LOCUS       NM_001349859            2973 bp    mRNA    linear   PRI 03-JUN-2024
DEFINITION  Homo sapiens transmembrane protein 183A (TMEM183A), transcript
            variant 12, mRNA.
ACCESSION   NM_001349859
VERSION     NM_001349859.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2973)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 2973)
  AUTHORS   Hubel,P., Urban,C., Bergant,V., Schneider,W.M., Knauer,B.,
            Stukalov,A., Scaturro,P., Mann,A., Brunotte,L., Hoffmann,H.H.,
            Schoggins,J.W., Schwemmle,M., Mann,M., Rice,C.M. and Pichlmair,A.
  TITLE     A protein-interaction network of interferon-stimulated genes
            extends the innate immune system landscape
  JOURNAL   Nat Immunol 20 (4), 493-502 (2019)
   PUBMED   30833792
REFERENCE   3  (bases 1 to 2973)
  AUTHORS   Ehret,G.B., O'Connor,A.A., Weder,A., Cooper,R.S. and Chakravarti,A.
  TITLE     Follow-up of a major linkage peak on chromosome 1 reveals
            suggestive QTLs associated with essential hypertension: GenNet
            study
  JOURNAL   Eur J Hum Genet 17 (12), 1650-1657 (2009)
   PUBMED   19536175
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   4  (bases 1 to 2973)
  AUTHORS   Davidsson,J., Andersson,A., Paulsson,K., Heidenblad,M.,
            Isaksson,M., Borg,A., Heldrup,J., Behrendtz,M., Panagopoulos,I.,
            Fioretos,T. and Johansson,B.
  TITLE     Tiling resolution array comparative genomic hybridization,
            expression and methylation analyses of dup(1q) in Burkitt lymphomas
            and pediatric high hyperdiploid acute lymphoblastic leukemias
            reveal clustered near-centromeric breakpoints and overexpression of
            genes in 1q22-32.3
  JOURNAL   Hum Mol Genet 16 (18), 2215-2225 (2007)
   PUBMED   17613536
  REMARK    GeneRIF: B4GALT3, DAP3, RGS16, TMEM183A and UCK2--were
            significantly overexpressed in dup(1q)-positive ALLs compared with
            high hyperdiploid ALLs without dup(1q).
REFERENCE   5  (bases 1 to 2973)
  AUTHORS   Yu,H., Jiang,H., Zhou,Q., Yang,J., Cun,Y., Su,B., Xiao,C. and
            Wang,W.
  TITLE     Origination and evolution of a human-specific transmembrane protein
            gene, c1orf37-dup
  JOURNAL   Hum Mol Genet 15 (11), 1870-1875 (2006)
   PUBMED   16644869
  REMARK    GeneRIF: c1orf37-dup encodes a novel transmembrane protein in
            humans which potentially endows new properties to cell surface
            interactions
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC096632.3.
            
            Transcript Variant: This variant (12) encodes isoform 7.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803614.121537.1,
                                           SRR1803616.109723.1 [ECO:0000332]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-233               AC096632.3         116785-117017
            234-401             AC096632.3         117797-117964
            402-561             AC096632.3         124043-124202
            562-742             AC096632.3         125114-125294
            743-823             AC096632.3         127635-127715
            824-979             AC096632.3         129947-130102
            980-2973            AC096632.3         132009-134002
FEATURES             Location/Qualifiers
     source          1..2973
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q32.1"
     gene            1..2973
                     /gene="TMEM183A"
                     /gene_synonym="C1orf37"
                     /note="transmembrane protein 183A"
                     /db_xref="GeneID:92703"
                     /db_xref="HGNC:HGNC:20173"
     exon            1..233
                     /gene="TMEM183A"
                     /gene_synonym="C1orf37"
                     /inference="alignment:Splign:2.1.0"
     exon            234..401
                     /gene="TMEM183A"
                     /gene_synonym="C1orf37"
                     /inference="alignment:Splign:2.1.0"
     CDS             332..1165
                     /gene="TMEM183A"
                     /gene_synonym="C1orf37"
                     /note="isoform 7 is encoded by transcript variant 12"
                     /codon_start=1
                     /product="transmembrane protein 183A isoform 7"
                     /protein_id="NP_001336788.1"
                     /db_xref="GeneID:92703"
                     /db_xref="HGNC:HGNC:20173"
                     /translation="MDAQEESIHERTVSRKKKSKRHKEELDGAGGEEYPMDIWLLLAS
                     YIRPEDIVNFSLICKNAWTVTCTAAFWTRLYRRHYTLDASLPLRLRPESMEKLRCLRA
                     CVIRSLYHMYEPFAARISKNPAIPESTPSTLKNSKCLLFWCRKIVGNRQEPMWEFNFK
                     FKKQSPRLKSKCTGGLQPPVQYEDVHTNPDQDCCLLQVTTLNFIFIPIVMGMIFTLFT
                     INVSTDMRHHRVRLVFQDSPVHGGRKLRSEQGVQVILDPVHSVRLFDWWHPQYPFSLR
                     A"
     exon            402..561
                     /gene="TMEM183A"
                     /gene_synonym="C1orf37"
                     /inference="alignment:Splign:2.1.0"
     exon            562..742
                     /gene="TMEM183A"
                     /gene_synonym="C1orf37"
                     /inference="alignment:Splign:2.1.0"
     exon            743..823
                     /gene="TMEM183A"
                     /gene_synonym="C1orf37"
                     /inference="alignment:Splign:2.1.0"
     exon            824..979
                     /gene="TMEM183A"
                     /gene_synonym="C1orf37"
                     /inference="alignment:Splign:2.1.0"
     exon            980..2973
                     /gene="TMEM183A"
                     /gene_synonym="C1orf37"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2950..2955
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TMEM183A"
                     /gene_synonym="C1orf37"
                     /note="hexamer: AATAAA"
     polyA_site      2973
                     /gene="TMEM183A"
                     /gene_synonym="C1orf37"
                     /note="major polyA site"
ORIGIN      
        1 gctggaccgt gccgaggtga gcgctcgcgt gcccgcggct ggagggcggc tcggtccggg
       61 ggcctgcagc gaggaggagg tgttggcggg gaagacgctg acgagagaag gcctcttcct
      121 tgagggttgg tgctgtgttg cagtgaccgt ggcggattac gccaactcgg atccggcggt
      181 cgtgaggtct ggacgagtca agaaagccgt agccaacgct gttcagcagg aagtaaaatc
      241 tctttgtggc ttggaagcct ctcaggttcc tgcagaggaa gctctttctg gggctggtga
      301 gccctgtgac atcatcgaca gcagtgatga gatggatgcc caggaggaaa gcatccatga
      361 gagaactgtc tccagaaaaa agaaaagcaa gagacacaaa gaagaactgg acggggctgg
      421 aggagaagag tatcccatgg atatttggct attgctggcc tcctatatcc gtcctgagga
      481 cattgtgaat ttttccctga tttgtaagaa tgcctggact gtcacttgca ctgctgcctt
      541 ttggaccagg ttgtaccgaa ggcactacac gctggatgct tccctgcctt tgcgtctgcg
      601 accagagtca atggagaagc tgcgctgtct ccgggcttgt gtgatccgat ctctgtacca
      661 tatgtatgag ccatttgctg ctcgaatctc caagaatcca gccattccag aaagcacccc
      721 cagcacatta aagaattcca aatgcttact tttctggtgc agaaagattg ttgggaacag
      781 acaggaacca atgtgggaat tcaacttcaa gttcaaaaaa cagtccccta ggttaaagag
      841 caagtgtaca ggaggattgc agcctcccgt tcagtacgaa gatgttcata ccaatccaga
      901 ccaggactgc tgcctactgc aggtcaccac cctcaatttc atctttattc cgattgtcat
      961 gggaatgata tttactctgt ttactatcaa tgtgagcacg gacatgcggc atcatcgagt
     1021 gagactggtg ttccaagatt cccctgtcca tggtggtcgg aaactgcgca gtgaacaggg
     1081 tgtgcaagtc atcctggacc cagtgcacag cgttcggctc tttgactggt ggcatcctca
     1141 gtacccattc tccctgagag cgtagttact gcttcccatc ccttgggggc agcctcgagt
     1201 gtagtccatt agtaatcaga ttccagtttg gacagggtgg ctggattgta tatctcgtta
     1261 gtaatgtaca tgctcttcag gttctagggc tcctgttagg ggagggagaa atgttgaatc
     1321 aagagggaaa acaactacta tgatttataa acatatttta atgtaaaaat ttgcatttaa
     1381 aaggagtggc cctgttttct gtgttaaaac cccatttggt gctattgagt ttgttcttta
     1441 ttcttttatc ccagtgaaaa ttgttgatct tgctgtaggg aaaaattaaa ctctttgaat
     1501 ctccaaacaa ggaagtttca gcattccctt atggatcaga ggaaccttag aggcctgaaa
     1561 ttgttgcttc cagtttagct gcccctcaaa ttcaagtgaa tattttccct tctcccttta
     1621 cccttctcca gaaataaagc aggtgacagg gttttcagaa tcttaccata ttgacttgtg
     1681 tatctttttt aaaaaataat ttgtgatatt tattgcatac attttctttt ggcagttttg
     1741 gattttaggt atttttttgc atgaggctga taatggtgat gatgacttta tacccttggt
     1801 actatactag gaactttaca tagtatctct acttctcaca gtcttgcaaa gtaggtgata
     1861 ttattcccat tttatagttg agaaaacgga attagtgact gtacctataa caccagtaaa
     1921 tgcagagcca agattctgac ccaggtcttt ttgttgtacc ataagtttaa aagatgagtc
     1981 tcatttttct tgtggtagat ggtggtaaaa aggagtaggc agagtgtaca tagataaaaa
     2041 aaagtaaaag ggtaagtaaa aaattgattg tggtatatgt tattctaatc agccaaaaaa
     2101 gtttagaaga ttgatgaaat gatcttttaa atatgtattt ctgaataaaa tgtaaaacca
     2161 agaaagttat ttcaggaagg atagtgaccc tttccttgaa ctgttagaag ggcatttatt
     2221 aggctaaaac gtcattaaca aaatgcattg catgttgaaa ccagcctctt gaaccataag
     2281 cacttagcga ctttgctctg ccctgtactg tgctgcttct gctgtcatcc tgtgtgccta
     2341 cagaagcctg gtcttccgtc catgcagaaa tgcttatgtc ctcctgttgt ttagatgact
     2401 cctattgttc aggtgtactc tgagaagaga atcacgtttt tctgttttgc taaggagaaa
     2461 accttgctgc ttgtctctcc tcccaccctc caccatccaa aattaaccag tgagctggat
     2521 attacctgga tattgccagg aggtgggcat taagacagta ttctttaaaa gtgaaaatct
     2581 tgtgaggcaa actgctaaat tcacattttt gttttttttt ttttaccatc ttccctagga
     2641 atattcctag aaagcatctg cttaattttg ctgctaacag ctaaccttat cccacgttga
     2701 gggtggtatt aaaactgttc acacagagtg agcctgggtc agtcaaaaac agaatttggg
     2761 catttgagtg ataacagaca acctaaggac aatgagcact ttgcagatct ctacaattaa
     2821 aagttgcctc tttgaggcag gaggggagaa gcacagtccc tgccaggttg cctgaactaa
     2881 agatgccatg gagcaggagt gtcttggtgc attgttcccc gcttaggagt acctttaaaa
     2941 agggggtgaa ataaatttgg cttaataatt gta
//
