LOCUS       NM_207316               1473 bp    mRNA    linear   PRI 10-JUN-2024
DEFINITION  Homo sapiens transmembrane protein 207 (TMEM207), mRNA.
ACCESSION   NM_207316
VERSION     NM_207316.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1473)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 1473)
  AUTHORS   Bunai,K., Okubo,H., Hano,K., Inoue,K., Kito,Y., Saigo,C.,
            Shibata,T. and Takeuchi,T.
  TITLE     TMEM207 hinders the tumour suppressor function of WWOX in oral
            squamous cell carcinoma
  JOURNAL   J Cell Mol Med 22 (2), 1026-1033 (2018)
   PUBMED   29164763
  REMARK    GeneRIF: Enforced expression of TMEM207 abrogated the binding of
            WWOX to HIF-1alpha, increased HIF-1alpha and GLUT-1 expression,
            even under normoxic conditions, and promoted tumour growth.
REFERENCE   3  (bases 1 to 1473)
  AUTHORS   Maeda,K., Saigo,C., Kito,Y., Sakuratani,T., Yoshida,K. and
            Takeuchi,T.
  TITLE     Expression of TMEM207 in Colorectal Cancer: Relation between
            TMEM207 and Intelectin-1
  JOURNAL   J Cancer 7 (2), 207-213 (2016)
   PUBMED   26819645
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1473)
  AUTHORS   Takeuchi,T., Adachi,Y. and Nagayama,T.
  TITLE     A WWOX-binding molecule, transmembrane protein 207, is related to
            the invasiveness of gastric signet-ring cell carcinoma
  JOURNAL   Carcinogenesis 33 (3), 548-554 (2012)
   PUBMED   22226915
  REMARK    GeneRIF: overexpression of TMEM207 may facilitate invasive activity
            and metastasis of gastric signet-ring cell carcinoma, which
            possibly occur through binding to WWOX and attenuation of its
            function.
REFERENCE   5  (bases 1 to 1473)
  AUTHORS   Clark,H.F., Gurney,A.L., Abaya,E., Baker,K., Baldwin,D., Brush,J.,
            Chen,J., Chow,B., Chui,C., Crowley,C., Currell,B., Deuel,B.,
            Dowd,P., Eaton,D., Foster,J., Grimaldi,C., Gu,Q., Hass,P.E.,
            Heldens,S., Huang,A., Kim,H.S., Klimowski,L., Jin,Y., Johnson,S.,
            Lee,J., Lewis,L., Liao,D., Mark,M., Robbie,E., Sanchez,C.,
            Schoenfeld,J., Seshagiri,S., Simmons,L., Singh,J., Smith,V.,
            Stinson,J., Vagts,A., Vandlen,R., Watanabe,C., Wieand,D., Woods,K.,
            Xie,M.H., Yansura,D., Yi,S., Yu,G., Yuan,J., Zhang,M., Zhang,Z.,
            Goddard,A., Wood,W.I., Godowski,P. and Gray,A.
  TITLE     The secreted protein discovery initiative (SPDI), a large-scale
            effort to identify novel human secreted and transmembrane proteins:
            a bioinformatics assessment
  JOURNAL   Genome Res 13 (10), 2265-2270 (2003)
   PUBMED   12975309
  REMARK    Erratum:[Genome Res. 2003 Dec;13(12):2759]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC009520.16.
            
            On Aug 6, 2020 this sequence version replaced NM_207316.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY358607.1, BC071780.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1970526, SAMEA2145774
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000354905.3/ ENSP00000346981.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-167               AC009520.16        154724-154890       c
            168-205             AC009520.16        152779-152816       c
            206-250             AC009520.16        146427-146471       c
            251-396             AC009520.16        145233-145378       c
            397-1473            AC009520.16        133644-134720       c
FEATURES             Location/Qualifiers
     source          1..1473
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q28"
     gene            1..1473
                     /gene="TMEM207"
                     /gene_synonym="UNQ846"
                     /note="transmembrane protein 207"
                     /db_xref="GeneID:131920"
                     /db_xref="HGNC:HGNC:33705"
                     /db_xref="MIM:614786"
     exon            1..167
                     /gene="TMEM207"
                     /gene_synonym="UNQ846"
                     /inference="alignment:Splign:2.1.0"
     CDS             93..533
                     /gene="TMEM207"
                     /gene_synonym="UNQ846"
                     /note="SRSR846"
                     /codon_start=1
                     /product="transmembrane protein 207 precursor"
                     /protein_id="NP_997199.1"
                     /db_xref="CCDS:CCDS3297.1"
                     /db_xref="GeneID:131920"
                     /db_xref="HGNC:HGNC:33705"
                     /db_xref="MIM:614786"
                     /translation="MSRSRLFSVTSAISTIGILCLPLFQLVLSDLPCEEDEMCVNYND
                     QHPNGWYIWILLLLVLVAALLCGAVVLCLQCWLRRPRIDSHRRTMAVFAVGDLDSIYG
                     TEAAVSPTVGIHLQTQTPDLYPVPAPCFGPLGSPPPYEEIVKTT"
     exon            168..205
                     /gene="TMEM207"
                     /gene_synonym="UNQ846"
                     /inference="alignment:Splign:2.1.0"
     exon            206..250
                     /gene="TMEM207"
                     /gene_synonym="UNQ846"
                     /inference="alignment:Splign:2.1.0"
     exon            251..396
                     /gene="TMEM207"
                     /gene_synonym="UNQ846"
                     /inference="alignment:Splign:2.1.0"
     exon            397..1473
                     /gene="TMEM207"
                     /gene_synonym="UNQ846"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1449..1454
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TMEM207"
                     /gene_synonym="UNQ846"
                     /note="hexamer: AATAAA"
     polyA_site      1473
                     /gene="TMEM207"
                     /gene_synonym="UNQ846"
                     /note="major polyA site"
ORIGIN      
        1 agcataactt atagagaagc tagtaagttc tgagaaagaa ggaaataaac acaggcacca
       61 aaccactatc ctaagttgac tgtcctttaa atatgtcaag atccagactt ttcagtgtca
      121 cctcagcgat ctcaacgata gggatcttgt gtttgccgct attccagttg gtgctctcgg
      181 acctaccatg cgaagaagat gaaatgtgtg taaattataa tgaccaacac cctaatggct
      241 ggtatatctg gatcctcctg ctgctggttt tggtggcagc tcttctctgt ggagctgtgg
      301 tcctctgcct ccagtgctgg ctgaggagac cccgaattga ttctcacagg cgcaccatgg
      361 cagtttttgc tgttggagac ttggactcta tttatgggac agaagcagct gtgagtccaa
      421 ctgttggaat tcaccttcaa actcaaaccc ctgacctata tcctgttcct gctccatgtt
      481 ttggcccttt aggctcccca cctccatatg aagaaattgt aaaaacaacc tgattttagg
      541 tgtggattat caatttaaag tattaacgac atctgtaatt ccaaaacatc aaatttagga
      601 atagttattt cagttgttgg aaatgtccag agatctattc atatagtctg aggaaggaca
      661 attcgacaaa agaatggatg ttggaaaaaa ttttggtcat ggagatgttt aaatagtaaa
      721 gtagcaggct tttgatgtgt cactgctgta tcatactttt atgctacaca accaaattaa
      781 tgcttctcca ctagtatcca aacaggcaac aattaggtgc tggaagtagt ttccatcaca
      841 tttaggactc cactgcagta tacagcacac cattttctgc tttaaactct ttcctagcat
      901 ggggtccata aaaattatta taatttaaca atagcccaag ccgagaatcc aacatgtcca
      961 gaaccagaac cagaaagata gtatttgaat gaaggtgagg ggagagagta ggaaaaagaa
     1021 aagtttggag ttgaagggta aaggataaat gaagaggaaa aggaaaagat tacaagtctc
     1081 agcaaaaaca agaggtttta tgccccaacc tgaagaggaa gaaattgtag atagaaggtg
     1141 aaggagattg ctgaagatat agagcacata taatgccaac acggggagaa aagaaaagtt
     1201 ccccttttac agtaatgaat gtggcctcca tagtccatag tgtttctctg gagcctcagg
     1261 gcttggcatt tattgcagca tcatgctaag aaccttcggc ataggtatct gttcccatga
     1321 ggactgcaga agtagcaatg agacatcttc aagtggcatt ttggcagtgg ccatcagcag
     1381 ggggacagac aaaaacatcc atcacagatg acatatgatc ttcagctgac aaatttgttg
     1441 aacaaaacaa taaacatcaa tagatatcta aaa
//
