LOCUS       NM_212558               5342 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens transmembrane protein 215 (TMEM215), mRNA.
ACCESSION   NM_212558
VERSION     NM_212558.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5342)
  AUTHORS   Liu,Y., Zheng,Q., He,G., Zhang,M., Yan,X., Yang,Z., Zhang,P.,
            Wang,L., Liu,J., Liang,L. and Han,H.
  TITLE     Transmembrane protein 215 promotes angiogenesis by maintaining
            endothelial cell survival
  JOURNAL   J Cell Physiol 234 (6), 9525-9534 (2019)
   PUBMED   30370660
  REMARK    GeneRIF: These results identified TMEM215 as a novel molecule
            involved in angiogenesis by regulating the survival of endothelial
            cells.
REFERENCE   2  (bases 1 to 5342)
  AUTHORS   Pajewski,N.M., Shrestha,S., Quinn,C.P., Parker,S.D., Wiener,H.,
            Aissani,B., McKinney,B.A., Poland,G.A., Edberg,J.C., Kimberly,R.P.,
            Tang,J. and Kaslow,R.A.
  TITLE     A genome-wide association study of host genetic determinants of the
            antibody response to Anthrax Vaccine Adsorbed
  JOURNAL   Vaccine 30 (32), 4778-4784 (2012)
   PUBMED   22658931
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BX647550.1, AL157884.9 and BM681172.1.
            
            On Nov 23, 2018 this sequence version replaced NM_212558.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BX647550.1, AK125320.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968189, SAMEA1968968
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000342743.6/ ENSP00000345468.5
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-980               BX647550.1         1-980
            981-4856            AL157884.9         78227-82102
            4857-5342           BM681172.1         17-502              c
FEATURES             Location/Qualifiers
     source          1..5342
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9p21.1"
     gene            1..5342
                     /gene="TMEM215"
                     /note="transmembrane protein 215"
                     /db_xref="GeneID:401498"
                     /db_xref="HGNC:HGNC:33816"
     exon            1..266
                     /gene="TMEM215"
                     /inference="alignment:Splign:2.1.0"
     exon            267..5342
                     /gene="TMEM215"
                     /inference="alignment:Splign:2.1.0"
     CDS             325..1032
                     /gene="TMEM215"
                     /codon_start=1
                     /product="transmembrane protein 215"
                     /protein_id="NP_997723.2"
                     /db_xref="CCDS:CCDS6530.1"
                     /db_xref="GeneID:401498"
                     /db_xref="HGNC:HGNC:33816"
                     /translation="MRPDDINPRTGLVVALVSVFLVFGFMFTVSGMKGETLGNIPLLA
                     IGPAICLPGIAAIALARKTEGCTKWPENELLWVRKLPCFRKPKDKEVVELLRTPSDLE
                     SGKGSSDELAKKAGLRGKPPPQSQGEVSVASSINSPTPTEEGECQSLVQNGHQEETSR
                     YLDGYCPSGSSLTYSALDVKCSARDRSECPEPEDSIFFVPQDSIIVCSYKQNSPYDRY
                     CCYINQIQGRWDHETIV"
     regulatory      1449..1454
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TMEM215"
                     /note="hexamer: AATAAA"
     polyA_site      1479
                     /gene="TMEM215"
                     /note="major polyA site"
     regulatory      3521..3526
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TMEM215"
                     /note="hexamer: AATAAA"
     polyA_site      3540
                     /gene="TMEM215"
     regulatory      5319..5324
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TMEM215"
                     /note="hexamer: AATAAA"
     polyA_site      5342
                     /gene="TMEM215"
ORIGIN      
        1 agactcagtg ctccctcctc ctcccgcgcc ccgcgctctg cgcgctgagc tggcgccggg
       61 ctccgcttgc acagcaccgg gaccgacggg cactgctggg agagccgctc tcccaggttc
      121 cacctccccg atgcagagtc cgtgggggaa accaggcttt cctcccagaa ccaagggagc
      181 gagccgaggg ggcagctgct gtgggggctt ctgaggagac agcctggctt ctttccctac
      241 ttcctggaga gggcaggaaa cctcagaata gaggaacgct gctccctggt cagcaagcag
      301 cccccaacct ggatggagtg aaacatgcgg cctgatgaca ttaacccgag gactgggctg
      361 gtggtggccc tggtcagtgt cttcctcgtc tttggtttca tgttcaccgt ctctgggatg
      421 aaaggggaga ctttgggaaa catccccctc ctggccatcg ggccagccat ctgcctacca
      481 ggcatcgcag ccattgccct ggccaggaaa accgagggat gcaccaagtg gccagagaac
      541 gagctgctgt gggtccgcaa attgccctgc ttccggaaac ccaaagacaa ggaggtggta
      601 gagctgctga ggaccccttc agacctagaa tccggcaagg ggagctcaga tgagctggct
      661 aagaaggcgg gcctcagggg gaagcctccc ccacaaagcc agggtgaggt gtccgtggcc
      721 agctccatca acagccccac acccacggag gaaggagaat gccagagcct cgtccagaat
      781 gggcatcagg aggagacgtc cagatacctg gacggctact gcccctcggg cagttccctc
      841 acctacagtg ccttggacgt caagtgctca gcaagggaca gatctgagtg ccctgagcct
      901 gaggatagca tcttctttgt gccccaggac agtatcatcg tttgctccta caagcagaac
      961 agcccgtatg acagatactg ttgttatatc aatcagatac aaggcaggtg ggaccacgag
     1021 accatcgtct aatctctgcc tacaaaggtg gctggattga tagaatatga ctaagcccag
     1081 ctccccgtgg aagcaaattg ctctgcttgg agagccttca cactgttaga aattgacctg
     1141 gtatgtgatg ggtgtgataa cctctggtac ccgagagtca tgtaaatagg catgttgggg
     1201 acacatttta gggaagggcg atgagggtta aggacactgg aagaggcagt gggtaggaaa
     1261 ggaagctact ccagttgctt cttaacaatt tacacaatgt taaatgtttt gtaaaataac
     1321 ccaaaaagtg ctatccagaa ccagctgaga gcaagataaa tctagagtgg gctgcagatg
     1381 tgaggcatca aatgatgcat gagctgacca cagggaaact gagctgcttt atgtttgaat
     1441 aagttgaaaa taaaattaat gatccgttat ataaagtaat ttttgcctgg ttaaaagctt
     1501 atcacacttg gtatttgctg aaagaaaaaa aaatcaagat acaagagtta aaccctcctt
     1561 agatgggatg gtttttggga aaagggtagt taaagagagt tggattatgt aactgagtct
     1621 tgtggcatta ttgtctgaca agatcatggt ctctaataaa gtaaaataag tgtgagcagc
     1681 tatgtgaaaa gttaacattt ttagatggct atgttacttc ttaaactctt cgtttaaatc
     1741 catttattgc atctttatct gaaatgggtt ttttctaaac atttactatc attcatgtat
     1801 tatttcctta ccaggtgcaa cattatttga aatgatactt tcatagattg gaatttgttt
     1861 tcatcaagac aaaatgaatt ttacatatat atccaagtct ttaacattgg cagacatgta
     1921 ctgataatta ccattcctac atacctttta aaatctgaaa actataaagt ctacacatta
     1981 gccttgaaca ttgcacataa tttgtatgaa atgcaatggt taaacctttg gaagtgtcat
     2041 tatttgtaca tttgttcaac tcctctcaca gactgtaaat gccagtgaaa caagaactca
     2101 tctactaaat ttaactgaag cctagatttt attaagctca cctgatcagt gaacattaca
     2161 tgataaaagt ctctttattt catacatttt tgctgctgag gaaaacaaca aatcacaatg
     2221 atatcctaaa atgtgctttc tatttcactt gctcaactgc aatagataag aaggctatca
     2281 agcagaatgc catttgatcc ccggtgaaga aaaatatgaa ttatatatag gaatggtgat
     2341 agagttcatc ttgaagatca gaagtatttt gtatccttca aagaatgatc attttaagtg
     2401 atcatatagt cttagtcact ttctcccaaa aggggaattg aggacaaaaa tttgggcata
     2461 tatgttttgt gtatttcaat tccaactctg caattctttc ttaagtatag caattgttct
     2521 gtcttaagaa tcatggtatt tttaaaaaat cataattttc aagtcaagtt caagatcaaa
     2581 aatatgtaat tattttagta gggcttaaat atcagaaatg agatgcatga tcttgggcaa
     2641 attttatctt cttacacctg agtttcctac tctgtgaagg gagggggaac tgatttacac
     2701 ttgattattt ctatcattca ttttcagtgt aaatattcta tggtgttatg tcaaaggcat
     2761 tttatatatt gccaggaaat gagttacagc aaaatgcatg ccaaagttat gaaatttatg
     2821 ataattatgt gacatacatt gcacagctac tactcaaaaa agaattttgt agatgtatga
     2881 aagcagatta ttcaacacaa tgcattcctg agaataaaat gaacataatc agagtaaaat
     2941 atttttgagg agaaaactta aaatgttggt ataactcaaa gtaatctaat acacaacctt
     3001 gcactaaatg tgattgacat ttggatttgg gatggggaga gatagtttcc taaaatcaca
     3061 gtaactttta ataattgtaa tgcattttga aaacagagaa tcatattttt ataatggtga
     3121 gaactatgca ataactcttt aggaatgaaa acttccttta agaagtttgc caccgttaga
     3181 gatgaggaga tagtgagaca gagagatgtt cacagagact cagcaaatct tagacaataa
     3241 tgctgcaatt ttctgaaaga agatgcttgc agtgtcaggt atggtttggg ggttggaaaa
     3301 gttacttttc tgatttcttg gaaccattta aaactccttt atatcattct gtctctttcc
     3361 aaattgaggg tcaactacta gtttagagat ataaggtatt ttatcttgtt ttcaagttct
     3421 acttcagaag aaaacctatt tcatgtttct tctcccatta cctacttaag atacttaagg
     3481 tatttaagta tgcatttgag gaaatatttt cctgtgctaa aataaaggtt tgcaaatgtt
     3541 ggtgtgagag gttttaactt tgaccagtga gaataaaatg tatgattgtg tgtgtgaatt
     3601 tctcctaaca tattaaccaa ctcctttcta tatgcaacaa ggtaacctgg tgccccaaat
     3661 caatacttgt aagtactatt cagagttaaa cttccaaagt caaaaaatat atatacacaa
     3721 aaaaagggga aaagccacat ttttttgaac agaggtagaa gagaaagaga aaaaaagtgt
     3781 ctcagccctt tagaggaaaa gagagcaact cattctgatg agttacacag ttttagcaaa
     3841 ttgttcttat caatataata gacatgagga ttgttcctgg tagccttcaa gagctcctag
     3901 acagatataa atttaagtag acattacttt attttgctgt taatccaagt agacattgcg
     3961 acttgattct gaataggcat tttattttca aaatttttct actgaatttc tcttgctctg
     4021 tatgcctact tattgtgcac atgggttgtt tttccaaact gcttcttgat tcttaagtga
     4081 gaattcagac atgatactca aacgagagca tattagacat ctgttttaag atttattttc
     4141 tgttgcagtc atcttggcaa acaaaatcca gatacagtta agttcaggct ctcttccaaa
     4201 ccctgctaag cagctgcttt gaaaatgttt tcaatactat ggatcttaat atccactgag
     4261 atgacaaatg taggaaagga agattcattc tgttaaatgt tttttctctt ttgcaatgtc
     4321 caagctctac ttatttatta atagcctccc tctgtaccca taacatcatt tatttggtga
     4381 attcactgtt attaatacta gtattttatc acagtaaaga aaaggtttct gaaaacccac
     4441 aacctcacta tcctaaagca actactgtgt ttctattttg gtatatcatc ttccaggctt
     4501 cctccacatg caaatgcagc atacatatta taatagtgtg tttttctttt ctctttgaat
     4561 tatattccat gcatgtttcc atgtttctat gtagtatttc taattatcaa tgaacgattg
     4621 tgtaatatgc cattttagtg atgttccata atttatcatg ccattcctta ttgctggcaa
     4681 gatactaagt tttatggatg attttgtatg tttttttcct attgctggtt acactgctat
     4741 attatttgtt atatgccaat agagaggaac tttactattg aacaggtatc tccttgtgga
     4801 tgagagagag gaggcagaaa tgtgtaaatg aatggaactc tccatattgt tgtgtgggtc
     4861 ttcccttcac tcttgtggat ataagaccca gggtgggaaa caaaacgatg cttcttccaa
     4921 aagatcctcc catcaggacc agaactagta tgtttaggag taagatggaa catttcccca
     4981 gctaagatac cagtggtgtg tttctcacaa ttagattaca gtggtgtcag tcttcaagag
     5041 catcgtgttc aacaagcaaa atgataaata gatgtaaaca ataataatga ctttgtaata
     5101 tgccaaaagc attttcttaa agtacctcat catatatttt ataatagatg tatttcatat
     5161 gtatatgtat tgtcgcctat cagtgactta caaatgaact ggaatttcag gaatctgata
     5221 gactctgccc ttgagttttc tgtgtttcag tttcctactg ggaaaaacta aactgaggat
     5281 ggaaatgggg acaaatgctt ggtttgccca aatatcttaa taaaagacta gattccattc
     5341 aa
//
