LOCUS       NM_001097620            6051 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens transmembrane protein 184A (TMEM184A), mRNA.
ACCESSION   NM_001097620
VERSION     NM_001097620.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6051)
  AUTHORS   Pugh,R.J., Slee,J.B., Farwell,S.L., Li,Y., Barthol,T., Patton,W.A.
            and Lowe-Krentz,L.J.
  TITLE     Transmembrane Protein 184A Is a Receptor Required for Vascular
            Smooth Muscle Cell Responses to Heparin
  JOURNAL   J Biol Chem 291 (10), 5326-5341 (2016)
   PUBMED   26769966
REFERENCE   2  (bases 1 to 6051)
  AUTHORS   Farwell,S.L., Kanyi,D., Hamel,M., Slee,J.B., Miller,E.A.,
            Cipolle,M.D. and Lowe-Krentz,L.J.
  TITLE     Heparin Decreases in Tumor Necrosis Factor alpha (TNFalpha)-induced
            Endothelial Stress Responses Require Transmembrane Protein 184A and
            Induction of Dual Specificity Phosphatase 1
  JOURNAL   J Biol Chem 291 (10), 5342-5354 (2016)
   PUBMED   26769965
  REMARK    GeneRIF: TMEM184A functions as a heparin receptor and mediates
            anti-inflammatory responses of endothelial cells involving
            decreased JNK and p38 activity.
REFERENCE   3  (bases 1 to 6051)
  AUTHORS   Best,D., Sahlender,D.A., Walther,N., Peden,A.A. and Adams,I.R.
  TITLE     Sdmg1 is a conserved transmembrane protein associated with germ
            cell sex determination and germline-soma interactions in mice
  JOURNAL   Development 135 (8), 1415-1425 (2008)
   PUBMED   18321981
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK172850.1, AC093734.3 and BM981655.1.
            
            On Nov 22, 2018 this sequence version replaced NM_001097620.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC026694.1, AK172850.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1966682,
                                           SAMEA1968189 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000297477.10/ ENSP00000297477.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2057              AK172850.1         2-2058
            2058-5613           AC093734.3         49093-52648         c
            5614-6051           BM981655.1         18-455              c
FEATURES             Location/Qualifiers
     source          1..6051
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7p22.3"
     gene            1..6051
                     /gene="TMEM184A"
                     /gene_synonym="SDMG1; SLC51C1"
                     /note="transmembrane protein 184A"
                     /db_xref="GeneID:202915"
                     /db_xref="HGNC:HGNC:28797"
     exon            1..92
                     /gene="TMEM184A"
                     /gene_synonym="SDMG1; SLC51C1"
                     /inference="alignment:Splign:2.1.0"
     CDS             93..1334
                     /gene="TMEM184A"
                     /gene_synonym="SDMG1; SLC51C1"
                     /note="sexually dimorphic, expressed in male gonads 1"
                     /codon_start=1
                     /product="transmembrane protein 184A"
                     /protein_id="NP_001091089.1"
                     /db_xref="CCDS:CCDS43537.1"
                     /db_xref="GeneID:202915"
                     /db_xref="HGNC:HGNC:28797"
                     /translation="MSNVSGILETAGVPLVSANWPQPSPPPAVPAGPQMDHMGNSSQG
                     APWLFLTSALARGVSGIFVWTALVLTCHQIYLHLRSYTVPQEQRYIIRLLLIVPIYAF
                     DSWLSLLLLGDHQYYVYFDSVRDCYEAFVIYSFLSLCFQYLGGEGAIMAEIRGKPIKS
                     SCLYGTCCLRGMTYSIGFLRFCKQATLQFCLVKPVMAVTTIILQAFGKYHDGDFNVRS
                     GYLYVTLIYNASVSLALYALFLFYFTTRELLRPFQPVLKFLTIKAVIFLSFWQGLLLA
                     ILERCGVIPEVETSGGNKLGAGTLAAGYQNFIICVEMLFASVALRYAFPCQVYAEKKE
                     NSPAPPAPMQSISSGIRETVSPQDIVQDAIHNFSPAYQHYTQQATHEAPRPGTHPSGG
                     SGGSRKSRSLEKRMLIPSEDL"
     exon            93..311
                     /gene="TMEM184A"
                     /gene_synonym="SDMG1; SLC51C1"
                     /inference="alignment:Splign:2.1.0"
     exon            312..477
                     /gene="TMEM184A"
                     /gene_synonym="SDMG1; SLC51C1"
                     /inference="alignment:Splign:2.1.0"
     exon            478..568
                     /gene="TMEM184A"
                     /gene_synonym="SDMG1; SLC51C1"
                     /inference="alignment:Splign:2.1.0"
     exon            569..644
                     /gene="TMEM184A"
                     /gene_synonym="SDMG1; SLC51C1"
                     /inference="alignment:Splign:2.1.0"
     exon            645..736
                     /gene="TMEM184A"
                     /gene_synonym="SDMG1; SLC51C1"
                     /inference="alignment:Splign:2.1.0"
     exon            737..906
                     /gene="TMEM184A"
                     /gene_synonym="SDMG1; SLC51C1"
                     /inference="alignment:Splign:2.1.0"
     exon            907..1104
                     /gene="TMEM184A"
                     /gene_synonym="SDMG1; SLC51C1"
                     /inference="alignment:Splign:2.1.0"
     exon            1105..6051
                     /gene="TMEM184A"
                     /gene_synonym="SDMG1; SLC51C1"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      2059
                     /gene="TMEM184A"
                     /gene_synonym="SDMG1; SLC51C1"
                     /note="major polyA site"
     regulatory      5417..5422
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TMEM184A"
                     /gene_synonym="SDMG1; SLC51C1"
                     /note="hexamer: AATAAA"
     polyA_site      5435
                     /gene="TMEM184A"
                     /gene_synonym="SDMG1; SLC51C1"
     regulatory      5604..5609
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TMEM184A"
                     /gene_synonym="SDMG1; SLC51C1"
                     /note="hexamer: AATAAA"
     polyA_site      5626
                     /gene="TMEM184A"
                     /gene_synonym="SDMG1; SLC51C1"
     regulatory      6032..6037
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TMEM184A"
                     /gene_synonym="SDMG1; SLC51C1"
                     /note="hexamer: AATATA"
     polyA_site      6051
                     /gene="TMEM184A"
                     /gene_synonym="SDMG1; SLC51C1"
                     /note="major polyA site"
ORIGIN      
        1 agttggggcc acgtggccat gagaatgacc agctaggctt ccctggaggc caggcctccc
       61 tggactgggc caggtgcttc ctgccagcaa agatgagtaa tgtctcaggg atcctggaga
      121 cagccggcgt ccccctggtg tcagcgaact ggccgcagcc cagcccccca ccggctgtgc
      181 cagctgggcc gcagatggac cacatgggga acagctccca gggggccccc tggctcttcc
      241 tcacctccgc actggcccga ggcgtctcgg ggatcttcgt gtggactgcc ctggtgctca
      301 cctgccacca gatctatctg cacctgcgct cctacaccgt gccacaggag caacgttaca
      361 tcatccgcct gctcctcatc gtgcccatct acgccttcga ctcctggctc agcctcctcc
      421 tcctcggaga ccaccagtac tacgtctact tcgactctgt gcgggactgc tacgaagcct
      481 ttgtcattta cagcttcctg agcctgtgtt tccagtacct gggaggcgag ggcgccatca
      541 tggctgagat tcgtggaaag cccatcaagt ccagctgctt gtacggcacc tgctgcctcc
      601 ggggcatgac ctactccatc gggttcctgc gcttctgtaa gcaggccact ctgcagttct
      661 gcctggtgaa gcccgtcatg gccgtcacca ccatcatcct ccaggcattt ggcaaatacc
      721 acgacgggga cttcaatgtc cgcagcggct acctctatgt gaccctcatc tacaacgcct
      781 ccgtcagcct cgccctctac gccctgttcc tcttctactt caccaccagg gagctcctgc
      841 ggcccttcca gcccgtcctc aagttcctca ccatcaaagc cgtcatcttc ctgtcgttct
      901 ggcaagggct gctgctggcc atcctggagc ggtgcggggt catcccggag gtggagacca
      961 gcggcgggaa caagctgggg gctggcacgc tggccgccgg ctaccagaac ttcatcatct
     1021 gcgtggagat gctgttcgcc tccgtggccc tgcgttatgc cttcccctgc caggtgtacg
     1081 cagagaagaa ggagaattca ccagcccccc cggcacccat gcagagcatc tccagcggca
     1141 tcagggagac agtgagcccc caggacatcg tgcaggacgc catccacaac ttctcccccg
     1201 cctaccagca ctacacgcag caggccacgc acgaggcgcc caggcccggc acccacccca
     1261 gcggcggctc cggcgggagc aggaagagcc ggagcctgga gaagcggatg ctgatcccct
     1321 cggaggacct gtaggggggc ctgggctgcc agtgctgtag ggacccaggc tgcccaggcc
     1381 tctggggaag aacagggtcc ccccacccac caactcctgc caaaggtggg gcctctcctg
     1441 agagcccacc tgtgaggccc tcggagccca cttcccatcc tccctccagc cagggggtca
     1501 gggcacctga tggccctggc aggcacccag gtgggcccgc caccgcagga gagggcacct
     1561 gagccaatcg gaagagcctg gggaccccct gggatcaccc agccatcagc cccaggagcc
     1621 actgtggggc ggagagtgag tgtggctgcg gggccttggc tgcacggacc ccatgggagc
     1681 tgtgagtggg tcagactccc tggttcagga gacagacagc ggacggatcc caggctgggc
     1741 agctggaggg aggggcgccg gggcgctggg cagccgggct ctgacacagt cagcagctcc
     1801 gggcgccgca ggccggcggg gtccacacag gctggccggg gctgggcctc cttggagcct
     1861 gctacggccc tcgtgggcac gtggagaagg gcccacgtgt ctccacacgc cagccacagg
     1921 ggagccctgg ccaggcgccc agccagggga gcgtgtgcct gggatgggtc acagaaccag
     1981 cgggcacctg tgaggctggc cagcaccgtg gggctgtggg aatcgctctt atttatattt
     2041 aaacaccttg gattttctac cgggtcttgg cttctgttcc cgcagggcat gagcctgagg
     2101 agcaggacgc ggtgggggtc acaggaggct gctgctcaga gtctgcatgc gggaaagggg
     2161 tcccacctgt ctggggtggg cagcctcgtg gtccagggca gtgcagggca gagcctgggc
     2221 tgtgcgatca cagccactgc ctttctcctg ggagcctcca cttcctccaa aacgggcctt
     2281 gtgccagccc cacccgcggc gagcggacaa ggccacgaag gcagggccct gagtacctgg
     2341 gcggggggga cactcccagg gggcacagag ggggctccca cctgggcacc tgcctcctgc
     2401 ccttctcttc ttcctccacg tgccaggtgg ggccctgggt ttgaggagcc tcggacgcgt
     2461 gccctgcccg caggaagctg gaggcgtgca agtggcctcg gaaatcgcgg ccgcaagaac
     2521 agtagccgcc cagggactaa gggggcttct gggaggacac acggctggcc cagggcgagg
     2581 ggtgtcactg cagggcgccc cccaggccca gggcccgtca ggggacagta cggtgacccg
     2641 gcctgcaggt ggcagtcagt tctgtgtgtc tggggcccgc agcacaggtt gggtgggggc
     2701 tggggcaggg gcagcagaag tgggcaaggc ctggggggct caggcactgg gcgtggagag
     2761 cagacaggaa gctccagtgg gcaccacccc gggaccgcgg ctcccacccg tgctgccccc
     2821 cacccatggc cacggtcacc aggaacagcg ggacctgggg tctccgaggg actcagcagg
     2881 gcgggcacag accagtggag tccgggctag agagggccag ctcccagcct cttgcttcct
     2941 gggctgagga catggggatc caaggccagt gggtctgcag ggcccagccc ggctgcctga
     3001 taagataggc tgagctcctc cctgcacggc tgcaaagacg cccacctgtc ttattggatc
     3061 cccacaggaa tagacccacc aggcggcccc cgtgtctcac tctgtcagca ggtccccagg
     3121 gacctgctgc cgaggggcag tttctggagg ctgggggcac tggctgggct ctaggcctgc
     3181 tctgcccttg ccgtggggaa ggccaccccg ataggggtca agttgctcaa atctgcgttt
     3241 ggagggtgtg tggccgaggg ctccctttct ggagacccag acaccgcctg ggctccgggc
     3301 ggcagaggct gaggtgtcag gggctgagcc cctatgtcag caacacctca ggcctgcact
     3361 ttaggacagg ggagaagtca gtttccgcca aatgccccct cagaccagcc gaggactgtg
     3421 ccaggaaact gacatgctca acgctcaagc cagctgggac agcgaccgag cccagagaga
     3481 cggagcaagt tgcctgaggt cacagagcag ggacttggac accaggcagc cggctccaca
     3541 gaggccctct ctcctccctg cctcctgacc ctcagacgcc tccgccccac gggtgaggct
     3601 gcttctgctt ctttccaaca cgactcgaag gaaagccctg agggccgagc ccgctctgcg
     3661 tggacggaag gcagcgtggg gcggtccagg ccggggctca acctgcctcg agggggagcg
     3721 tgggcgcatg tgagcgggag ggacggagac tagcgtggtt ccagtgtcgt catcgctgct
     3781 aaaaaagggg tttcccggtg acaggccccg acagaggagc aggccatgag gcaggcagga
     3841 gccgcgtatc tgggcccagc gcacccgcca agctctctag cctctcctgg cctcagtatc
     3901 cttctctggg agatggtcca gctgaaaatc cccagcatcc acaagaaacg gtggaagccc
     3961 tgggggccct ggcctggccc gggtgcaggc tgcatggccg ggcggggcgg tgtctccttt
     4021 cacagcttcc ccgtctgtcc gcagcctcca ggagccccac acagggctgg ggctctgtgc
     4081 ccccaactca cacccgtcgg ctcccccagg aggagcaggc tgggcccaga gccgcagggt
     4141 gggctgcagg gaggtctgac ttagctgggg aaagtgccat ccctgccatt gctagtgaca
     4201 agctcgggct gctgtggccc cagcacagat tcaacactca ctgcgctatg tgccagctgt
     4261 tgcacactca cctccacacc caactcacag gaagcaaggc tgggaaggag ggaactggcc
     4321 ccaggccaca cagatgctgc gagttgggat tatgatcggg tgcagtggct cacacctgta
     4381 attccagcac ttggggaggc caaggcgagt ggattgcttg agcccaggag tctgagacca
     4441 gcctgggcaa catggtgaaa ccccatctct acaaaaaaaa aatacaaaaa ttagctgggc
     4501 gtggtggtgc gtgccggcgg tcccagctac tcaggaggct gagatgggag gattgcttga
     4561 gcctgggagg tcgaggctgc agtgaactgt gatcacgccc ctgcactcca gcttgggtga
     4621 caaagcaaga tactgtctca aaaaactcga gttgggattt caccctgcgt ggtccagcac
     4681 tgaacagcgt tcacacctcg gtcagctcag ccccaaaaac ggggaaggcc gggcggggtg
     4741 gggacggcat gcgggcaggc ccgtggcttt tcggaggagt ccacgggctt ccggccactg
     4801 tgcaggggcg ctttgctctc tgctcccaga cagaccctgt cttgctcaca gcttcctgca
     4861 ggctcctctg agagtccagc aaagctgggc gagatgtctc ccagggaagg ggaacactga
     4921 cagccgtgct gctctctgct ccttccactg gaagggagag gctgcatgga cagggggctc
     4981 cgggtggggc agatggggac actcaggact gcggcctgac cctcagagac tgagcccagg
     5041 acgtggtcac ctgaccagca cctcccccgt ggctgtccca gcctcacggt cacggcccag
     5101 cagtccggga aagccactta cacgtagtgc ccggatcctg accccggtga gggacaggca
     5161 gggtcccctg ggattggggg gggggtgtgg ttcttggccc aagaaagccc cagctgaaag
     5221 caccagctac gcaacgaaag ggtctgaaac cagaaaattc tttattgcaa aggtacaaaa
     5281 gcagtcacag cagcaggacg cacggcaata aattaggtgg tggccgcagg gacggggcag
     5341 ggcggcggcg gccagacacg ggcccacatg tgatctgttt tcaataattt atatcatgat
     5401 aaaaagcagc acaaaaaata aataatgaaa tggaactgcc aagtagcaca gaagccaggg
     5461 tgaggcggtg tggcggcgtg gcggcatagg gggccggggt ccccacgccc tggaaacgca
     5521 aagacctgga tctctttggg aagccggagg cacggagaca gaaaacaaac ccacgtgaca
     5581 aagagtccct cgtctttttc ttaaataaaa aaatccatat attaaatcat gacaatgaaa
     5641 tttcaacaat ctgaaaagaa aagcagaaca caccgtgctt ccccggccca gctctgggcg
     5701 gtgacagcgg ctccgtccac cctggggacc agggagtccc ttctccagca aagcactgca
     5761 ggccaagggc aggtagaagc ccacggccca caagacgtgg acaccaagaa ccccaagacg
     5821 ggacagaacc ggccacccgc tgcggcctgt cctgcggggc ccagctgcct ggtacagtcc
     5881 gtggggagat gaagggggac ggcgggcagc ccgggcctcc gctttgctcc caactcccac
     5941 ctgtgcccgt gcccccggct ctgctctgat agatttacag tatcaaactg gaaaagaaag
     6001 attgttacga aaaatctgta gataaactgt gaatataatt ttatatctct a
//
