LOCUS       NM_001258277            3233 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens transmembrane protein 200A (TMEM200A), transcript
            variant 2, mRNA.
ACCESSION   NM_001258277
VERSION     NM_001258277.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3233)
  AUTHORS   Fang,F., Zhang,T., Lei,H. and Shen,X.
  TITLE     TMEM200A is a potential prognostic biomarker and correlated with
            immune infiltrates in gastric cancer
  JOURNAL   PeerJ 11, e15613 (2023)
   PUBMED   37404478
  REMARK    GeneRIF: TMEM200A is a potential prognostic biomarker and
            correlated with immune infiltrates in gastric cancer.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3233)
  AUTHORS   Deng,H., Li,T., Wei,F., Han,W., Xu,X. and Zhang,Y.
  TITLE     High expression of TMEM200A is associated with a poor prognosis and
            immune infiltration in gastric cancer
  JOURNAL   Pathol Oncol Res 29, 1610893 (2023)
   PUBMED   36741965
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3233)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 3233)
  AUTHORS   Du,M., Zhang,X., Hoffmeister,M., Schoen,R.E., Baron,J.A.,
            Berndt,S.I., Brenner,H., Carlson,C.S., Casey,G., Chan,A.T.,
            Curtis,K.R., Duggan,D., Gauderman,W.J., Giovannucci,E.L., Gong,J.,
            Harrison,T.A., Hayes,R.B., Henderson,B.E., Hopper,J.L., Hsu,L.,
            Hudson,T.J., Hutter,C.M., Jenkins,M.A., Jiao,S., Kocarnik,J.M.,
            Kolonel,L.N., Le Marchand,L., Lin,Y., Newcomb,P.A., Rudolph,A.,
            Seminara,D., Thornquist,M.D., Ulrich,C.M., White,E., Wu,K.,
            Zanke,B.W., Campbell,P.T., Slattery,M.L., Peters,U.,
            Chang-Claude,J. and Potter,J.D.
  CONSRTM   Colon Cancer Family Registry and Genetics and Epidemiology of
            Colorectal Cancer Consortium
  TITLE     No evidence of gene-calcium interactions from genome-wide analysis
            of colorectal cancer risk
  JOURNAL   Cancer Epidemiol Biomarkers Prev 23 (12), 2971-2976 (2014)
   PUBMED   25192705
REFERENCE   5  (bases 1 to 3233)
  AUTHORS   Pickard,B.S., Malloy,M.P., Clark,L., Lehellard,S., Ewald,H.L.,
            Mors,O., Porteous,D.J., Blackwood,D.H. and Muir,W.J.
  TITLE     Candidate psychiatric illness genes identified in patients with
            pericentric inversions of chromosome 18
  JOURNAL   Psychiatr Genet 15 (1), 37-44 (2005)
   PUBMED   15722956
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL121947.14, AB067500.1 and AB052099.1.
            
            On Feb 27, 2020 this sequence version replaced NM_001258277.1.
            
            Transcript Variant: This variant (2) contains an alternate exon in
            the 5' UTR, compared to variant 1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB067500.1, BC044246.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000296978.4/ ENSP00000296978.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-264               AL121947.14        129398-129661
            265-3229            AB067500.1         548-3512
            3230-3233           AB052099.1         5020-5023
FEATURES             Location/Qualifiers
     source          1..3233
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6q23.1"
     gene            1..3233
                     /gene="TMEM200A"
                     /gene_synonym="KIAA1913; TTMA; TTMC"
                     /note="transmembrane protein 200A"
                     /db_xref="GeneID:114801"
                     /db_xref="HGNC:HGNC:21075"
     exon            1..508
                     /gene="TMEM200A"
                     /gene_synonym="KIAA1913; TTMA; TTMC"
                     /inference="alignment:Splign:2.1.0"
     exon            509..572
                     /gene="TMEM200A"
                     /gene_synonym="KIAA1913; TTMA; TTMC"
                     /inference="alignment:Splign:2.1.0"
     exon            573..3233
                     /gene="TMEM200A"
                     /gene_synonym="KIAA1913; TTMA; TTMC"
                     /inference="alignment:Splign:2.1.0"
     CDS             589..2064
                     /gene="TMEM200A"
                     /gene_synonym="KIAA1913; TTMA; TTMC"
                     /note="two transmembrane C"
                     /codon_start=1
                     /product="transmembrane protein 200A"
                     /protein_id="NP_001245206.1"
                     /db_xref="CCDS:CCDS5140.1"
                     /db_xref="GeneID:114801"
                     /db_xref="HGNC:HGNC:21075"
                     /translation="MIATGGVITGLAALKRQDSARSQQHVNLSPSPATQEKKPIRRRP
                     RADVVVVRGKIRLYSPSGFFLILGVLISIIGIAMAVLGYWPQKEHFIDAETTLSTNET
                     QVIRNEGGVVVRFFEQHLHSDKMKMLGPFTMGIGIFIFICANAILHENRDKETKIIHM
                     RDIYSTVIDIHTLRIKEQRQMNGMYTGLMGETEVKQNGSSCASRLAANTIASFSGFRS
                     SFRMDSSVEEDELMLNEGKSSGHLMPPLLSDSSVSVFGLYPPPSKTTDDKTSGSKKCE
                     TKSIVSSSISAFTLPVIKLNNCVIDEPSIDNITEDADNLKSRSRNLSMDSLVVPLPNT
                     SESFQPVSTVLPRNNSIGESLSSQYKSSMALGPGAGQLLSPGAARRQFGSNTSLHLLS
                     SHSKSLDLDRGPSTLTVQAEQRKHPSWPRLDRNNSKGYMKLENKEDPMDRLLVPQVAI
                     KKDFTNKEKLLMISRSHNNLSFEHDEFLSNNLKRGTSETRF"
     regulatory      3207..3212
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TMEM200A"
                     /gene_synonym="KIAA1913; TTMA; TTMC"
                     /note="hexamer: ATTAAA"
     polyA_site      3233
                     /gene="TMEM200A"
                     /gene_synonym="KIAA1913; TTMA; TTMC"
                     /note="major polyA site"
ORIGIN      
        1 atctggagcc gagcagaaaa cttttcccct cccgttcccg gtcccttttg tctttcttgg
       61 acgcggtggc ggcgccgcct gagcggcgac tccctctccc ctgcccggct tgctgcgccc
      121 ggtgccctcc gagggcaggc gcgcctggac tctgcgcccg gatggcggcg gccctctgtg
      181 agcaccggca gcggcgcatc ccctgccccg aggcctccgg tgcccccccg gcgcgggcat
      241 aggggcgccc ccaccctccg tccgcttgca ccccttgcca cccgccccct cgcctgactc
      301 atccgcccgc ggtggccgcc cgagccctgg gatggggagg gagaccgcgg ctgcccgcgg
      361 cggccgagat tcccgctgac gcccccgacc ctgccgcctt cttcgtccgc ctccagaggc
      421 gcccgacgtc ccgacagctc ctggagtgag accaggactg agaacaggga gaggcgaccc
      481 gacccccagg gcccggtgct caggacagca cacagagccg ctgaaaacga ctgaagagag
      541 caagggattt cctgggacat ctggctctgg agagtaaaag gccaagctat gatagcaact
      601 ggtggagtga taactggcct ggccgccttg aaaaggcaag actctgccag atcacagcag
      661 catgtcaacc tcagcccgtc tcctgctacc caagagaaga agcccatcag gcgccggccc
      721 cgggcagatg ttgtggttgt tcgtggcaaa atccggcttt attccccatc tggttttttt
      781 cttattttag gagtgctcat ctccattata ggaattgcta tggccgttct tggatattgg
      841 ccccaaaaag aacattttat tgatgctgaa acaacactgt caacaaatga aactcaggtc
      901 attcggaatg aaggcggtgt ggtggttcgc ttctttgagc agcatttgca ttctgataag
      961 atgaaaatgc ttggcccatt caccatgggg attggcattt tcattttcat ttgtgctaat
     1021 gccattcttc atgaaaaccg tgacaaagag accaaaatca tacacatgag ggatatctat
     1081 tccacagtca ttgacattca cacgctaaga atcaaggagc aaaggcaaat gaacggcatg
     1141 tacactggtt tgatgggaga aacagaagta aaacagaatg ggagctcctg tgcctcgaga
     1201 ttggcagcaa atacgatcgc ctctttctcg ggttttcgga gcagttttcg aatggacagc
     1261 tccgtggagg aggatgaact tatgttaaat gaaggtaaga gttctgggca tcttatgccc
     1321 cctttgctct ctgacagctc tgtgtctgtc tttggcctct atccacctcc ttccaagaca
     1381 actgatgata agaccagcgg ctctaagaaa tgtgaaacca agtcaattgt gtcatcgtcc
     1441 atcagtgctt ttacattgcc tgtgatcaaa cttaataact gtgttattga tgagcccagt
     1501 atagataaca tcactgaaga tgctgacaac ctcaaaagta ggtcaaggaa tttgtcaatg
     1561 gattcccttg tggttccttt gcccaacacc agtgaatcct tccagcccgt cagcacagtg
     1621 ctaccaagga ataattccat tggggagtcg ttgtcgagtc agtacaagtc atctatggct
     1681 ctcggacctg gggctggaca gctcttgtct cctggggctg ccagaagaca gtttgggtcc
     1741 aatacatcct tgcatttgct ctcgtcacac tcaaagtcct tggacttaga ccggggtccc
     1801 tccactctaa ctgttcaggc agaacaacgg aaacatccaa gttggcctag gttggatcgg
     1861 aacaacagca agggatatat gaaactagag aacaaagaag acccgatgga taggttgctt
     1921 gtgccccaag ttgccatcaa aaaggacttt accaataagg agaagcttct tatgatttca
     1981 agatctcaca ataatttgag ttttgaacat gatgagtttt tgagtaacaa cctaaagagg
     2041 ggaacttctg aaacaaggtt ttaatgttaa aagaatatat cattttacaa gggtatatat
     2101 tttaaaacga ttttcactgg tgtttccttc ttaaagtatt ggctgtaagc ctttttaatc
     2161 aaatggtttg tagtgtatta gaattggctg cttagttctg taatgaagat ggttgtatgt
     2221 ttgggttact tgtgactgca gtactctatg ttaccacaca tgattttatt tttctcttcc
     2281 tttgaaagca tgatctcttt tattaatatg aatgcaaaat gcttgcatcc aaattaaagc
     2341 ttattttctt tacttttaag ttctttgatt gccctattca taaaatgaaa tgtccagtat
     2401 ggaaaacata gggtaccaaa gtgtggacca ggagtacaaa ttcagtccca atactcaata
     2461 cgtattatag atgactatga gtgcaaacct taggatgtga ttttctgaat aattgttctt
     2521 tgtaggattt ggttacatta tttaaaatga aaaagatcta gttttagtgt gagctcagta
     2581 atgttaattg gttaagttca ttgtgaatct tgagttttag ataagtagtt atttttttca
     2641 atatcacttc tgtttttagt gatattatat caagaaacaa cgtattcaag agccatggct
     2701 gacagtgcca gatatactta gggataaaca tcaaaatgca attatagttg ctataacgtt
     2761 agatactcgg aatcaaaatt tatttgcaag ctgacttgat aaactaaatg aaccaataaa
     2821 atttgtagaa atgctatcct gaaataatta tatacatgaa gacaatgttg actaatgaat
     2881 taagatacat tatatactag ttaatgctaa ctagtctcag tacctgtttt tagccatctg
     2941 ttactgtcca atagcacctc attcccacat tctattttcc cccggtattc tttagatcct
     3001 agtatttgga aaacaatcgg ctaaccttga catttctttt taccttcata tgccactatc
     3061 tcggtagttc aaaaaaattt agttcttgat aaattgcctt gaagtttacc ttgtgctgga
     3121 gagccttatg ataactccaa agactttctt acggtataat acatgttgtt taggattgtg
     3181 tttcttagtc actgaagata ataaatatta aaatggatgt tttcatcaga aaa
//
