LOCUS       NM_138391               3031 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens transmembrane protein 183A (TMEM183A), transcript
            variant 1, mRNA.
ACCESSION   NM_138391
VERSION     NM_138391.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3031)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 3031)
  AUTHORS   Hubel,P., Urban,C., Bergant,V., Schneider,W.M., Knauer,B.,
            Stukalov,A., Scaturro,P., Mann,A., Brunotte,L., Hoffmann,H.H.,
            Schoggins,J.W., Schwemmle,M., Mann,M., Rice,C.M. and Pichlmair,A.
  TITLE     A protein-interaction network of interferon-stimulated genes
            extends the innate immune system landscape
  JOURNAL   Nat Immunol 20 (4), 493-502 (2019)
   PUBMED   30833792
REFERENCE   3  (bases 1 to 3031)
  AUTHORS   Ehret,G.B., O'Connor,A.A., Weder,A., Cooper,R.S. and Chakravarti,A.
  TITLE     Follow-up of a major linkage peak on chromosome 1 reveals
            suggestive QTLs associated with essential hypertension: GenNet
            study
  JOURNAL   Eur J Hum Genet 17 (12), 1650-1657 (2009)
   PUBMED   19536175
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   4  (bases 1 to 3031)
  AUTHORS   Davidsson,J., Andersson,A., Paulsson,K., Heidenblad,M.,
            Isaksson,M., Borg,A., Heldrup,J., Behrendtz,M., Panagopoulos,I.,
            Fioretos,T. and Johansson,B.
  TITLE     Tiling resolution array comparative genomic hybridization,
            expression and methylation analyses of dup(1q) in Burkitt lymphomas
            and pediatric high hyperdiploid acute lymphoblastic leukemias
            reveal clustered near-centromeric breakpoints and overexpression of
            genes in 1q22-32.3
  JOURNAL   Hum Mol Genet 16 (18), 2215-2225 (2007)
   PUBMED   17613536
  REMARK    GeneRIF: B4GALT3, DAP3, RGS16, TMEM183A and UCK2--were
            significantly overexpressed in dup(1q)-positive ALLs compared with
            high hyperdiploid ALLs without dup(1q).
REFERENCE   5  (bases 1 to 3031)
  AUTHORS   Yu,H., Jiang,H., Zhou,Q., Yang,J., Cun,Y., Su,B., Xiao,C. and
            Wang,W.
  TITLE     Origination and evolution of a human-specific transmembrane protein
            gene, c1orf37-dup
  JOURNAL   Hum Mol Genet 15 (11), 1870-1875 (2006)
   PUBMED   16644869
  REMARK    GeneRIF: c1orf37-dup encodes a novel transmembrane protein in
            humans which potentially endows new properties to cell surface
            interactions
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DC364887.1, AK291426.1 and AC096632.3.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_138391.5.
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803616.19854.1,
                                           SRR1803617.140748.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000367242.4/ ENSP00000356211.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-18                DC364887.1         8-25
            19-1678             AK291426.1         1-1660
            1679-3031           AC096632.3         132650-134002
FEATURES             Location/Qualifiers
     source          1..3031
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q32.1"
     gene            1..3031
                     /gene="TMEM183A"
                     /gene_synonym="C1orf37"
                     /note="transmembrane protein 183A"
                     /db_xref="GeneID:92703"
                     /db_xref="HGNC:HGNC:20173"
     exon            1..201
                     /gene="TMEM183A"
                     /gene_synonym="C1orf37"
                     /inference="alignment:Splign:2.1.0"
     CDS             93..1223
                     /gene="TMEM183A"
                     /gene_synonym="C1orf37"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /codon_start=1
                     /product="transmembrane protein 183A isoform 1"
                     /protein_id="NP_612400.3"
                     /db_xref="CCDS:CCDS1432.1"
                     /db_xref="GeneID:92703"
                     /db_xref="HGNC:HGNC:20173"
                     /translation="MARGPGPLGRPRPDTVAMPKRGKRLKFRAHDACSGRVTVADYAN
                     SDPAVVRSGRVKKAVANAVQQEVKSLCGLEASQVPAEEALSGAGEPCDIIDSSDEMDA
                     QEESIHERTVSRKKKSKRHKEELDGAGGEEYPMDIWLLLASYIRPEDIVNFSLICKNA
                     WTVTCTAAFWTRLYRRHYTLDASLPLRLRPESMEKLRCLRACVIRSLYHMYEPFAARI
                     SKNPAIPESTPSTLKNSKCLLFWCRKIVGNRQEPMWEFNFKFKKQSPRLKSKCTGGLQ
                     PPVQYEDVHTNPDQDCCLLQVTTLNFIFIPIVMGMIFTLFTINVSTDMRHHRVRLVFQ
                     DSPVHGGRKLRSEQGVQVILDPVHSVRLFDWWHPQYPFSLRA"
     exon            202..291
                     /gene="TMEM183A"
                     /gene_synonym="C1orf37"
                     /inference="alignment:Splign:2.1.0"
     exon            292..459
                     /gene="TMEM183A"
                     /gene_synonym="C1orf37"
                     /inference="alignment:Splign:2.1.0"
     exon            460..619
                     /gene="TMEM183A"
                     /gene_synonym="C1orf37"
                     /inference="alignment:Splign:2.1.0"
     exon            620..800
                     /gene="TMEM183A"
                     /gene_synonym="C1orf37"
                     /inference="alignment:Splign:2.1.0"
     exon            801..881
                     /gene="TMEM183A"
                     /gene_synonym="C1orf37"
                     /inference="alignment:Splign:2.1.0"
     exon            882..1037
                     /gene="TMEM183A"
                     /gene_synonym="C1orf37"
                     /inference="alignment:Splign:2.1.0"
     exon            1038..3031
                     /gene="TMEM183A"
                     /gene_synonym="C1orf37"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3008..3013
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TMEM183A"
                     /gene_synonym="C1orf37"
                     /note="hexamer: AATAAA"
     polyA_site      3031
                     /gene="TMEM183A"
                     /gene_synonym="C1orf37"
                     /note="major polyA site"
ORIGIN      
        1 ctcgcgagag ttagcggcct ccggtgtggg atggccgcgg agccgggcgg agctggcttg
       61 cggctcccgg ggccggctct ccggccggag acatggcccg ggggcccggc ccgctaggca
      121 ggcctcgccc cgatacggtc gccatgccca agagaggaaa gcgactcaag ttccgggccc
      181 acgacgcctg ctccggccga gtgaccgtgg cggattacgc caactcggat ccggcggtcg
      241 tgaggtctgg acgagtcaag aaagccgtag ccaacgctgt tcagcaggaa gtaaaatctc
      301 tttgtggctt ggaagcctct caggttcctg cagaggaagc tctttctggg gctggtgagc
      361 cctgtgacat catcgacagc agtgatgaga tggatgccca ggaggaaagc atccatgaga
      421 gaactgtctc cagaaaaaag aaaagcaaga gacacaaaga agaactggac ggggctggag
      481 gagaagagta tcccatggat atttggctat tgctggcctc ctatatccgt cctgaggaca
      541 ttgtgaattt ttccctgatt tgtaagaatg cctggactgt cacttgcact gctgcctttt
      601 ggaccaggtt gtaccgaagg cactacacgc tggatgcttc cctgcctttg cgtctgcgac
      661 cagagtcaat ggagaagctg cgctgtctcc gggcttgtgt gatccgatct ctgtaccata
      721 tgtatgagcc atttgctgct cgaatctcca agaatccagc cattccagaa agcaccccca
      781 gcacattaaa gaattccaaa tgcttacttt tctggtgcag aaagattgtt gggaacagac
      841 aggaaccaat gtgggaattc aacttcaagt tcaaaaaaca gtcccctagg ttaaagagca
      901 agtgtacagg aggattgcag cctcccgttc agtacgaaga tgttcatacc aatccagacc
      961 aggactgctg cctactgcag gtcaccaccc tcaatttcat ctttattccg attgtcatgg
     1021 gaatgatatt tactctgttt actatcaatg tgagcacgga catgcggcat catcgagtga
     1081 gactggtgtt ccaagattcc cctgtccatg gtggtcggaa actgcgcagt gaacagggtg
     1141 tgcaagtcat cctggaccca gtgcacagcg ttcggctctt tgactggtgg catcctcagt
     1201 acccattctc cctgagagcg tagttactgc ttcccatccc ttgggggcag cctcgagtgt
     1261 agtccattag taatcagatt ccagtttgga cagggtggct ggattgtata tctcgttagt
     1321 aatgtacatg ctcttcaggt tctagggctc ctgttagggg agggagaaat gttgaatcaa
     1381 gagggaaaac aactactatg atttataaac atattttaat gtaaaaattt gcatttaaaa
     1441 ggagtggccc tgttttctgt gttaaaaccc catttggtgc tattgagttt gttctttatt
     1501 cttttatccc agtgaaaatt gttgatcttg ctgtagggaa aaattaaact ctttgaatct
     1561 ccaaacaagg aagtttcagc attcccttat ggatcagagg aaccttagag gcctgaaatt
     1621 gttgcttcca gtttagctgc ccctcaaatt caagtgaata ttttcccttc tccctttacc
     1681 cttctccaga aataaagcag gtgacagggt tttcagaatc ttaccatatt gacttgtgta
     1741 tcttttttaa aaaataattt gtgatattta ttgcatacat tttcttttgg cagttttgga
     1801 ttttaggtat ttttttgcat gaggctgata atggtgatga tgactttata cccttggtac
     1861 tatactagga actttacata gtatctctac ttctcacagt cttgcaaagt aggtgatatt
     1921 attcccattt tatagttgag aaaacggaat tagtgactgt acctataaca ccagtaaatg
     1981 cagagccaag attctgaccc aggtcttttt gttgtaccat aagtttaaaa gatgagtctc
     2041 atttttcttg tggtagatgg tggtaaaaag gagtaggcag agtgtacata gataaaaaaa
     2101 agtaaaaggg taagtaaaaa attgattgtg gtatatgtta ttctaatcag ccaaaaaagt
     2161 ttagaagatt gatgaaatga tcttttaaat atgtatttct gaataaaatg taaaaccaag
     2221 aaagttattt caggaaggat agtgaccctt tccttgaact gttagaaggg catttattag
     2281 gctaaaacgt cattaacaaa atgcattgca tgttgaaacc agcctcttga accataagca
     2341 cttagcgact ttgctctgcc ctgtactgtg ctgcttctgc tgtcatcctg tgtgcctaca
     2401 gaagcctggt cttccgtcca tgcagaaatg cttatgtcct cctgttgttt agatgactcc
     2461 tattgttcag gtgtactctg agaagagaat cacgtttttc tgttttgcta aggagaaaac
     2521 cttgctgctt gtctctcctc ccaccctcca ccatccaaaa ttaaccagtg agctggatat
     2581 tacctggata ttgccaggag gtgggcatta agacagtatt ctttaaaagt gaaaatcttg
     2641 tgaggcaaac tgctaaattc acatttttgt tttttttttt ttaccatctt ccctaggaat
     2701 attcctagaa agcatctgct taattttgct gctaacagct aaccttatcc cacgttgagg
     2761 gtggtattaa aactgttcac acagagtgag cctgggtcag tcaaaaacag aatttgggca
     2821 tttgagtgat aacagacaac ctaaggacaa tgagcacttt gcagatctct acaattaaaa
     2881 gttgcctctt tgaggcagga ggggagaagc acagtccctg ccaggttgcc tgaactaaag
     2941 atgccatgga gcaggagtgt cttggtgcat tgttccccgc ttaggagtac ctttaaaaag
     3001 ggggtgaaat aaatttggct taataattgt a
//
