LOCUS       NM_001130924            3815 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens transmembrane protein 201 (TMEM201), transcript
            variant 1, mRNA.
ACCESSION   NM_001130924
VERSION     NM_001130924.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3815)
  AUTHORS   Chen,D., Lou,Y., Lu,J., Fan,X., Zhu,Q. and Sun,H.
  TITLE     Characterization of the Clinical Significance and Immunological
            Landscapes of a Novel TMEMs Signature in Hepatocellular Carcinoma
            and the Contribution of TMEM201 to Hepatocarcinogenesis
  JOURNAL   Int J Mol Sci 24 (12), 10285 (2023)
   PUBMED   37373430
  REMARK    GeneRIF: Characterization of the Clinical Significance and
            Immunological Landscapes of a Novel TMEMs Signature in
            Hepatocellular Carcinoma and the Contribution of TMEM201 to
            Hepatocarcinogenesis.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3815)
  AUTHORS   Zhang,Y., Kong,Y., Guo,H., Liu,Y., Zang,Y. and Li,J.
  TITLE     Inner nuclear membrane protein TMEM201 maintains endothelial cell
            migration and angiogenesis by interacting with the LINC complex
  JOURNAL   J Mol Cell Biol 14 (3) (2022)
   PUBMED   35311970
  REMARK    GeneRIF: Inner nuclear membrane protein TMEM201 maintains
            endothelial cell migration and angiogenesis by interacting with the
            LINC complex.
REFERENCE   3  (bases 1 to 3815)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 3815)
  AUTHORS   Bergqvist,C., Niss,F., Figueroa,R.A., Beckman,M., Maksel,D.,
            Jafferali,M.H., Kulyte,A., Strom,A.L. and Hallberg,E.
  TITLE     Monitoring of chromatin organization in live cells by FRIC. Effects
            of the inner nuclear membrane protein Samp1
  JOURNAL   Nucleic Acids Res 47 (9), e49 (2019)
   PUBMED   30793190
  REMARK    GeneRIF: We also found that peripheral heterochromatin depended on
            the levels of the inner nuclear membrane protein Samp1, suggesting
            an important role in promoting peripheral heterochromatin. Taken
            together, FRIC is a powerful and robust new tool to study dynamic
            chromatin redistribution in live cells.
REFERENCE   5  (bases 1 to 3815)
  AUTHORS   Larsson,V.J., Jafferali,M.H., Vijayaraghavan,B., Figueroa,R.A. and
            Hallberg,E.
  TITLE     Mitotic spindle assembly and gamma-tubulin localisation depend on
            the integral nuclear membrane protein Samp1
  JOURNAL   J Cell Sci 131 (8) (2018)
   PUBMED   29514856
  REMARK    GeneRIF: Authors show that Samp1 is involved in the recruitment of
            HAUS6 and gamma-tubulin to the mitotic spindle. Samp1 is the first
            inner nuclear membrane protein shown to have a function in mitotic
            spindle assembly.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3815)
  AUTHORS   Vijayaraghavan,B., Jafferali,M.H., Figueroa,R.A. and Hallberg,E.
  TITLE     Samp1, a RanGTP binding transmembrane protein in the inner nuclear
            membrane
  JOURNAL   Nucleus 7 (4), 415-423 (2016)
   PUBMED   27541860
REFERENCE   7  (bases 1 to 3815)
  AUTHORS   Jafferali,M.H., Vijayaraghavan,B., Figueroa,R.A., Crafoord,E.,
            Gudise,S., Larsson,V.J. and Hallberg,E.
  TITLE     MCLIP, an effective method to detect interactions of transmembrane
            proteins of the nuclear envelope in live cells
  JOURNAL   Biochim Biophys Acta 1838 (10), 2399-2403 (2014)
   PUBMED   24950247
  REMARK    GeneRIF: the nucleoplasmic domains of Samp1 and Emerin can bind
            directly to each other.
REFERENCE   8  (bases 1 to 3815)
  AUTHORS   Gudise,S., Figueroa,R.A., Lindberg,R., Larsson,V. and Hallberg,E.
  TITLE     Samp1 is functionally associated with the LINC complex and A-type
            lamina networks
  JOURNAL   J Cell Sci 124 (Pt 12), 2077-2085 (2011)
   PUBMED   21610090
REFERENCE   9  (bases 1 to 3815)
  AUTHORS   Figueroa,R., Gudise,S., Larsson,V. and Hallberg,E.
  TITLE     A transmembrane inner nuclear membrane protein in the mitotic
            spindle
  JOURNAL   Nucleus 1 (3), 249-253 (2010)
   PUBMED   21327071
  REMARK    Review article
REFERENCE   10 (bases 1 to 3815)
  AUTHORS   Buch,C., Lindberg,R., Figueroa,R., Gudise,S., Onischenko,E. and
            Hallberg,E.
  TITLE     An integral protein of the inner nuclear membrane localizes to the
            mitotic spindle in mammalian cells
  JOURNAL   J Cell Sci 122 (Pt 12), 2100-2107 (2009)
   PUBMED   19494128
  REMARK    GeneRIF: characterization of a transmembrane protein of the nuclear
            envelope that we name spindle-associated membrane protein 1
            (Samp1); Samp1 defines a specific membrane domain associated with
            the mitotic spindle
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC137291.1, BX648377.1, BG828926.1 and BE676679.1.
            
            On Nov 22, 2018 this sequence version replaced NM_001130924.2.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803611.117295.1,
                                           SRR9304716.324777.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000340381.11/ ENSP00000344503.6
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-292               BC137291.1         38-329
            293-1251            BX648377.1         1-959
            1252-1744           BG828926.1         158-650
            1745-3811           BX648377.1         1381-3447
            3812-3815           BE676679.1         6-9                 c
FEATURES             Location/Qualifiers
     source          1..3815
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p36.22"
     gene            1..3815
                     /gene="TMEM201"
                     /gene_synonym="Ima1; NET5; SAMP1"
                     /note="transmembrane protein 201"
                     /db_xref="GeneID:199953"
                     /db_xref="HGNC:HGNC:33719"
     exon            1..133
                     /gene="TMEM201"
                     /gene_synonym="Ima1; NET5; SAMP1"
                     /inference="alignment:Splign:2.1.0"
     CDS             21..2021
                     /gene="TMEM201"
                     /gene_synonym="Ima1; NET5; SAMP1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     spindle-associated membrane protein 1; RP13-15M17.2"
                     /codon_start=1
                     /product="transmembrane protein 201 isoform 1"
                     /protein_id="NP_001124396.2"
                     /db_xref="CCDS:CCDS44055.2"
                     /db_xref="GeneID:199953"
                     /db_xref="HGNC:HGNC:33719"
                     /translation="MEGVSALLARCPTAGLAGGLGVTACAAAGVLLYRIARRMKPTHT
                     MVNCWFCNQDTLVPYGNRNCWDCPHCEQYNGFQENGDYNKPIPAQYLEHLNHVVSSAP
                     SLRDPSQPQQWVSSQVLLCKRCNHHQTTKIKQLAAFAPREEGRYDEEVEVYRHHLEQM
                     YKLCRPCQAAVEYYIKHQNRQLRALLLSHQFKRREADQTHAQNFSSAVKSPVQVILLR
                     ALAFLACAFLLTTALYGASGHFAPGTTVPLALPPGGNGSATPDNGTTPGAEGWRQLLG
                     LLPEHMAEKLCEAWAFGQSHQTGVVALGLLTCLLAMLLAGRIRLRRIDAFCTCLWALL
                     LGLHLAEQHLQAASPSWLDTLKFSTTSLCCLVGFTAAVATRKATGPRRFRPRRFFPGD
                     SAGLFPTSPSLAIPHPSVGGSPASLFIPSPPSFLPLANQQLFRSPRRTSPSSLPGRLS
                     RALSLGTIPSLTRADSGYLFSGSRPPSQVSRSGEFPVSDYFSLLSGSCPSSPLPSPAP
                     SVAGSVASSSGSLRHRRPLISPARLNLKGQKLLLFPSPPGEAPTTPSSSDEHSPHNGS
                     LFTMEPPHVPRKPPLQDVKHALDLRSKLERGSACSNRSIKKEDDSSQSSTCVVDTTTR
                     GCSEEAATWRGRFGPSLVRGLLAVSLAANALFTSVFLYQSLR"
     exon            134..254
                     /gene="TMEM201"
                     /gene_synonym="Ima1; NET5; SAMP1"
                     /inference="alignment:Splign:2.1.0"
     exon            255..449
                     /gene="TMEM201"
                     /gene_synonym="Ima1; NET5; SAMP1"
                     /inference="alignment:Splign:2.1.0"
     exon            450..626
                     /gene="TMEM201"
                     /gene_synonym="Ima1; NET5; SAMP1"
                     /inference="alignment:Splign:2.1.0"
     exon            627..976
                     /gene="TMEM201"
                     /gene_synonym="Ima1; NET5; SAMP1"
                     /inference="alignment:Splign:2.1.0"
     exon            977..1180
                     /gene="TMEM201"
                     /gene_synonym="Ima1; NET5; SAMP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1181..1413
                     /gene="TMEM201"
                     /gene_synonym="Ima1; NET5; SAMP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1414..1485
                     /gene="TMEM201"
                     /gene_synonym="Ima1; NET5; SAMP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1486..1785
                     /gene="TMEM201"
                     /gene_synonym="Ima1; NET5; SAMP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1786..1923
                     /gene="TMEM201"
                     /gene_synonym="Ima1; NET5; SAMP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1924..3815
                     /gene="TMEM201"
                     /gene_synonym="Ima1; NET5; SAMP1"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      3815
                     /gene="TMEM201"
                     /gene_synonym="Ima1; NET5; SAMP1"
                     /note="major polyA site"
ORIGIN      
        1 gtccttccac gcggagagcc atggagggag tgagcgcgct gctggcccgc tgccccacgg
       61 ccggcctggc cggcggcctg ggggtcacgg cgtgcgccgc ggccggcgtg ttgctctacc
      121 ggatcgcgcg gaggatgaag ccaacgcaca cgatggtcaa ctgctggttc tgcaaccagg
      181 atacgctggt gccctatggg aaccgcaact gctgggactg tccccactgc gagcagtaca
      241 acggcttcca ggagaacggc gactacaaca agccgatccc cgcccagtac ttggagcacc
      301 tgaaccacgt ggtgagcagc gcgcccagcc tgcgcgaccc ttcgcagccg cagcagtggg
      361 tgagcagcca agtcctgctg tgcaagaggt gcaaccacca ccagaccacc aagatcaagc
      421 agctggccgc cttcgctccc cgcgaggagg gcaggtatga cgaggaggtc gaggtgtacc
      481 ggcatcacct ggagcagatg tacaagctgt gccggccgtg ccaagcggct gtggagtact
      541 acatcaagca ccagaaccgc cagctgcgcg ccctgttgct cagccaccag ttcaagcgcc
      601 gggaggccga ccagacccac gcacagaact tctcctccgc cgtgaagtcc ccggtccagg
      661 tcatcctgct ccgtgccctc gccttcctgg cctgcgcctt cctactgacc accgcgctgt
      721 atggggccag cggacacttc gccccaggca ccactgtgcc cctggccctg ccacctggtg
      781 gcaatggctc agccacacct gacaatggca ccacccctgg ggccgagggc tggcggcagt
      841 tgctgggcct actccccgag cacatggcgg agaagctgtg tgaggcctgg gcctttgggc
      901 agagccacca gacgggcgtc gtggcactgg gcctactcac ctgcctgctg gcaatgctgc
      961 tggctggccg catcaggctc cggaggatcg atgccttctg cacctgcctg tgggccctgc
     1021 tgctggggct gcacctggct gagcagcacc tgcaggccgc ctcgcctagc tggctagaca
     1081 cgctcaagtt cagcaccaca tctttgtgct gcctggttgg cttcacggcg gctgtggcca
     1141 caaggaaggc aacgggccca cggaggttcc ggccccgaag gttcttccca ggagactctg
     1201 ccggcctttt ccccaccagc cccagcttgg ccatccctca cccgagtgtc ggaggctctc
     1261 cagcgtctct gttcatcccc agcccgccca gcttcctgcc cctcgccaac cagcagctct
     1321 tccggtctcc tcgacggacc tcaccctcct cattgcctgg ccgcctcagc cgggccctct
     1381 ctctgggaac cataccctct ctgactcgag cagactccgg ctatctgttc agcggtagcc
     1441 gcccaccatc tcaggtgtct cgatctgggg agtttcctgt ttcagattac ttctctcttc
     1501 tgtcggggag ctgcccctcc tccccactcc cttccccagc gccttccgtg gccggctcgg
     1561 tggcctccag ctccggctct ctgcgccacc gcaggcccct catcagccct gcccggctca
     1621 acctgaaggg acagaagctg ctgctgttcc cgtcaccccc tggagaggcc cccaccacgc
     1681 ccagcagctc cgatgagcac tcgcctcaca acggcagcct cttcaccatg gagccgcccc
     1741 atgttccccg gaagccgccc ctgcaggacg tgaagcacgc cctggacctg agatccaagc
     1801 tggaaagagg cagtgcctgc agcaaccgct ccatcaagaa agaggacgac tcttcccagt
     1861 catctacctg tgtggtggac accaccacca ggggctgctc ggaggaggcc gccacctgga
     1921 gaggtcgttt cggcccttcc ctggtccggg gcctcctggc cgtgagcttg gccgccaacg
     1981 ccctgttcac ctcggtgttt ctgtaccaga gcctgcgctg acccaccgtt ggagcccctc
     2041 ggaggggagc aacccggtgc ctgctgcttc accactgccg gcctcaggac cctccctgga
     2101 ggggctgcca cctctgccct catctccagg gccttgacct cactggactg tgactgtcct
     2161 caggacacct gcccctcctc acctaacgga ctgcagggct gagcatgtgt ctgaggtcac
     2221 actctctgcc cactcacctc cttggctgac atcggttgtg tttggtgctg acactctgat
     2281 cccgaagcca gggagcccca aggggctgca tgaccctggg gtgccccaca cagttcagcc
     2341 ctgcctggca gggacgccag tactactgta actgcagcag gagctgcccg gcctgccttc
     2401 tggccccacg cccacaggcg tagtcacatc tttgtactgt actcccctgt ctcacctggg
     2461 gcaacctcag agccccacta agctgaaggc cccctggggg agggggaagc atggtcctta
     2521 tcatctgccc tatcttgccc cttcctgtgg agtgggcaga agggctcccg ggatcctcag
     2581 agctcccagg tctgagcagc caaaggccca gctgggcctc caggaccagc gcgagcccct
     2641 gccccaccct cccctgcccc atgtgccctg ctttgtgacc tctgttgacc ttcctggaag
     2701 cagccccatt accctgagaa tgcggagcgc cctggcccac ctcgccctgt gtttccaggc
     2761 ctgcacgtct ggtccttcag ctgcacatgg aactgcaggg caggctggcg gggggccttc
     2821 agatctcaga tgagactgca ccccttcgac caccctactg ggcacctgcc tccagcccct
     2881 gagaactcca tcttccccta gttctgccca ggagcccctg agaaccccat cttcccctgg
     2941 ttctcttgcc cactcccctg ctggggctcc ttcctggcac tgaggagggg cgctcccaat
     3001 gctgtgaggc agcggggagg gaccgtgcac ccgtggctat cagagcccct ccgctgtccc
     3061 accctgggcc tgggacacgg gcctggggca gtgtgtgtct gctggtcatg tgctggtgcc
     3121 agttggggag gaatcagctg tctcggtgga ttctgagact cactgtgggg cgggaagaag
     3181 ggtcttcact ctgccattca gggataaagt ttaattttat ttttctacac attttgccag
     3241 gtcaggcatt ttgctagtaa gcaggatgcc cccaactctc cctgccatgg aggattcttt
     3301 tttttaagct ttgggtgctt ttttaatact ttttttttta atgtggggaa ggagcttgct
     3361 ctgacgtcac cctcctctcc cctgactcct gtcctgagag ctgtggatgc cgcctcctgc
     3421 cctgcctacc cctgaaacgt ggggaatggg ggccccagga cagcatcagg acttttgagt
     3481 ccagctgcca gcaatggttc caactcggag gcagcgcctc ttggtcccca tttctgtata
     3541 gcaggcgtgt gtgtgtgtgt cgaggttttt tattttttgc ttaatcaaac tccattccca
     3601 aatgcactcc atctctggct ctgagggcgc tccctcctct cagccgggca gcctggcctc
     3661 tcctgcccag acctgcggtc ccagcatccc ccagagccag ggaacaggcc cagcgggagg
     3721 gggttttatg ttttgtttca aacagaaaac acaaccttat ttttctttac aaaagcaaaa
     3781 aaggaaacca aaaaagatac agcctttgaa tgatg
//
