LOCUS       NM_018241               4164 bp    mRNA    linear   PRI 10-FEB-2024
DEFINITION  Homo sapiens transmembrane protein 184C (TMEM184C), mRNA.
ACCESSION   NM_018241
VERSION     NM_018241.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4164)
  AUTHORS   Akaishi,J., Onda,M., Okamoto,J., Miyamoto,S., Nagahama,M., Ito,K.,
            Yoshida,A. and Shimizu,K.
  TITLE     Down-regulation of an inhibitor of cell growth, transmembrane
            protein 34 (TMEM34), in anaplastic thyroid cancer
  JOURNAL   J Cancer Res Clin Oncol 133 (4), 213-218 (2007)
   PUBMED   17072649
  REMARK    GeneRIF: Recently, by cDNA microarray anal., we identified
            transmembrane protein 34 (TMEM34) that down-regulated in anaplastic
            thyroid cancer cell lines as compared to normal thyroid tissues.
            Transfection of TMEM34 into KTA2 cells led to inhibition of cell
            growth
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA018837.1, AK001708.1, BM712423.1, AC093835.3 and AF305823.1.
            
            On May 17, 2019 this sequence version replaced NM_018241.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803616.48298.1,
                                           SRR1803614.201094.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000296582.8/ ENSP00000296582.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-603               DA018837.1         10-612
            604-1314            AK001708.1         556-1266
            1315-1828           BM712423.1         44-557
            1829-2182           AK001708.1         1781-2134
            2183-2183           AC093835.3         20709-20709
            2184-2962           AK001708.1         2135-2913
            2963-2966           AF305823.1         1646-1649
            2967-4164           AC093835.3         21493-22690
FEATURES             Location/Qualifiers
     source          1..4164
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4q31.23"
     gene            1..4164
                     /gene="TMEM184C"
                     /gene_synonym="SLC51C3; TMEM34"
                     /note="transmembrane protein 184C"
                     /db_xref="GeneID:55751"
                     /db_xref="HGNC:HGNC:25587"
                     /db_xref="MIM:613937"
     exon            1..683
                     /gene="TMEM184C"
                     /gene_synonym="SLC51C3; TMEM34"
                     /inference="alignment:Splign:2.1.0"
     CDS             561..1877
                     /gene="TMEM184C"
                     /gene_synonym="SLC51C3; TMEM34"
                     /note="transmembrane protein 34"
                     /codon_start=1
                     /product="transmembrane protein 184C"
                     /protein_id="NP_060711.2"
                     /db_xref="CCDS:CCDS3770.1"
                     /db_xref="GeneID:55751"
                     /db_xref="HGNC:HGNC:25587"
                     /db_xref="MIM:613937"
                     /translation="MPCTCTWRNWRQWIRPLVAVIYLVSIVVAVPLCVWELQKLEVGI
                     HTKAWFIAGIFLLLTIPISLWVILQHLVHYTQPELQKPIIRILWMVPIYSLDSWIALK
                     YPGIAIYVDTCRECYEAYVIYNFMGFLTNYLTNRYPNLVLILEAKDQQKHFPPLCCCP
                     PWAMGEVLLFRCKLGVLQYTVVRPFTTIVALICELLGIYDEGNFSFSNAWTYLVIINN
                     MSQLFAMYCLLLFYKVLKEELSPIQPVGKFLCVKLVVFVSFWQAVVIALLVKVGVISE
                     KHTWEWQTVEAVATGLQDFIICIEMFLAAIAHHYTFSYKPYVQEAEEGSCFDSFLAMW
                     DVSDIRDDISEQVRHVGRTVRGHPRKKLFPEDQDQNEHTSLLSSSSQDAISIASSMPP
                     SPMGHYQGFGHTVTPQTTPTTAKISDEILSDTIGEKKEPSDKSVDS"
     exon            684..814
                     /gene="TMEM184C"
                     /gene_synonym="SLC51C3; TMEM34"
                     /inference="alignment:Splign:2.1.0"
     exon            815..851
                     /gene="TMEM184C"
                     /gene_synonym="SLC51C3; TMEM34"
                     /inference="alignment:Splign:2.1.0"
     exon            852..1057
                     /gene="TMEM184C"
                     /gene_synonym="SLC51C3; TMEM34"
                     /inference="alignment:Splign:2.1.0"
     exon            1058..1132
                     /gene="TMEM184C"
                     /gene_synonym="SLC51C3; TMEM34"
                     /inference="alignment:Splign:2.1.0"
     exon            1133..1226
                     /gene="TMEM184C"
                     /gene_synonym="SLC51C3; TMEM34"
                     /inference="alignment:Splign:2.1.0"
     exon            1227..1339
                     /gene="TMEM184C"
                     /gene_synonym="SLC51C3; TMEM34"
                     /inference="alignment:Splign:2.1.0"
     exon            1340..1439
                     /gene="TMEM184C"
                     /gene_synonym="SLC51C3; TMEM34"
                     /inference="alignment:Splign:2.1.0"
     exon            1440..1611
                     /gene="TMEM184C"
                     /gene_synonym="SLC51C3; TMEM34"
                     /inference="alignment:Splign:2.1.0"
     exon            1612..4164
                     /gene="TMEM184C"
                     /gene_synonym="SLC51C3; TMEM34"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2642..2647
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TMEM184C"
                     /gene_synonym="SLC51C3; TMEM34"
                     /note="hexamer: AATAAA"
     regulatory      2646..2651
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TMEM184C"
                     /gene_synonym="SLC51C3; TMEM34"
                     /note="hexamer: AATAAG"
     polyA_site      2664
                     /gene="TMEM184C"
                     /gene_synonym="SLC51C3; TMEM34"
                     /note="major polyA site"
     polyA_site      2674
                     /gene="TMEM184C"
                     /gene_synonym="SLC51C3; TMEM34"
     polyA_site      3438
                     /gene="TMEM184C"
                     /gene_synonym="SLC51C3; TMEM34"
     regulatory      3590..3595
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TMEM184C"
                     /gene_synonym="SLC51C3; TMEM34"
                     /note="hexamer: GATAAA"
     polyA_site      3614
                     /gene="TMEM184C"
                     /gene_synonym="SLC51C3; TMEM34"
     regulatory      4056..4061
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TMEM184C"
                     /gene_synonym="SLC51C3; TMEM34"
                     /note="hexamer: AACAAA"
     regulatory      4098..4103
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TMEM184C"
                     /gene_synonym="SLC51C3; TMEM34"
                     /note="hexamer: AAGAAA"
     polyA_site      4099
                     /gene="TMEM184C"
                     /gene_synonym="SLC51C3; TMEM34"
     polyA_site      4115
                     /gene="TMEM184C"
                     /gene_synonym="SLC51C3; TMEM34"
ORIGIN      
        1 ggtttggcct tgggttccgc tgtaggggag gtcccgtgcg aaagaatgag gagatcctgg
       61 ggccttacct actagcggaa tcgactgaag agacgcctgc cagtgcggga ggtaggaagc
      121 tcgatcccca aagaaaagag cgagtgggca ggcagctgcg agacagaacc ggagtgtgca
      181 gggtccctag aggccggttc ctggtctgtg ctgctctcct ggaagccatg gtacaggcag
      241 agctcagggc gatccccagg tgagggcagc ggctctgcct gggattccac cgcagtacaa
      301 ccgggtagat gcggggtgga gaagaaagga tgttgcctgc actgctcgcc aatagcaccc
      361 tgagaggcta catttgcaga agcagcagca gcagaagaca cagcgccggt ccaggaggcg
      421 gctcgagctg ttcgtaaagt cgcccgacag ctttttctcc gtagtatgcg agttgacaaa
      481 acagccagag aacagggctc cccattacaa tcttttcgag atcttttccc ttgctaaccg
      541 gatctgattt gtgcgaaaac atgccttgca cttgtacctg gaggaactgg agacagtgga
      601 ttcgaccttt agtagcggtc atctacctgg tgtcaatagt ggttgcggtt cccctatgcg
      661 tgtgggaatt acagaaactg gaggttggaa tacacaccaa ggcttggttt attgctggaa
      721 tctttttgct gttgactatt cctatatcac tgtgggtgat attgcaacac ttagtgcatt
      781 atacacaacc tgaactacaa aaaccaataa taaggattct ttggatggta cctatttaca
      841 gtttagatag ttggatagct ttgaaatatc ccggaattgc aatatatgtg gatacctgca
      901 gagaatgcta tgaagcttat gtaatttaca actttatggg attccttacc aattatctaa
      961 ctaaccggta tccaaatctg gtattaatcc ttgaagccaa agatcaacag aaacatttcc
     1021 ctcctttatg ttgctgtcca ccatgggcta tgggagaagt attgctgttt aggtgcaaac
     1081 taggtgtatt acagtacaca gttgtcagac ctttcaccac catcgttgct ttaatctgtg
     1141 agctgcttgg tatatatgac gaagggaact ttagcttttc aaatgcttgg acttatttgg
     1201 ttataataaa caacatgtca cagttgtttg ccatgtattg tctcctgctc ttttataaag
     1261 tactaaaaga agaactgagc ccaatccaac ctgttggcaa atttctttgt gtaaagctgg
     1321 tggtttttgt ttctttttgg caagcagtag ttattgcttt gttggtaaaa gttggcgtta
     1381 tttctgaaaa gcatacgtgg gaatggcaaa ctgtagaagc tgtggccacc ggactccagg
     1441 attttattat ctgtattgag atgttcctcg ctgccattgc tcatcattac acattctcat
     1501 ataaaccata tgtccaagaa gcagaagagg gctcatgctt tgattccttt cttgccatgt
     1561 gggatgtctc agatattaga gatgatattt ctgaacaagt aaggcatgtt ggacggacag
     1621 tcaggggaca tcccaggaaa aaattgtttc ccgaggatca agatcaaaat gaacatacaa
     1681 gtttattatc atcatcatca caagatgcaa tttccattgc ttcttctatg ccaccttcac
     1741 ccatgggtca ctaccaaggg tttggacaca ctgtgactcc ccagactaca cctaccacag
     1801 ctaagatatc tgatgaaatc cttagtgata ctataggaga gaaaaaagaa ccttcagata
     1861 aatccgtgga ttcctgaaca gtatggaaaa gcaaactgtg caactactac attatatcat
     1921 tacctggtat cccatggatt ttgtgcttgg gacagaccat aaatgatgga aaatgtcaac
     1981 acaaaaatag ctgaaagcca ggtacaacta ctgcatttat atatgtaagt tttgtatatc
     2041 aaaaataatt ggtctaaatt tcctagactt agacttgatt tcttaacatt agggtatcgc
     2101 atactcaaat ggtagacaat gaccccaact aaatcttcct gatgttacac tgctttatca
     2161 agaggatgga cttttttttt tttgagacag acagagtctt gctctgtcac ccaggctgga
     2221 gtgcagtggc gcaatctcgg gtcactgcaa gctctgcctc ccaagttcat gccattctcc
     2281 tgcctcagcc tcccaagtag ctgggactac aggcacctgc caccatgccc agctaatttt
     2341 ttttttttca gtagagacag ggtctcacca tgttagccag gatggtcttg atctgacctc
     2401 gtgatccgcc gacctcggcc tcccaaagtg ctggaattac aggcgtgagc cactgcgcct
     2461 ggccaagaat ggacattttt taaaaaaaca tcagtacttc ctaccactgc tgcatgagta
     2521 taatgctccg gaattatcag aaagcataat gcagaaatac gaattagtgg aacttaatca
     2581 tgtgccatat aagcttacct aacaaacagt tatatcccta ttcctcaact gaatgtcttt
     2641 caataaataa gaatttatca tttattttct gcaacttttt tatgtctcat tctttaaaca
     2701 ttaaaaaccc ttaatatttt aacaaaaatt tcttgattag aggcacagtg aaaaagaagt
     2761 caaaaaaaaa agttctactt ttcatcagtg ctattaaagg tggcagcaaa tgtaaatctt
     2821 ggctgaatgg tcttaattac tcattaaacc acagtcagaa agacatatag gtgctatttg
     2881 ggaaaacttt ttattaccta ggatggggtt tctctaattg ctaatcacaa ccccactggg
     2941 tcatgtttga cattttataa tgaaaataaa acagaaagtg ccatagtatg ttacagaaag
     3001 caaagatgag tattgtttct caaagccttt gctttatgta tttatacaca tactcattca
     3061 tatctatcta tatatataga gagagatagt ggttcacagt aatcatacaa agtctttatt
     3121 ccatccacta ttataaacat ttctattaaa actaaaactg ggctctatgt aaaaacccca
     3181 aagatacaca cacaaaaaaa atctgtttgt tagaactcaa gtgaattcag taaagttgca
     3241 gaatacaaaa tcaacataca aaaagcatta gcatttttat acataaataa tgaaaataat
     3301 gacctaactg aaaaattaag atgccattta tgatagcata aaaaaaatac ttacttagga
     3361 ataaatttaa caccaaggca gtaaaagatc tgtatgtaca ctgaaaacta tgaaacactg
     3421 atgaaagaaa gacacaaata aatggaaagg tatcccgtgc tcatggatca gaataatact
     3481 gttaaaatgg tcacactacc caaagcaatt cagaatcaat gcaatcctat caaaattcca
     3541 atggcattat ttacacaaac agaaaaaaat cctaaaattc atatgtaacg ataaaagacc
     3601 ctgaataggc aaaagaatac tgaggaaaaa atgttggaga catcacattt cctaattata
     3661 aattatacta caaaactata gtaatcaaga cagtatggta ctggtataaa aacacataca
     3721 caggccagtg ggacagaaga aagagtccag atataaatcc aaacatacac agtcaactaa
     3781 tttttgacaa agacaccaag aagacacatc ggggaaagaa cagtcttcat taagtgttct
     3841 taatgaagat gctgggaaaa ctgcacttcc acatgcaaaa caatgaaatc agacccttat
     3901 cttagaccta cacaacaatc aattcaaaat ggataaaaga cctaaatgta agaccagaaa
     3961 ctatagaaga gaacatagga gaaaagttcc tggacactga cccttggcaa tgattttttg
     4021 gatatcacac caaaagctca gtcaacaaaa acaaaaacaa atgtgactac atcaaaccaa
     4081 aaagcttctg acagtaaaag aaacagtcaa caaaatgaaa cagtagccta cagattgagt
     4141 aaaaaatatt tgtaaggcat atat
//
