LOCUS       NM_012264               3587 bp    mRNA    linear   PRI 09-FEB-2025
DEFINITION  Homo sapiens transmembrane protein 184B (TMEM184B), transcript
            variant 1, mRNA.
ACCESSION   NM_012264
VERSION     NM_012264.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3587)
  AUTHORS   Larsen,E.G., Cho,T.S., McBride,M.L., Feng,J., Manivannan,B.,
            Madura,C., Klein,N.E., Wright,E.B., Wickstead,E.S.,
            Garcia-Verdugo,H.D., Jarvis,C., Khanna,R., Hu,H.,
            Largent-Milnes,T.M. and Bhattacharya,M.R.C.
  TITLE     Transmembrane protein TMEM184B is necessary for
            interleukin-31-induced itch
  JOURNAL   Pain 163 (5), e642-e653 (2022)
   PUBMED   34629389
REFERENCE   2  (bases 1 to 3587)
  AUTHORS   Bhattacharya,M.R., Geisler,S., Pittman,S.K., Doan,R.A., Weihl,C.C.,
            Milbrandt,J. and DiAntonio,A.
  TITLE     TMEM184b Promotes Axon Degeneration and Neuromuscular Junction
            Maintenance
  JOURNAL   J Neurosci 36 (17), 4681-4689 (2016)
   PUBMED   27122027
REFERENCE   3  (bases 1 to 3587)
  AUTHORS   Fukumoto,I., Hanazawa,T., Kinoshita,T., Kikkawa,N., Koshizuka,K.,
            Goto,Y., Nishikawa,R., Chiyomaru,T., Enokida,H., Nakagawa,M.,
            Okamoto,Y. and Seki,N.
  TITLE     MicroRNA expression signature of oral squamous cell carcinoma:
            functional role of microRNA-26a/b in the modulation of novel cancer
            pathways
  JOURNAL   Br J Cancer 112 (5), 891-900 (2015)
   PUBMED   25668004
  REMARK    GeneRIF: Data shows that miR-26a and miR-26b were significantly
            downregulated and their direct target, TMEM184B significantly
            up-regulated in oral squamous cell carcinoma cells.
REFERENCE   4  (bases 1 to 3587)
  AUTHORS   Lindstrom,S., Thompson,D.J., Paterson,A.D., Li,J., Gierach,G.L.,
            Scott,C., Stone,J., Douglas,J.A., dos-Santos-Silva,I.,
            Fernandez-Navarro,P., Verghase,J., Smith,P., Brown,J., Luben,R.,
            Wareham,N.J., Loos,R.J., Heit,J.A., Pankratz,V.S., Norman,A.,
            Goode,E.L., Cunningham,J.M., deAndrade,M., Vierkant,R.A., Czene,K.,
            Fasching,P.A., Baglietto,L., Southey,M.C., Giles,G.G., Shah,K.P.,
            Chan,H.P., Helvie,M.A., Beck,A.H., Knoblauch,N.W., Hazra,A.,
            Hunter,D.J., Kraft,P., Pollan,M., Figueroa,J.D., Couch,F.J.,
            Hopper,J.L., Hall,P., Easton,D.F., Boyd,N.F., Vachon,C.M. and
            Tamimi,R.M.
  TITLE     Genome-wide association study identifies multiple loci associated
            with both mammographic density and breast cancer risk
  JOURNAL   Nat Commun 5, 5303 (2014)
   PUBMED   25342443
  REMARK    Erratum:[Nat Commun. 2015 Sep 09;6:8358. doi: 10.1038/ncomms9358..
            PMID: 26349435]
            Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK292652.1, BC012983.2 and BQ004586.1.
            
            On Nov 23, 2018 this sequence version replaced NM_012264.4.
            
            Transcript Variant: This variant (1) is the most frequently
            occurring transcript variant. The resulting protein (isoform a) is
            the longer protein. Variants 1 and 2 encode the same protein.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660807.227989.1, BC015489.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000361906.8/ ENSP00000355210.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1528              AK292652.1         25-1552
            1529-3348           BC012983.2         877-2696
            3349-3587           BQ004586.1         19-257              c
FEATURES             Location/Qualifiers
     source          1..3587
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="22"
                     /map="22q13.1"
     gene            1..3587
                     /gene="TMEM184B"
                     /gene_synonym="C22orf5; FM08; HS5O6A; HSPC256; SLC51C2"
                     /note="transmembrane protein 184B"
                     /db_xref="GeneID:25829"
                     /db_xref="HGNC:HGNC:1310"
     exon            1..127
                     /gene="TMEM184B"
                     /gene_synonym="C22orf5; FM08; HS5O6A; HSPC256; SLC51C2"
                     /inference="alignment:Splign:2.1.0"
     exon            128..377
                     /gene="TMEM184B"
                     /gene_synonym="C22orf5; FM08; HS5O6A; HSPC256; SLC51C2"
                     /inference="alignment:Splign:2.1.0"
     CDS             186..1409
                     /gene="TMEM184B"
                     /gene_synonym="C22orf5; FM08; HS5O6A; HSPC256; SLC51C2"
                     /note="isoform a is encoded by transcript variant 1;
                     putative MAPK-activating protein FM08"
                     /codon_start=1
                     /product="transmembrane protein 184B isoform a"
                     /protein_id="NP_036396.2"
                     /db_xref="CCDS:CCDS13969.2"
                     /db_xref="GeneID:25829"
                     /db_xref="HGNC:HGNC:1310"
                     /translation="MTVRGDVLAPDPASPTTAAASPSVSVIPEGSPTAMEQPVFLMTT
                     AAQAISGFFVWTALLITCHQIYMHLRCYSCPNEQRYIVRILFIVPIYAFDSWLSLLFF
                     TNDQYYVYFGTVRDCYEALVIYNFLSLCYEYLGGESSIMSEIRGKPIESSCMYGTCCL
                     WGKTYSIGFLRFCKQATLQFCVVKPLMAVSTVVLQAFGKYRDGDFDVTSGYLYVTIIY
                     NISVSLALYALFLFYFATRELLSPYSPVLKFFMVKSVIFLSFWQGMLLAILEKCGAIP
                     KIHSARVSVGEGTVAAGYQDFIICVEMFFAALALRHAFTYKVYADKRLDAQGRCAPMK
                     SISSSLKETMNPHDIVQDAIHNFSPAYQQYTQQSTLEPGPTWRGGAHGLSRSHSLSGA
                     RDNEKTLLLSSDDEF"
     exon            378..543
                     /gene="TMEM184B"
                     /gene_synonym="C22orf5; FM08; HS5O6A; HSPC256; SLC51C2"
                     /inference="alignment:Splign:2.1.0"
     exon            544..634
                     /gene="TMEM184B"
                     /gene_synonym="C22orf5; FM08; HS5O6A; HSPC256; SLC51C2"
                     /inference="alignment:Splign:2.1.0"
     exon            635..710
                     /gene="TMEM184B"
                     /gene_synonym="C22orf5; FM08; HS5O6A; HSPC256; SLC51C2"
                     /inference="alignment:Splign:2.1.0"
     exon            711..802
                     /gene="TMEM184B"
                     /gene_synonym="C22orf5; FM08; HS5O6A; HSPC256; SLC51C2"
                     /inference="alignment:Splign:2.1.0"
     exon            803..972
                     /gene="TMEM184B"
                     /gene_synonym="C22orf5; FM08; HS5O6A; HSPC256; SLC51C2"
                     /inference="alignment:Splign:2.1.0"
     exon            973..1167
                     /gene="TMEM184B"
                     /gene_synonym="C22orf5; FM08; HS5O6A; HSPC256; SLC51C2"
                     /inference="alignment:Splign:2.1.0"
     exon            1168..3587
                     /gene="TMEM184B"
                     /gene_synonym="C22orf5; FM08; HS5O6A; HSPC256; SLC51C2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3533..3538
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TMEM184B"
                     /gene_synonym="C22orf5; FM08; HS5O6A; HSPC256; SLC51C2"
                     /note="hexamer: AATAAA"
     regulatory      3545..3550
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TMEM184B"
                     /gene_synonym="C22orf5; FM08; HS5O6A; HSPC256; SLC51C2"
                     /note="hexamer: AAGAAA"
     polyA_site      3554
                     /gene="TMEM184B"
                     /gene_synonym="C22orf5; FM08; HS5O6A; HSPC256; SLC51C2"
                     /note="major polyA site"
     regulatory      3565..3570
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TMEM184B"
                     /gene_synonym="C22orf5; FM08; HS5O6A; HSPC256; SLC51C2"
                     /note="hexamer: AATATA"
     polyA_site      3566
                     /gene="TMEM184B"
                     /gene_synonym="C22orf5; FM08; HS5O6A; HSPC256; SLC51C2"
     polyA_site      3587
                     /gene="TMEM184B"
                     /gene_synonym="C22orf5; FM08; HS5O6A; HSPC256; SLC51C2"
ORIGIN      
        1 actccactgg gcccgggacg cgccggcggc ggcggagact ccggggctgc ggcgccgccc
       61 gccccgcccg cagagtccgg ctgccgcgca tcgtccgcag acgccgccac cgccatgggc
      121 tcctgaggct agcttgtcac tttctgcaaa ggtttccctc agggagcctc ctgctgccag
      181 gcaccatgac agtgaggggg gatgtgctgg ccccggatcc agcgtcgccc acgaccgcag
      241 cagcctcgcc cagcgtctcc gtgatccccg agggcagccc cactgccatg gagcagcctg
      301 tgttcctgat gacaactgcc gctcaggcca tctctggctt cttcgtgtgg acggccctgc
      361 tcatcacatg ccaccagatc tacatgcacc tgcgctgcta cagctgcccc aacgagcagc
      421 gctacatcgt gcgcatcctc ttcatcgtgc ccatctacgc ctttgactcc tggctcagcc
      481 tcctcttctt caccaacgac cagtactacg tgtacttcgg caccgtccgc gactgctatg
      541 aggccttggt catctataat ttcctgagcc tgtgctatga gtacctagga ggagaaagtt
      601 ccatcatgtc ggagatcaga ggaaaaccca ttgagtccag ctgtatgtat ggcacctgct
      661 gcctctgggg aaagacttat tccatcggat ttctgaggtt ctgcaaacag gccaccctgc
      721 agttctgtgt ggtgaagcca ctcatggcgg tcagcactgt ggtcctccag gccttcggca
      781 agtaccggga tggggacttt gacgtcacca gtggctacct ctacgtgacc atcatctaca
      841 acatctccgt cagcctggcc ctctacgccc tcttcctctt ctacttcgcc acccgggagc
      901 tgctcagccc ctacagcccc gtcctcaagt tcttcatggt caagtccgtc atctttcttt
      961 ccttctggca aggcatgctc ctggccatcc tggagaagtg tggggccatc cccaaaatcc
     1021 actcggcccg cgtgtcggtg ggcgagggca ccgtggctgc cggctaccag gacttcatca
     1081 tctgtgtgga gatgttcttt gcagccctgg ccctgcggca cgccttcacc tacaaggtct
     1141 atgctgacaa gaggctggac gcacaaggcc gctgtgcccc catgaagagc atctccagca
     1201 gcctcaagga gaccatgaac ccgcacgaca tcgtgcagga cgccatccac aacttctcac
     1261 ctgcctacca gcagtacacg cagcagtcca ccctggagcc tgggcccacc tggcgtggtg
     1321 gcgcccacgg cctctcccgc tcccacagcc tcagtggcgc ccgcgacaac gagaagactc
     1381 tcctgctcag ctctgatgat gaattctagg tgcgggctgc agtggcggaa gtgctggcgc
     1441 catagccacg gtcaggctgt gccccacctc cagcctcacc accaggccag gaggcagctg
     1501 gcacagtgct cacgccgcct ttatttattg gaccagaaac actcacatgt cacttccaga
     1561 ggaacggggg acagccaggc tcgcccatgg gccttcagga atatttatac atggcccagc
     1621 ctgcactgcc cgggcgaggg cagaggacac tgggagcaag gcttatgccc ctgctgcccg
     1681 tcctgtgctg ggggcatgct gggaccagcc gcacccaggc cccaatgctt gtgtgtggac
     1741 cagcggctgc agccttctag cccctcctcc ccgcgagact ctcaggctga ggtcggcaag
     1801 ccgtggctcc cccacacacc gtgcaatacc ctgtctgacc tgggctcttc ccgcctgcat
     1861 ccctcccctg tccacctttg tccagtgcta gattcacctc accccgggca ggagtgggga
     1921 tgtgggcgct ctgtggtcct cccctcctga cccaggcctc tgtggcatgc tgcaaggatc
     1981 agagccagac accaggagtc acaggcccca cccaggaagg gcattcaggg cccctgggca
     2041 ccgcttctgt tgaagcaggg gcttctgggc ccctgggtat ccccacctgt cgtggccaca
     2101 cctctgcctg cctcatgccc cttccccctg gcctaccaag gacagcccac agcccgcact
     2161 gccggctcac ttgggtcctt cctcgatagc tttgggcaga gcccttgctt cctggctgct
     2221 tcagggctca ggggctccca gccctccttc ccaggctgat gctgggtcct ctctctcttt
     2281 ggggcttctc cctcccgttt caggggaaag gtctgagtct ccacgtttca gaccagcttc
     2341 tgggggaagg cagtccggca gggagaccgg gaggggtggc cacacagtgg ggagctggga
     2401 ggtgggggga atggtcccag actcctctcg gggcccctat ccacacaggg cctggtgttc
     2461 taccccatct ggcccctggc ccatctcttc tgtgccttag tcacatatga aagcgcccct
     2521 ccctggctcc ccatctgtcc cacacgctcc ctggggctct tagttcagct gctggcactc
     2581 gcaggatcct gcagtgctgg gcccagagcc cttggacagg cctcaggagt ggtcaggacc
     2641 accaagcccc tcctctcccc ctccacacct ctagacctgg ggcctccgga acccccagca
     2701 ggctgggctt atactagctc ctgacttagg aagagcctcg tgtcacaaca cgtgtcccta
     2761 caggcaaagt gtcctggcat ttaaaaccca gattatccct gggtttgggc tgcagtcacc
     2821 tggagaagct ggtagggtaa gggagaggga ccctgccggt gttcactggg gattctttct
     2881 tttggtcctt cctggaatga acaggttccc tccctgccac ctgtgaggag agttggggcc
     2941 cagccgtctt cctggcctcc ttcctttcct cgtggcagag gcctgcatgt gggtgccaga
     3001 ggccagctct ccccctccat cttggggggg cggagcagtt gggcccaagc tgcccgggag
     3061 ggtgggtgca gacacaggct gaggaccagc cctggccctg ccccgccatc tgctttcacc
     3121 aagctgtctc tccaccgtgg cttcccttct ccctccaggc caaagtgctg ctgattccca
     3181 ctcccttggt tttcgcctgc ccagcgttgc tgtttgcgtg gagggtgggg ggagctcagt
     3241 ggcagggaat cagcggtccg tggggtcgtg gggacgggaa catgtgcccg accgctccat
     3301 cccctcctcc tccttaggat gcataaccta ccttgtcttt ttttttttta attttctttc
     3361 caggtagagt agctctttgt acataaagaa tacttgaaaa attaattgta tgatgtatga
     3421 gaagacagag tctcctagtt ttgtatcttg ttgtatgact gccatgagtt ccaccagaaa
     3481 gccactctat tttggtctct gtgacatttt aaatgcgtga cagaagtgag caaataaagt
     3541 gaggaagaaa tctatatatg agataatata gattgtattg aaatctc
//
