LOCUS       NM_017727               2978 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens transmembrane protein 214 (TMEM214), transcript
            variant 1, mRNA.
ACCESSION   NM_017727
VERSION     NM_017727.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2978)
  AUTHORS   Li,C., Wei,J., Li,Y., He,X., Zhou,Q., Yan,J., Zhang,J., Liu,Y.,
            Liu,Y. and Shu,H.B.
  TITLE     Transmembrane Protein 214 (TMEM214) mediates endoplasmic reticulum
            stress-induced caspase 4 enzyme activation and apoptosis
  JOURNAL   J Biol Chem 288 (24), 17908-17917 (2013)
   PUBMED   23661706
  REMARK    GeneRIF: TMEM214 is essential for endoplasmic reticulum (ER)
            stress-induced apoptosis by acting as an anchor for recruitment of
            procaspase 4 to the ER and its subsequent activation.
REFERENCE   2  (bases 1 to 2978)
  AUTHORS   Fong,K.W., Leung,J.W., Li,Y., Wang,W., Feng,L., Ma,W., Liu,D.,
            Songyang,Z. and Chen,J.
  TITLE     MTR120/KIAA1383, a novel microtubule-associated protein, promotes
            microtubule stability and ensures cytokinesis
  JOURNAL   J Cell Sci 126 (Pt 3), 825-837 (2013)
   PUBMED   23264731
REFERENCE   3  (bases 1 to 2978)
  AUTHORS   Lehner,B. and Sanderson,C.M.
  TITLE     A protein interaction framework for human mRNA degradation
  JOURNAL   Genome Res 14 (7), 1315-1323 (2004)
   PUBMED   15231747
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CF994632.1 and AL833725.1.
            
            On Nov 23, 2018 this sequence version replaced NM_017727.4.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803611.140896.1,
                                           SRR1660803.107853.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000238788.14/ ENSP00000238788.9
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-81                CF994632.1         87-167
            82-2978             AL833725.1         1-2897
FEATURES             Location/Qualifiers
     source          1..2978
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2p23.3"
     gene            1..2978
                     /gene="TMEM214"
                     /note="transmembrane protein 214"
                     /db_xref="GeneID:54867"
                     /db_xref="HGNC:HGNC:25983"
                     /db_xref="MIM:615301"
     exon            1..202
                     /gene="TMEM214"
                     /inference="alignment:Splign:2.1.0"
     CDS             52..2121
                     /gene="TMEM214"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /codon_start=1
                     /product="transmembrane protein 214 isoform 1"
                     /protein_id="NP_060197.4"
                     /db_xref="CCDS:CCDS42664.1"
                     /db_xref="GeneID:54867"
                     /db_xref="HGNC:HGNC:25983"
                     /db_xref="MIM:615301"
                     /translation="MATKTAGVGRWEVVKKGRRPGVGAGAGGRGGGRNRRALGEANGV
                     WKYDLTPAIQTTSTLYERGFENIMKRQNKEQVPPPAVEPKKPGNKKQPKKVATPPNQN
                     QKQGRFRSLEEALKALDVADLQKELDKSQSVFSGNPSIWLKDLASYLNYKLQAPLSEP
                     TLSQHTHDYPYSLVSRELRGIIRGLLAKAAGSLELFFDHCLFTMLQELDKTPGESLHG
                     YRICIQAILQDKPKIATANLGKFLELLRSHQSRPAKCLTIMWALGQAGFANLTEGLKV
                     WLGIMLPVLGIKSLSPFAITYLDRLLLMHPNLTKGFGMIGPKDFFPLLDFAYMPNNSL
                     TPSLQEQLCQLYPRLKVLAFGAKPDSTLHTYFPSFLSRATPSCPPEMKKELLSSLTEC
                     LTVDPLSASVWRQLYPKHLSQSSLLLEHLLSSWEQIPKKVQKSLQETIQSLKLTNQEL
                     LRKGSSNNQDVVTCDMACKGLLQQVQGPRLPWTRLLLLLLVFAVGFLCHDLRSHSSFQ
                     ASLTGRLLRSSGFLPASQQACAKLYSYSLQGYSWLGETLPLWGSHLLTVVRPSLQLAW
                     AHTNATVSFLSAHCASHLAWFGDSLTSLSQRLQIQLPDSVNQLLRYLRELPLLFHQNV
                     LLPLWHLLLEALAWAQEHCHEACRGEVTWDCMKTQLSEAVHWTWLCLQDITVAFLDWA
                     LALISQQ"
     exon            203..402
                     /gene="TMEM214"
                     /inference="alignment:Splign:2.1.0"
     exon            403..553
                     /gene="TMEM214"
                     /inference="alignment:Splign:2.1.0"
     exon            554..688
                     /gene="TMEM214"
                     /inference="alignment:Splign:2.1.0"
     exon            689..771
                     /gene="TMEM214"
                     /inference="alignment:Splign:2.1.0"
     exon            772..877
                     /gene="TMEM214"
                     /inference="alignment:Splign:2.1.0"
     exon            878..959
                     /gene="TMEM214"
                     /inference="alignment:Splign:2.1.0"
     exon            960..1061
                     /gene="TMEM214"
                     /inference="alignment:Splign:2.1.0"
     exon            1062..1203
                     /gene="TMEM214"
                     /inference="alignment:Splign:2.1.0"
     exon            1204..1295
                     /gene="TMEM214"
                     /inference="alignment:Splign:2.1.0"
     exon            1296..1344
                     /gene="TMEM214"
                     /inference="alignment:Splign:2.1.0"
     exon            1345..1458
                     /gene="TMEM214"
                     /inference="alignment:Splign:2.1.0"
     exon            1459..1576
                     /gene="TMEM214"
                     /inference="alignment:Splign:2.1.0"
     exon            1577..1673
                     /gene="TMEM214"
                     /inference="alignment:Splign:2.1.0"
     exon            1674..1842
                     /gene="TMEM214"
                     /inference="alignment:Splign:2.1.0"
     exon            1843..1994
                     /gene="TMEM214"
                     /inference="alignment:Splign:2.1.0"
     exon            1995..2978
                     /gene="TMEM214"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2953..2958
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TMEM214"
                     /note="hexamer: AATAAA"
     polyA_site      2978
                     /gene="TMEM214"
                     /note="major polyA site"
ORIGIN      
        1 gcgccggacc ggaaagccgg ggaagtggcc gaggagggag ggctgcgagc catggcgacc
       61 aagacggcgg gcgtggggcg gtgggaggta gtgaagaagg gtcggcggcc tggggtcggc
      121 gccggcgccg gcggccgagg aggcggcagg aaccgcaggg cgctcgggga agcaaacgga
      181 gtgtggaaat acgacctgac ccctgcaatc cagaccacaa gcacccttta tgagcggggc
      241 tttgagaata tcatgaagcg gcagaataag gagcaggtcc caccccctgc tgtggaacct
      301 aagaaaccag ggaacaagaa gcagccaaag aaggtggcaa ctcctcccaa ccaaaaccag
      361 aagcagggcc gcttccgcag cctggaggaa gcactgaaag ctctggatgt ggcagacctg
      421 cagaaggaac tggacaagag ccagagtgtg ttctctggaa acccatccat atggttgaag
      481 gacctggcca gctatctcaa ctacaagcta caagctcctc taagtgaacc cacgctgagc
      541 cagcatactc atgattatcc ctacagcctg gtgagccggg agctacgtgg gatcatccga
      601 gggctgctgg cgaaggcagc agggtctctg gagctctttt ttgaccactg tctgttcacc
      661 atgttgcaag agctggataa gacaccaggg gagtcactac atggttaccg catctgtatc
      721 caggccatcc tgcaagacaa gcccaagatt gccacggcaa acctaggcaa gttcctggaa
      781 ctgctgaggt cccaccagag ccgaccagca aagtgtctca ccatcatgtg ggccctgggt
      841 caagcaggtt ttgccaacct caccgaggga ctgaaagtgt ggctggggat catgctgcct
      901 gtgctgggca tcaagtctct gtctcccttt gccatcacat acctggatcg gctgctcctg
      961 atgcatccca accttaccaa gggcttcggc atgattggcc ccaaggactt cttcccactt
     1021 ctggactttg cctatatgcc gaacaactcc ctgacaccca gcctgcagga gcagctgtgt
     1081 cagctctacc cccgactgaa agtgctggca tttggagcaa agccggattc caccctgcat
     1141 acctacttcc cttctttcct gtccagagcc acccctagct gtccccctga gatgaagaaa
     1201 gagctcctga gcagcctgac tgagtgcctg acggtggacc ccctcagtgc cagcgtctgg
     1261 aggcagctgt accctaagca cctgtcacag tccagccttc tgctggagca cttgctcagc
     1321 tcctgggagc agattcccaa gaaggtacag aagtctttgc aagaaaccat tcagtccctc
     1381 aagcttacca accaggagct gctgaggaag ggtagcagta acaaccagga tgtcgtcacc
     1441 tgtgacatgg cctgcaaggg cctgttgcag caggttcagg gtcctcggct gccctggacg
     1501 cggctcctcc tgttgctgct ggtcttcgct gtaggcttcc tgtgccatga cctccggtca
     1561 cacagctcct tccaggcctc ccttactggc cggttgcttc gatcatctgg cttcttacct
     1621 gctagccaac aagcgtgtgc caagctctac tcctacagtc tgcaaggcta cagctggctg
     1681 ggggagacac tgccgctctg gggctcccac ctgctcaccg tggtgcggcc cagcttgcag
     1741 ctggcctggg ctcacaccaa tgccacagtc agcttccttt ctgcccactg tgcctctcac
     1801 cttgcgtggt ttggtgacag tctcaccagt ctctctcaga ggctacagat ccagctcccc
     1861 gattccgtga atcagctact ccgctatctg agagagctgc ccctgctttt ccaccagaat
     1921 gtgctgctgc cactgtggca cctcttgctt gaggccctgg cctgggccca ggagcactgc
     1981 catgaggcat gcagaggtga ggtgacctgg gactgcatga agacacagct cagtgaggct
     2041 gtccactgga cctggctttg cctacaggac attacagtgg ctttcttgga ctgggcactt
     2101 gccctgatat cccagcagta ggccctgcct tcctggccac tgatttctgc atgggtagac
     2161 catccaagac tgcagcgggt agaaggtggc agttcttcat gggagtcttt ttaacttggt
     2221 gcctgagttc tctcctaggc aagtggccag ttgcctccac ctcagttctt ccatctttgg
     2281 tggggacagg gcccagcagc atctcagcct cctacccaca attccactga acacttttct
     2341 ggccctactg cacatggccc ccagcctcca tccttgtgct ggtagcctct cacaactccg
     2401 cccttgccct ctgccttcca cttccttcca tctcatttct aaaccccaaa cagctcatct
     2461 ctaaaaagat agaactccca gcaggtggct tctgtgttct tctgacaaat gattcctgct
     2521 tctccagact ttagcagcct cctgttccca ttcttggtca cagctctagc cacagcagaa
     2581 ggaaaggggc ttccagaaga atatagcacc gcattgggaa acagcagcct cacctccacc
     2641 tgaagcctgg gtgtggctgt cagtggacat ggggagctgg atggaaatgc ctctcacttc
     2701 aaaatgccca gcctgcccca aatgcctcta agcccctccc tgtcccctcc cttgtagtcc
     2761 tacttcttcc aactttccat tccccatcat gctgggggtc ttggtcacaa ggctcagctt
     2821 ctctccactg tccatccctc ctatcatctg tagagcagag cacaggcagt tgtgtgcctt
     2881 gggcccaggg aaccctccat caacctgaga caggactcag tatatggttc ttgggtatgc
     2941 cctaccaggt ggaataaagg acacagattt gatttcta
//
