LOCUS       NM_139172                605 bp    mRNA    linear   PRI 05-APR-2024
DEFINITION  Homo sapiens transmembrane protein 190 (TMEM190), mRNA.
ACCESSION   NM_139172
VERSION     NM_139172.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 605)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 605)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 605)
  AUTHORS   de Mateo,S., Castillo,J., Estanyol,J.M., Ballesca,J.L. and Oliva,R.
  TITLE     Proteomic characterization of the human sperm nucleus
  JOURNAL   Proteomics 11 (13), 2714-2726 (2011)
   PUBMED   21630459
REFERENCE   4  (bases 1 to 605)
  AUTHORS   Nishimura,H., Gupta,S., Myles,D.G. and Primakoff,P.
  TITLE     Characterization of mouse sperm TMEM190, a small transmembrane
            protein with the trefoil domain: evidence for co-localization with
            IZUMO1 and complex formation with other sperm proteins
  JOURNAL   Reproduction 141 (4), 437-451 (2011)
   PUBMED   21273369
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            HY050559.1, AF442729.1 and HY223996.1.
            
            On Nov 23, 2018 this sequence version replaced NM_139172.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC128189.1, AF442729.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2142586
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000291934.4/ ENSP00000291934.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-10                HY050559.1         2-11
            11-603              AF442729.1         1-593
            604-605             HY223996.1         31-32               c
FEATURES             Location/Qualifiers
     source          1..605
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.42"
     gene            1..605
                     /gene="TMEM190"
                     /gene_synonym="MDAC1"
                     /note="transmembrane protein 190"
                     /db_xref="GeneID:147744"
                     /db_xref="HGNC:HGNC:29632"
     exon            1..86
                     /gene="TMEM190"
                     /gene_synonym="MDAC1"
                     /inference="alignment:Splign:2.1.0"
     CDS             29..562
                     /gene="TMEM190"
                     /gene_synonym="MDAC1"
                     /codon_start=1
                     /product="transmembrane protein 190 precursor"
                     /protein_id="NP_631911.1"
                     /db_xref="CCDS:CCDS33113.1"
                     /db_xref="GeneID:147744"
                     /db_xref="HGNC:HGNC:29632"
                     /translation="MLGCGIPALGLLLLLQGSADGNGIQGFFYPWSCEGDIWDRESCG
                     GQAAIDSPNLCLRLRCCYRNGVCYHQRPDENVRRKHMWALVWTCSGLLLLSCSICLFW
                     WAKRRDVLHMPGFLAGPCDMSKSVSLLSKHRGTKKTPSTGSVPVALSKESRDVEGGTE
                     GEGTEEGEETEGEEEED"
     exon            87..122
                     /gene="TMEM190"
                     /gene_synonym="MDAC1"
                     /inference="alignment:Splign:2.1.0"
     exon            123..248
                     /gene="TMEM190"
                     /gene_synonym="MDAC1"
                     /inference="alignment:Splign:2.1.0"
     exon            249..333
                     /gene="TMEM190"
                     /gene_synonym="MDAC1"
                     /inference="alignment:Splign:2.1.0"
     exon            334..605
                     /gene="TMEM190"
                     /gene_synonym="MDAC1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      585..590
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TMEM190"
                     /gene_synonym="MDAC1"
                     /note="hexamer: AATACA"
     polyA_site      605
                     /gene="TMEM190"
                     /gene_synonym="MDAC1"
                     /note="major polyA site"
ORIGIN      
        1 agtggcccca ggggtctggg gaggtgacat gttgggctgt gggatcccag cgctgggcct
       61 gctcctgctg ctgcagggct cggcagacgg aaatggaatc cagggattct tctacccatg
      121 gagctgtgag ggtgacatat gggaccggga gagctgtggg ggccaggcgg ccatcgatag
      181 ccccaacctc tgcctgcgtc tccggtgctg ctaccgcaat ggggtctgct accaccagcg
      241 tccagacgaa aacgtgcgga ggaagcacat gtgggcgctg gtctggacgt gcagcggcct
      301 cctcctcctg agctgcagca tctgcttgtt ctggtgggcc aagcgccggg acgtgctgca
      361 tatgcccggt ttcctggcgg gtccgtgtga catgtccaag tccgtctcgc tgctctccaa
      421 gcaccgaggg accaagaaga cgccgtccac gggcagcgtg ccagtcgccc tgtccaaaga
      481 gtccagggat gtggagggag gcaccgaggg ggaagggacg gaggagggtg aggagacaga
      541 gggcgaggaa gaggaggatt aggggagtcc ccgggggact gctcaataca gatacggtgg
      601 acgga
//
