LOCUS       NM_024600               1833 bp    mRNA    linear   PRI 08-JUN-2024
DEFINITION  Homo sapiens transmembrane protein 204 (TMEM204), transcript
            variant 1, mRNA.
ACCESSION   NM_024600
VERSION     NM_024600.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1833)
  AUTHORS   Kearsey,J., Petit,S., De Oliveira,C. and Schweighoffer,F.
  TITLE     A novel four transmembrane spanning protein, CLP24. A hypoxically
            regulated cell junction protein
  JOURNAL   Eur J Biochem 271 (13), 2584-2592 (2004)
   PUBMED   15206924
  REMARK    GeneRIF: suggests that CLP24 is a novel, hypoxically regulated
            tetraspan adherens junction protein that modulates cell adhesion,
            paracellular permeability and angiogenesis
REFERENCE   2  (bases 1 to 1833)
  AUTHORS   Clark,H.F., Gurney,A.L., Abaya,E., Baker,K., Baldwin,D., Brush,J.,
            Chen,J., Chow,B., Chui,C., Crowley,C., Currell,B., Deuel,B.,
            Dowd,P., Eaton,D., Foster,J., Grimaldi,C., Gu,Q., Hass,P.E.,
            Heldens,S., Huang,A., Kim,H.S., Klimowski,L., Jin,Y., Johnson,S.,
            Lee,J., Lewis,L., Liao,D., Mark,M., Robbie,E., Sanchez,C.,
            Schoenfeld,J., Seshagiri,S., Simmons,L., Singh,J., Smith,V.,
            Stinson,J., Vagts,A., Vandlen,R., Watanabe,C., Wieand,D., Woods,K.,
            Xie,M.H., Yansura,D., Yi,S., Yu,G., Yuan,J., Zhang,M., Zhang,Z.,
            Goddard,A., Wood,W.I., Godowski,P. and Gray,A.
  TITLE     The secreted protein discovery initiative (SPDI), a large-scale
            effort to identify novel human secreted and transmembrane proteins:
            a bioinformatics assessment
  JOURNAL   Genome Res 13 (10), 2265-2270 (2003)
   PUBMED   12975309
  REMARK    Erratum:[Genome Res. 2003 Dec;13(12):2759]
REFERENCE   3  (bases 1 to 1833)
  AUTHORS   Kutsenko,A.S., Gizatullin,R.Z., Al-Amin,A.N., Wang,F., Kvasha,S.M.,
            Podowski,R.M., Matushkin,Y.G., Gyanchandani,A., Muravenko,O.V.,
            Levitsky,V.G., Kolchanov,N.A., Protopopov,A.I., Kashuba,V.I.,
            Kisselev,L.L., Wasserman,W., Wahlestedt,C. and Zabarovsky,E.R.
  TITLE     NotI flanking sequences: a tool for gene discovery and verification
            of the human genome
  JOURNAL   Nucleic Acids Res 30 (14), 3163-3170 (2002)
   PUBMED   12136098
REFERENCE   4  (bases 1 to 1833)
  AUTHORS   Daniels,R.J., Peden,J.F., Lloyd,C., Horsley,S.W., Clark,K.,
            Tufarelli,C., Kearney,L., Buckle,V.J., Doggett,N.A., Flint,J. and
            Higgs,D.R.
  TITLE     Sequence, structure and pathology of the fully annotated terminal 2
            Mb of the short arm of human chromosome 16
  JOURNAL   Hum Mol Genet 10 (4), 339-352 (2001)
   PUBMED   11157797
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AY676494.1 and BC105785.1.
            
            On Nov 22, 2018 this sequence version replaced NM_024600.5.
            
            Summary: C16ORF30 plays a role in cell adhesion and cellular
            permeability at adherens junctions (Kearsey et al., 2004 [PubMed
            15206924]).[supplied by OMIM, Mar 2008].
            
            Transcript Variant: This variant (1) represents the longer
            transcript. Both variants encode the same protein.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.76690.1, AY676494.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000566264.2/ ENSP00000454945.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1307              AY676494.1         11-1317
            1308-1833           BC105785.1         817-1342
FEATURES             Location/Qualifiers
     source          1..1833
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16p13.3"
     gene            1..1833
                     /gene="TMEM204"
                     /gene_synonym="C16orf30; CLP24"
                     /note="transmembrane protein 204"
                     /db_xref="GeneID:79652"
                     /db_xref="HGNC:HGNC:14158"
                     /db_xref="MIM:611002"
     exon            1..890
                     /gene="TMEM204"
                     /gene_synonym="C16orf30; CLP24"
                     /inference="alignment:Splign:2.1.0"
     CDS             611..1291
                     /gene="TMEM204"
                     /gene_synonym="C16orf30; CLP24"
                     /note="claudin-like protein 24; claudin-like protein of 24
                     kDa"
                     /codon_start=1
                     /product="transmembrane protein 204"
                     /protein_id="NP_078876.2"
                     /db_xref="CCDS:CCDS42098.1"
                     /db_xref="GeneID:79652"
                     /db_xref="HGNC:HGNC:14158"
                     /db_xref="MIM:611002"
                     /translation="MTVQRLVAAAVLVALVSLILNNVAAFTSNWVCQTLEDGRRRSVG
                     LWRSCWLVDRTRGGPSPGARAGQVDAHDCEALGWGSEAAGFQESRGTVKLQFDMMRAC
                     NLVATAALTAGQLTFLLGLVGLPLLSPDAPCWEEAMAAAFQLASFVLVIGLVTFYRIG
                     PYTNLSWSCYLNIGACLLATLAAAMLIWNILHKREDCMAPRVIVISRSLTARFRRGLD
                     NDYVESPC"
     exon            891..1046
                     /gene="TMEM204"
                     /gene_synonym="C16orf30; CLP24"
                     /inference="alignment:Splign:2.1.0"
     exon            1047..1833
                     /gene="TMEM204"
                     /gene_synonym="C16orf30; CLP24"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1814..1819
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TMEM204"
                     /gene_synonym="C16orf30; CLP24"
                     /note="hexamer: AATAAA"
     polyA_site      1833
                     /gene="TMEM204"
                     /gene_synonym="C16orf30; CLP24"
                     /note="major polyA site"
ORIGIN      
        1 catttcctct ctgctgagag ccagggaagg cgagctctgc gcacacgggc gtccctgcag
       61 cagccactct gctttccagg accggccaac tgccctggag gcatccacac aggggcccag
      121 gcagcacaga ggagctgtga acccgctcca caccggccac cctgcccgga gcctggcact
      181 cacagcaggc cggtgctaag gagtgtggcg cgggctcgac tcccactgct gccggcctcc
      241 cgagtgactc tgttttccac tgctgcaggc gagaagaggc acgcgcggca caggccggcc
      301 tccgcttccc gggaagacgg cgcactcctg gccctgggtt cttgctgctg cccaccctct
      361 gctccctggg atgggccccg aggcgagcag cttcagcaca ggcctggccc tgctccaggt
      421 gcaggaagga ggataaggcc gggccgagag gcggcacacc tggaccatcc catgggcctc
      481 cgcccgcgcc gccccgagga tgagtggtga tgtcctctag ccacccctag cagcgtcggc
      541 tctccctgga cgtgcggccg cggactggga cttggctttc tccggataag cggcggcacc
      601 ggcgtcagcg atgaccgtgc agagactcgt ggccgcggcc gtgctggtgg ccctggtctc
      661 actcatcctc aacaacgtgg cggccttcac ctccaactgg gtgtgccaga cgctggagga
      721 tgggcgcagg cgcagcgtgg ggctgtggag gtcctgctgg ctggtggaca ggacccgggg
      781 agggccgagc cctggggcca gagccggcca ggtggacgca catgactgtg aggcgctggg
      841 ctggggctcc gaggcagccg gcttccagga gtcccgaggc accgtcaaac tgcagttcga
      901 catgatgcgc gcctgcaacc tggtggccac ggccgcgctc accgcaggcc agctcacctt
      961 cctcctgggg ctggtgggcc tgcccctgct gtcacccgac gccccgtgct gggaggaggc
     1021 catggccgct gcattccaac tggcgagttt tgtcctggtc atcgggctcg tgactttcta
     1081 cagaattggc ccatacacca acctgtcctg gtcctgctac ctgaacattg gcgcctgcct
     1141 tctggccacg ctggcggcag ccatgctcat ctggaacatt ctccacaaga gggaggactg
     1201 catggccccc cgggtgattg tcatcagccg ctccctgaca gcgcgctttc gccgtgggct
     1261 ggacaatgac tacgtggagt caccatgctg agtcgccctt ctcagcgctc catcaacgca
     1321 cacctgctat cgtggaacag cctagaaacc aagggactcc accaccaagt cacttcccct
     1381 gctcgtgcag aggcacggga tgagtctggg tgacctctgc gccatgcgtg cgagacacgt
     1441 gtgcgtttac tgttatgtcg gtcatatgtc tgtacgtgtc gtgggccaac ctcgttctgc
     1501 ctccagcttt cctggttagc gcaacgcggc tccacgacca cacgcacttc agggtggaag
     1561 ctggaagctg agacacaggt taggtggcgc gaggctgccc tgcgctccgc tttgctttgg
     1621 gattaattta ttctgcatct gctgagaggg gcaccccagc catatcttac actttggtaa
     1681 agcagaaaac caggaaaatt ttcttaaaat atccacaata ttccttgagt gagtcagaat
     1741 ctatagccgg ttagtgatgg tttcagacag aatcgtgttc gtgtctgttt tgctcgattc
     1801 ttttcctaag ttaaataaat gcaagcctct gaa
//
