LOCUS       NM_032842               3455 bp    mRNA    linear   PRI 09-FEB-2024
DEFINITION  Homo sapiens transmembrane protein 209 (TMEM209), transcript
            variant 1, mRNA.
ACCESSION   NM_032842
VERSION     NM_032842.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3455)
  AUTHORS   Fujitomo,T., Daigo,Y., Matsuda,K., Ueda,K. and Nakamura,Y.
  TITLE     Critical function for nuclear envelope protein TMEM209 in human
            pulmonary carcinogenesis
  JOURNAL   Cancer Res 72 (16), 4110-4118 (2012)
   PUBMED   22719065
  REMARK    GeneRIF: Findings indicate that TMEM209 overexpression and
            TMEM209-NUP205 interaction are critical drivers of lung cancer
            proliferation.
REFERENCE   2  (bases 1 to 3455)
  AUTHORS   Girard,A., Sachidanandam,R., Hannon,G.J. and Carmell,M.A.
  TITLE     A germline-specific class of small RNAs binds mammalian Piwi
            proteins
  JOURNAL   Nature 442 (7099), 199-202 (2006)
   PUBMED   16751776
REFERENCE   3  (bases 1 to 3455)
  AUTHORS   Yamada,T., Mitsuya,K., Kayashima,T., Yamasaki,K., Ohta,T.,
            Yoshiura,K., Matsumoto,N., Yamada,H., Minakami,H., Oshimura,M.,
            Niikawa,N. and Kishino,T.
  TITLE     Imprinting analysis of 10 genes and/or transcripts in a 1.5-Mb
            MEST-flanking region at human chromosome 7q32
  JOURNAL   Genomics 83 (3), 402-412 (2004)
   PUBMED   14962666
REFERENCE   4  (bases 1 to 3455)
  AUTHORS   Schirmer,E.C., Florens,L., Guan,T., Yates,J.R. 3rd and Gerace,L.
  TITLE     Nuclear membrane proteins with potential disease links found by
            subtractive proteomics
  JOURNAL   Science 301 (5638), 1380-1382 (2003)
   PUBMED   12958361
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC045618.1, AI589217.1 and AC087071.2.
            
            On Nov 22, 2018 this sequence version replaced NM_032842.3.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC045618.1, SRR1660803.76872.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000397622.7/ ENSP00000380747.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2037              BC045618.1         1-2037
            2038-2468           BC045618.1         2039-2469
            2469-3452           BC045618.1         2471-3454
            3453-3453           AI589217.1         16-16               c
            3454-3455           AC087071.2         132141-132142       c
FEATURES             Location/Qualifiers
     source          1..3455
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q32.2"
     gene            1..3455
                     /gene="TMEM209"
                     /gene_synonym="NET31"
                     /note="transmembrane protein 209"
                     /db_xref="GeneID:84928"
                     /db_xref="HGNC:HGNC:21898"
     exon            1..34
                     /gene="TMEM209"
                     /gene_synonym="NET31"
                     /inference="alignment:Splign:2.1.0"
     CDS             32..1717
                     /gene="TMEM209"
                     /gene_synonym="NET31"
                     /note="isoform 1 is encoded by transcript variant 1;
                     testicular tissue protein Li 202"
                     /codon_start=1
                     /product="transmembrane protein 209 isoform 1"
                     /protein_id="NP_116231.2"
                     /db_xref="CCDS:CCDS47712.1"
                     /db_xref="GeneID:84928"
                     /db_xref="HGNC:HGNC:21898"
                     /translation="MMQGEAHPSASLIDRTIKMRKETEARKVVLAWGLLNVSMAGMIY
                     TEMTGKLISSYYNVTYWPLWYIELALASLFSLNALFDFWRYFKYTVAPTSLVVSPGQQ
                     TLLGLKTAVVQTTPPHDLAATQIPPAPPSPSIQGQSVLSYSPSRSPSTSPKFTTSCMT
                     GYSPQLQGLSSGGSGSYSPGVTYSPVSGYNKLASFSPSPPSPYPTTVGPVESSGLRSR
                     YRSSPTVYNSPTDKEDYMTDLRTLDTFLRSEEEKQHRVKLGSPDSTSPSSSPTFWNYS
                     RSMGDYAQTLKKFQYQLACRSQAPCANKDEADLSSKQAAEEVWARVAMNRQLLDHMDS
                     WTAKFRNWINETILVPLVQEIESVSTQMRRMGCPELQIGEASITSLKQAALVKAPLIP
                     TLNTIVQYLDLTPNQEYLFERIKELSQGGCMSSFRWNRGGDFKGRKWDTDLPTDSAII
                     MHVFCTYLDSRLPPHPKYPDGKTFTSQHFVQTPNKPDVTNENVFCIYQSAINPPHYEL
                     IYQRHVYNLPKGRNNMFHTLLMFLYIIKTKESGMLGRVNLGLSGVNILWIFGE"
     exon            35..171
                     /gene="TMEM209"
                     /gene_synonym="NET31"
                     /inference="alignment:Splign:2.1.0"
     exon            172..230
                     /gene="TMEM209"
                     /gene_synonym="NET31"
                     /inference="alignment:Splign:2.1.0"
     exon            231..362
                     /gene="TMEM209"
                     /gene_synonym="NET31"
                     /inference="alignment:Splign:2.1.0"
     exon            363..604
                     /gene="TMEM209"
                     /gene_synonym="NET31"
                     /inference="alignment:Splign:2.1.0"
     exon            605..806
                     /gene="TMEM209"
                     /gene_synonym="NET31"
                     /inference="alignment:Splign:2.1.0"
     exon            807..982
                     /gene="TMEM209"
                     /gene_synonym="NET31"
                     /inference="alignment:Splign:2.1.0"
     exon            983..1054
                     /gene="TMEM209"
                     /gene_synonym="NET31"
                     /inference="alignment:Splign:2.1.0"
     exon            1055..1151
                     /gene="TMEM209"
                     /gene_synonym="NET31"
                     /inference="alignment:Splign:2.1.0"
     exon            1152..1277
                     /gene="TMEM209"
                     /gene_synonym="NET31"
                     /inference="alignment:Splign:2.1.0"
     exon            1278..1375
                     /gene="TMEM209"
                     /gene_synonym="NET31"
                     /inference="alignment:Splign:2.1.0"
     exon            1376..1490
                     /gene="TMEM209"
                     /gene_synonym="NET31"
                     /inference="alignment:Splign:2.1.0"
     exon            1491..1588
                     /gene="TMEM209"
                     /gene_synonym="NET31"
                     /inference="alignment:Splign:2.1.0"
     exon            1589..1662
                     /gene="TMEM209"
                     /gene_synonym="NET31"
                     /inference="alignment:Splign:2.1.0"
     exon            1663..3455
                     /gene="TMEM209"
                     /gene_synonym="NET31"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3420..3425
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TMEM209"
                     /gene_synonym="NET31"
                     /note="hexamer: ATTAAA"
     polyA_site      3455
                     /gene="TMEM209"
                     /gene_synonym="NET31"
                     /note="major polyA site"
ORIGIN      
        1 ggcgcgagcc tgcgttttcc ggccagagga catgatgcag ggggaggcac accctagtgc
       61 ttcccttatt gacagaacca tcaagatgag aaaagaaaca gaggctagga aagtggtctt
      121 agcctgggga ctcctaaatg tatctatggc tggaatgata tatactgaaa tgactggaaa
      181 attgattagt tcatactaca atgtgacata ctggcccctc tggtatattg agcttgccct
      241 tgcatctctc ttcagcctta atgccttatt tgatttttgg agatatttca aatatactgt
      301 ggcaccaaca agtctggttg ttagtcctgg acagcaaaca cttttagggt tgaaaacagc
      361 tgttgtacag actacgcctc cacatgatct ggcagcaacc caaatccctc ccgctccacc
      421 ttccccttca attcagggtc agagtgtgtt gagttatagc ccttctcgtt cgcccagtac
      481 cagtcccaag ttcaccacca gctgtatgac tggttacagc cctcagctgc aaggtctgtc
      541 ctcaggtggc agtggttctt atagccctgg agtgacctac tcgcccgtca gtggttataa
      601 taagttggcg agctttagcc cctctcctcc ttctccgtac cctaccactg ttggaccagt
      661 ggagagcagt ggattgagat ctcgctaccg ttcttcacct accgtctaca actcacctac
      721 tgacaaagaa gactacatga ccgacctacg aactttggat acttttctca gaagtgaaga
      781 ggagaaacag catagggtta agctggggag cccagattct acctctcctt ccagcagtcc
      841 tactttctgg aactatagtc gttctatggg ggattatgca caaactttaa agaagtttca
      901 gtatcagctt gcctgtaggt ctcaggcccc atgtgctaac aaagatgaag ccgatctcag
      961 ctctaaacaa gccgcagaag aggtctgggc aagagtggct atgaatagac aacttcttga
     1021 tcatatggat tcatggacag ctaaatttag aaattggatc aatgagacaa tattagtgcc
     1081 acttgttcaa gagattgagt ctgtcagcac acagatgaga cgaatgggtt gtccagagct
     1141 acagatagga gaggctagta ttactagctt gaaacaagct gccctggtta aagcgcctct
     1201 cattccgact ttgaacacaa tcgttcagta tctagacctt actccaaatc aggaatactt
     1261 gtttgaaagg atcaaagaac tatctcaggg aggttgtatg agctcatttc gatggaacag
     1321 aggtggcgac ttcaaaggac gaaagtggga tacagacctg cccaccgatt ctgctatcat
     1381 catgcatgta ttttgcacct accttgattc cagattacct ccacatccga agtatcccga
     1441 cggaaaaact tttacttctc agcactttgt tcagacacca aataaaccag atgttacaaa
     1501 tgagaatgtt ttttgcattt atcagagtgc tatcaaccct ccccattatg agctcatcta
     1561 ccagcgtcat gtatacaacc tgccaaaggg cagaaataat atgtttcata cattgttgat
     1621 gtttctctac atcataaaga ccaaagagtc aggaatgctt gggagagtta atcttggtct
     1681 atctggtgtg aatatattgt ggatctttgg cgagtagcaa gtcatatatt taattctgac
     1741 atttagacta tttcactgaa ccagaagtcg aaactaaaca tctctgagcc actgactctt
     1801 ctgaaataaa atacacatgg gtgtatgtta cagactcttt agatttaaca gaaaatgtag
     1861 ctgttatgaa atgtaattgt aaaaatatgt cccgtatctt ctatatcgag acattgcctt
     1921 taattttata tcgcttttca gaaatttcag ttgactacaa aactgcaacc cttcggattt
     1981 ttattgactc aaaatagtgc cattcccctt aatgaaatag attttgagtc tttttttcat
     2041 tgtaaccccc aaatgagaat catctacctg attcttgtac caaaaaaaaa tttttttcag
     2101 tctttttttt ttttagagag ggtctctgtc aacgcagact ggagtgcagt ggcacgatct
     2161 tagctcacta caacttctgc ctcccaggct caagcaattc tcctgcctca gcctcctgag
     2221 tagctgggat tacaggcatg caccaccacg cccagctaat ttttgtattt ttagtagaga
     2281 cagggtttca ccatgttggc caggctggtc ccgaactcct gacctcaggt gatccaccca
     2341 cctcggcctc ccaaagtgct gggattatag gtgcgagcca ctgcgcccag cctcagttat
     2401 tttatttaac agtgtaagta cttagaaagt aagaaaattg ctgatttagt tttttttttt
     2461 ttttttttaa tgtttcccca gcattctgca agttaggcca aagcccacat tcaaagaaat
     2521 gagattaact cttaagtaat gtattaagtt tatgtatatt ttaaaatatt attaaaggag
     2581 gtttgaaagt attgacattt aaaaagtcaa cacttagatt aaatttagct ggtagtttta
     2641 atttgggttt tagttaagag tgtgaggaca tcaggaaaac tgtttactac tttggtttta
     2701 gcagctcagt tttactattc cataatgtgt tatttttaaa gttctctttt taagatcaca
     2761 gtgatatcct atcttcaaat tttttaaata tgttcaaaat atctggaggg tgagaagtta
     2821 ccaagtttgt atgttttgtt tgactcacca tctttatttt ctgtatatgt agtagctggc
     2881 aattgcatat attttcttga ttaacatatt agagactgct tccatcatct tatgtaaacc
     2941 tggaaacagc tgaaactagt cttttctgaa gaaccgtgta tcagtgttag atgtgcatcc
     3001 cgttttgtca ttccctcaga ctttgaatac agtcattact ctctggaaga gaaatgtaag
     3061 tatatttttt gttatctgca gtatggttta acatgtatta ataatacaca tatgcagact
     3121 cactaaagta tccccagtaa ttagtaaatt ccaaatttaa gtcagtacag ttctgtattt
     3181 gtaaattctg tctttcaaaa agttgttcgt gtttttaaaa gttgatgtcc aaaggaaagg
     3241 agcttctttt aagtactttt ggtgtatgtt gaatatttat ttgctatgat attctagaag
     3301 aaaatatcaa acatgttaaa tataagaaca tgttaaaatt taaatttgct atttcaaaag
     3361 ttactgaaga tgtcttggaa taacaattgt catgctgtta aactagttgc atatacttca
     3421 ttaaaagcac catggagaaa cattttaaca atgca
//
