LOCUS       NM_001004313            2813 bp    mRNA    linear   PRI 09-JUN-2024
DEFINITION  Homo sapiens transmembrane protein 220 (TMEM220), transcript
            variant 1, mRNA.
ACCESSION   NM_001004313 XM_371016
VERSION     NM_001004313.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2813)
  AUTHORS   Li,T., Guan,L., Tang,G., He,B., Huang,L., Wang,J., Li,M., Bai,Y.,
            Li,X. and Zhang,H.
  TITLE     Downregulation of TMEM220 promotes tumor progression in
            Hepatocellular Carcinoma
  JOURNAL   Cancer Gene Ther 29 (6), 835-844 (2022)
   PUBMED   34321624
  REMARK    GeneRIF: Downregulation of TMEM220 promotes tumor progression in
            Hepatocellular Carcinoma.
REFERENCE   2  (bases 1 to 2813)
  AUTHORS   Rong,H., Li,Y., Hu,S., Gao,L., Yi,T., Xie,Y., Cai,P., Li,J.,
            Dai,X., Ye,M. and Liao,Q.
  TITLE     Prognostic signatures and potential pathogenesis of eRNAs-related
            genes in colon adenocarcinoma
  JOURNAL   Mol Carcinog 61 (1), 59-72 (2022)
   PUBMED   34622496
  REMARK    GeneRIF: Prognostic signatures and potential pathogenesis of
            eRNAs-related genes in colon adenocarcinoma.
REFERENCE   3  (bases 1 to 2813)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 2813)
  AUTHORS   Choi,B., Han,T.S., Min,J., Hur,K., Lee,S.M., Lee,H.J., Kim,Y.J. and
            Yang,H.K.
  TITLE     MAL and TMEM220 are novel DNA methylation markers in human gastric
            cancer
  JOURNAL   Biomarkers 22 (1), 35-44 (2017)
   PUBMED   27329150
  REMARK    GeneRIF: MAL and TMEM220 were specifically methylated and were
            down-regulated in human gastric cancer
REFERENCE   5  (bases 1 to 2813)
  AUTHORS   Brandler,W.M., Morris,A.P., Evans,D.M., Scerri,T.S., Kemp,J.P.,
            Timpson,N.J., St Pourcain,B., Smith,G.D., Ring,S.M., Stein,J.,
            Monaco,A.P., Talcott,J.B., Fisher,S.E., Webber,C. and Paracchini,S.
  TITLE     Common variants in left/right asymmetry genes and pathways are
            associated with relative hand skill
  JOURNAL   PLoS Genet 9 (9), e1003751 (2013)
   PUBMED   24068947
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC002347.3.
            
            On Aug 31, 2019 this sequence version replaced NM_001004313.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY550194.1, AK289624.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000341871.8/ ENSP00000339830.4
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-244               AC002347.3         14361-14604
            245-274             AC002347.3         15324-15353
            275-335             AC002347.3         18120-18180
            336-459             AC002347.3         19250-19373
            460-519             AC002347.3         21055-21114
            520-2813            AC002347.3         28796-31089
FEATURES             Location/Qualifiers
     source          1..2813
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17p13.1"
     gene            1..2813
                     /gene="TMEM220"
                     /note="transmembrane protein 220"
                     /db_xref="GeneID:388335"
                     /db_xref="HGNC:HGNC:33757"
     exon            1..244
                     /gene="TMEM220"
                     /inference="alignment:Splign:2.1.0"
     CDS             173..655
                     /gene="TMEM220"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /codon_start=1
                     /product="transmembrane protein 220 isoform 1"
                     /protein_id="NP_001004313.1"
                     /db_xref="CCDS:CCDS32567.1"
                     /db_xref="GeneID:388335"
                     /db_xref="HGNC:HGNC:33757"
                     /translation="MAPALWRACNGLMAAFFALAALVQVNDPDAEVWVVVYTIPAVLT
                     LLVGLNPEVTGNVIWKSISAIHILFCTVWAVGLASYLLHRTQQNILHEEEGRELSGLV
                     IITAWIILCHSSSKNPVGGRIQLAIAIVITLFPFISWVYIYINKEMRSSWPTHCKTVI
                     "
     exon            245..274
                     /gene="TMEM220"
                     /inference="alignment:Splign:2.1.0"
     exon            275..335
                     /gene="TMEM220"
                     /inference="alignment:Splign:2.1.0"
     exon            336..459
                     /gene="TMEM220"
                     /inference="alignment:Splign:2.1.0"
     exon            460..519
                     /gene="TMEM220"
                     /inference="alignment:Splign:2.1.0"
     exon            520..2813
                     /gene="TMEM220"
                     /inference="alignment:Splign:2.1.0"
     regulatory      655..660
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TMEM220"
                     /note="hexamer: AATAAA"
     polyA_site      682
                     /gene="TMEM220"
                     /note="major polyA site"
     regulatory      2002..2007
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TMEM220"
                     /note="hexamer: ATTAAA"
     polyA_site      2021
                     /gene="TMEM220"
     regulatory      2279..2284
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TMEM220"
                     /note="hexamer: TATAAA"
     polyA_site      2298
                     /gene="TMEM220"
ORIGIN      
        1 cttcgctccc cgcccccggg cggagcgacg gccacggcag tgtccccaag gcaccgaaac
       61 cgaggcgggg gtctcggtcc ctccgcgcaa ggaggaaggc ggaccgtacg tggcaggact
      121 caccgccccg cacgtggcag gactcaccgc cccgcgccgt gttctccgag ccatggcgcc
      181 agcgctgtgg cgggcctgca acggactcat ggccgccttc ttcgcgctgg cggccttggt
      241 gcaggtaaat gacccagatg cagaggtgtg ggtggtggtg tacacaatcc ctgcagtact
      301 gaccctgctt gttggactta accctgaagt cacaggtaat gttatttgga aaagtatctc
      361 tgcaatacac atactctttt gtacggtgtg ggctgttggc ttggcgtcct acctcttgca
      421 tcgtacacaa cagaacatct tacatgagga agaaggcagg gagctgtctg gtctggtgat
      481 tattacagca tggattatcc tgtgccacag ttcctcaaag aatccagttg gtggaagaat
      541 tcaattggct attgccattg taatcacact tttcccattt atctcatggg tctacatata
      601 tattaacaag gaaatgcggt cctcttggcc aactcactgc aagacagtaa tttaaataaa
      661 ttcaagaact tcgtttttaa aatgaatatt ttcaatcaat tttttataaa cattagggga
      721 acaagccagg agtttatttc aggtaatttg ggctaatagt tttaaaactc caaataactt
      781 tttaagggtg catataattc gatgtaagat tggatgggac aagtaagaga tggtctgata
      841 ttttccagac gactttctgc agggtcttgt gtcataatgt agtggaaaag gctagagaat
      901 agaagtttaa aaatacgagt tctaacttaa ctttgtaact atgtaatttg ggcaaatata
      961 taaacctcct ggtggatatt tatctataaa ataggattaa tgccagatct acttacttac
     1021 acagtaacaa ggatcaatct agataatgta agaacactct gaagatataa agtgtttgga
     1081 aagattacgg agggctgccc atgattaaaa tagaggggag cagggattgg gtaatatact
     1141 gaaatagaca ttcaagagag ggctataccc cgatcttttt ttttttttaa gacagtccca
     1201 ctctattgcc caggctggag tgcagtggca tgatcatggc tcactgcagt cctgacctcc
     1261 cggggctcag gtgatcctcc tacctcagcc tcccaagaag ctacgactac aagtgtgcac
     1321 caccatgccc ggctaaattt ttttaaattt tttgtagagg cagggtttca ccgtgttgtc
     1381 caggctggtc ttgaattcct gagttcaagc gatctgtcca ccttggcctc ccaaagtgct
     1441 gggattacag gtgtgagcca ccatgcccag tccagcccta aactaatctt atccagagct
     1501 ggcatagtgc agtgaactaa aggagaactc tagatgaatc aaatgagcag gcatgtcttg
     1561 gaaagaaagg gaagctggat agaataaagg aattagggac caaacaagaa ggcaataggg
     1621 actataacta cattctaaat gagaaataag gtcaaaatct atatacattc tttataaatg
     1681 gatgtccaaa gtaatcctag ggaggagagc tttttttttt ttcatttcca ttttcattta
     1741 aaaatggata cttgattatt ggaaaactta caattgtgtt tggaacaact tgggtatttg
     1801 aatctaattt tccaattgca aattttatga tacctaaata cagataaagt atttccaatg
     1861 aaaatttagt gtccaaatga gtggggctat aaatgtaaaa tacactggat tttaaagaca
     1921 tggtagaaaa agaacagaaa atattttttg tattgattac atgttgaaac aatattttgg
     1981 ctataatggg ttaaatatac tattaaagtt gattttatct gtttctgttt acttttattt
     2041 acgtggctta cattgcattt ctgttggaca gtcctgtatt taagtatcta gatggcaaca
     2101 ttttacatac acaagcatca aactctgtgg tcagatactg ttttttctga tctaggaaag
     2161 agatctggga aatacttcac tcaaaaagaa cgagtagtgc cttccacagg ttaggagagt
     2221 gtaaatgagt ctggtagttt gtctattttt attgtcttta ttactatagt aaatattcta
     2281 taaatatttg ttaaaggagg tatgtgtatt ttgtttttgt tattggcaca gtggccactg
     2341 aatggtgaga aattatctaa gattaagact tgaatgagta aaaaggggga aaacaaatct
     2401 agttgatatt aaaacagtca aagtgaaact taagggtcag taaaatacac ataaaggatt
     2461 tgagttttcc agtgtatatt ttgcttacat atttgtggct tttataactc ctttagtatt
     2521 aataaactac tgaagtcaca tgcaaaaaaa aaacagactc atttgcaaat tccctgtggg
     2581 ctctatccat tgaccaagtc atgtttactt ctgtgcttaa agacagtaat gttcaagatg
     2641 tgctttcatc atgtatgcct ctcccatatc agactacgaa attatgtgac tattcatagt
     2701 ctctttcgca tcttcagtta agcatataaa aggcactttt ggtggaatag tcttttgaag
     2761 agtattaatg aaattgaatt taagtattat tattaaattt aatatttcta tta
//
