LOCUS       NM_001256541            1684 bp    mRNA    linear   PRI 08-JUN-2024
DEFINITION  Homo sapiens transmembrane protein 204 (TMEM204), transcript
            variant 2, mRNA.
ACCESSION   NM_001256541
VERSION     NM_001256541.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1684)
  AUTHORS   Kearsey,J., Petit,S., De Oliveira,C. and Schweighoffer,F.
  TITLE     A novel four transmembrane spanning protein, CLP24. A hypoxically
            regulated cell junction protein
  JOURNAL   Eur J Biochem 271 (13), 2584-2592 (2004)
   PUBMED   15206924
  REMARK    GeneRIF: suggests that CLP24 is a novel, hypoxically regulated
            tetraspan adherens junction protein that modulates cell adhesion,
            paracellular permeability and angiogenesis
REFERENCE   2  (bases 1 to 1684)
  AUTHORS   Clark,H.F., Gurney,A.L., Abaya,E., Baker,K., Baldwin,D., Brush,J.,
            Chen,J., Chow,B., Chui,C., Crowley,C., Currell,B., Deuel,B.,
            Dowd,P., Eaton,D., Foster,J., Grimaldi,C., Gu,Q., Hass,P.E.,
            Heldens,S., Huang,A., Kim,H.S., Klimowski,L., Jin,Y., Johnson,S.,
            Lee,J., Lewis,L., Liao,D., Mark,M., Robbie,E., Sanchez,C.,
            Schoenfeld,J., Seshagiri,S., Simmons,L., Singh,J., Smith,V.,
            Stinson,J., Vagts,A., Vandlen,R., Watanabe,C., Wieand,D., Woods,K.,
            Xie,M.H., Yansura,D., Yi,S., Yu,G., Yuan,J., Zhang,M., Zhang,Z.,
            Goddard,A., Wood,W.I., Godowski,P. and Gray,A.
  TITLE     The secreted protein discovery initiative (SPDI), a large-scale
            effort to identify novel human secreted and transmembrane proteins:
            a bioinformatics assessment
  JOURNAL   Genome Res 13 (10), 2265-2270 (2003)
   PUBMED   12975309
  REMARK    Erratum:[Genome Res. 2003 Dec;13(12):2759]
REFERENCE   3  (bases 1 to 1684)
  AUTHORS   Kutsenko,A.S., Gizatullin,R.Z., Al-Amin,A.N., Wang,F., Kvasha,S.M.,
            Podowski,R.M., Matushkin,Y.G., Gyanchandani,A., Muravenko,O.V.,
            Levitsky,V.G., Kolchanov,N.A., Protopopov,A.I., Kashuba,V.I.,
            Kisselev,L.L., Wasserman,W., Wahlestedt,C. and Zabarovsky,E.R.
  TITLE     NotI flanking sequences: a tool for gene discovery and verification
            of the human genome
  JOURNAL   Nucleic Acids Res 30 (14), 3163-3170 (2002)
   PUBMED   12136098
REFERENCE   4  (bases 1 to 1684)
  AUTHORS   Daniels,R.J., Peden,J.F., Lloyd,C., Horsley,S.W., Clark,K.,
            Tufarelli,C., Kearney,L., Buckle,V.J., Doggett,N.A., Flint,J. and
            Higgs,D.R.
  TITLE     Sequence, structure and pathology of the fully annotated terminal 2
            Mb of the short arm of human chromosome 16
  JOURNAL   Hum Mol Genet 10 (4), 339-352 (2001)
   PUBMED   11157797
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL031719.12, BC004932.1 and BC105785.1.
            
            On Jun 1, 2019 this sequence version replaced NM_001256541.1.
            
            Summary: C16ORF30 plays a role in cell adhesion and cellular
            permeability at adherens junctions (Kearsey et al., 2004 [PubMed
            15206924]).[supplied by OMIM, Mar 2008].
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. Both variants encode the same protein.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC004932.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2146236
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-63                AL031719.12        11130-11192
            64-1165             BC004932.1         1-1102
            1166-1684           BC105785.1         824-1342
FEATURES             Location/Qualifiers
     source          1..1684
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16p13.3"
     gene            1..1684
                     /gene="TMEM204"
                     /gene_synonym="C16orf30; CLP24"
                     /note="transmembrane protein 204"
                     /db_xref="GeneID:79652"
                     /db_xref="HGNC:HGNC:14158"
                     /db_xref="MIM:611002"
     exon            1..119
                     /gene="TMEM204"
                     /gene_synonym="C16orf30; CLP24"
                     /inference="alignment:Splign:2.1.0"
     exon            120..741
                     /gene="TMEM204"
                     /gene_synonym="C16orf30; CLP24"
                     /inference="alignment:Splign:2.1.0"
     CDS             462..1142
                     /gene="TMEM204"
                     /gene_synonym="C16orf30; CLP24"
                     /note="claudin-like protein 24; claudin-like protein of 24
                     kDa"
                     /codon_start=1
                     /product="transmembrane protein 204"
                     /protein_id="NP_001243470.1"
                     /db_xref="CCDS:CCDS42098.1"
                     /db_xref="GeneID:79652"
                     /db_xref="HGNC:HGNC:14158"
                     /db_xref="MIM:611002"
                     /translation="MTVQRLVAAAVLVALVSLILNNVAAFTSNWVCQTLEDGRRRSVG
                     LWRSCWLVDRTRGGPSPGARAGQVDAHDCEALGWGSEAAGFQESRGTVKLQFDMMRAC
                     NLVATAALTAGQLTFLLGLVGLPLLSPDAPCWEEAMAAAFQLASFVLVIGLVTFYRIG
                     PYTNLSWSCYLNIGACLLATLAAAMLIWNILHKREDCMAPRVIVISRSLTARFRRGLD
                     NDYVESPC"
     exon            742..897
                     /gene="TMEM204"
                     /gene_synonym="C16orf30; CLP24"
                     /inference="alignment:Splign:2.1.0"
     exon            898..1684
                     /gene="TMEM204"
                     /gene_synonym="C16orf30; CLP24"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1665..1670
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TMEM204"
                     /gene_synonym="C16orf30; CLP24"
                     /note="hexamer: AATAAA"
     polyA_site      1684
                     /gene="TMEM204"
                     /gene_synonym="C16orf30; CLP24"
                     /note="major polyA site"
ORIGIN      
        1 agtccagccc acagtcttag cagggcagca gccctgcagc ctccccgctg gcacggtcac
       61 aggccgctct gaggactgga gggaccagcc gcccacagag ccccgagccc gtggtcccgg
      121 cgagaagagg cacgcgcggc acaggccggc ctccgcttcc cgggaagacg gcgcactcct
      181 ggccctgggt tcttgctgct gcccaccctc tgctccctgg gatgggcccc gaggcgagca
      241 gcttcagcac aggcctggcc ctgctccagg tgcaggaagg aggataaggc cgggccgaga
      301 ggcggcacac ctggaccatc ccatgggcct ccgcccgcgc cgccccgagg atgagtggtg
      361 atgtcctcta gccaccccta gcagcgtcgg ctctccctgg acgtgcggcc gcggactggg
      421 acttggcttt ctccggataa gcggcggcac cggcgtcagc gatgaccgtg cagagactcg
      481 tggccgcggc cgtgctggtg gccctggtct cactcatcct caacaacgtg gcggccttca
      541 cctccaactg ggtgtgccag acgctggagg atgggcgcag gcgcagcgtg gggctgtgga
      601 ggtcctgctg gctggtggac aggacccggg gagggccgag ccctggggcc agagccggcc
      661 aggtggacgc acatgactgt gaggcgctgg gctggggctc cgaggcagcc ggcttccagg
      721 agtcccgagg caccgtcaaa ctgcagttcg acatgatgcg cgcctgcaac ctggtggcca
      781 cggccgcgct caccgcaggc cagctcacct tcctcctggg gctggtgggc ctgcccctgc
      841 tgtcacccga cgccccgtgc tgggaggagg ccatggccgc tgcattccaa ctggcgagtt
      901 ttgtcctggt catcgggctc gtgactttct acagaattgg cccatacacc aacctgtcct
      961 ggtcctgcta cctgaacatt ggcgcctgcc ttctggccac gctggcggca gccatgctca
     1021 tctggaacat tctccacaag agggaggact gcatggcccc ccgggtgatt gtcatcagcc
     1081 gctccctgac agcgcgcttt cgccgtgggc tggacaatga ctacgtggag tcaccatgct
     1141 gagtcgccct tctcagcgct ccatcaacgc acacctgcta tcgtggaaca gcctagaaac
     1201 caagggactc caccaccaag tcacttcccc tgctcgtgca gaggcacggg atgagtctgg
     1261 gtgacctctg cgccatgcgt gcgagacacg tgtgcgttta ctgttatgtc ggtcatatgt
     1321 ctgtacgtgt cgtgggccaa cctcgttctg cctccagctt tcctggttag cgcaacgcgg
     1381 ctccacgacc acacgcactt cagggtggaa gctggaagct gagacacagg ttaggtggcg
     1441 cgaggctgcc ctgcgctccg ctttgctttg ggattaattt attctgcatc tgctgagagg
     1501 ggcaccccag ccatatctta cactttggta aagcagaaaa ccaggaaaat tttcttaaaa
     1561 tatccacaat attccttgag tgagtcagaa tctatagccg gttagtgatg gtttcagaca
     1621 gaatcgtgtt cgtgtctgtt ttgctcgatt cttttcctaa gttaaataaa tgcaagcctc
     1681 tgaa
//
