LOCUS       NM_001190844            2031 bp    mRNA    linear   PRI 09-FEB-2024
DEFINITION  Homo sapiens transmembrane protein 221 (TMEM221), mRNA.
ACCESSION   NM_001190844 XM_001718752 XM_001719696
VERSION     NM_001190844.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2031)
  AUTHORS   Aramaki,T., Sasai,N., Yakura,R. and Sasai,Y.
  TITLE     Jiraiya attenuates BMP signaling by interfering with type II BMP
            receptors in neuroectodermal patterning
  JOURNAL   Dev Cell 19 (4), 547-561 (2010)
   PUBMED   20951346
REFERENCE   2  (bases 1 to 2031)
  AUTHORS   Choy,K.W., Wang,C.C., Ogura,A., Lau,T.K., Rogers,M.S., Ikeo,K.,
            Gojobori,T., Lam,D.S. and Pang,C.P.
  TITLE     Genomic annotation of 15,809 ESTs identified from pooled early
            gestation human eyes
  JOURNAL   Physiol Genomics 25 (1), 9-15 (2006)
   PUBMED   16368877
REFERENCE   3  (bases 1 to 2031)
  AUTHORS   Grimwood,J., Gordon,L.A., Olsen,A., Terry,A., Schmutz,J.,
            Lamerdin,J., Hellsten,U., Goodstein,D., Couronne,O.,
            Tran-Gyamfi,M., Aerts,A., Altherr,M., Ashworth,L., Bajorek,E.,
            Black,S., Branscomb,E., Caenepeel,S., Carrano,A., Caoile,C.,
            Chan,Y.M., Christensen,M., Cleland,C.A., Copeland,A., Dalin,E.,
            Dehal,P., Denys,M., Detter,J.C., Escobar,J., Flowers,D.,
            Fotopulos,D., Garcia,C., Georgescu,A.M., Glavina,T., Gomez,M.,
            Gonzales,E., Groza,M., Hammon,N., Hawkins,T., Haydu,L., Ho,I.,
            Huang,W., Israni,S., Jett,J., Kadner,K., Kimball,H., Kobayashi,A.,
            Larionov,V., Leem,S.H., Lopez,F., Lou,Y., Lowry,S., Malfatti,S.,
            Martinez,D., McCready,P., Medina,C., Morgan,J., Nelson,K.,
            Nolan,M., Ovcharenko,I., Pitluck,S., Pollard,M., Popkie,A.P.,
            Predki,P., Quan,G., Ramirez,L., Rash,S., Retterer,J., Rodriguez,A.,
            Rogers,S., Salamov,A., Salazar,A., She,X., Smith,D., Slezak,T.,
            Solovyev,V., Thayer,N., Tice,H., Tsai,M., Ustaszewska,A., Vo,N.,
            Wagner,M., Wheeler,J., Wu,K., Xie,G., Yang,J., Dubchak,I.,
            Furey,T.S., DeJong,P., Dickson,M., Gordon,D., Eichler,E.E.,
            Pennacchio,L.A., Richardson,P., Stubbs,L., Rokhsar,D.S.,
            Myers,R.M., Rubin,E.M. and Lucas,S.M.
  TITLE     The DNA sequence and biology of human chromosome 19
  JOURNAL   Nature 428 (6982), 529-535 (2004)
   PUBMED   15057824
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC010319.10 and BY797043.2.
            
            On Nov 22, 2018 this sequence version replaced NM_001190844.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BM925642.1, SRR1803611.484958.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2144120, SAMEA2145245
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000341130.6/ ENSP00000342162.5
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-101               AC010319.10        42920-43020
            102-491             BY797043.2         1-390
            492-492             AC010319.10        43411-43411
            493-680             BY797043.2         392-579
            681-2031            AC010319.10        54729-56079
FEATURES             Location/Qualifiers
     source          1..2031
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.11"
     gene            1..2031
                     /gene="TMEM221"
                     /gene_synonym="Jiraiya"
                     /note="transmembrane protein 221"
                     /db_xref="GeneID:100130519"
                     /db_xref="HGNC:HGNC:21943"
     exon            1..526
                     /gene="TMEM221"
                     /gene_synonym="Jiraiya"
                     /inference="alignment:Splign:2.1.0"
     CDS             207..1082
                     /gene="TMEM221"
                     /gene_synonym="Jiraiya"
                     /note="Putative transmembrane protein ENSP00000342162"
                     /codon_start=1
                     /product="transmembrane protein 221"
                     /protein_id="NP_001177773.1"
                     /db_xref="CCDS:CCDS54230.1"
                     /db_xref="GeneID:100130519"
                     /db_xref="HGNC:HGNC:21943"
                     /translation="MARSYGGRVLAAMTLLGIAAAVLAALGAQLLFQLQAGRAELRGL
                     RAEGLGQELGAGPGLPEDAAGTLLPLAAALAALVLVLGFTCLLLAALCGHLGAELARG
                     PGPRRSDWFLYDCRLLRHVALGLFCCGISVYLAALSIYALLLFEIETGAAAASILGSG
                     TLVLVAVLTHTLLRAARAARRGLHELSPPSFEDDLARPAEVSKASPRAQPQQGIHRRT
                     PYSTCPEPGDPFGSMATATAPAALEGGWESSLPASRMHRTLSAGLGHWDGVTHEMRRM
                     LGHRPGSMGKDSTLV"
     exon            527..612
                     /gene="TMEM221"
                     /gene_synonym="Jiraiya"
                     /inference="alignment:Splign:2.1.0"
     exon            613..2031
                     /gene="TMEM221"
                     /gene_synonym="Jiraiya"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2011..2016
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TMEM221"
                     /gene_synonym="Jiraiya"
                     /note="hexamer: AGTAAA"
     polyA_site      2031
                     /gene="TMEM221"
                     /gene_synonym="Jiraiya"
                     /note="major polyA site"
ORIGIN      
        1 gagattcggc gtcccggctg cgaccagcac cccggagccc ccgtccgtct ggcgaccccc
       61 agcccagtcc ccgaactttc agacactccc tgcggccccg ccccctcggg gaccccctga
      121 ggaccctcgg attcccccca actcccctgc cctctaaaac cacttcaatt cctcaactct
      181 tcccccggcc cgcaggaacc cccgccatgg cccgttctta cggcggccgg gtgctggctg
      241 caatgaccct gctgggcatc gcggcggccg tgctggcggc gctgggcgcg cagctgctgt
      301 ttcagctgca ggcgggccgc gccgagctgc gggggctgcg cgccgagggg ctgggccagg
      361 agctgggcgc cggccccggg ctgccagagg acgcggccgg gacgctgctg ccgctggccg
      421 ccgcgctggc cgcgctggtg ctcgtgctgg ggttcacctg cttgctgctc gccgcgctct
      481 gtggccacct gggcgccgag ctggcgcggg ggcctggccc caggaggtct gactggtttc
      541 tctacgactg ccgcctcctc agacatgtgg cccttggcct tttctgctgt gggatctccg
      601 tctatttagc agcactgtcc atctatgcct tgctactttt cgagatcgag acaggcgcag
      661 cagctgcttc catcctcggc tcgggcaccc tggttctggt ggctgtgctg acccacactc
      721 tcctccgggc tgcccgggct gcccgccgtg ggctccatga gttgtccccg ccatcctttg
      781 aagacgacct cgcccgccct gccgaagtct ccaaggccag ccccagagct cagcctcagc
      841 agggtatcca tcgtcggacc ccctattcaa cctgtccaga gcctggggac ccctttgggt
      901 ccatggccac tgccacagca cctgcagccc tggagggagg ctgggagagc agcctgcctg
      961 catccagaat gcaccggaca ctgtcggctg gcctggggca ctgggacggg gttacgcacg
     1021 agatgcgtcg aatgctgggc cacagaccag ggagcatggg gaaggactcc acactggtgt
     1081 gagcccaggg atgaggaata gagacctggt gtaagaaaag gataccatag agataggttc
     1141 gggttcagct gcagtagcag taggacttga tttttctctc attttattgc atccttggct
     1201 tttgtcctca aggttgcctc gtggcacaaa ataattgcca gagctccagc cttcacctcc
     1261 tcattctgag ggaaagtcag aggccagcgc tggctaggtg tctcctggaa gtcttcccag
     1321 gaagcctcga aacccttctt tttatatccc actggccaga acagagcgaa atggccatac
     1381 cttgctgcag gggaggctgg gaaatgtggc tgtccagatg gatgagattc tgttacaggc
     1441 ataaggggag cggggggctt aggcagtgat tctctaagtg tctccatcca tttcacagat
     1501 gaggaaacgg aggccccaag agaggcagtg actcaccagg gggcccacgg ccaggactga
     1561 gcaccagagc caggattctc acctgaaccc cataatctcc atgctgctga tgtgcaagtc
     1621 tcagactctg caaaatccac tgcaccccct cgggctgtga acatttcaaa tccatgtgtg
     1681 ccaagcttgg agcagcccag ggccaggggc acggctggag agctggaccc aggttcctgg
     1741 ctgtggaccc atggctgagg gcttagctgc tttgtgcctc agtttcctca tctgtaatat
     1801 ggggacacga agtggccctg tctccaaggg ctctgacaag acacatgact tcatgtgagg
     1861 cattccgggg acccccacac aataggtcct caatgtgtgt taatcgttct catgctgctg
     1921 ctgcttttgg ggtgtaggca tgggtagttt ctggggctca aggaaataac agaggggtct
     1981 ccaaaggtct cctgtcttgc acaacccaca agtaaactct gatattcact a
//
