LOCUS       NM_053045               1567 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens transmembrane protein 203 (TMEM203), mRNA.
ACCESSION   NM_053045
VERSION     NM_053045.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1567)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 1567)
  AUTHORS   Li,Y., James,S.J., Wyllie,D.H., Wynne,C., Czibula,A., Bukhari,A.,
            Pye,K., Bte Mustafah,S.M., Fajka-Boja,R., Szabo,E., Angyal,A.,
            Hegedus,Z., Kovacs,L., Hill,A.V.S., Jefferies,C.A., Wilson,H.L.,
            Yongliang,Z. and Kiss-Toth,E.
  TITLE     TMEM203 is a binding partner and regulator of STING-mediated
            inflammatory signaling in macrophages
  JOURNAL   Proc Natl Acad Sci U S A 116 (33), 16479-16488 (2019)
   PUBMED   31346090
  REMARK    GeneRIF: Identification of TMEM203 sheds light into the control of
            STING-mediated innate immune responses.
REFERENCE   3  (bases 1 to 1567)
  AUTHORS   Shambharkar,P.B., Bittinger,M., Latario,B., Xiong,Z.,
            Bandyopadhyay,S., Davis,V., Lin,V., Yang,Y., Valdez,R. and
            Labow,M.A.
  TITLE     TMEM203 Is a Novel Regulator of Intracellular Calcium Homeostasis
            and Is Required for Spermatogenesis
  JOURNAL   PLoS One 10 (5), e0127480 (2015)
   PUBMED   25996873
  REMARK    GeneRIF: Tmem203 is an evolutionarily conserved regulator of
            cellular calcium homeostasis, is required for spermatogenesis and
            provides a causal link between intracellular calcium regulation and
            spermiogenesis.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1567)
  AUTHORS   Orvedahl,A., Sumpter,R. Jr., Xiao,G., Ng,A., Zou,Z., Tang,Y.,
            Narimatsu,M., Gilpin,C., Sun,Q., Roth,M., Forst,C.V., Wrana,J.L.,
            Zhang,Y.E., Luby-Phelps,K., Xavier,R.J., Xie,Y. and Levine,B.
  TITLE     Image-based genome-wide siRNA screen identifies selective autophagy
            factors
  JOURNAL   Nature 480 (7375), 113-117 (2011)
   PUBMED   22020285
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL929554.20 and BC009461.1.
            
            On Nov 22, 2018 this sequence version replaced NM_053045.1.
            
            ##Evidence-Data-START##
            Transcript is intronless :: BC009461.1, SRR1163657.370835.1
                                        [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000343666.6/ ENSP00000375053.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-10                AL929554.20        118902-118911       c
            11-1567             BC009461.1         1-1557
FEATURES             Location/Qualifiers
     source          1..1567
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9q34.3"
     gene            1..1567
                     /gene="TMEM203"
                     /gene_synonym="HBEBP1"
                     /note="transmembrane protein 203"
                     /db_xref="GeneID:94107"
                     /db_xref="HGNC:HGNC:28217"
                     /db_xref="MIM:616499"
     exon            1..1567
                     /gene="TMEM203"
                     /gene_synonym="HBEBP1"
                     /inference="alignment:Splign:2.1.0"
     CDS             235..645
                     /gene="TMEM203"
                     /gene_synonym="HBEBP1"
                     /note="HBeAg-binding protein 1"
                     /codon_start=1
                     /product="transmembrane protein 203"
                     /protein_id="NP_444273.1"
                     /db_xref="CCDS:CCDS35185.1"
                     /db_xref="GeneID:94107"
                     /db_xref="HGNC:HGNC:28217"
                     /db_xref="MIM:616499"
                     /translation="MLFSLRELVQWLGFATFEIFVHLLALLVFSVLLALRVDGLVPGL
                     SWWNVFVPFFAADGLSTYFTTIVSVRLFQDGEKRLAVLRLFWVLTVLSLKFVFEMLLC
                     QKLAEQTRELWFGLITSPLFILLQLLMIRACRVN"
     regulatory      1540..1545
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TMEM203"
                     /gene_synonym="HBEBP1"
                     /note="hexamer: AATAAA"
     polyA_site      1567
                     /gene="TMEM203"
                     /gene_synonym="HBEBP1"
                     /note="major polyA site"
ORIGIN      
        1 gtgggggcat ggcgtccgat cgaggcgggc gttcacgggc ggccagggtt gagtcccggg
       61 tcggggccgg gggattgccg gcgcatcagg gccgagggct ggggctggcg gggccgctcg
      121 ctgcctctcg ctcgcagcag cggcggcagg cgcgggcgag ggccacgggg agaggagacg
      181 cagccccgcg ggtggcacgc tcggccgggc cccggcccgc gctcaacggg cgcgatgctc
      241 ttctcgctcc gggagctggt gcagtggcta ggcttcgcca ccttcgagat cttcgtgcac
      301 ctgctggccc tgttggtgtt ctctgtgctg ctggcactgc gtgtggatgg cctggtcccg
      361 ggcctctcct ggtggaacgt gttcgtgcct ttcttcgccg ctgacgggct cagcacctac
      421 ttcaccacca tcgtgtccgt gcgcctcttc caggatggag agaagcggct ggcggtgctc
      481 cgccttttct gggtacttac ggtcctgagt ctcaagttcg tcttcgagat gctgttgtgc
      541 cagaagctgg cggagcagac tcgggagctc tggttcggcc tcattacgtc cccgctcttc
      601 attctcctgc agctgctcat gatccgcgcc tgtcgggtca actagcctca ccgaggtgcc
      661 ggagagggag cgctggacaa ctagaatgtt gacctcgagc cgaggcccta cttgcagcgc
      721 accggaggag aggctctcta gtctgaaggc accgccggct tgcgccgagc tgagtgccgg
      781 gtttccctat tccaatcctg tttgaaatgg tttcttcagc agggcttaaa agagcagcct
      841 tcatcctgaa aatgtatttc cttttgttta atgctttgag tagataatcc tgaattgagg
      901 tcatgaggag gccccccagg ccagacagtc ctgaacccct ctgacacttg gaaactgaat
      961 ataagtaaaa tgtccaggtg gactctgagt atttcctgtg gatcctggga aagtactgtt
     1021 gcacaaaggc tgcaaagctg gactcaggaa tgtcctccaa ccagcagcgc tgacctaaga
     1081 gctccctgtg ccgtctatcc agaccagact tcggtagatg cctttgttag atctatcaca
     1141 tgtaaacgag cttgtatctc cttccctgtg ccacgagaga gattggcttt ttattccagt
     1201 ctaggcagag acagaagaat gttgaataag agcacgatta gagtcctgtc tggttatctg
     1261 ttgcccaaga aaagaactct gctgtccagg cactgcttgg cttactatcc cagcaaagac
     1321 tgcagttttg tggacttttg accaccttgg gctggcactc ttagcacacc tgagacagat
     1381 ttaagcctcc ctaagagact gaagagagga acaggtgtca gatactcata ggcactgaga
     1441 tctacaaatg ggaagcttgt gagtggccca tctttgttgg cctacgaact ttggtttgat
     1501 gccagtcagg tgccacatga gaacctttgc tgagatgcaa ataaagtaag agaatgtttt
     1561 cctgaaa
//
