LOCUS       NM_001136002            2147 bp    mRNA    linear   PRI 03-SEP-2024
DEFINITION  Homo sapiens transmembrane protein 229A (TMEM229A), mRNA.
ACCESSION   NM_001136002 XM_001127856 XM_001127941 XM_001132569 XM_001721439
VERSION     NM_001136002.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2147)
  AUTHORS   Liang,Y.X., Xie,Y.P., Yu,H.M., Zhu,W.J., Yin,C.Y., Dong,Z.H. and
            Zhang,X.L.
  TITLE     Whole-Exome Sequencing and Experimental Validation Unveil the Roles
            of TMEM229A Q200del Mutation in Lung Adenocarcinoma
  JOURNAL   Clin Respir J 18 (8), e70006 (2024)
   PUBMED   39188060
  REMARK    GeneRIF: Whole-Exome Sequencing and Experimental Validation Unveil
            the Roles of TMEM229A Q200del Mutation in Lung Adenocarcinoma.
REFERENCE   2  (bases 1 to 2147)
  AUTHORS   Zhang,X., He,Y., Jiang,Y., Bao,Y., Chen,Q., Xie,D., Yu,H. and
            Wang,X.
  TITLE     TMEM229A suppresses non-small cell lung cancer progression via
            inactivating the ERK pathway
  JOURNAL   Oncol Rep 46 (2) (2021)
   PUBMED   34184076
  REMARK    GeneRIF: TMEM229A suppresses nonsmall cell lung cancer progression
            via inactivating the ERK pathway.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC004690.2, BC157828.1 and BU741231.1.
            
            On May 17, 2019 this sequence version replaced NM_001136002.1.
            
            ##Evidence-Data-START##
            Transcript is intronless :: BC157828.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000455783.3/ ENSP00000395244.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-640               AC004690.2         123305-123944       c
            641-1262            BC157828.1         594-1215
            1263-2141           AC004690.2         121804-122682       c
            2142-2147           BU741231.1         21-26               c
FEATURES             Location/Qualifiers
     source          1..2147
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q31.32"
     gene            1..2147
                     /gene="TMEM229A"
                     /note="transmembrane protein 229A"
                     /db_xref="GeneID:730130"
                     /db_xref="HGNC:HGNC:37279"
     exon            1..2147
                     /gene="TMEM229A"
                     /inference="alignment:Splign:2.1.0"
     CDS             65..1207
                     /gene="TMEM229A"
                     /codon_start=1
                     /product="transmembrane protein 229A"
                     /protein_id="NP_001129474.1"
                     /db_xref="CCDS:CCDS47694.1"
                     /db_xref="GeneID:730130"
                     /db_xref="HGNC:HGNC:37279"
                     /translation="MAGSDVDSEGPARRGGAARRPGAPGGPGSEAAAGCPEPLSTAEA
                     PAESATLPAWMRLYFYGMHGITLDVLVSSARRFARSPDLRMLGFSSPYRCLLHSLTHF
                     ALEKVYLQQRRCPNAFVFNFLLYPSAHVGLQTLAGQALLLSLGGGAGVAVAPGALDLA
                     LQYVLALYHCQVFLKRFLRLRYGRQRRRQQQQQQQQQQQQRRGALPVPPGARVPTAAG
                     ARRRRPRGPRGAGGAPSQGLPDLPRFLFFGMHGFLDEIFFTFFFNVLGQGDGTTSGHT
                     SLWSFFMYGSCSFVVEKLYFHLHYSRGWGTWKRVPIYVIFIYVWELSWGLGLRTCGAC
                     SWDYSHYPLNFMGLITLMYLPGWIFLSVYQDLISNVLWRVQYVPAN"
     regulatory      2124..2129
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TMEM229A"
                     /note="hexamer: AATGAA"
     polyA_site      2147
                     /gene="TMEM229A"
                     /note="major polyA site"
ORIGIN      
        1 gcagctccgc gcacccggca gcggcggcgg tgcagcctcg ggcgttcgga cagcctccga
       61 gcccatggcg gggagcgacg tggacagcga gggccccgca cggaggggcg gcgcggcgcg
      121 gcgtccgggg gcccctggcg ggccaggaag cgaggcggca gccggctgcc cggagccgct
      181 gtccactgct gaagcgccgg ctgagagcgc cacgctgccc gcctggatgc gcctctactt
      241 ctacgggatg cacgggatca ccctggacgt gctggtgtcc tcggcccggc gcttcgcccg
      301 cagcccggac ctgcggatgc taggcttctc ctcgccctac cgctgcctgc tgcactcgct
      361 cacccatttc gccctggaga aggtgtacct gcagcagcgg cgctgtccca acgccttcgt
      421 cttcaatttc ctcctctacc cctcggccca cgtggggctg cagaccctag cgggccaggc
      481 gctactactc agcctgggcg gcggggcggg ggtcgcggtg gcgccagggg cgctggacct
      541 ggcgctgcag tacgtgctgg cgctctacca ctgccaagtg ttcctgaagc gcttcctgcg
      601 cttgcggtac gggcgacaga ggcggcggca gcagcaacag cagcagcagc agcagcagca
      661 gcagcggagg ggcgcgctcc ccgtccctcc cggcgcccgg gtccctactg cggccggagc
      721 ccggcggcga cgaccccgtg gccccagggg cgccggggga gcccccagcc aggggctgcc
      781 cgacctaccc cgctttcttt tcttcggaat gcacggcttt ctggatgaga tcttcttcac
      841 cttcttcttc aacgtactgg ggcaggggga cgggacaacc agcggccaca cgtcgctctg
      901 gtccttcttt atgtacggca gctgcagttt cgtggtggaa aagctctact tccacctcca
      961 ctacagccgc ggttggggca cttggaagcg ggtgcccatc tacgtgatct tcatctacgt
     1021 gtgggagctg tcctggggtc tgggactccg cacgtgcggg gcttgttcct gggactattc
     1081 tcactacccg ctcaatttta tgggcctcat caccctgatg tatttacctg gctggatatt
     1141 ccttagtgtg taccaggacc taatttccaa cgtgttgtgg agggtgcagt acgtaccagc
     1201 taactaaaac caaaaaagaa agaaagaaaa ggaaaaagtc actggattcc cacgaatgga
     1261 tgcgatttat ttttacacat ttaaaatgaa gtgggttttt tagtccttta atttttatac
     1321 gctttactaa actcttccaa attgttttat tccacctttt agtttttcta tttgaaaccc
     1381 gtgtataata tactttgaaa cactactcga aacataattc aaagtacttt atttgccaat
     1441 gttttaaaac atttacaagc ccaaacgttt acacgcccaa acagcaaaac cgttatacct
     1501 taacatcaga atgatgtagt agtgtttacc catctggcaa cagatgagtg acagctacta
     1561 attttttttt ttttggcggg gggggatctt taaatcagag accagtgatt tttacaagat
     1621 ttggctaaat tttctgattc agtgatttgt tttactttct ttttaatcta atttcatttt
     1681 aattccttgc catatttacc aatgactgaa gaaactcaat gtcttgtact cttgagacta
     1741 cagttaatag ctcttaaagt gcctccgtct agcacacaag tgaaaagagg ctgaaaaatg
     1801 tgaaagcacg ttctatgaac agatttttaa atgagaggtc ttttctagca actcacacag
     1861 gtgacactgt gttaagatat ttgatctcca tcctggaaat gattgctttc caatgtgggt
     1921 aagccttaaa cagcaggtgt gttaacgttg atcagatcct gtgttatcta tggctgtaaa
     1981 tttttgttac tgtgcaataa tgtaaaatgt ttaccttaca tagccgaggg ccaagtgaaa
     2041 ttatatcacc ttccacagtg ttctaactcc aaggaccctt ttctacatgg aacttcaagg
     2101 gcagaaacat tacctttgaa taaaatgaac ctgaatgttc actctaa
//
