LOCUS       NM_001195541            1345 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens transmembrane protein 225B (TMEM225B), transcript
            variant 1, mRNA.
ACCESSION   NM_001195541 XM_002342742 XM_002344372 XM_002346019 XM_002346905
VERSION     NM_001195541.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1345)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 1345)
  AUTHORS   Polasek,O., Marusic,A., Rotim,K., Hayward,C., Vitart,V.,
            Huffman,J., Campbell,S., Jankovic,S., Boban,M., Biloglav,Z.,
            Kolcic,I., Krzelj,V., Terzic,J., Matec,L., Tometic,G., Nonkovic,D.,
            Nincevic,J., Pehlic,M., Zedelj,J., Velagic,V., Juricic,D.,
            Kirac,I., Belak Kovacevic,S., Wright,A.F., Campbell,H. and Rudan,I.
  TITLE     Genome-wide association study of anthropometric traits in Korcula
            Island, Croatia
  JOURNAL   Croat Med J 50 (1), 7-16 (2009)
   PUBMED   19260139
REFERENCE   3  (bases 1 to 1345)
  AUTHORS   Harrington,J.J., Sherf,B., Rundlett,S., Jackson,P.D., Perry,R.,
            Cain,S., Leventhal,C., Thornton,M., Ramachandran,R.,
            Whittington,J., Lerner,L., Costanzo,D., McElligott,K., Boozer,S.,
            Mays,R., Smith,E., Veloso,N., Klika,A., Hess,J., Cothren,K., Lo,K.,
            Offenbacher,J., Danzig,J. and Ducar,M.
  TITLE     Creation of genome-wide protein expression libraries using random
            activation of gene expression
  JOURNAL   Nat Biotechnol 19 (5), 440-445 (2001)
   PUBMED   11329013
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DB477974.1, DB462723.1, AA781117.1 and HY200726.1.
            
            On Nov 23, 2018 this sequence version replaced NM_001195541.2.
            
            Transcript Variant: This variant (1) represents the longest
            transcript. Variants 1-3 all encode the same protein.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189667.29651.1,
                                           SRR5189667.333299.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2148093
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000431679.6/ ENSP00000492416.1
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-38                DB477974.1         204-241
            39-515              DB462723.1         2-478
            516-1065            AA781117.1         3-552               c
            1066-1345           HY200726.1         30-309              c
FEATURES             Location/Qualifiers
     source          1..1345
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q22.1"
     gene            1..1345
                     /gene="TMEM225B"
                     /gene_synonym="GS1-259H13.2"
                     /note="transmembrane protein 225B"
                     /db_xref="GeneID:100289187"
                     /db_xref="HGNC:HGNC:53075"
     exon            1..115
                     /gene="TMEM225B"
                     /gene_synonym="GS1-259H13.2"
                     /inference="alignment:Splign:2.1.0"
     exon            116..196
                     /gene="TMEM225B"
                     /gene_synonym="GS1-259H13.2"
                     /inference="alignment:Splign:2.1.0"
     exon            197..407
                     /gene="TMEM225B"
                     /gene_synonym="GS1-259H13.2"
                     /inference="alignment:Splign:2.1.0"
     CDS             200..865
                     /gene="TMEM225B"
                     /gene_synonym="GS1-259H13.2"
                     /note="transmembrane protein 225-like"
                     /codon_start=1
                     /product="transmembrane protein 225B"
                     /protein_id="NP_001182470.1"
                     /db_xref="CCDS:CCDS87525.1"
                     /db_xref="GeneID:100289187"
                     /db_xref="HGNC:HGNC:53075"
                     /translation="MLTLEDKDMKGFSWAIVPALTSLGYLIILVVSIFPFWVRLTNEE
                     SHEVFFSGLFENCFNAKCWKPRPLSIYIILGRVFLLSAVFLAFVTTFIMMPFASEFFP
                     RTWKQNFVLACISFFTGACAFLALVLHALEIKALRMKLGPLQFSVLWPYYVLGFGIFL
                     FIVAGTICLIQEMVCPCWHLLSTSQSMEEDHGSLYLDNLESLGGEPSSVQKETQVTAE
                     TVI"
     exon            408..554
                     /gene="TMEM225B"
                     /gene_synonym="GS1-259H13.2"
                     /inference="alignment:Splign:2.1.0"
     exon            555..692
                     /gene="TMEM225B"
                     /gene_synonym="GS1-259H13.2"
                     /inference="alignment:Splign:2.1.0"
     exon            693..1345
                     /gene="TMEM225B"
                     /gene_synonym="GS1-259H13.2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1102..1107
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TMEM225B"
                     /gene_synonym="GS1-259H13.2"
                     /note="hexamer: AATAAA"
     polyA_site      1127
                     /gene="TMEM225B"
                     /gene_synonym="GS1-259H13.2"
                     /note="major polyA site"
     regulatory      1325..1330
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TMEM225B"
                     /gene_synonym="GS1-259H13.2"
                     /note="hexamer: ATTAAA"
     polyA_site      1345
                     /gene="TMEM225B"
                     /gene_synonym="GS1-259H13.2"
ORIGIN      
        1 aacggaagct ccaggagcgc ggtggagcct ggagtggagg gcgagggtcc caccgtgacc
       61 cgcctggagg gcagcccagc tctgggacgc gaaaccgcct acgacggtgc cgcagcagtt
      121 ccaagagcct ctgagttcct gccttttttc atctctgaat ccccaccatt ggcctacatt
      181 gggagtgggg cgacctgtga tgctgacgtt agaggacaag gacatgaagg gattctcctg
      241 ggccatagtc ccagccttaa cctccctagg ctacctgatt atactggtgg tctccatctt
      301 tcccttctgg gtgcgactga caaacgagga gtcccacgaa gtctttttca gtggcctatt
      361 tgagaactgc ttcaatgcca aatgctggaa gcctcgaccc ttatccattt acatcatcct
      421 cggccgggtt ttcctgctct ctgcagtttt cttggctttc gtcaccacct tcatcatgat
      481 gccctttgca tccgagttct tcccgaggac ctggaagcaa aactttgtgt tagcctgcat
      541 cagcttcttc acaggggcct gtgccttcct ggctttggtg ctgcatgccc tggagatcaa
      601 ggctctgagg atgaagctcg gccccctgca gttctccgtg ctgtggcctt actacgtgct
      661 gggcttcggc atctttctgt tcatagtggc tggtaccatc tgcctcattc aagaaatggt
      721 ttgcccttgc tggcacttgt tgtccacttc ccagagtatg gaggaggacc acgggagcct
      781 gtacctggac aatctggaga gtttgggagg agaaccgagc tcagtacaaa aggagacaca
      841 ggtgacagca gaaacagtca tctagcccag gacatggctt ctttaccctt cttcaagcca
      901 tgtgagtgta cacatgtagc tgtttgtagt cctccccacc ctctctgcca gtatctgtgc
      961 ctttgaggag cttcttgcgt gtcagatcaa ctctccacct ccccatactc acagtgattc
     1021 tatcttgctt gtatgtgaaa tttgctaaaa gtcctttcaa ctcttctgag cttcctaagt
     1081 gacgtttttg caggtatttt caataaaaag aagggctact ttgttcatcc atatctcaaa
     1141 aaccaagtcc gcagggcagg aggggaggga ggaatattac aagataacca agtgaaatgg
     1201 gattttgtga aacagaaacc gtacagaata cagaatatac tcgggggaat gacaactatt
     1261 tgggctggtg gcacaggggt aaaagaattt accaagacgg ttgtagataa agaaaggcag
     1321 atttattaaa ggaagtataa aagta
//
