LOCUS       NM_198536               1256 bp    mRNA    linear   PRI 09-FEB-2025
DEFINITION  Homo sapiens transmembrane protein 205 (TMEM205), transcript
            variant 1, mRNA.
ACCESSION   NM_198536 XM_496288
VERSION     NM_198536.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1256)
  AUTHORS   Saini,U., Smith,B.Q., Dorayappan,K.D.P., Yoo,J.Y., Maxwell,G.L.,
            Kaur,B., Konishi,I., O'Malley,D., Cohn,D.E. and Selvendiran,K.
  TITLE     Targeting TMEM205 mediated drug resistance in ovarian clear cell
            carcinoma using oncolytic virus
  JOURNAL   J Ovarian Res 15 (1), 130 (2022)
   PUBMED   36476493
  REMARK    Erratum:[J Ovarian Res. 2023 Feb 13;16(1):38. doi:
            10.1186/s13048-023-01111-7.. PMID: 36782250]
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1256)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 1256)
  AUTHORS   Gallenito,M.J., Qasim,T.S., Tutol,J.N., Prakash,V., Dodani,S.C. and
            Meloni,G.
  TITLE     A recombinant platform to characterize the role of transmembrane
            protein hTMEM205 in Pt(II)-drug resistance and extrusion
  JOURNAL   Metallomics 12 (10), 1542-1554 (2020)
   PUBMED   32789331
  REMARK    GeneRIF: A recombinant platform to characterize the role of
            transmembrane protein hTMEM205 in Pt(II)-drug resistance and
            extrusion.
REFERENCE   4  (bases 1 to 1256)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   5  (bases 1 to 1256)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   6  (bases 1 to 1256)
  AUTHORS   Wang,Y., Yin,J.Y., Li,X.P., Chen,J., Qian,C.Y., Zheng,Y., Fu,Y.L.,
            Chen,Z.Y., Zhou,H.H. and Liu,Z.Q.
  TITLE     The association of transporter genes polymorphisms and lung cancer
            chemotherapy response
  JOURNAL   PLoS One 9 (3), e91967 (2014)
   PUBMED   24643204
  REMARK    GeneRIF: The genetic polymorphisms in OCT2, AQP2, AQP9 and TMEM205
            may contribute to chemotherapy response in lung cancer patients.
            Publication Status: Online-Only
REFERENCE   7  (bases 1 to 1256)
  AUTHORS   Shen,D.W., Ma,J., Okabe,M., Zhang,G., Xia,D. and Gottesman,M.M.
  TITLE     Elevated expression of TMEM205, a hypothetical membrane protein, is
            associated with cisplatin resistance
  JOURNAL   J Cell Physiol 225 (3), 822-828 (2010)
   PUBMED   20589834
  REMARK    GeneRIF: Results indicate that a novel mechanism for cisplatin
            resistance is mediated by TMEM205 overexpression.
REFERENCE   8  (bases 1 to 1256)
  AUTHORS   Clark,H.F., Gurney,A.L., Abaya,E., Baker,K., Baldwin,D., Brush,J.,
            Chen,J., Chow,B., Chui,C., Crowley,C., Currell,B., Deuel,B.,
            Dowd,P., Eaton,D., Foster,J., Grimaldi,C., Gu,Q., Hass,P.E.,
            Heldens,S., Huang,A., Kim,H.S., Klimowski,L., Jin,Y., Johnson,S.,
            Lee,J., Lewis,L., Liao,D., Mark,M., Robbie,E., Sanchez,C.,
            Schoenfeld,J., Seshagiri,S., Simmons,L., Singh,J., Smith,V.,
            Stinson,J., Vagts,A., Vandlen,R., Watanabe,C., Wieand,D., Woods,K.,
            Xie,M.H., Yansura,D., Yi,S., Yu,G., Yuan,J., Zhang,M., Zhang,Z.,
            Goddard,A., Wood,W.I., Godowski,P. and Gray,A.
  TITLE     The secreted protein discovery initiative (SPDI), a large-scale
            effort to identify novel human secreted and transmembrane proteins:
            a bioinformatics assessment
  JOURNAL   Genome Res 13 (10), 2265-2270 (2003)
   PUBMED   12975309
  REMARK    Erratum:[Genome Res. 2003 Dec;13(12):2759]
REFERENCE   9  (bases 1 to 1256)
  AUTHORS   Wistow,G., Bernstein,S.L., Wyatt,M.K., Ray,S., Behal,A.,
            Touchman,J.W., Bouffard,G., Smith,D. and Peterson,K.
  TITLE     Expressed sequence tag analysis of human retina for the NEIBank
            Project: retbindin, an abundant, novel retinal cDNA and alternative
            splicing of other retina-preferred gene transcripts
  JOURNAL   Mol Vis 8, 196-204 (2002)
   PUBMED   12107411
  REMARK    Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BE889078.1, BC064948.1 and BC091472.1.
            
            On Nov 22, 2018 this sequence version replaced NM_198536.2.
            
            Transcript Variant: This variant (1) is the longest transcript.
            Variants 1, 2, 3, 4, 5 and 6 encode the same protein.
            
            ##Evidence-Data-START##
            Transcript exon combination :: ERR279831.10791.1,
                                           SRR1163655.96630.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2142670, SAMEA2144835
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000354882.10/ ENSP00000346954.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-222               BE889078.1         38-259
            223-1252            BC064948.1         1-1030
            1253-1256           BC091472.1         719-722
FEATURES             Location/Qualifiers
     source          1..1256
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.2"
     gene            1..1256
                     /gene="TMEM205"
                     /gene_synonym="UNQ501"
                     /note="transmembrane protein 205"
                     /db_xref="GeneID:374882"
                     /db_xref="HGNC:HGNC:29631"
                     /db_xref="MIM:613771"
     exon            1..749
                     /gene="TMEM205"
                     /gene_synonym="UNQ501"
                     /inference="alignment:Splign:2.1.0"
     CDS             650..1219
                     /gene="TMEM205"
                     /gene_synonym="UNQ501"
                     /note="MBC3205"
                     /codon_start=1
                     /product="transmembrane protein 205"
                     /protein_id="NP_940938.1"
                     /db_xref="CCDS:CCDS32909.1"
                     /db_xref="GeneID:374882"
                     /db_xref="HGNC:HGNC:29631"
                     /db_xref="MIM:613771"
                     /translation="MEEGGNLGGLIKMVHLLVLSGAWGMQMWVTFVSGFLLFRSLPRH
                     TFGLVQSKLFPFYFHISMGCAFINLCILASQHAWAQLTFWEASQLYLLFLSLTLATVN
                     ARWLEPRTTAAMWALQTVEKERGLGGEVPGSHQGPDPYRQLREKDPKYSALRQNFFRY
                     HGLSSLCNLGCVLSNGLCLAGLALEIRSL"
     exon            750..913
                     /gene="TMEM205"
                     /gene_synonym="UNQ501"
                     /inference="alignment:Splign:2.1.0"
     exon            914..1256
                     /gene="TMEM205"
                     /gene_synonym="UNQ501"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1237..1242
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TMEM205"
                     /gene_synonym="UNQ501"
                     /note="hexamer: AATAAA"
     polyA_site      1256
                     /gene="TMEM205"
                     /gene_synonym="UNQ501"
                     /note="major polyA site"
ORIGIN      
        1 gaaacccacg aggggacgcg gccgaggagg gtcgctgtcc acccgggggc gtgggagtga
       61 ggtaccagat tcagcccatt tggccccgac gcctctgttc tcggaatccg ggtgctgcgg
      121 attgaggtcc cggttcctaa cggtgggatc ggtgtcctcg ggatgagatt tggcgtttcc
      181 tcggggcttt ggtgggatcg gtgtcctcag gatgagattt agggtttcct cggggctttc
      241 gggatcttca cctaatatcc ggtattattt tatgagagga gtggtcttgg ctgtcagaac
      301 tggatccctg gggtgatatt tgggaattag tggagtgatc tctgaagacc tagggctatg
      361 atctggagct gctgtggctg aaatttgggg cctctgaagt ggcatggaga ttgaggtcca
      421 gagagcctga gatcttgagg gctgacattt ggagagatgg ggtcgagggt tgtctttggg
      481 ccttgactgc tttgggcctt tctcactctc attcccggga tgctttgcca gaatctctgc
      541 tggattggcc gtaaccctgt ccccgagcgg gctcacaggg tctgaaggcc acgcatgagg
      601 caaaggtaaa gttctgagcc acccggtgcc tccttcccag gactgcaaga tggaggaagg
      661 cgggaaccta ggaggcctga ttaagatggt ccatctactg gtcttgtcag gtgcctgggg
      721 catgcaaatg tgggtgacct tcgtctcagg cttcctgctt ttccgaagcc ttccccgaca
      781 taccttcgga ctagtgcaga gcaaactctt ccccttctac ttccacatct ccatgggctg
      841 tgccttcatc aacctctgca tcttggcttc acagcatgct tgggctcagc tcacattctg
      901 ggaggccagc cagctttacc tgctgttcct gagccttacg ctggccactg tcaacgcccg
      961 ctggctggaa ccccgcacca cagctgccat gtgggccctg caaaccgtgg agaaggagcg
     1021 aggcctgggt ggggaggtac caggcagcca ccagggtccc gatccctacc gccagctgcg
     1081 agagaaggac cccaagtaca gtgctctccg ccagaatttc ttccgctacc atgggctgtc
     1141 ctctctttgc aatctgggct gcgtcctgag caatgggctc tgtctcgctg gccttgccct
     1201 ggaaataagg agcctctagc atgggccctg catgctaata aatgcttctt cagaaa
//
