LOCUS       NM_003492               1452 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens transmembrane protein 187 (TMEM187), mRNA.
ACCESSION   NM_003492
VERSION     NM_003492.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1452)
  AUTHORS   Hernangomez-Laderas,A., Cilleros-Portet,A., Martinez Velasco,S.,
            Mari,S., Legarda,M., Gonzalez-Garcia,B.P., Tutau,C.,
            Garcia-Santisteban,I., Irastorza,I., Fernandez-Jimenez,N. and
            Bilbao,J.R.
  TITLE     Sex bias in celiac disease: XWAS and monocyte eQTLs in women
            identify TMEM187 as a functional candidate gene
  JOURNAL   Biol Sex Differ 14 (1), 86 (2023)
   PUBMED   38072919
  REMARK    GeneRIF: Sex bias in celiac disease: XWAS and monocyte eQTLs in
            women identify TMEM187 as a functional candidate gene.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1452)
  AUTHORS   Zaghloul,H.M., Abdelshafy,S.S., Abdelaleem,E.A., Ali,H.M. and
            Khattab,R.A.M.
  TITLE     Transmembrane Protein 187 (TMEM187) and Interleukin 1 Receptor
            Associated Kinase (IRAK1) gene polymorphism association with
            rheumatoid arthritis susceptibility in Egyptian patients
  JOURNAL   Egypt J Immunol 30 (3), 171-179 (2023)
   PUBMED   37440666
  REMARK    GeneRIF: Transmembrane Protein 187 (TMEM187) and Interleukin 1
            Receptor Associated Kinase (IRAK1) gene polymorphism association
            with rheumatoid arthritis susceptibility in Egyptian patients.
REFERENCE   3  (bases 1 to 1452)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 1452)
  AUTHORS   Khalifa,O., Balandraud,N., Lambert,N., Auger,I., Roudier,J.,
            Senechal,A., Genevieve,D., Picard,C., Lefranc,G., Touitou,I.,
            Mrenda,B.M., Benedito,C., Pardoux,E., Gagez,A.L., Pers,Y.M.,
            Jorgensen,C., Mahjoub,T. and Apparailly,F.
  TITLE     TMEM187-IRAK1 Polymorphisms Associated with Rheumatoid Arthritis
            Susceptibility in Tunisian and French Female Populations: Influence
            of Geographic Origin
  JOURNAL   J Immunol Res 2017, 4915950 (2017)
   PUBMED   28271077
  REMARK    GeneRIF: study investigated association between 3 polymorphisms in
            the Xq28 region containing TMEM187 and IRAK1 (rs13397, rs1059703,
            and rs1059702) with rheumatoid arthritis (RA)susceptibility;
            results replicated association of the 3 Xq28 polymorphisms with RA
            risk in Tunisian and French populations and suggested that RA
            susceptibility is associated with TMEM187-IRAK1 polymorphisms in
            women
REFERENCE   5  (bases 1 to 1452)
  AUTHORS   Denoeud,F., Kapranov,P., Ucla,C., Frankish,A., Castelo,R.,
            Drenkow,J., Lagarde,J., Alioto,T., Manzano,C., Chrast,J., Dike,S.,
            Wyss,C., Henrichsen,C.N., Holroyd,N., Dickson,M.C., Taylor,R.,
            Hance,Z., Foissac,S., Myers,R.M., Rogers,J., Hubbard,T., Harrow,J.,
            Guigo,R., Gingeras,T.R., Antonarakis,S.E. and Reymond,A.
  TITLE     Prominent use of distal 5' transcription start sites and discovery
            of a large number of additional exons in ENCODE regions
  JOURNAL   Genome Res 17 (6), 746-759 (2007)
   PUBMED   17567994
REFERENCE   6  (bases 1 to 1452)
  AUTHORS   Faranda,S., Frattini,A., Zucchi,I., Patrosso,C., Milanesi,L.,
            Montagna,C. and Vezzoni,P.
  TITLE     Characterization and fine localization of two new genes in Xq28
            using the genomic sequence/EST database screening approach
  JOURNAL   Genomics 34 (3), 323-327 (1996)
   PUBMED   8786131
REFERENCE   7  (bases 1 to 1452)
  AUTHORS   Zoppe,M., Frattini,A., Faranda,S. and Vezzoni,P.
  TITLE     The complete sequence of the host cell factor 1 (HCFC1) gene and
            its promoter: a role for YY1 transcription factor in the regulation
            of its expression
  JOURNAL   Genomics 34 (1), 85-91 (1996)
   PUBMED   8661027
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from U52112.2 and BC008203.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_003492.2.
            
            Summary: This gene consists of two exons and encodes a multi-pass
            membrane protein. An alternatively spliced transcript variant
            encoding the same protein has been found, but its biological
            validity is not determined. [provided by RefSeq, May 2010].
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC008203.1, SRR3476690.546291.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000369982.5/ ENSP00000358999.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-38                U52112.2           125688-125725
            39-1452             BC008203.1         1-1414
FEATURES             Location/Qualifiers
     source          1..1452
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xq28"
     gene            1..1452
                     /gene="TMEM187"
                     /gene_synonym="CXorf12; DXS9878E; ITBA1"
                     /note="transmembrane protein 187"
                     /db_xref="GeneID:8269"
                     /db_xref="HGNC:HGNC:13705"
                     /db_xref="MIM:300059"
     exon            1..107
                     /gene="TMEM187"
                     /gene_synonym="CXorf12; DXS9878E; ITBA1"
                     /inference="alignment:Splign:2.1.0"
     exon            108..1452
                     /gene="TMEM187"
                     /gene_synonym="CXorf12; DXS9878E; ITBA1"
                     /inference="alignment:Splign:2.1.0"
     CDS             321..1106
                     /gene="TMEM187"
                     /gene_synonym="CXorf12; DXS9878E; ITBA1"
                     /codon_start=1
                     /product="transmembrane protein 187"
                     /protein_id="NP_003483.1"
                     /db_xref="CCDS:CCDS14739.1"
                     /db_xref="GeneID:8269"
                     /db_xref="HGNC:HGNC:13705"
                     /db_xref="MIM:300059"
                     /translation="MNPEWGQAFVHVAVAGGLCAVAVFTGIFDSVSVQVGYEHYAEAP
                     VAGLPAFLAMPFNSLVNMAYTLLGLSWLHRGGAMGLGPRYLKDVFAAMALLYGPVQWL
                     RLWTQWRRAAVLDQWLTLPIFAWPVAWCLYLDRGWRPWLFLSLECVSLASYGLALLHP
                     QGFEVALGAHVVAAVGQALRTHRHYGSTTSATYLALGVLSCLGFVVLKLCDHQLARWR
                     LFQCLTGHFWSKVCDVLQFHFAFLFLTHFNTHPRFHPSGGKTR"
     polyA_site      1452
                     /gene="TMEM187"
                     /gene_synonym="CXorf12; DXS9878E; ITBA1"
                     /note="major polyA site"
ORIGIN      
        1 accggcgctg ctcggatcct cccttttcgg agatttgaat ttcccccagc gaggcgagtg
       61 aggcgaaata cccgtatggt gatagctggc cttttcgcgc caatactgaa aaaggcagaa
      121 cgttcctccg ctggcgccag ccaatcagca ggactcctgc cttccttcgg ggcaaggtcg
      181 cagcatctgc ctcggaaatc acgaaatcac ggggcttctt tctgctggct cagccgggag
      241 gcccagagtg ttctgcagag gctgcgtatt gaaggctgct ctctgaagct ccctgcccca
      301 ggtcacgccg ccggttccag atgaatccag agtgggggca ggccttcgtg cacgtggccg
      361 tggccggtgg cctctgtgcc gtggctgtgt tcacgggcat tttcgacagt gtttccgtgc
      421 aagtgggcta tgagcactac gccgaggcgc ccgtggccgg cctccctgcc ttcctggcca
      481 tgccgttcaa ctcactcgtg aacatggcct acacgctgct ggggctgtcg tggctgcaca
      541 ggggcggcgc gatggggctg ggtccccgct acctgaagga cgtgttcgca gccatggccc
      601 tgctctatgg ccccgtgcag tggctgcgcc tgtggacgca gtggcgccgt gccgcggtgc
      661 tggaccagtg gctcacactg cccatctttg catggcccgt ggcctggtgc ctctacctag
      721 accgcggctg gcggccctgg ctgttcctct ctcttgagtg cgtctccctg gccagttatg
      781 gcctcgctct gctgcatccc cagggcttcg aggtcgcact gggtgctcac gtggtggccg
      841 ctgtggggca ggcgctgcgc acccacaggc actatggcag caccacctcg gctacctact
      901 tagctttggg ggtgctctct tgcctgggct ttgtggtcct caagctgtgt gaccatcagc
      961 tcgcacggtg gcgtctcttc cagtgcctca caggccactt ctggtccaag gtctgtgacg
     1021 tgctccagtt ccactttgcg tttttgtttc tgacgcattt caacactcac ccaagattcc
     1081 atccctctgg cgggaagacg cgttgaaccc agggaagaac ctgctgaaaa ccgatgaccc
     1141 ccagcattga aatggactct gagatggcag cgtggtgcca gtgtcagaca tcctgtgtgt
     1201 gatgatatgc actgatcaca caagactgcc ctttcctgag aagctgcggg cttcggtgtg
     1261 gaggggtgga gtgctgtgat ctcgacaact tactttcaaa gacataaagc acagatctcc
     1321 gcacagggga tgtgtgtgtt cctgatgtaa tttgcataac ttttctgtag tttgaaatgt
     1381 ttccaaataa atattggcaa ggggagtgga aatgacacca agaagcccct catgctcatg
     1441 gttggacaga ga
//
