /inference="alignment:Splign:2.1.0"
     exon            401..558
                     /gene="TMEM232"
                     /inference="alignment:Splign:2.1.0"
     exon            559..658
                     /gene="TMEM232"
                     /inference="alignment:Splign:2.1.0"
     exon            659..825
                     /gene="TMEM232"
                     /inference="alignment:Splign:2.1.0"
     exon            826..959
                     /gene="TMEM232"
                     /inference="alignment:Splign:2.1.0"
     exon            960..1083
                     /gene="TMEM232"
                     /inference="alignment:Splign:2.1.0"
     exon            1084..1333
                     /gene="TMEM232"
                     /inference="alignment:Splign:2.1.0"
     exon            1334..1512
                     /gene="TMEM232"
                     /inference="alignment:Splign:2.1.0"
     exon            1513..1760
                     /gene="TMEM232"
                     /inference="alignment:Splign:2.1.0"
     exon            1761..1854
                     /gene="TMEM232"
                     /inference="alignment:Splign:2.1.0"
     exon            1855..3115
                     /gene="TMEM232"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2478..2483
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TMEM232"
                     /note="hexamer: AATAAA"
     polyA_site      2500
                     /gene="TMEM232"
                     /note="major polyA site"
     regulatory      3092..3097
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TMEM232"
                     /note="hexamer: AATAAA"
     polyA_site      3115
                     /gene="TMEM232"
ORIGIN      
        1 gtccttagca accagccttg gttcccagcg gctcagagcg cagcgaattt atgatttatg
       61 aatatgcctg ttaacaaatc acctatgatt aatacatgtg gaggcatatc ttccccttat
      121 catgaagagc tctggaaatt aaattttcaa catttaagtg gagaaagggg tcataaatca
      181 aggccaacat tttcaatcac aaaagaattc atcttgagat tcaatcaaac acaaaattcc
      241 aaagagaagg aagaattgtt ggaactagct agaaaaatca ttctcagatg taagagaaaa
      301 ttgggtctca aaaccctggg ctctggaagg catgtgcatc ttcctgctgc atggactgaa
      361 gtaatatatc tggctcaatg caaaggggaa atccaagatg aatctttaaa tatgctttat
      421 gcatctctgg accatgcttc ctttgattat gatcatctgc ctgccttatt ttttgttgcg
      481 gaatcggttt tatacagact gtgttgtgat gcatccctca aaacatattt atattcagtt
      541 gaaataaagc tagcaaagat tggctatttg gtcttcttac gactttttat atttttcctg
      601 catggtcatc tagaaagttt taaacaacat ttacttaggc ttcaaccata tttatacgca
      661 ctttctttct ctggagcatc atatcacaag tatccaaaca tcttttcaaa tgtgcaattc
      721 atcctgaaag cctcggaaat tataggtaaa agagaactcc gttctgaatc catttttaga
      781 cctgtggaag ataagaaaag atatgagaac acagattctg atatgggagg atatgaaatt
      841 aaccacctgc tctggcactg tgttgctgct tggtcttgtg ttcagaataa cagtcctcag
      901 ttgaataacg tgcttgaaca tctcgtcttc cataagacac agcttcaaaa gaaatgctgg
      961 ttggattcag tactggcttt actggtcctt ggggaggctg ccaaattaaa catggcctgc
     1021 ttgaaagctt taatggacgt agtgagagat tttgtttcaa gcattatgtc tgttcaaaat
     1081 caggaagaaa gttgcaaggt agatgatttt tcctgggcct ggaatgtagt ctacatatat
     1141 acagtaattc ttgcagaaat ctgcttgtat gcagccactt ctgatttgcg aaaaactgct
     1201 ttaattggtt tctgtcactg taaaagttca caaaaaaata ttttatactt ggacaaatca
     1261 gtacctccag aattaaagga aacaagtatt ttaagtcttt tggaatattt ctcttcaaaa
     1321 atgtcagaga actgtgatca agtagtctgg actggttact atggcttagt gtataacctg
     1381 gtgaaaattt catgggaact tcaaggagac gaagaacagg atggacttag aaacatgata
     1441 tggcaaacat tgcagaaaac aaaggattat gaggaagatg tacgaatcca aaatgcaatc
     1501 aatatagctc aggctgagtt aaatgaccca actgatcctt tcactagata tagtacaaat
     1561 atttcatcaa atgtaggaga agaagttttc tccaaatata ttgggtggag aattgccaac
     1621 actctttcca aactattctt tccccccatt gaggcccatt ttcttccttt gaagaaacca
     1681 tcaataaaaa aggatcaaac aaaatatcca aataaaaagc tggagtctgt gaaaaagcaa
     1741 gttctacatt tcactgtaag ggaacatcct tctgtatcag aaattcccat gtttccatat
     1801 ccagatttct tcaccaaggc agataaagag ttggcaaaaa tcattgacca tcactggcag
     1861 gaagagctaa agatccgaga aaaagaagat gcaatatgca aggcccaaga acttaaagat
     1921 aaaaagttag cagagaaaaa tcactttcaa gaagttatga agaaaagaga agagaaacta
     1981 cataagcaaa ccaagcccta tgaacttcct tataggaagg aagtaattta attagaaaag
     2041 aaaatgtcac ctcccaaaat tgaggactac atggcagaaa tacataggat gaaaaatacc
     2101 aagatagcta catagtaaga gaactttctt gtcattaaat ggaggtattg tttagaaaga
     2161 atttgttttc ctgatacaag ctgtttgttt aatagttatt tcttagttct aaattaatga
     2221 ccaactttta atcacacttg aatgaagtga tttcactagt caaaaatttc caagactaca
     2281 tctagtattt ttctcaattg acctttatct catgattgta cagcatactt gataactgat
     2341 tctcagaaca ttgatattca tcaaacaaac agtttgatgg aaattcatta caaattaatt
     2401 aatgggtcac cagataagaa ttatttcttg aaaacagaat gaacataaac taacaatcct
     2461 gtaattacta ttattcaaat aaaaacagta tggcatctta tttgattggc attttatagt
     2521 caatttatac caaaccaaac aaaccctatt tcagagattt gaatctggga gggctggtca
     2581 tcttagattg attggcttga tctttaacag atgccagagg ggattcctga gagatggtgg
     2641 ttttactctg ttctgtgagt ttatgagaat gaattcttat gaacctggaa ggtccaggag
     2701 caactgctga agacattcat agaaatagga gttattttag aaatggaact tcacttcatc
     2761 tgaagttctg aacctatgag taagagtaat agggtggagt ttttgtgatg tcttatattc
     2821 ctttcctgaa aactgaaaaa tatagataat actcatacct cgatttcaca cagatgactt
     2881 ggtgatactc aagagacaga gacttttatc aggggtgtca aactcaaatg actaccaggt
     2941 cagaaaggta acataaatta gtgaagccgg ctaaggaata cctatcccat atagagaaat
     3001 ttcccatcac tcggttacat tccaaaatgt atgtcagtat tgtaaaatca tccagccttt
     3061 caagaagctt ttaaatggga ttatttttca aaataaaagt agctaagtaa ccaaa
//
