LOCUS       NM_015421               1439 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens transmembrane protein 186 (TMEM186), mRNA.
ACCESSION   NM_015421
VERSION     NM_015421.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1439)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   2  (bases 1 to 1439)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   3  (bases 1 to 1439)
  AUTHORS   Sanchez-Caballero,L., Elurbe,D.M., Baertling,F.,
            Guerrero-Castillo,S., van den Brand,M., van Strien,J., van
            Dam,T.J.P., Rodenburg,R., Brandt,U., Huynen,M.A. and
            Nijtmans,L.G.J.
  TITLE     TMEM70 functions in the assembly of complexes I and V
  JOURNAL   Biochim Biophys Acta Bioenerg 1861 (8), 148202 (2020)
   PUBMED   32275929
REFERENCE   4  (bases 1 to 1439)
  AUTHORS   Formosa,L.E., Muellner-Wong,L., Reljic,B., Sharpe,A.J.,
            Jackson,T.D., Beilharz,T.H., Stojanovski,D., Lazarou,M.,
            Stroud,D.A. and Ryan,M.T.
  TITLE     Dissecting the Roles of Mitochondrial Complex I Intermediate
            Assembly Complex Factors in the Biogenesis of Complex I
  JOURNAL   Cell Rep 31 (3), 107541 (2020)
   PUBMED   32320651
REFERENCE   5  (bases 1 to 1439)
  AUTHORS   Hendrickson,S.L., Lautenberger,J.A., Chinn,L.W., Malasky,M.,
            Sezgin,E., Kingsley,L.A., Goedert,J.J., Kirk,G.D., Gomperts,E.D.,
            Buchbinder,S.P., Troyer,J.L. and O'Brien,S.J.
  TITLE     Genetic variants in nuclear-encoded mitochondrial genes influence
            AIDS progression
  JOURNAL   PLoS One 5 (9), e12862 (2010)
   PUBMED   20877624
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1439)
  AUTHORS   Simpson,J.C., Wellenreuther,R., Poustka,A., Pepperkok,R. and
            Wiemann,S.
  TITLE     Systematic subcellular localization of novel proteins identified by
            large-scale cDNA sequencing
  JOURNAL   EMBO Rep 1 (3), 287-292 (2000)
   PUBMED   11256614
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BG682191.1, AC012173.9 and CA433910.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_015421.3.
            
            Summary: This gene encodes a potential transmembrane protein.
            [provided by RefSeq, Dec 2012].
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189655.215795.1,
                                           SRR1803614.203837.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968189, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000333050.7/ ENSP00000331640.6
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-573               BG682191.1         10-582
            574-1171            AC012173.9         19312-19909         c
            1172-1439           CA433910.1         18-285              c
FEATURES             Location/Qualifiers
     source          1..1439
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16p13.2"
     gene            1..1439
                     /gene="TMEM186"
                     /gene_synonym="C16orf51"
                     /note="transmembrane protein 186"
                     /db_xref="GeneID:25880"
                     /db_xref="HGNC:HGNC:24530"
                     /db_xref="MIM:620433"
     exon            1..28
                     /gene="TMEM186"
                     /gene_synonym="C16orf51"
                     /inference="alignment:Splign:2.1.0"
     CDS             26..667
                     /gene="TMEM186"
                     /gene_synonym="C16orf51"
                     /codon_start=1
                     /product="transmembrane protein 186"
                     /protein_id="NP_056236.2"
                     /db_xref="CCDS:CCDS10535.1"
                     /db_xref="GeneID:25880"
                     /db_xref="HGNC:HGNC:24530"
                     /db_xref="MIM:620433"
                     /translation="MAALLRAVRRFRGKAVWERPLHGLWCCSGQEDPKRWVGSSSPIS
                     KEKLPNAETEKFWMFYRFDAIRTFGFLSRLKLAQTALTVVALPPGYYLYSQGLLTLNT
                     VCLMSGISGFALTMLCWMSYFLRRLVGILYLNESGTMLRVAHLNFWGWRQDTYCPMAD
                     VIPLTETKDRPQEMFVRIQRYSGKQTFYVTLRYGRILDRERFTQVFGVHQMLK"
     exon            29..1439
                     /gene="TMEM186"
                     /gene_synonym="C16orf51"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1136..1141
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TMEM186"
                     /gene_synonym="C16orf51"
                     /note="hexamer: AATAAA"
     regulatory      1143..1148
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TMEM186"
                     /gene_synonym="C16orf51"
                     /note="hexamer: AATAAA"
     polyA_site      1166
                     /gene="TMEM186"
                     /gene_synonym="C16orf51"
                     /note="major polyA site"
     polyA_site      1171
                     /gene="TMEM186"
                     /gene_synonym="C16orf51"
                     /note="major polyA site"
     regulatory      1419..1424
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TMEM186"
                     /gene_synonym="C16orf51"
                     /note="hexamer: AATAAA"
     polyA_site      1439
                     /gene="TMEM186"
                     /gene_synonym="C16orf51"
ORIGIN      
        1 acttccggca gcaggtggtg gggccatggc tgcccttctc cgagctgtgc gtaggtttcg
       61 gggaaaagct gtgtgggaaa ggcctctcca tgggctgtgg tgctgcagtg ggcaggagga
      121 tcctaagagg tgggtgggca gcagttcacc catctcgaag gagaaactac caaacgcaga
      181 gactgagaaa ttctggatgt tttaccgttt tgatgccatc agaaccttcg ggttcctgtc
      241 acgactgaag ttggcacaga ctgccctgac agtggtagct ttgccaccag gctattactt
      301 gtactcccag ggcctcctca ctctcaacac cgtgtgcctc atgagtggga tatcgggctt
      361 tgccctgacc atgctgtgct ggatgagcta tttcttacgg agactggttg gtatcctgta
      421 tctgaatgag tctggcacca tgctgcgggt ggcccatctg aacttctggg gctggcggca
      481 ggacacatac tgtcccatgg cagatgtgat tcccctgaca gaaaccaagg accggcctca
      541 ggagatgttt gtgcgtatcc agcggtacag tgggaaacag accttctacg tcaccctgcg
      601 ctatggacgc atcctggaca gagagcgttt cacacaggtg tttggggtac atcagatgct
      661 caagtgaaca actgggacct ggacctctgg gtaaccctgg gtcgcctgga ttaacaggaa
      721 ggctgagggt gtgggcaagg ctgaagaaag gggactgggt acttggagac tttgcctggg
      781 cccctgggaa catgtgtttt gtggtgaata aattcacaag gcaagagctg gtgtacaggt
      841 ttaggaaaaa ggctctaagc aagttcttac agcacttgtt tgtgacattc agtcagataa
      901 tggccagaag tttttgttaa gagccagttc ttagaagaac ctatgccaag gtcacccata
      961 gagtccattg gtgtgaaaga gaaaggcaaa gaggtgtggc gggggagcgt aagatttgga
     1021 gtcagaagtc tcagttctgt catttgtcct ggagcaggtt attgagtctc tttgaatctt
     1081 ggttttcaca tctgtaaaat ggaaagtcct gcttgtttca tgggatgggt gtgggaataa
     1141 acaataaatg tcaaacgtgt ggcagactca acagcctaca gcagatatta ttaagcattt
     1201 ggtcagaggt tttagcaggg agaaaggctt cgagcagtca gcagggactt ccagagccct
     1261 gtgctgtgcc cctcacatat ccagcggcag aagggtctgt caggatgtta actacacatt
     1321 gacgagcaga tgtcgtccag gtaggcacga aaccccagtt gagatttgtt caccacccag
     1381 aggtctagag gctcttgctt tggatggccc tgcagtgtaa taaagccaaa tgcaccgga
//
