LOCUS       NM_018279               5662 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens transmembrane protein 19 (TMEM19), mRNA.
ACCESSION   NM_018279
VERSION     NM_018279.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5662)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 5662)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC073612.17 and BC008596.1.
            
            On May 17, 2019 this sequence version replaced NM_018279.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803613.112377.1,
                                           SRR1660803.193564.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000266673.10/ ENSP00000266673.5
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-16                AC073612.17        22344-22359         c
            17-3055             BC008596.1         1-3039
            3056-4675           AC073612.17        4381-6000           c
            4676-5662           AC073612.17        3394-4380           c
FEATURES             Location/Qualifiers
     source          1..5662
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q21.1"
     gene            1..5662
                     /gene="TMEM19"
                     /note="transmembrane protein 19"
                     /db_xref="GeneID:55266"
                     /db_xref="HGNC:HGNC:25605"
     exon            1..729
                     /gene="TMEM19"
                     /inference="alignment:Splign:2.1.0"
     CDS             600..1610
                     /gene="TMEM19"
                     /codon_start=1
                     /product="transmembrane protein 19"
                     /protein_id="NP_060749.2"
                     /db_xref="CCDS:CCDS9002.1"
                     /db_xref="GeneID:55266"
                     /db_xref="HGNC:HGNC:25605"
                     /translation="MTDLNDNICKRYIKMITNIVILSLIICISLAFWIISMTASTYYG
                     NLRPISPWRWLFSVVVPVLIVSNGLKKKSLDHSGALGGLVVGFILTIANFSFFTSLLM
                     FFLSSSKLTKWKGEVKKRLDSEYKEGGQRNWVQVFCNGAVPTELALLYMIENGPGEIP
                     VDFSKQYSASWMCLSLLAALACSAGDTWASEVGPVLSKSSPRLITTWEKVPVGTNGGV
                     TVVGLVSSLLGGTFVGIAYFLTQLIFVNDLDISAPQWPIIAFGGLAGLLGSIVDSYLG
                     ATMQYTGLDESTGMVVNSPTNKARHIAGKPILDNNAVNLFSSVLIALLLPTAAWGFWP
                     RG"
     exon            730..843
                     /gene="TMEM19"
                     /inference="alignment:Splign:2.1.0"
     exon            844..981
                     /gene="TMEM19"
                     /inference="alignment:Splign:2.1.0"
     exon            982..1236
                     /gene="TMEM19"
                     /inference="alignment:Splign:2.1.0"
     exon            1237..1446
                     /gene="TMEM19"
                     /inference="alignment:Splign:2.1.0"
     exon            1447..5662
                     /gene="TMEM19"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2639..2644
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TMEM19"
                     /note="hexamer: ACTAAA"
     polyA_site      2660
                     /gene="TMEM19"
                     /note="major polyA site"
     regulatory      4648..4653
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TMEM19"
                     /note="hexamer: AATAAA"
     polyA_site      4671
                     /gene="TMEM19"
                     /note="major polyA site"
     regulatory      4781..4786
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TMEM19"
                     /note="hexamer: ATTAAA"
     polyA_site      4807
                     /gene="TMEM19"
     regulatory      5644..5649
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TMEM19"
                     /note="hexamer: AATACA"
     polyA_site      5662
                     /gene="TMEM19"
ORIGIN      
        1 atgcccacag cgggcgaggc gctagaggcg ggggcgccgg gaggcgcggg ctttgctcct
       61 ggggtctcgg ccttggccgg ctggacctga ccctagggcg gcttgcgcag ctgtcgggac
      121 gtgactgcgt tcagccgcgt cgggcgtgct tcccagactt gcccaagttc gggtgcccta
      181 gctgcccctt tgcagccgct ggcctacccg gcccgcgggt gagaaggttg cgacgggagg
      241 tgggtggaac tcgccagcgc cgggaccgcg gattggctgc ctcggctttc tcttttcccc
      301 gtgggctccg gcgtgaggcg ctgaagcggc cggcagccgg cgaccggccc tcaccgtccg
      361 ccgggttgcg ctctgctttt gcggtgaggc gttgaccacg cccatatgaa ttggagctct
      421 ccgccagtag gagtttccgg aaggagtttg aatttttgtg atttttatgc ttgtttggtc
      481 ggtggaatat gttgggattt atgtttgcct ctgaacaagt gtcttgctca catcgtaaat
      541 gactttctct ccgaaacgct aaatattctt tcccgcagga gctcatatcc ttattttcca
      601 tgacagatct taacgacaat atatgcaaaa gatatataaa gatgataact aatatagtta
      661 tactgagcct gatcatttgc atttcgttag ctttctggat tatatcaatg actgcaagca
      721 cctattatgg taacttacga cctatttctc cgtggcgttg gctgttttct gttgttgttc
      781 ctgttctgat cgtctctaat ggccttaaaa agaaaagtct agatcacagt ggggctctag
      841 gagggctagt cgttggattt atcctaacca ttgcaaattt cagctttttt acctctttgc
      901 tgatgttttt cttgtcttct tcgaaactca ctaaatggaa gggagaagtg aagaagcgtc
      961 tagattcaga atataaggaa ggtgggcaaa ggaattgggt tcaggtgttc tgtaatggag
     1021 ctgtacccac agaactggcc ctgctgtaca tgatagaaaa tggccccggg gaaatcccag
     1081 tcgatttttc caagcagtac tccgcttcct ggatgtgttt gtctctcttg gctgcactgg
     1141 cctgctctgc tggagacaca tgggcttcag aagttggccc agttctgagt aaaagttctc
     1201 caagactgat aacaacctgg gagaaagttc cagttggtac caatggagga gttacagtgg
     1261 tgggccttgt ctccagtctc cttggtggta cctttgtggg cattgcatac ttcctcacac
     1321 agctgatttt tgtgaatgat ttagacattt ctgccccgca gtggccaatt attgcatttg
     1381 gtggtttagc tggattacta ggatcaattg tggactcata cttaggggct acaatgcagt
     1441 atactgggtt ggatgaaagc actggcatgg tggtcaacag cccaacaaat aaggcaaggc
     1501 acatagcagg gaaacccatt cttgataaca acgcagtgaa tctgttttct tctgttctta
     1561 ttgccctctt gctcccaact gctgcttggg gtttttggcc cagggggtga actttatttc
     1621 atttccacag gttgaaactg gtgagtccag ctaaatttgc aattccaact ttcatcctaa
     1681 gaataataac tgtaatggca aagcggaaat gccagttcct cctgtattcc attgagatgg
     1741 gatttcacat tttcctctca tcaactcccc tgtaatagct agcgtctttc tagtgaaaga
     1801 gaagaattcc tagaacttat gcattttttt cctgctgaat ggaagtcttg agcaatgaag
     1861 ctatattgtc cctacatatt actatatatt gaactgaaag ttcttacata atcaatgtca
     1921 agttttgtct tattttgttt tgtttgttta aaccagtgta ggaaataaaa gtgatgatat
     1981 ttaaaatagt tctcagttga agcagagaaa tgccactgtg ctagttgccc aaatgttgta
     2041 tctattttaa atagtttaag ctgatgtgta tgggagccta aacaagtgta gtatcctgaa
     2101 cttctcccat taattgctat tcacaattgg gaaaagtgtg gagattggtt cctagtgagt
     2161 tttgtggcct actccacatt tgttcttcct tcctcagggt tagtgatgaa aaaaagtaaa
     2221 tatctttttc atatgtccat tagaatgtat gaaaaaaatc attttaacta aaagcaaaag
     2281 aattttatct tatatctaaa aaatatataa cttactatat gtttcagttg ctctctgaac
     2341 aaaaattatc ttcaatttaa tatgtggaat gtgttttcta gctttctttg aattatgtat
     2401 ggcaacctgg tttagcactg gcatcctgaa cagttaagag tcactgggaa attattgtat
     2461 ttctttataa atttactgtc atatcaattg ctggaaaatg ctatgatttt tctattatta
     2521 ccttctaagt tgtattctct cttacactgt agcctcaact aaggcaattc tgctatgttt
     2581 gttcttcact atgatttact gtgtgccaaa ggagttttga cagggtacag agtattttac
     2641 taaaagtatt tttaaatgtt tctcatgtga tttctgtacc ttcttcctcc tgcccctttt
     2701 gcttttttaa agaaactggg gaaggattta tgaatacacc accaccagag tggataatgc
     2761 ttagaattct ttattggtgg ccctactatg gtgatgatct agaactgact tacttcagga
     2821 cagaagaaaa aacaatcaca cccttaacct ttaagccagt tagatcaggg ggttgcaaca
     2881 attgggttaa actttgggta tacattggaa gcaccagggc atgtttgctt tttttgttta
     2941 tgtgtttgtt ttttgagaca gagtctcaca ctgtggccca ggctggactc cagcacagtg
     3001 gcatgatctc agctccgcct cctgggttca cgtgattctc atgcctcagc ctcccaagta
     3061 gctgggatca caggcgtgca ccatcacgcc cggctaattt ttgtattttc agtagagaca
     3121 gggtttcgcc acgttggcta ggctggtctc gaactcctga cctcaagtga tctgcccatc
     3181 tcagcctccc aaagatctat tacaagatgt gagccactgt gcccagccac cagggcatgt
     3241 ttttaaaaaa gtactgatgt ctgggtttca cactgcaaaa ttctgattta tctgatctaa
     3301 ggtacagcct ggatattgag actttttaaa gctctgactg tacattgaat catcatgtaa
     3361 ggagttttta aaacattgtt gccagggccc ctttctagac caagttagtc agaatgttgg
     3421 acaatgaggc ccatgcatgg gtatttttac aaagctctct gggagattct aatgcttaac
     3481 caaattgaga agcactgaat aagaatatcc tgggccgggc gcactggctc atgcctgtaa
     3541 tcccagcatt ttggaaggcc gaggcgggtg gatcacttga ggtcaggagt tcgagaccag
     3601 cctggccaac atggtgaaac accgtctcta ctaaaaatac aaaaaattag gtgtggtggt
     3661 gcgtgcctgt attcccagcc actcaggagg ctgaggcagg agaatcgctg gaacctggga
     3721 tgtggaggtt gcagtgagcc aagattgcac cactgtactc cagcctgggc aacagaggga
     3781 gactccatct agactccatc tcaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
     3841 agaatattct aagcactaga actacataag aatgtcctaa agcactgtat ctaagcactt
     3901 gaaaagaatg ggacttttcg gttttaggga gataactatt agcaaccaca caatatgtta
     3961 tctttatgga tgaataactt ctggtaatga cacagtgtct tacagctaca tcatttataa
     4021 aatcatgtgt cagttttcac acagcctgca catcgttctg acatgccctt tttttccctg
     4081 gagatttatc ctcatgacat acaaggggac aaaaatattt attgggactg tctttgaatt
     4141 tagtagaatc actgtatcat taacagtttg gggaagtact gctttgcagt cctttatttg
     4201 aaaacttagg tctagctgtg ttttgcatca aaatttttga gctattcaaa aactaatagg
     4261 atctgtgtaa aatatttcac tcaaaactac taaaaaaaag tctgggatgg cagctcatta
     4321 tcaaatatac tcctattttt gtggtgattt atgaacatcc ccactaagta taactaaaga
     4381 tcataaagag cctcagatca agtttggtca ggttttgtca ccaagctttg taaataaact
     4441 ggttttcata gctttttgga gatgagaatt gaggataaga aattgtgtct ctgtcctttt
     4501 tttttttttt tgttaagtct tacatgtatt ttactgtaac atcttttgaa ttggatattt
     4561 aactaattca acatattttt cctctttgca gaatgggcag ttcatgttaa aatcactttt
     4621 catggaaaga gctctatgta acagcataat aaaactgcct acctagcagc ataaaggtgt
     4681 actgtttctt atcatactgt tccatgatag aagagagcag atatatgtgg cttggggcag
     4741 ctcctgaaga agacttgcag gagtagcatg ttgaaaactc attaaatgga gccaccaaga
     4801 gaccaaagaa ttgatacagc aggtcattct attattagct tttctcatta cttgagttat
     4861 ctgtttctca catatatctt tcctgtttct agctgctgta cacataggat gctgcctgca
     4921 gaaatagcag ccccgcccca attagataaa ggactagtat agagaaaaag catgtgaaat
     4981 gatgttttaa actttgccgc atacctgtga tatgaacagc tgctgcctgt taggcacagt
     5041 gggtatacta gggcccaatc atctgatctt cctgaagttt tatgtaatgt tcccagtgct
     5101 atcacaatga gaatgatcta tactagccac cagatctcag gtgaattgtg gtgtgcttta
     5161 aaaatgaaaa cacagccgga cgaggtggct tatgcctgta atcctaacac tttgggaggc
     5221 cgaggcgggc agatcacgag gtcaggagtt caagaccagc ccggccaaca cagtgaaacc
     5281 ccatctctta gccgggcatg gtggcgcatg cctgtagtcc cagctattca ggaggctgag
     5341 gcgtgagaat cacttgaacc caggaggcag aggtttcagt aagcagagag cgtgccaccg
     5401 cactccagcc tgggtgacag agcaagactc catcttgaaa aaaaaaggaa aacacaatta
     5461 tgtggcttaa ttatttaatc tcctttatgg agtatctgtt tttataactc caagtggttc
     5521 ttgatatttt aaaaatactt aagcattcaa tatgtattca ttgaattaag ttgtttgact
     5581 ctaatcattg tttcttttaa gaatgactgg aaggtgataa tcagcaccat attcctggag
     5641 gaaaatacaa aatgaaaaac ca
//
