LOCUS       NM_024121               5922 bp    mRNA    linear   PRI 10-FEB-2024
DEFINITION  Homo sapiens transmembrane protein 185B (TMEM185B), mRNA.
ACCESSION   NM_024121 NR_000034
VERSION     NM_024121.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5922)
  AUTHORS   Maurer,M.H., Grunewald,S., Gassler,N., Rossner,M., Propst,F.,
            Wurz,R., Weber,D., Kuner,T., Kuschinsky,W. and Schneider,A.
  TITLE     Cloning of a novel neuronally expressed orphan G-protein-coupled
            receptor which is up-regulated by erythropoietin, interacts with
            microtubule-associated protein 1b and colocalizes with the
            5-hydroxytryptamine 2a receptor
  JOURNAL   J Neurochem 91 (4), 1007-1017 (2004)
   PUBMED   15525354
  REMARK    GeneRIF: The mouse ee3 is an orphan G-protein-coupled receptor with
            potential connections to erythropoietin and 5HT2a receptor
            signalling. ee3_2, a similar gene, is also described, along with
            human orthologs.
REFERENCE   2  (bases 1 to 5922)
  AUTHORS   Shaw,M.A., Chiurazzi,P., Romain,D.R., Neri,G. and Gecz,J.
  TITLE     A novel gene, FAM11A, associated with the FRAXF CpG island is
            transcriptionally silent in FRAXF full mutation
  JOURNAL   Eur J Hum Genet 10 (11), 767-772 (2002)
   PUBMED   12404111
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC012363.6.
            
            On Nov 23, 2018 this sequence version replaced NM_024121.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript is intronless :: SRR7346977.2455782.1,
                                        SRR7346977.2694627.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000426077.3/ ENSP00000453399.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-5922              AC012363.6         62204-68125         c
FEATURES             Location/Qualifiers
     source          1..5922
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q14.2"
     gene            1..5922
                     /gene="TMEM185B"
                     /gene_synonym="FAM11B"
                     /note="transmembrane protein 185B"
                     /db_xref="GeneID:79134"
                     /db_xref="HGNC:HGNC:18896"
     exon            1..5922
                     /gene="TMEM185B"
                     /gene_synonym="FAM11B"
                     /inference="alignment:Splign:2.1.0"
     CDS             425..1477
                     /gene="TMEM185B"
                     /gene_synonym="FAM11B"
                     /note="transmembrane protein 185B (pseudogene); family
                     with sequence similarity 11, member B; ee3_2; putative
                     transmembrane protein 185B"
                     /codon_start=1
                     /product="transmembrane protein 185B"
                     /protein_id="NP_077026.2"
                     /db_xref="CCDS:CCDS58722.1"
                     /db_xref="GeneID:79134"
                     /db_xref="HGNC:HGNC:18896"
                     /translation="MNPRGLFQDFNPSKFLIYTCLLLFSVLLPLRLDGIIQWSYWAVF
                     APIWLWKLLVVAGASVGAGVWARNPRYRTEGEACVEFKAMLIAVGIHLLLLMFEVLVC
                     DRVERGTHFWLLVFMPLFFVSPVSVAACVWGFRHDRSLELEILCSVNILQFIFIALKL
                     DRIIHWPWLVVFVPLWILMSFLCLVVLYYIVWSLLFLRSLDVVAEQRRTHVTMAISWI
                     TIVVPLLTFEVLLVHRLDGHNTFSYVSIFVPLWLSLLTLMATTFRRKGGNHWWFGIRR
                     DFCQFLLEIFPFLREYGNISYDLHHEDSEDAEETSVPEAPKIAPIFGKKARVVITQSP
                     GKYVPPPPKLNIDMPD"
     regulatory      1904..1909
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TMEM185B"
                     /gene_synonym="FAM11B"
                     /note="hexamer: TATAAA"
     polyA_site      1923
                     /gene="TMEM185B"
                     /gene_synonym="FAM11B"
                     /note="major polyA site"
     regulatory      3036..3041
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TMEM185B"
                     /gene_synonym="FAM11B"
                     /note="hexamer: AATAAA"
     polyA_site      3069
                     /gene="TMEM185B"
                     /gene_synonym="FAM11B"
     regulatory      5902..5907
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TMEM185B"
                     /gene_synonym="FAM11B"
                     /note="hexamer: AATAAA"
     polyA_site      5922
                     /gene="TMEM185B"
                     /gene_synonym="FAM11B"
                     /note="major polyA site"
ORIGIN      
        1 actcccgcct ccatgttccc ggagtcgcct ggaagcgtcc gcccaaggtc gcgggccgct
       61 tggggagtca gcagcgcgcc aggccccttc gggccccaca cgcattaggt gccttcttga
      121 tgggtacgga gtgaacgcgg gcggcggcgg gaccgaggca gcgcccagtt tgtaaccgcc
      181 gcgccgcccg tgcccgcgcg cgccacaccc cagcgcgctt ccggccgggc cacgtgaccg
      241 cgcgtgcacg tgttccggcc tctccgcttc gccgctccga acctcctcct ggtcgtcccg
      301 gcattcgtcc acgcggagcc ggcttgggcg gggcccggga ggcggcggcc ggagaagccg
      361 cggagacgcg agcgccgagc gtcgcgaggg agcaggcccg ggcaggcaag cggcggcctc
      421 cgccatgaac cccaggggcc tgttccagga cttcaacccc agtaagtttc tcatctacac
      481 ctgcctgctg ctcttctcgg tgctgctgcc cctccgcctg gacggcatca tccaatggag
      541 ctactgggcc gtctttgccc ccatatggct gtggaagctt ctagtcgtcg caggcgcctc
      601 cgtgggcgcg ggcgtttggg cccgcaaccc tcgctaccgc accgagggag aggcctgtgt
      661 ggagttcaaa gccatgctga tcgctgtggg catccacctg ctgctgctca tgttcgaagt
      721 cctggtctgc gacagggtgg agaggggcac ccacttctgg ctgctggtct tcatgcctct
      781 cttcttcgtg tcccccgtgt ccgtggctgc ctgcgtctgg ggctttcgac acgataggtc
      841 gctggagctg gagatcctgt gctcggtcaa catcctgcag ttcatcttca tcgccctaaa
      901 gctggacagg attattcact ggccgtggct ggtggtgttt gtgcccctgt ggatcctcat
      961 gtcgttcctt tgcctggtcg tcctctatta catcgtctgg tccctcctgt tcctgcggtc
     1021 cctggatgtg gttgccgagc agcggagaac acacgtgacc atggctatca gttggataac
     1081 gattgtcgtg cctctgctca cttttgaggt cctgctggtt cacagattgg atggccacaa
     1141 tacattctcc tacgtctcca tatttgtccc cctttggctt tccttactaa ctttaatggc
     1201 cacaacattt aggcgaaagg ggggcaatca ttggtggttt ggcattcgca gagacttctg
     1261 tcagtttctg cttgaaattt tcccattttt aagagaatat gggaacattt catatgatct
     1321 ccatcacgaa gatagtgaag atgctgaaga aacatcagtt ccagaagctc cgaaaattgc
     1381 tccaatattt ggaaagaagg ccagagtagt tataacccag agccctggga aatacgttcc
     1441 cccccctccc aagttaaata ttgatatgcc agattaaact cctagagagg acccaggcac
     1501 acacagactc cacttggcct tcgcctcttg ttcattcatc ccaaacctgg aaatggaaac
     1561 aggcttcaaa cactcgtctc acgccgtgtt tgagatcacc gcctcatcag tatgcatcat
     1621 agatggaggt ggtttcagta tgtgggtgtg tgtgatgtgt acctgggtaa gagacttgct
     1681 ttccaggttc gcactttcag gtgtagctgg gggcagtaag tcgaattgtt ttagtaggtc
     1741 ctcaaaagga ataaccacac agctgtttgt ttaaatgcta ctgtacctat caaaactatt
     1801 gtttaaaaag tatttttata cactgctaat ctaaaattgt atttcagatt gtgcctgtca
     1861 taacaatagc aaatgtaaaa agttctcttt cccaccactt gtttataaac ctcatagttg
     1921 atatttttag tgttcctact gttaaaatac tctctccttg ggctttgctg atactggtct
     1981 ttaatattct gataggtgaa tttttctaat ggaatgaacc catgcatata tagtatttat
     2041 atgaatattt tagcagtgta atatgttgaa ttctagttct ctgcattacc attattacgt
     2101 taaagtattt tttaaagctt aggtgtgaag atatgtgtct attgcagatg tccttgaaaa
     2161 ctgcataaaa cagtatgtgc ctggtgtgga tcttaccaaa gtactaggca tgaatgtagg
     2221 gactgcaaat cccatgggtc ttaatattta ggtgttagta accaaggtct ctggtagtac
     2281 ccgttagtag aggaagaggc cactgccctt gggaacttgt gacaggctct agtgtggtac
     2341 caggccataa agtgacactg ttatttagca acttgaattt ttccacacag gtagtaactg
     2401 tgtggaaata agcaacaagt ggtttgtcca tttctaagaa tcttaaacta ttagttggct
     2461 gtagtgtgaa gcattacttg tcattggaaa gatggagaga gtggccttaa ccggaagtgg
     2521 tcagtagaag caggtgtcat tttaagggcc aaactttaat ctgtcagcaa tagggaaaca
     2581 actgttcaaa ttatctttgt agataagaac agtgtttctt ttttcttttc ttttgttttt
     2641 ttgtttgttt gttttgtttt gttttgagac agagtttcac tcttgttgcc caggctggag
     2701 tgcaatggca caatcttgat ctcagctcgc cgcagcctcc gcctcccggt tcaagcgatt
     2761 cttctgcctc agcctcgcga gtagctggga ttacaggcat gcaccaccac gcctggctaa
     2821 tttcgtattt ttaatagaga cagggtttct ccatgttggt caggctggtc tcaaactcct
     2881 gacttgaggt gatctgcccg ccttggcctc ccaaagtgct gggattacag gcgggaacca
     2941 ctgcacccgg caggtacagt gtttctttag gtgctggtgg tacaccaggg aatcagggca
     3001 gaagctggat cctgcaagag taatgtttga gaacaaataa atactttcga aaggaggtcg
     3061 aaacaaaaag gagtgtaggt gttattactg cagagaagac tgaatggagt ccacttttct
     3121 tattagtaac ttactaaaaa tgatctcaaa tgggctccac acactttgcc ctggccatga
     3181 ggcaaacttg ttgggtttgg agaaaaacac ataaccctaa attcactatt tttgccctat
     3241 ataaaacatt aaaataacat gctctgtaca catgctgtca acaaaagcca gctctaggaa
     3301 cctgagtgcc agaatgcctg agggagctac agctgggctt agttggctgg gattgagctc
     3361 gctgtctgag ggagctcgct ctgtctctct cacactggca gtttacacca gccggcagcc
     3421 ctgagcagca gtgggtgtaa ctttttataa ataaggattc attgattcat tcatattctc
     3481 aatatttctt gaagacctac cccgagccaa gcatggtgcc aggcagtggg gatgcagtgg
     3541 agagcaaaca gccctgccca tgcaaagtgt cctgtacggt gagaagtgtg agctgcaccc
     3601 acaaagggaa agagcccagt gcagcttttg caaaatgcag ggaaggatgc tgctagcctc
     3661 agggtgacct agaactttaa gctcatcttt gttttcagga gcccagtgcc tcccctccac
     3721 ccctaaagaa tatctcaaag acgtggattt tcatttcagt aagatttagg ggtgcatggg
     3781 caggcagtgc tggaggaact gggaggcagg tttggaggct gcagtgggac cactggcccc
     3841 tcctggctac agtttcaggc caggagcttg ttggcacctg gtgcaaactc ccaaacctga
     3901 ggggtcccca caacccccca gcccatctta acttcctctt cccccaagct atctggtgtt
     3961 ggaaagccag catctagtgt ggaaacaagc tttctcacca ggtaggccat ccgctgtcag
     4021 gaccattagg taaaaacaga agtgacaggt tgtaggaagt cgttcgatct gtgaggctgc
     4081 gagcacttca gtgcctggga tttacctaac tgccatgaaa cactgattat ccagcattca
     4141 gcatgtgtca gattctgtaa ctatttctcc tgtgatgtat cagtcagctt ttgctgcaaa
     4201 acagcatcag aaatctcagt ggtctacaac tagattccca ttcttgggta gtctacaagt
     4261 tggcttctag gttatgctcc aggctggggg tctgatcacg tctgctccac aacatgtccc
     4321 gtattctggg tccctggttg aagcagcagc ttaccttggg ccgtgttctt tctcatggca
     4381 gaagcacagg aggccaagcc ctaccttgca agcacaaata cagcccctgc tcactttctg
     4441 ttggccacaa cacatggcca tgcctgacct ctgtggggtg aggcagtgca tggccaagga
     4501 acaagcacag tccacacagg gggctgtcac tccgtgacct cagtattaca aaatggttct
     4561 caaggagtcg caaaatgtgt ggcagatcat ccatgatttg tttcccgtgt gctttacgaa
     4621 tatcctgaaa tttttaaaag ctgtttccat tagaagggat ctgttgggga tttgaggtga
     4681 gatgagaaag accctgcatt ccagcccctc agttagcagt ggtgaggccg gagtactcca
     4741 cacgggacag ttttaggaaa gtgctggaat ccaaagtttc tccggagggc tatgcaaggc
     4801 gctttggaaa ggcgaagcct gggcgcaggg agcccagcca tgtaggtaga agcagcagac
     4861 ggtgagggag gccatcccca cctggccctg ccagggccct gactcagtga aggaagctgt
     4921 tgggatacag gtcattcagc cgggcaggaa agatgggatg aagcccagca agttcacagg
     4981 gatccgggaa gttgtgtggc tggaaaccca ggcagggctg caccacaggg accatttgct
     5041 ggagatgcag cacttgccac agccaccacc actgacagca tgacacccac aaaaagggag
     5101 cctccagctg cacccctgct gctgcgagta cttcctcagc tgtctgccat gagcttaagg
     5161 ttaagtacca ggagggagga tatgattggg caaacctcag gcatgtgttc attctgtagc
     5221 ttccagaaca tgcgaggaga gagcatctgg ctcctttgtc tcgaggagga gggggcagga
     5281 ctctgccaga actcactcga taaaagattt tcccaaaagg aagggtgttc agatgacaaa
     5341 agtccactac accactttcc ttggctatct gatgcacccc catcttccca tgcgcgcacc
     5401 tcagaaatca ggctcccacc tgacataaca caaccatgcc tcacaaaaag acagtggttt
     5461 atcccttccc taggagaaaa gagaggcaat gccaagctgc ttcatcaact gttaatactt
     5521 cttccagccc gcaacccagg atatctgcag gtgtctctcc ctctggtttg gtcatggctc
     5581 tctctgttct agaatgtatg ggttaaagtc ggctgccaca ccatgccctc ggcagtgtgg
     5641 tccaaggacc cctgagggtc ctcaaggtcc ttcctttccc aaccccacgt ggttttcttc
     5701 agtcaggata ccatactgca acagaccgaa ggcggaagca gctatgagga tgcagcagcc
     5761 ttctgttaag ccaggcttta aggatctgca aaaatgtaaa acgatgccac tcctactgat
     5821 gaaatatatt gttttggaaa atataggttt aaaaattttt ttaaggtaac atgtaatgga
     5881 tgtatagtct tcaaatggat gaataaatgt ttttcagagt ta
//
