LOCUS       NM_001080501            1273 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens transmembrane protein 223 (TMEM223), mRNA.
ACCESSION   NM_001080501 XM_495878
VERSION     NM_001080501.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1273)
  AUTHORS   Dennerlein,S., Poerschke,S., Oeljeklaus,S., Wang,C.,
            Richter-Dennerlein,R., Sattmann,J., Bauermeister,D., Hanitsch,E.,
            Stoldt,S., Langer,T., Jakobs,S., Warscheid,B. and Rehling,P.
  TITLE     Defining the interactome of the human mitochondrial ribosome
            identifies SMIM4 and TMEM223 as respiratory chain assembly factors
  JOURNAL   Elife 10, e68213 (2021)
   PUBMED   34969438
  REMARK    GeneRIF: Defining the interactome of the human mitochondrial
            ribosome identifies SMIM4 and TMEM223 as respiratory chain assembly
            factors.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1273)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   3  (bases 1 to 1273)
  AUTHORS   Sanchez-Caballero,L., Elurbe,D.M., Baertling,F.,
            Guerrero-Castillo,S., van den Brand,M., van Strien,J., van
            Dam,T.J.P., Rodenburg,R., Brandt,U., Huynen,M.A. and
            Nijtmans,L.G.J.
  TITLE     TMEM70 functions in the assembly of complexes I and V
  JOURNAL   Biochim Biophys Acta Bioenerg 1861 (8), 148202 (2020)
   PUBMED   32275929
REFERENCE   4  (bases 1 to 1273)
  AUTHORS   Hendrickson,S.L., Lautenberger,J.A., Chinn,L.W., Malasky,M.,
            Sezgin,E., Kingsley,L.A., Goedert,J.J., Kirk,G.D., Gomperts,E.D.,
            Buchbinder,S.P., Troyer,J.L. and O'Brien,S.J.
  TITLE     Genetic variants in nuclear-encoded mitochondrial genes influence
            AIDS progression
  JOURNAL   PLoS One 5 (9), e12862 (2010)
   PUBMED   20877624
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1273)
  AUTHORS   Tsuritani,K., Irie,T., Yamashita,R., Sakakibara,Y., Wakaguri,H.,
            Kanai,A., Mizushima-Sugano,J., Sugano,S., Nakai,K. and Suzuki,Y.
  TITLE     Distinct class of putative 'non-conserved' promoters in humans:
            comparative studies of alternative promoters of human and mouse
            genes
  JOURNAL   Genome Res 17 (7), 1005-1014 (2007)
   PUBMED   17567985
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC020914.1, BU684551.1 and AP001160.4.
            
            On May 17, 2019 this sequence version replaced NM_001080501.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1163658.144469.1, BM844030.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000307366.8/ ENSP00000303987.7
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-802               BC020914.1         3-804
            803-929             BU684551.1         18-144              c
            930-1273            AP001160.4         67272-67615         c
FEATURES             Location/Qualifiers
     source          1..1273
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q12.3"
     gene            1..1273
                     /gene="TMEM223"
                     /gene_synonym="Mrx15"
                     /note="transmembrane protein 223"
                     /db_xref="GeneID:79064"
                     /db_xref="HGNC:HGNC:28464"
                     /db_xref="MIM:620434"
     exon            1..328
                     /gene="TMEM223"
                     /gene_synonym="Mrx15"
                     /inference="alignment:Splign:2.1.0"
     CDS             13..621
                     /gene="TMEM223"
                     /gene_synonym="Mrx15"
                     /codon_start=1
                     /product="transmembrane protein 223"
                     /protein_id="NP_001073970.1"
                     /db_xref="CCDS:CCDS44628.1"
                     /db_xref="GeneID:79064"
                     /db_xref="HGNC:HGNC:28464"
                     /db_xref="MIM:620434"
                     /translation="MAAPWRRWPTGLLAVLRPLLTCRPLQGTTLQRDVLLFEHDRGRF
                     FTILGLFCAGQGVFWASMAVAAVSRPPVPVQPLDAEVPNRGPFDLRSALWRYGLAVGC
                     GAIGALVLGAGLLFSLRSVRSVVLRAGGQQVTLTTHAPFGLGAHFTVPLKQVSCMAHR
                     GEVPAMLPLKVKGRRFYFLLDKTGHFPNTKLFDNTVGAYRSL"
     exon            329..1273
                     /gene="TMEM223"
                     /gene_synonym="Mrx15"
                     /inference="alignment:Splign:2.1.0"
     regulatory      876..881
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TMEM223"
                     /gene_synonym="Mrx15"
                     /note="hexamer: AATAAA"
     polyA_site      916
                     /gene="TMEM223"
                     /gene_synonym="Mrx15"
                     /note="major polyA site"
     polyA_site      923
                     /gene="TMEM223"
                     /gene_synonym="Mrx15"
     regulatory      1013..1018
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TMEM223"
                     /gene_synonym="Mrx15"
                     /note="hexamer: AATATA"
     polyA_site      1035
                     /gene="TMEM223"
                     /gene_synonym="Mrx15"
ORIGIN      
        1 agtcggctgg ccatggcggc gccttggagg cgatggccca cggggctgct agccgtgctg
       61 cggcccctgc tcacctgccg gcccctgcaa ggcacgacgc tgcaacggga tgtgctgctc
      121 tttgagcatg atcggggccg cttcttcacc atcctcgggc tgttctgcgc gggccagggc
      181 gtcttctggg cttccatggc tgtggcagcc gtgtcccggc ccccggttcc ggtgcagcct
      241 ctggatgcgg aggtcccaaa tcgtggcccc ttcgacctgc gctccgcgct ctggcgctac
      301 ggtctggccg tcggctgcgg cgccatcgga gccctcgtac tcggtgctgg tcttctcttc
      361 tctctccggt ctgtgcgctc agtggtgctt cgagctggag ggcagcaggt gaccctcacc
      421 actcatgccc cctttggctt gggggcccat ttcacagttc ctttgaagca ggtatcttgc
      481 atggcccacc ggggtgaagt ccctgccatg ctacctctga aagtcaaagg ccgacgcttc
      541 tatttcctct tggacaaaac tggacacttc cctaacacaa aactctttga caatactgtg
      601 ggtgcctacc ggagcttgtg aagaaatgac ctcaagtcac tcacctctcc aagaggagga
      661 taaaaactga accttgggga gccaggtgtg ttggttcaca cctgttgtaa tcccagcact
      721 ttgggagggt gaggcaggag cactgctcga gcccaggctg ggcaacatag cgagaccttg
      781 tctctattta caaaaaaaaa aacaaaaaaa aacgccaatc ttagaatgga gtaacaacca
      841 gggtcacaca aggaggtcaa gattcattaa caacaaataa aggagcagtc atccctaggg
      901 cagctgccta acagtacctc taagtttcag tccatgtctg cttagccttc actccttcct
      961 cctatctagt tgtactttaa catcaaaaac tcactactaa gatgaagaca gtaatataat
     1021 attttggtac aaaaacagct gcaggaagag gtggaggggg gcctgtcatt atgtttcccc
     1081 cccacccccc aacgaaagga aaactaagac tcccaacata aacagggcct tgaggggggg
     1141 gattacaggc acttgggcat ggagtcttcg gctgcaggaa gcactccgct tattcttcag
     1201 gaatgggaaa ggcgtgaccc aacgagagca tctgtctcag agctccactc agggtcaccc
     1261 ctctccagag gcc
//
