LOCUS       NM_001083613             946 bp    mRNA    linear   PRI 09-FEB-2025
DEFINITION  Homo sapiens transmembrane protein 219 (TMEM219), transcript
            variant 1, mRNA.
ACCESSION   NM_001083613
VERSION     NM_001083613.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 946)
  AUTHORS   D'Addio,F., Assi,E., Maestroni,A., Rossi,G., Usuelli,V.,
            Petrazzuolo,A., Nardini,M., Loretelli,C., Ben Nasr,M. and
            Fiorina,P.
  TITLE     TMEM219 regulates the transcription factor expression and
            proliferation of beta cells
  JOURNAL   Front Endocrinol (Lausanne) 15, 1306127 (2024)
   PUBMED   38318298
  REMARK    GeneRIF: TMEM219 regulates the transcription factor expression and
            proliferation of beta cells.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 946)
  AUTHORS   D'Addio,F., Maestroni,A., Assi,E., Ben Nasr,M., Amabile,G.,
            Usuelli,V., Loretelli,C., Bertuzzi,F., Antonioli,B., Cardarelli,F.,
            El Essawy,B., Solini,A., Gerling,I.C., Bianchi,C., Becchi,G.,
            Mazzucchelli,S., Corradi,D., Fadini,G.P., Foschi,D., Markmann,J.F.,
            Orsi,E., Skrha,J. Jr., Camboni,M.G., Abdi,R., James Shapiro,A.M.,
            Folli,F., Ludvigsson,J., Del Prato,S., Zuccotti,G. and Fiorina,P.
  TITLE     The IGFBP3/TMEM219 pathway regulates beta cell homeostasis
  JOURNAL   Nat Commun 13 (1), 684 (2022)
   PUBMED   35115561
  REMARK    GeneRIF: The IGFBP3/TMEM219 pathway regulates beta cell
            homeostasis.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 946)
  AUTHORS   Zhou,Y., He,C.H., Yang,D.S., Nguyen,T., Cao,Y., Kamle,S., Lee,C.M.,
            Gochuico,B.R., Gahl,W.A., Shea,B.S., Lee,C.G. and Elias,J.A.
  TITLE     Galectin-3 Interacts with the CHI3L1 Axis and Contributes to
            Hermansky-Pudlak Syndrome Lung Disease
  JOURNAL   J Immunol 200 (6), 2140-2153 (2018)
   PUBMED   29427412
REFERENCE   4  (bases 1 to 946)
  AUTHORS   Lee,C.M., He,C.H., Nour,A.M., Zhou,Y., Ma,B., Park,J.W., Kim,K.H.,
            Dela Cruz,C., Sharma,L., Nasr,M.L., Modis,Y., Lee,C.G. and
            Elias,J.A.
  TITLE     IL-13Ralpha2 uses TMEM219 in chitinase 3-like-1-induced signalling
            and effector responses
  JOURNAL   Nat Commun 7, 12752 (2016)
   PUBMED   27629921
  REMARK    GeneRIF: critical role in Chi3l1-induced IL-13Ralpha2 mediated
            signalling and tissue responses
            Erratum:[Nat Commun. 2016 Nov 14;7:13541. doi:
            10.1038/ncomms13541.. PMID: 27841275]
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 946)
  CONSRTM   Schizophrenia Working Group of the Psychiatric Genomics Consortium
  TITLE     Biological insights from 108 schizophrenia-associated genetic loci
  JOURNAL   Nature 511 (7510), 421-427 (2014)
   PUBMED   25056061
REFERENCE   6  (bases 1 to 946)
  AUTHORS   Baxter,R.C.
  TITLE     Insulin-like growth factor binding protein-3 (IGFBP-3): Novel
            ligands mediate unexpected functions
  JOURNAL   J Cell Commun Signal 7 (3), 179-189 (2013)
   PUBMED   23700234
REFERENCE   7  (bases 1 to 946)
  AUTHORS   Ingermann,A.R., Yang,Y.F., Han,J., Mikami,A., Garza,A.E.,
            Mohanraj,L., Fan,L., Idowu,M., Ware,J.L., Kim,H.S., Lee,D.Y. and
            Oh,Y.
  TITLE     Identification of a novel cell death receptor mediating
            IGFBP-3-induced anti-tumor effects in breast and prostate cancer
  JOURNAL   J Biol Chem 285 (39), 30233-30246 (2010)
   PUBMED   20353938
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DB506492.1 and BC050051.1.
            
            On Nov 24, 2018 this sequence version replaced NM_001083613.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189655.18695.1, HM005516.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000279396.11/ ENSP00000279396.6
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-267               DB506492.1         50-316
            268-946             BC050051.1         344-1022
FEATURES             Location/Qualifiers
     source          1..946
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16p11.2"
     gene            1..946
                     /gene="TMEM219"
                     /gene_synonym="IGFBP-3R; IGFBP3R"
                     /note="transmembrane protein 219"
                     /db_xref="GeneID:124446"
                     /db_xref="HGNC:HGNC:25201"
                     /db_xref="MIM:620290"
     exon            1..54
                     /gene="TMEM219"
                     /gene_synonym="IGFBP-3R; IGFBP3R"
                     /inference="alignment:Splign:2.1.0"
     exon            55..256
                     /gene="TMEM219"
                     /gene_synonym="IGFBP-3R; IGFBP3R"
                     /inference="alignment:Splign:2.1.0"
     CDS             92..814
                     /gene="TMEM219"
                     /gene_synonym="IGFBP-3R; IGFBP3R"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; insulin-like growth factor-binding protein 3
                     receptor; testicular tissue protein Li 203"
                     /codon_start=1
                     /product="insulin-like growth factor-binding protein 3
                     receptor isoform 1 precursor"
                     /protein_id="NP_001077082.1"
                     /db_xref="CCDS:CCDS42145.1"
                     /db_xref="GeneID:124446"
                     /db_xref="HGNC:HGNC:25201"
                     /db_xref="MIM:620290"
                     /translation="MGNCQAGHNLHLCLAHHPPLVCATLILLLLGLSGLGLGSFLLTH
                     RTGLRSPDIPQDWVSFLRSFGQLTLCPRNGTVTGKWRGSHVVGLLTTLNFGDGPDRNK
                     TRTFQATVLGSQMGLKGSSAGQLVLITARVTTERTAGTCLYFSAVPGILPSSQPPISC
                     SEEGAGNATLSPRMGEECVSVWSHEGLVLTKLLTSEELALCGSRLLVLGSFLLLFCGL
                     LCCVTAMCFHPRRESHWSRTRL"
     exon            257..446
                     /gene="TMEM219"
                     /gene_synonym="IGFBP-3R; IGFBP3R"
                     /inference="alignment:Splign:2.1.0"
     exon            447..676
                     /gene="TMEM219"
                     /gene_synonym="IGFBP-3R; IGFBP3R"
                     /inference="alignment:Splign:2.1.0"
     exon            677..847
                     /gene="TMEM219"
                     /gene_synonym="IGFBP-3R; IGFBP3R"
                     /inference="alignment:Splign:2.1.0"
     exon            848..946
                     /gene="TMEM219"
                     /gene_synonym="IGFBP-3R; IGFBP3R"
                     /inference="alignment:Splign:2.1.0"
     regulatory      926..931
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TMEM219"
                     /gene_synonym="IGFBP-3R; IGFBP3R"
                     /note="hexamer: AATAAA"
     polyA_site      946
                     /gene="TMEM219"
                     /gene_synonym="IGFBP-3R; IGFBP3R"
                     /note="major polyA site"
ORIGIN      
        1 gcggccccgc tcgtgacgtc gcggggggcg ccggcctccg cccggccccg agggcaggct
       61 ctccccggag gctcagcccc ctctgctccc catgggcaac tgccaggcag ggcacaacct
      121 gcacctgtgt ctggcccacc acccacctct ggtctgtgcc actttgatcc tgctgctcct
      181 tggcctctct ggcctgggcc ttggcagctt cctcctcacc cacaggactg gcctgcgcag
      241 ccctgacatc ccccaggact gggtctcttt tttgagatct tttggccagc tgaccctgtg
      301 tcccaggaat gggacagtca cagggaagtg gcgagggtct cacgtcgtgg gcttgctgac
      361 caccttgaac ttcggagacg gtccagacag gaacaagacc cggacattcc aggccacagt
      421 cctgggaagt cagatgggat tgaaaggatc ttctgcagga caactggtcc ttatcacagc
      481 cagggtgacc acagaaagga ctgcaggaac ctgcctatat tttagtgctg ttccaggaat
      541 cctaccctcc agccagccac ccatatcctg ctcagaggag ggggctggaa atgccaccct
      601 gagccctaga atgggtgagg aatgtgttag tgtctggagc catgaaggcc ttgtgctgac
      661 caagctgctc acctcggagg agctggctct gtgtggctcc aggctgctgg tcttgggctc
      721 cttcctgctt ctcttctgtg gccttctctg ctgtgtcact gctatgtgct tccacccgcg
      781 ccgggagtcc cactggtcta gaacccggct ctgagggcac tggcctagtt cccgacttgt
      841 ttctcaggtg tgaatcaact tcttgggcct tggctctgag ttggaaaagg ttttagaaaa
      901 agtgaagagc tggaatgtgg gggaaaataa aaagcttttt tgccca
//
