LOCUS       NM_001013743            1141 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens transmembrane protein 225 (TMEM225), transcript
            variant 1, mRNA.
ACCESSION   NM_001013743 XM_290501
VERSION     NM_001013743.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1141)
  AUTHORS   Matsuura,M. and Yogo,K.
  TITLE     TMEM225: a possible protein phosphatase 1gamma2 (PP1gamma2)
            regulator localizes to the equatorial segment in mouse spermatozoa
  JOURNAL   Mol Reprod Dev 82 (2), 139-148 (2015)
   PUBMED   25605614
REFERENCE   2  (bases 1 to 1141)
  AUTHORS   Wu,J.H., Lemaitre,R.N., Manichaikul,A., Guan,W., Tanaka,T., Foy,M.,
            Kabagambe,E.K., Djousse,L., Siscovick,D., Fretts,A.M., Johnson,C.,
            King,I.B., Psaty,B.M., McKnight,B., Rich,S.S., Chen,Y.D.,
            Nettleton,J.A., Tang,W., Bandinelli,S., Jacobs,D.R. Jr.,
            Browning,B.L., Laurie,C.C., Gu,X., Tsai,M.Y., Steffen,L.M.,
            Ferrucci,L., Fornage,M. and Mozaffarian,D.
  TITLE     Genome-wide association study identifies novel loci associated with
            concentrations of four plasma phospholipid fatty acids in the de
            novo lipogenesis pathway: results from the Cohorts for Heart and
            Aging Research in Genomic Epidemiology (CHARGE) consortium
  JOURNAL   Circ Cardiovasc Genet 6 (2), 171-183 (2013)
   PUBMED   23362303
REFERENCE   3  (bases 1 to 1141)
  AUTHORS   Hendrickx,A., Beullens,M., Ceulemans,H., Den Abt,T., Van Eynde,A.,
            Nicolaescu,E., Lesage,B. and Bollen,M.
  TITLE     Docking motif-guided mapping of the interactome of protein
            phosphatase-1
  JOURNAL   Chem Biol 16 (4), 365-371 (2009)
   PUBMED   19389623
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AP002407.3, AA437068.1, AY634366.1 and BX091037.1.
            
            On Nov 23, 2018 this sequence version replaced NM_001013743.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189655.145476.1, AY634366.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2148093
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000375026.7/ ENSP00000364166.2
            RefSeq Select criteria :: based on expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-28                AP002407.3         3165-3192           c
            29-37               AA437068.1         1-9
            38-645              AY634366.1         1-608
            646-830             BX091037.1         459-643
            831-1135            AY634366.1         794-1098
            1136-1141           AP002407.3         442-447             c
FEATURES             Location/Qualifiers
     source          1..1141
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q24.1"
     gene            1..1141
                     /gene="TMEM225"
                     /gene_synonym="PMP22CD; PPP1R154; SPATA47"
                     /note="transmembrane protein 225"
                     /db_xref="GeneID:338661"
                     /db_xref="HGNC:HGNC:32390"
     exon            1..426
                     /gene="TMEM225"
                     /gene_synonym="PMP22CD; PPP1R154; SPATA47"
                     /inference="alignment:Splign:2.1.0"
     CDS             246..923
                     /gene="TMEM225"
                     /gene_synonym="PMP22CD; PPP1R154; SPATA47"
                     /note="isoform 1 is encoded by transcript variant 1; PMP22
                     claudin domain-containing protein; protein phosphatase 1,
                     regulatory subunit 154; spermatogenesis associated 47"
                     /codon_start=1
                     /product="transmembrane protein 225 isoform 1"
                     /protein_id="NP_001013765.2"
                     /db_xref="CCDS:CCDS31697.1"
                     /db_xref="GeneID:338661"
                     /db_xref="HGNC:HGNC:32390"
                     /translation="MVHVSNRSIQGMNILFSSWAVVLMVMGITLDKWVELISEDERAK
                     MNHSPWMMCCPALWPEDDLKVVRIMMTSSLGLSFLLNLILGMKFTYLIPQNKYIQLFT
                     TILSFFSGISLLWALILYHNKLKQGQSMHFSSYRITWIMYTAYLNVFFLSVCGVLSLL
                     ECKLSTSSCTCLNIHKSDNECKESENSIEDISLPECTAMPRSIVRAHTVNSLNKKVQT
                     RHVTWAL"
     exon            427..573
                     /gene="TMEM225"
                     /gene_synonym="PMP22CD; PPP1R154; SPATA47"
                     /inference="alignment:Splign:2.1.0"
     exon            574..708
                     /gene="TMEM225"
                     /gene_synonym="PMP22CD; PPP1R154; SPATA47"
                     /inference="alignment:Splign:2.1.0"
     exon            709..1141
                     /gene="TMEM225"
                     /gene_synonym="PMP22CD; PPP1R154; SPATA47"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1117..1122
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TMEM225"
                     /gene_synonym="PMP22CD; PPP1R154; SPATA47"
                     /note="hexamer: AATAAA"
     polyA_site      1141
                     /gene="TMEM225"
                     /gene_synonym="PMP22CD; PPP1R154; SPATA47"
                     /note="major polyA site"
ORIGIN      
        1 aaaccaatag atgattccat ggcagttggc agtcctgaca gcaggctggc cctgatagat
       61 aacggaagtg aggaagggtg agagttatct atcttctctg ttttatagac tacttcagct
      121 tctgctgtta ccaatgcctc agcaaccact gaaagttcag atatcaccct tcttgtaact
      181 aatcaaatca aggaagagat ctacaaaata gtggtggtgg ttccagctag aaattttcac
      241 tcacaatggt gcatgtttca aatagaagta tccagggtat gaacatactt ttctcctcct
      301 gggccgtagt cttaatggtg atgggaatca ccttagataa atgggttgaa ttgatttcag
      361 aagatgaaag agccaagatg aaccacagtc cttggatgat gtgttgccct gctctttggc
      421 cagaagatga cctgaaagtg gtcaggatta tgatgacgtc gagccttggc ctttccttcc
      481 tccttaactt aatcctgggt atgaaattca cctatctgat tcctcaaaat aaatatatac
      541 aactcttcac taccatcctc agtttcttct caggtatctc tctgctctgg gcactcatac
      601 tatatcacaa taagctgaag caaggtcaat ccatgcactt ctctagttat aggatcacct
      661 ggatcatgta tactgcttac ttaaatgttt tcttcttgtc tgtctgtgga gtcctctctc
      721 tcctagagtg caagttgtct accagtagct gtacctgcct gaacatccat aaatctgaca
      781 acgaatgtaa ggaatctgag aattctatcg aagatatttc attaccagaa tgcactgcaa
      841 tgcctcgtag cattgtccgt gcacacactg tgaattccct aaacaaaaaa gtccaaacac
      901 gtcacgtaac ctgggctctg tgatttggca atctatttct tgcagtatat gctcatcttt
      961 atggaaaaag ctttgtgggt gtgtgctgtg tctccaacca tgttgtctct atttggaatt
     1021 atggttgggg tttgtaaaaa gatctggaag atggtttttt aaaaaatcct ggcctgctga
     1081 acgaatagtt tcttctgcaa catttgttgt taatataata aatattatca tataaataat
     1141 a
//
