LOCUS       NM_001003682            2468 bp    mRNA    linear   PRI 09-FEB-2024
DEFINITION  Homo sapiens transmembrane protein 200B (TMEM200B), transcript
            variant 2, mRNA.
ACCESSION   NM_001003682 XM_033704
VERSION     NM_001003682.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2468)
  AUTHORS   Pickard,B.S., Malloy,M.P., Clark,L., Lehellard,S., Ewald,H.L.,
            Mors,O., Porteous,D.J., Blackwood,D.H. and Muir,W.J.
  TITLE     Candidate psychiatric illness genes identified in patients with
            pericentric inversions of chromosome 18
  JOURNAL   Psychiatr Genet 15 (1), 37-44 (2005)
   PUBMED   15722956
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC082989.1, BC064375.1, BC110336.1 and AI367819.1.
            
            On Nov 22, 2018 this sequence version replaced NM_001003682.3.
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. Both variants 1 and 2 encode the same protein.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC082989.1, SRR14038197.2690691.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1970526 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000521452.2/ ENSP00000428459.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-63                BC082989.1         7-69
            64-1597             BC064375.1         56-1589
            1598-2463           BC110336.1         1688-2553
            2464-2468           AI367819.1         27-31               c
FEATURES             Location/Qualifiers
     source          1..2468
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p35.3"
     gene            1..2468
                     /gene="TMEM200B"
                     /gene_synonym="TTMB"
                     /note="transmembrane protein 200B"
                     /db_xref="GeneID:399474"
                     /db_xref="HGNC:HGNC:33785"
     exon            1..48
                     /gene="TMEM200B"
                     /gene_synonym="TTMB"
                     /inference="alignment:Splign:2.1.0"
     exon            49..2468
                     /gene="TMEM200B"
                     /gene_synonym="TTMB"
                     /inference="alignment:Splign:2.1.0"
     CDS             69..992
                     /gene="TMEM200B"
                     /gene_synonym="TTMB"
                     /note="two transmembrane B; transmembrane protein TTMA;
                     two transmembrane domain-containing family member B"
                     /codon_start=1
                     /product="transmembrane protein 200B"
                     /protein_id="NP_001003682.1"
                     /db_xref="CCDS:CCDS30658.1"
                     /db_xref="GeneID:399474"
                     /db_xref="HGNC:HGNC:33785"
                     /translation="MTAGSPEECGEVRRSPEGRVSRLGRRLGRRRRPRSPPEPLRVRA
                     RLRLRSPSGAFAALGALVVLVGMGIAVAGYWPHRAGAPGSRAANASSPQMSELRREGR
                     GGGRAHGPHERLRLLGPVIMGVGLFVFICANTLLYENRDLETRRLRQGVLRAQALRPP
                     DGPGWDCALLPSPGPRSPRAVGCAEPEIWDPSPRRGTSPVPSVRSLRSEPANPRLGLP
                     ALLNSYPLKGPGLPPPWGPRTQTGHVIITVQPSGSCIEHSKSLDLGLGELLLGAPAAR
                     DCAHRSWPRLDRLSLGGYAKLGGGGDLGARV"
     regulatory      2448..2453
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TMEM200B"
                     /gene_synonym="TTMB"
                     /note="hexamer: AATAAA"
     polyA_site      2468
                     /gene="TMEM200B"
                     /gene_synonym="TTMB"
                     /note="major polyA site"
ORIGIN      
        1 ctccgcgcgc ggactgggac ccggacccgc gcggcgctgc ggcgccagag cgcccagacg
       61 acggcgagat gacggccggg agccccgaag aatgcgggga ggtgcggagg agccccgagg
      121 gccgcgtctc tcgcttgggc cgccgcctgg gccgccgccg gcgcccgcgc tccccgcccg
      181 agcctctgcg ggtgcgggcg cggctgcggc tgcgctcgcc gtcgggggcg ttcgcggcgc
      241 tgggggcgct cgtggtactg gtgggtatgg gcattgcagt ggccggctac tggccgcacc
      301 gggccggggc cccagggtcc cgggccgcca atgccagctc gccccagatg agcgagctgc
      361 gacgcgaggg tcgcggcggg ggccgggctc acggcccgca cgagcggctg cggctcctcg
      421 ggccggtgat catgggcgtc ggcctgttcg tgttcatctg cgccaacaca ctgctgtatg
      481 agaaccgaga cttggagacg cgacggctcc gccagggggt gctgcgggcc caggcgctcc
      541 ggccccccga cggcccgggc tgggactgcg ccctccttcc cagccccggc cctaggagtc
      601 cccgagccgt aggctgcgca gagccagaaa tctgggaccc gtccccgcgt cggggtactt
      661 cacccgtccc gtcagtgcgg agtctgcgtt cagagcccgc taatcctcgc ttggggttac
      721 ctgccttgct caacagctac ccgctgaagg gccccgggct gcccccaccc tggggtccac
      781 ggacgcagac tggccatgtg atcatcaccg tgcagccgtc tggctcctgc attgaacatt
      841 ccaagtctct ggatctgggc cttggggagc tcctccttgg ggccccagca gctcgggact
      901 gtgctcaccg aagctggcca cggctggacc gcctcagtct tgggggctat gccaaattgg
      961 gaggaggagg ggacttgggg gcccgggtct gaagagaggg gagacagcct gctctgaggc
     1021 tgcagcatgg accatgctaa taggaccaaa ggaccaggag tcccaacgtc taatagatgt
     1081 ttcagtcaca tcccaggctg gggatggatg ctctgaccac agcagctgtg aagggcatcc
     1141 tgacctgcat gcgggcagag aaatgccagc tgcaccaggg ctcagtgagc tggagagggt
     1201 gcgtttcact gtggggtgtg gaggactcgc ctcaggaatt tcttcagcct ctgtaagtgg
     1261 ccttagccct aacagggctg gaggtccagg ccagggtgac tgggagatgt acccagtgtc
     1321 ttggcaaacc caagaaagtg gtgggcaagg gcccctaaga ctgggaggta ggttgggatg
     1381 ttacaggctg gggcaggctc cctccaaggc ggcactggtg atggagtgtg gggcctctgg
     1441 gaagatggac cacgggatga gactctccac tgccatctgg gacggggact gagccttgaa
     1501 ctcctaccac ctcaatccct ttcttccctc agccatctgg ggtatatccc tctagagcta
     1561 cactactgcc aatgccttca tactgagttc tgggcccttc tgcaaataag tctgagaagc
     1621 cccttctctc cttcctttat cgtggcctat gctgcagaat ctcactgcag ctggcaaaag
     1681 gcattggcca gctctcagaa atccctttac tcaacgttga agctgcattt tggtcaatgt
     1741 gggtaactta ctttagaaaa tgacttgagt ttaggtctcc cccacccata tttaattttt
     1801 cccaagttgc tggtagaaga gaaatttaaa agtggatcaa tcctcacaga gagagttctt
     1861 tttgttgttg tttattgaaa aaaatgcaat acaagaagca agaccaaaca gatatctaaa
     1921 cactacaacc acttctacta cgaaaggcca aaacagcaga cttgattatt gcctgtgtag
     1981 tctaaagatt ctgccaatct gattctgctg cccgagttcc tattttttca agaaatgtaa
     2041 acaactactt gatatgattc ataattttaa aaaaaattta caaagctcct tcatttttgt
     2101 caccaaaata atacatttga gagagatttg tagaaacaac cagcctgggg ctgagatcct
     2161 gggcagaaat ttcccgtgag catcaaaagg cgtcagtcag gccgcagctc tggctccagt
     2221 tcccgaggtt tgttgtctcc tcacccccag ctgccaagca tccccccaac acacactgat
     2281 gggcccagcg gtggaggggg gggtggggac ggggatgggt cacggggccc tgacgggtcc
     2341 cgcagttagg ctccctgagc cctcggctta taaatacagg tcttgctttg tgggtgggtg
     2401 ccagagtcct catgtggctt ggaggaaatc tttatttctc aaattaaaat aaaattgcag
     2461 cgagagtt
//
