LOCUS       NM_014187                776 bp    mRNA    linear   PRI 04-OCT-2024
DEFINITION  Homo sapiens transmembrane protein 208 (TMEM208), transcript
            variant 1, mRNA.
ACCESSION   NM_014187
VERSION     NM_014187.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 776)
  AUTHORS   Yang,J. and Song,T.
  TITLE     Exploring the Role and Prognostic Value of TMEM208 in Head and Neck
            Squamous Cell Carcinoma
  JOURNAL   Asian Pac J Cancer Prev 25 (3), 909-919 (2024)
   PUBMED   38546073
  REMARK    GeneRIF: Exploring the Role and Prognostic Value of TMEM208 in Head
            and Neck Squamous Cell Carcinoma.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 776)
  AUTHORS   Dutta,D., Kanca,O., Shridharan,R.V., Marcogliese,P.C., Steger,B.,
            Morimoto,M., Frost,F.G., Macnamara,E., Wangler,M.F., Yamamoto,S.,
            Jenny,A., Adams,D., Malicdan,M.C. and Bellen,H.J.
  CONSRTM   Undiagnosed Diseases Network
  TITLE     Loss of the endoplasmic reticulum protein Tmem208 affects cell
            polarity, development, and viability
  JOURNAL   Proc Natl Acad Sci U S A 121 (9), e2322582121 (2024)
   PUBMED   38381787
  REMARK    GeneRIF: Loss of the endoplasmic reticulum protein Tmem208 affects
            cell polarity, development, and viability.
REFERENCE   3  (bases 1 to 776)
  AUTHORS   Yang,J., Hirata,T., Liu,Y.S., Guo,X.Y., Gao,X.D., Kinoshita,T. and
            Fujita,M.
  TITLE     Human SND2 mediates ER targeting of GPI-anchored proteins with low
            hydrophobic GPI attachment signals
  JOURNAL   FEBS Lett 595 (11), 1542-1558 (2021)
   PUBMED   33838053
  REMARK    GeneRIF: Human SND2 mediates ER targeting of GPI-anchored proteins
            with low hydrophobic GPI attachment signals.
REFERENCE   4  (bases 1 to 776)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 776)
  AUTHORS   Lei,P., Xiao,Y., Li,P., Xie,P., Wang,H., Huang,S., Song,P. and
            Zhao,Y.
  TITLE     hSnd2/TMEM208 is an HIF-1alpha-targeted gene and contains a WH2
            motif
  JOURNAL   Acta Biochim Biophys Sin (Shanghai) 52 (3), 328-331 (2020)
   PUBMED   32002553
  REMARK    GeneRIF: hSnd2/TMEM208 is an HIF-1alpha-targeted gene and contains
            a WH2 motif.
REFERENCE   6  (bases 1 to 776)
  AUTHORS   Hassdenteufel,S., Sicking,M., Schorr,S., Aviram,N.,
            Fecher-Trost,C., Schuldiner,M., Jung,M., Zimmermann,R. and Lang,S.
  TITLE     hSnd2 protein represents an alternative targeting factor to the
            endoplasmic reticulum in human cells
  JOURNAL   FEBS Lett 591 (20), 3211-3224 (2017)
   PUBMED   28862756
  REMARK    GeneRIF: Snd2 protein represents an alternative targeting factor to
            the endoplasmic reticulum in human cells.
REFERENCE   7  (bases 1 to 776)
  AUTHORS   Zhao,Y., Hu,J., Miao,G., Qu,L., Wang,Z., Li,G., Lv,P., Ma,D. and
            Chen,Y.
  TITLE     Transmembrane protein 208: a novel ER-localized protein that
            regulates autophagy and ER stress
  JOURNAL   PLoS One 8 (5), e64228 (2013)
   PUBMED   23691174
  REMARK    GeneRIF: novel ER-located protein regulates both ER stress and
            autophagy
            Publication Status: Online-Only
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BI838179.1 and BC003080.2.
            
            On Nov 22, 2018 this sequence version replaced NM_014187.3.
            
            Summary: This gene encodes a highly conserved protein which is
            localized in the endoplasmic reticulum (ER). The protein is linked
            to autophagy and ER stress. Knockdown of this gene increased
            autophagy and triggered ER stress. Alternative splicing results in
            multiple transcript variants. [provided by RefSeq, Dec 2015].
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189652.31429.1,
                                           SRR5189655.218246.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000304800.14/ ENSP00000305892.9
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-10                BI838179.1         18-27
            11-776              BC003080.2         1-766
FEATURES             Location/Qualifiers
     source          1..776
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16q22.1"
     gene            1..776
                     /gene="TMEM208"
                     /gene_synonym="hSND2; HSPC171; SND2"
                     /note="transmembrane protein 208"
                     /db_xref="GeneID:29100"
                     /db_xref="HGNC:HGNC:25015"
                     /db_xref="MIM:620781"
     exon            1..95
                     /gene="TMEM208"
                     /gene_synonym="hSND2; HSPC171; SND2"
                     /inference="alignment:Splign:2.1.0"
     CDS             90..611
                     /gene="TMEM208"
                     /gene_synonym="hSND2; HSPC171; SND2"
                     /note="isoform 1 is encoded by transcript variant 1;
                     SRP-independent targeting 2 homolog"
                     /codon_start=1
                     /product="transmembrane protein 208 isoform 1"
                     /protein_id="NP_054906.2"
                     /db_xref="CCDS:CCDS45511.1"
                     /db_xref="GeneID:29100"
                     /db_xref="HGNC:HGNC:25015"
                     /db_xref="MIM:620781"
                     /translation="MAPKGKVGTRGKKQIFEENRETLKFYLRIILGANAIYCLVTLVF
                     FYSSASFWAWLALGFSLAVYGASYHSMSSMARAAFSEDGALMDGGMDLNMEQGMAEHL
                     KDVILLTAIVQVLSCFSLYVWSFWLLAPGRALYLLWVNVLGPWFTADSGTPAPEHNEK
                     RQRRQERRQMKRL"
     exon            96..191
                     /gene="TMEM208"
                     /gene_synonym="hSND2; HSPC171; SND2"
                     /inference="alignment:Splign:2.1.0"
     exon            192..251
                     /gene="TMEM208"
                     /gene_synonym="hSND2; HSPC171; SND2"
                     /inference="alignment:Splign:2.1.0"
     exon            252..388
                     /gene="TMEM208"
                     /gene_synonym="hSND2; HSPC171; SND2"
                     /inference="alignment:Splign:2.1.0"
     exon            389..473
                     /gene="TMEM208"
                     /gene_synonym="hSND2; HSPC171; SND2"
                     /inference="alignment:Splign:2.1.0"
     exon            474..776
                     /gene="TMEM208"
                     /gene_synonym="hSND2; HSPC171; SND2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      757..762
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TMEM208"
                     /gene_synonym="hSND2; HSPC171; SND2"
                     /note="hexamer: AATAAA"
     polyA_site      776
                     /gene="TMEM208"
                     /gene_synonym="hSND2; HSPC171; SND2"
                     /note="major polyA site"
ORIGIN      
        1 ggaagtgcat gagctgccga tgtggtgctt agtgattgcg gtttcggtcg ctctcccgtg
       61 tttcccgggc tgggtatttg cctcgcacca tggcgcccaa gggcaaagtg ggcacgagag
      121 ggaagaagca gatatttgaa gagaacagag agactctgaa gttctacctg cggatcatac
      181 tgggggccaa tgccatttac tgccttgtga cgttggtctt cttttactca tctgcctcat
      241 tttgggcctg gttggccctg ggctttagtc tggcagtgta tggggccagc taccactcta
      301 tgagctcgat ggcacgagca gcgttctctg aggatggggc cctgatggat ggtggcatgg
      361 acctcaacat ggagcagggc atggcagagc accttaagga tgtgatccta ctgacagcca
      421 tcgtgcaggt gctcagctgc ttctctctct atgtctggtc cttctggctt ctggctccag
      481 gccgggccct ttacctcctg tgggtgaatg tgctgggccc ctggttcact gcagacagtg
      541 gcaccccagc accagagcac aatgagaaac ggcagcgccg acaggagcgg cggcagatga
      601 agcggttata gccattgaca ttgtggccac aggccactgg ccctgggtgg ctctgtcagg
      661 gtgcacagcc cctcatgcct ggagcaatga gggtctagtc caggggccaa aagcagtctg
      721 aggtattggg tatacttata ctctataggg tcgttgaata aatggcttag aatgtg
//
