LOCUS       NM_001100389            9953 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens transmembrane protein 192 (TMEM192), mRNA.
ACCESSION   NM_001100389
VERSION     NM_001100389.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 9953)
  AUTHORS   Shyu,R.Y., Wang,C.H., Wu,C.C., Chen,M.L., Lee,M.C., Wang,L.K.,
            Jiang,S.Y. and Tsai,F.M.
  TITLE     Tazarotene-Induced Gene 1 Enhanced Cervical Cell Autophagy through
            Transmembrane Protein 192
  JOURNAL   Mol Cells 39 (12), 877-887 (2016)
   PUBMED   27989102
  REMARK    GeneRIF: Authors found that transmembrane protein 192 (TMEM192)
            interacted with TIG1. Authors also found that both TIG1A and TIG1B
            isoforms interacted and co-localized with TMEM192 in HtTA cervical
            cancer cells. The expression of TIG1 induced the expression of
            autophagy-related proteins.
REFERENCE   2  (bases 1 to 9953)
  AUTHORS   Liu,Z., Lv,Y.J., Song,Y.P., Li,X.H., Du,Y.N., Wang,C.H. and Hu,L.K.
  TITLE     Lysosomal membrane protein TMEM192 deficiency triggers crosstalk
            between autophagy and apoptosis in HepG2 hepatoma cells
  JOURNAL   Oncol Rep 28 (3), 985-991 (2012)
   PUBMED   22736246
  REMARK    GeneRIF: TMEM192 deficiency can induce autophagy in tumor cells,
            and can further activate apoptosis by the mitochondrial pathway
            through autophagy.
REFERENCE   3  (bases 1 to 9953)
  AUTHORS   Behnke,J., Eskelinen,E.L., Saftig,P. and Schroder,B.
  TITLE     Two dileucine motifs mediate late endosomal/lysosomal targeting of
            transmembrane protein 192 (TMEM192) and a C-terminal cysteine
            residue is responsible for disulfide bond formation in TMEM192
            homodimers
  JOURNAL   Biochem J 434 (2), 219-231 (2011)
   PUBMED   21143193
REFERENCE   4  (bases 1 to 9953)
  AUTHORS   Schroder,B., Wrocklage,C., Hasilik,A. and Saftig,P.
  TITLE     Molecular characterisation of 'transmembrane protein 192'
            (TMEM192), a novel protein of the lysosomal membrane
  JOURNAL   Biol Chem 391 (6), 695-704 (2010)
   PUBMED   20370317
  REMARK    GeneRIF: TMEM192 was found to be strongly expressed in human
            kidney, liver, lung and pancreas tissue. The widespread tissue
            distribution could suggest an important role of TMEM192 for
            lysosomal function.
REFERENCE   5  (bases 1 to 9953)
  AUTHORS   Adams,M.D., Kerlavage,A.R., Fleischmann,R.D., Fuldner,R.A.,
            Bult,C.J., Lee,N.H., Kirkness,E.F., Weinstock,K.G., Gocayne,J.D.,
            White,O. et al.
  TITLE     Initial assessment of human gene diversity and expression patterns
            based upon 83 million nucleotides of cDNA sequence
  JOURNAL   Nature 377 (6547 Suppl), 3-174 (1995)
   PUBMED   7566098
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AA346826.1, BC036301.1, AC108465.3 and AW137472.1.
            
            On Nov 22, 2018 this sequence version replaced NM_001100389.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript was available
            for the full length of the gene. The extent of this transcript is
            supported by transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803617.187766.1,
                                           SRR1803617.228340.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000306480.11/ ENSP00000305069.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-43                AA346826.1         13-55
            44-1449             BC036301.1         1-1406
            1450-4338           AC108465.3         23025-25913         c
            4339-4483           AW137472.1         17-161              c
            4484-9953           AC108465.3         17410-22879         c
FEATURES             Location/Qualifiers
     source          1..9953
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4q32.3"
     gene            1..9953
                     /gene="TMEM192"
                     /note="transmembrane protein 192"
                     /db_xref="GeneID:201931"
                     /db_xref="HGNC:HGNC:26775"
                     /db_xref="MIM:620677"
     exon            1..114
                     /gene="TMEM192"
                     /inference="alignment:Splign:2.1.0"
     CDS             88..903
                     /gene="TMEM192"
                     /codon_start=1
                     /product="transmembrane protein 192"
                     /protein_id="NP_001093859.1"
                     /db_xref="CCDS:CCDS43279.1"
                     /db_xref="GeneID:201931"
                     /db_xref="HGNC:HGNC:26775"
                     /db_xref="MIM:620677"
                     /translation="MAAGGRMEDGSLDITQSIEDDPLLDAQLLPHHSLQAHFRPRFHP
                     LPTVIIVNLLWFIHLVFVVLAFLTGVLCSYPNPNEDKCPGNYTNPLKVQTVIILGKVI
                     LWILHLLLECYIQYHHSKIRNRGYNLIYRSTRHLKRLALMIQSSGNTVLLLILCMQHS
                     FPEPGRLYLDLILAILALELICSLICLLIYTVKIRRFNKAKPEPDILEEEKIYAYPSN
                     ITSETGFRTISSLEEIVEKQGDTIEYLKRHNALLSKRLLALTSSDLGCQPSRT"
     exon            115..261
                     /gene="TMEM192"
                     /inference="alignment:Splign:2.1.0"
     exon            262..526
                     /gene="TMEM192"
                     /inference="alignment:Splign:2.1.0"
     exon            527..661
                     /gene="TMEM192"
                     /inference="alignment:Splign:2.1.0"
     exon            662..764
                     /gene="TMEM192"
                     /inference="alignment:Splign:2.1.0"
     exon            765..9953
                     /gene="TMEM192"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2110..2115
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TMEM192"
                     /note="hexamer: ATTAAA"
     polyA_site      2138
                     /gene="TMEM192"
                     /note="major polyA site"
     regulatory      3426..3431
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TMEM192"
                     /note="hexamer: AATGAA"
     polyA_site      3442
                     /gene="TMEM192"
                     /note="major polyA site"
     regulatory      5598..5603
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TMEM192"
                     /note="hexamer: TATAAA"
     polyA_site      5619
                     /gene="TMEM192"
     regulatory      6117..6122
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TMEM192"
                     /note="hexamer: AATAAA"
     polyA_site      6140
                     /gene="TMEM192"
     regulatory      9932..9937
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TMEM192"
                     /note="hexamer: AATAAA"
     polyA_site      9953
                     /gene="TMEM192"
ORIGIN      
        1 agaaggtggc gagtttcgcg gccagaggct tacaggtcca ggtggagagg ccgggctggc
       61 cagggcttcg gcctccggcg tcgggaaatg gcggcggggg gcaggatgga ggacggttcc
      121 ttggatatca cccagagtat tgaagacgac ccacttctgg atgcccagct tctcccacac
      181 cactcattac aagctcactt tagaccccga ttccatcctc ttcctacagt catcatagtg
      241 aatcttctgt ggtttattca tctcgtgttt gttgttttag catttttaac aggtgtgctt
      301 tgttcttatc ctaatccaaa tgaggacaag tgcccaggaa attacacaaa cccattgaaa
      361 gttcagacgg ttataatcct tgggaaagtt attttgtgga ttctccattt actccttgaa
      421 tgctacatcc agtatcacca cagcaaaatc agaaaccgag gctataactt gatctaccga
      481 tcaacaaggc atctcaagag acttgcgttg atgatacagt cctctggcaa cacagtgctt
      541 ctcctcatac tgtgcatgca gcactccttc ccagagcctg gcagattgta tcttgacctc
      601 attctggcca tcttggcact ggaactcatc tgttccctga tatgtctcct catttacaca
      661 gtgaaaatcc ggagatttaa taaagctaaa ccagagcctg atatacttga agaagaaaaa
      721 atctatgctt accccagcaa tattacctcg gagactggat tcagaactat ttcaagccta
      781 gaagaaattg ttgaaaagca aggagacacc attgaatacc tgaagcgaca caatgcgctg
      841 ctgagtaagc gattgttggc tctcacttcc tcagacctgg gctgtcagcc aagtagaacg
      901 tgagaggctc acggtcatga cagcaattgc agaggaaccc agagtaattg agactgactg
      961 accacctgac aagctgccac ggggaactgc agcttttgct gaatagcatt ttacagtgtt
     1021 tgttggaaac ctgaatttgg ttctgacttc tgtggctgtt taaaatatag ggcttgtggg
     1081 tcacttgaaa agtacctgta gaagcccgga taacttgagg ggaatgtctg tttgtacttt
     1141 tggaaattat ttaactgctt ggtttatcct aggatcagag gctaaacaac tccatagtca
     1201 acacttttcc acctgacatt agaaccctgt aatgatttca ttatggatag gggaagtcta
     1261 acaagacaat cgattttaaa cagggtttta atcaaataag ttcttcccac ttttaagctg
     1321 atgaaagaag tcattatttc ttgtgaatat tttttcctgg agagccttat catgtatttt
     1381 atatgcttat gtggtgttgg atgacatcat ggaccatata gcttttatag agaatttttc
     1441 tcaccatagg actgaggtct caccaggtga tctactatgc aaattcctac agttttctat
     1501 tcttaagaaa taagggctgg gcacggcgga tcatgaggtc aggaaattga gaccatcctg
     1561 gctaacacgg tgaaaccctg tctctactaa aaatacaaaa aaaattagcc gagcatggtg
     1621 gcgggcacct gtagtcccag ccacctggga ggctgaggca ggagaatggt gtggacccag
     1681 gaggcggagc ttgcagtgag ccgagatcac gccactgcac tccagcctgg gcgacagagc
     1741 gagactccgt ctcaaaaaaa caaaaaagaa aaagaaaaga aataagatat gatgattgat
     1801 tacttggacc agtgttagac cgacctgtgt tagacgaacc tgtgttgcct attatattgg
     1861 cagcaccttc cattagcaat agctgaaaaa ttcagagaag aatttagaac tttcacttta
     1921 tttttgccat tcttcaagaa gttgctgtat atttcagtct ggttatacct tcaattgatc
     1981 aataacttca attataggaa aggcatcttc tataatttta aattactgta aaaaaaagat
     2041 accttttaaa gccttggatt atacttaaaa attgtaatgg aagaaatgca tattaagtta
     2101 tatgcagata ttaaacatat ctgattctga agataaaact gaagtatttt tcagagcaaa
     2161 tggcattatt tctccatttt tcctagtatg cccctttaat ttgtcagttt gctgttagca
     2221 ctgttatatg ctgccttaga aagacttttg gttgaaggct gaatatgagg ggaggggata
     2281 tttatgactg tgttaatctt ttttgatcat tagctgaata ttcaatattt gatatgtaac
     2341 catataggga tgtgttcgat ataactatat aggcaaggga tatattgatt tggccacatc
     2401 tatttgactt atggagggca aatacctgtt tcttttagat acagccattg ccggggcatt
     2461 ctaaaagttt tctactaaga taaagatgat tgtgtatggc tgggagcagt tgctcatgcc
     2521 tgtaatctta gtactttggg aggctgaggc aggaggatca ctcaaggcca ggagtttgag
     2581 accagcctgg gcaacaatga gacactgtct ctcaaaaaaa aaaaaaaaag atcgtgtgtc
     2641 acctgcacac aacattcaca aactaaagcc aaattgtatt tttaaaattt cctttctccc
     2701 ttccgttttt ttttgttttt tgggggtttt tttttttgtt gttgtttttg agacagagtc
     2761 tcaccctgtc gcccaggctg gagtgcaatg gcgcctttct ttctttcttt ttttttcaga
     2821 cggagtctcg ctctgttgcc caggctggag cgcagtagca tgatctcggc tcactgcaac
     2881 ctccgcctcc cgggattaag aaattctcct acctcagcct gctgagtagc tgggattaca
     2941 ggcacatgcc accatgcctg gctaattttt gtatttttag tacaggcggg gtttcaccat
     3001 gctggccagg ctggtctcaa actcctgacc ttttgatccg ccctccttgg cctcccaaag
     3061 tgttgggatt acaggcatga gccactgtgc ccggccttcc tttcttttta ataagtgtat
     3121 gtatctcaaa gccattgcct tctctagaaa tctgtttctc tgttctggaa gagcctataa
     3181 actttgcctt cagttgtttt tcttttcaaa agggaacacc agtggtagat gattaactct
     3241 tatttatttt taaaatttaa tttggatcta tagtcagtat ctgagattta taggatgaac
     3301 tttggtttac aaggaacagt gtagttaaaa agttagggtg cctatgttct tatgtaatca
     3361 tcaacatgtt tgttgtataa tcatcaacat ttttctgaat gcaatgatga acatttcaaa
     3421 caataaatga aaatgaaact aagtatcaga agtagcaaaa cagctgatgc agtggcttac
     3481 gcctgtaatc ccagcacttc gggaggctga ggcaggtgga tcacctgagg ttaggagctc
     3541 aagaccagcc tggccaacat agtaaaaccc catctttact aaaaatacaa aataagccag
     3601 gcatggtggc acgcatctgt aatcccagct actcaggagg ctgaggcagg agaatcgctt
     3661 gaacacagga ggcagaggtt gcagtgagct gaaattgcac cactgcattc cagcttgggc
     3721 aacagagcta gactcgatct caaaaaaaaa agaagtaaca aaacagaaaa atgaacaaaa
     3781 caatttaaat gttaaacatt ctattcacca ggctggtaat tgtgctagca ctgaggatac
     3841 aaaaattaaa gactctggtt ggcagcttac attctaaaga gagcgaggaa tagatttcca
     3901 gactctgtgc taagtgcagt aatgacagta ggcccaacat gctgtaggag ctccacgtca
     3961 gggggtaccc tgggggcagg agggtagagg gttttaagaa tgtcagacag aacaatgagt
     4021 aaagtaggaa ggcaaatagc tacaaaatat cacaagcact gtgtatagct ggaaccaaaa
     4081 gtgtgaggca ggacctgggt ggagaggtag acagggtcag agcttggagg gccttgatac
     4141 tatgctggaa gactgcactt tatcttgttg ataatgggat cctctgaagc atttcaagca
     4201 aggaagtgac aatgtcagtt ttagtttcag caggatcaga tggtagttca atatggagga
     4261 aatatgtgtg gcagaaagat atggccctga actagggcag gtatagtaaa ccttttatta
     4321 taagtatgta tgtgtatagg tatatagata gatataggta tatatgtatg tatatgtatt
     4381 ccaaatgaca acagtatcat gacttattat aaagttaaaa gctcattttt taaaaaatgg
     4441 caatatggaa aaatataaag caaaacaatt atttgaaatc tcactaccaa gggattatac
     4501 caatgtacac tttttttgtt ttgttttttt ttttagtctc atctgtctcc caggctggag
     4561 tgcagtggtg tgatctgggc tcactgcaac ctccttctac cgggttcaag caattctcct
     4621 gcctcagcct cccaagtagc tagtactaca gatgcatgcc actatttttt agtacaaaaa
     4681 tattaaaaat ttgggtcggg tgtggtagct tacgcctgta ataccagcac tttgggaggc
     4741 caaggtgggt ggatcacaag gtcaggagtt agagaccagc ctggccaaga tggtgaaacc
     4801 ccatctctac taagaataca aatatcagcc aggtgtggtg cagggtgcct gtaatcccag
     4861 ctactctgga ggctaaggca ggagaattgc ttgaacccag caggtggagg ttgcagtgag
     4921 gcaagatcac gccactgtac tctagcctgg gccacagagc aggctccatc tcaaaaaaaa
     4981 aaaaaaatac taaaaatttt gtatttcggc tgggcacggt ggctcacacc tgtaatctca
     5041 gcactttggg aggccgaggc ggacagatca cgaggtcagc agatcgaggc catcctggcc
     5101 agcatggtga aaccctatct ctacaaaaaa tacaaaaata ttagcaacat tagctgggtg
     5161 tggtggtgcg cgcctgtaat cccagctact caggaggctg aggcaggaga attgcttgag
     5221 cctgggaggc agagattgca gtgaaccaag atggtgccac tgcactccag cctggcgaca
     5281 gagcagagcg agactccatc acaaaaaaaa aaaaagaaag aaaagaaaaa aaattgtatt
     5341 tctagtagag acggggattc accatgttgg ccaggctgat cttgaattcc ttacctcagg
     5401 tgatccacct gctttggcct cccaaaatgc tgggattata ggcatgagcc agctcacctg
     5461 gtctccatac ccttaccaat agtgggtgtt accttattta agtcttgacc catctgatga
     5521 gtgtgtcatt gtttcaaatt gtatttcttt ggatactaat gaagtgttaa acattttttc
     5581 caaattatat ggtcttttat aaatctttta tgacatgtat attcaagtcc tttgcttatt
     5641 attgtcccag gatattcttt ttcttaacaa ctagaatctt ctggttgggc gtggtggctc
     5701 ccgcctgtaa tcccagcact ttgggaggcc aaggcaggca gatcacttga ggtcaggagt
     5761 tcgagaccag cctgaccaac atggagaaac cccatttcta ctaaaaatac aaaattaagg
     5821 ctgggcgcag tggctcacac cggtaattcc agcactttgg gaggccgagg caggcggatc
     5881 atgaggtcag gagttcgaga ccagcctgac caacatggag aaaccccgtc tctactaaaa
     5941 atacaaaata gccaggtgca gtgaagtgca cctgtaatcc cagctactca ggaggctgag
     6001 gcaggagaat tgcttgaacc cgggaggtgg aggttgcagt gagccgagat cgcaccactg
     6061 cactccagcc tgggtgacag agcgagactc tgtctcaata aataaataaa taaataaata
     6121 aatcttgaat acaaaactca catctggtaa actcttgagt tcttgaagaa tcaaactttg
     6181 aatatgtgac aatcacaaat ttgagatctc aaaacattct ctaggtttcc taaggaaaat
     6241 tgtttcattc gcaaaccagg gaagcctatc tctaattctt ctcccttcct ctctatccag
     6301 tctcaccttt cactctacta ctctactgaa actgttcttg gcaaggtcac caatagcttc
     6361 cttccacatt gcttaaattg gagatgaatg catacgtctc ctcttttaac ttatcagcaa
     6421 cacttggctc agttgattga gggggggtct gcccctccac acctgtgggt atttctcgtc
     6481 aggtgggacg agagactgag aaaagaaata agacacagag acaaagtata aagaaagaac
     6541 agtgggccca ggggaccagc acacccagca tgcgaggacc tgcaccggcg ccggtctctt
     6601 gagttctgtt agtatttatt gatcattatt tttaatatct tgacgagggg agtgtagcgg
     6661 ggcaacaggt ggggagaagg tcagcaggga aacgtgagca aaggaatctg tatcatgaat
     6721 aagttcaagg aaaggtactg tgtccggatg tgcatgtagg ctagatttac gtttctcttt
     6781 acacaaacat ttcagtgtag caaagagtaa cagagcagta ttgctgccag catatctcgc
     6841 ctccagccac agggcagttt tctcctatct cagaatagaa cgaatgggaa tggtcagctt
     6901 tacaccgaga cattccattc ccagggacga gcaggagaca gaagccttcc tcttatctca
     6961 actgcaaaga ggcctccctc tttcactact cctcctcagc acagaccctt tacaggtgtc
     7021 gggctggggg atggtaaggc ctttcctttc ccacgaggcc gtatctcagg ctgtctcagt
     7081 gggaggaaac cttggacaat acccaggctt tcttgggcag aggtccctgc ggctttccgc
     7141 agtgcattgt gtccctggtt aatcgagaat ggagaaaggc gatgactttt accaagcata
     7201 ccacctgcaa acatattgtt aacaaggcac atcctgcaca gccctaaatc cattaaactg
     7261 atccaataca gcacatgttt ctgtgagcac agggttgggg ctaaagttat aggttaacag
     7321 catctcaaag cagaaacaat ttttcttagt acagatcaaa atggagtttc ttatgtcttc
     7381 tttttctaca tagacacagt aacaatctga tctctctctt ttccccacag ttgatcactt
     7441 cctccttgac tctttatttc agcttggctt ccaggacact acattctcct cattttcttc
     7501 tacttcacta gcttcttctt ttgtctgctt tgcaagttgc tttttgttgg tattctccag
     7561 ggctcaaccc ctgggcctct tggcttctcc atcagcgttc actctcttgg tggtctcaca
     7621 caatctcatg actttgatag aatttatgag ctgataattt ccaaatgtga atcttcagcc
     7681 aggccttcct ccctgaactc cagacttatg tgtccaactg ccccttctag atcactactt
     7741 gggtatataa aaaaacacct caaacagaac atgtccccag ctgagctatc tgccacagtc
     7801 tcttccaccc ctgtaatggc agctcctctt tctctcaaac cctatagaca gttaatcagc
     7861 aaatcctgct ggcttttcct ttaaaacata cccagagtcc aaccaattct tggcaccccc
     7921 aatgctactt ccccagccac tataatcttc acctggacta ttataatagt ctttcggttt
     7981 tttggttttg tttttttttt ttgggggagg gagtctcgct ctgttgccca ggctggagtg
     8041 cagtggcgcg atctgggctc actgcaacct ccgcctccca ggttcaagtg attctcttgc
     8101 ttcagcctcc tgagtagctg ggattaccgg cacataccac cacacccagc taattttttt
     8161 atatttttag tagaaagggg gtttcaccat gttagccagg ctggtcttga actccggacc
     8221 tcaggtcatc cacccgcctt ggcctcccaa agtgctgcaa ttacaggcat gagtcactgt
     8281 gcctggccct attataatag tgtttttctt tttctttttc tttctttctt ttttcttgag
     8341 atggagtctc actcgtgtcg cacaggctgg agtgcagtgg cgcagtctcg gctcactaca
     8401 acctccgctg cccaggttca agcaattctc cttcctcagc ctcctgagta gctgggatta
     8461 taggtgtgct ttttttattt ttagtagaga cgaggtttca ccatgctgac taggctggtc
     8521 tggaactcct gacctcatga tcctccctcc ttggcctccc aaagtactgg gattacaggc
     8581 atgagccacc acacctggcc tataagagtc ttttaagtga tctttctgct tctcactacc
     8641 tctccaccct gaccccccag ccccatgcac acacacaaaa agcagccaac aatatccttc
     8701 taaaacacta ctctgatggt tccctttttc attcagtaaa agccaaagcc tggacagtgg
     8761 ccttcaggga cctagaaaat ctccacttcc caccccaccc cacctcctct ctcctactct
     8821 tcctttgtgt accctgcgtc ggtcacactg tggcttttgg attgctaagc acattcttac
     8881 ctgaggacct ttgcggttgc tgttccctct gcctggaagg atcaactccc atatatcttt
     8941 ttcaagtctt tgttcaaatg tcacttgtgg ccaggtgtgg tggctaaccc ctgtaatccc
     9001 agcactttgg gaggctgagg tgggtggatc acttgaggtc aggagttggg agaccggcct
     9061 ggccaacacg atgaaaccct gtctctactg aaaatacaaa aattagccag gcgtggtggc
     9121 acgtgtctgt aatcccagct attcaggagg ctgaggcagg agaatcactt gaacctggga
     9181 ggtggaggtt gcagtgagcc aagatcgcac agctgtactc cagcctgggt gacaagagtg
     9241 agaatccgtc ccccccccaa aaaaaaaaaa tcctcccact tcagtcagcc tcctgagtag
     9301 ctgggattat agatgtgcac cacaccacca cacgtaactt ttattatagt atattgctat
     9361 aattattcta ttttgttatt aatgttgtta ctctctgtgc ctaatttata aatttaactt
     9421 tattgtagtt atgtgtggat aggaaaaaat atagtgttcg tagggtttag tactatctgt
     9481 ggctccaggc atcacctgag gtcttgcaat gattcccctg cagacctgtg gctccaggca
     9541 tcacctgagg tcttgtaatg tttcccctgt agataagggg aaaatactgc atgtaactta
     9601 cttgtttact ttgtctgtgt ctcctgatag aatgtaagct ctatcttttg cttactactg
     9661 tgtccttcat acatagaaca gtgtctggca caaagtaggc actcaatata cgttgatgaa
     9721 ttaatgtcac taacttcagt gatttcacta ctggaattgt agtagaaaaa ctatgctcac
     9781 acatgctcaa agcctgttcc tgtaatccag ctgtaacctg ggctctgttt tcactttctg
     9841 tttatgatgt cctgaactga gagattattt ttttaaggtc ttgtttaaaa gtttatgtct
     9901 aggatacact aaaaaataac aacatatcag aaataaaaga gataagactg cta
//
