LOCUS       NM_001322956            3028 bp    mRNA    linear   PRI 10-JUN-2024
DEFINITION  Homo sapiens transmembrane protein 183A (TMEM183A), transcript
            variant 3, mRNA.
ACCESSION   NM_001322956 XM_005245612
VERSION     NM_001322956.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3028)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 3028)
  AUTHORS   Hubel,P., Urban,C., Bergant,V., Schneider,W.M., Knauer,B.,
            Stukalov,A., Scaturro,P., Mann,A., Brunotte,L., Hoffmann,H.H.,
            Schoggins,J.W., Schwemmle,M., Mann,M., Rice,C.M. and Pichlmair,A.
  TITLE     A protein-interaction network of interferon-stimulated genes
            extends the innate immune system landscape
  JOURNAL   Nat Immunol 20 (4), 493-502 (2019)
   PUBMED   30833792
REFERENCE   3  (bases 1 to 3028)
  AUTHORS   Ehret,G.B., O'Connor,A.A., Weder,A., Cooper,R.S. and Chakravarti,A.
  TITLE     Follow-up of a major linkage peak on chromosome 1 reveals
            suggestive QTLs associated with essential hypertension: GenNet
            study
  JOURNAL   Eur J Hum Genet 17 (12), 1650-1657 (2009)
   PUBMED   19536175
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   4  (bases 1 to 3028)
  AUTHORS   Davidsson,J., Andersson,A., Paulsson,K., Heidenblad,M.,
            Isaksson,M., Borg,A., Heldrup,J., Behrendtz,M., Panagopoulos,I.,
            Fioretos,T. and Johansson,B.
  TITLE     Tiling resolution array comparative genomic hybridization,
            expression and methylation analyses of dup(1q) in Burkitt lymphomas
            and pediatric high hyperdiploid acute lymphoblastic leukemias
            reveal clustered near-centromeric breakpoints and overexpression of
            genes in 1q22-32.3
  JOURNAL   Hum Mol Genet 16 (18), 2215-2225 (2007)
   PUBMED   17613536
  REMARK    GeneRIF: B4GALT3, DAP3, RGS16, TMEM183A and UCK2--were
            significantly overexpressed in dup(1q)-positive ALLs compared with
            high hyperdiploid ALLs without dup(1q).
REFERENCE   5  (bases 1 to 3028)
  AUTHORS   Yu,H., Jiang,H., Zhou,Q., Yang,J., Cun,Y., Su,B., Xiao,C. and
            Wang,W.
  TITLE     Origination and evolution of a human-specific transmembrane protein
            gene, c1orf37-dup
  JOURNAL   Hum Mol Genet 15 (11), 1870-1875 (2006)
   PUBMED   16644869
  REMARK    GeneRIF: c1orf37-dup encodes a novel transmembrane protein in
            humans which potentially endows new properties to cell surface
            interactions
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC096632.3.
            
            On Aug 13, 2020 this sequence version replaced NM_001322956.1.
            
            Transcript Variant: This variant (3) encodes isoform 3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803613.135713.1,
                                           SRR1803611.28497.1 [ECO:0000332]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-201               AC096632.3         116528-116728
            202-291             AC096632.3         116928-117017
            292-459             AC096632.3         117797-117964
            460-616             AC096632.3         124046-124202
            617-797             AC096632.3         125114-125294
            798-878             AC096632.3         127635-127715
            879-1034            AC096632.3         129947-130102
            1035-3028           AC096632.3         132009-134002
FEATURES             Location/Qualifiers
     source          1..3028
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q32.1"
     gene            1..3028
                     /gene="TMEM183A"
                     /gene_synonym="C1orf37"
                     /note="transmembrane protein 183A"
                     /db_xref="GeneID:92703"
                     /db_xref="HGNC:HGNC:20173"
     exon            1..201
                     /gene="TMEM183A"
                     /gene_synonym="C1orf37"
                     /inference="alignment:Splign:2.1.0"
     CDS             93..1220
                     /gene="TMEM183A"
                     /gene_synonym="C1orf37"
                     /note="isoform 3 is encoded by transcript variant 3"
                     /codon_start=1
                     /product="transmembrane protein 183A isoform 3"
                     /protein_id="NP_001309885.1"
                     /db_xref="GeneID:92703"
                     /db_xref="HGNC:HGNC:20173"
                     /translation="MARGPGPLGRPRPDTVAMPKRGKRLKFRAHDACSGRVTVADYAN
                     SDPAVVRSGRVKKAVANAVQQEVKSLCGLEASQVPAEEALSGAGEPCDIIDSSDEMDA
                     QEESIHERTVSRKKKSKRHKELDGAGGEEYPMDIWLLLASYIRPEDIVNFSLICKNAW
                     TVTCTAAFWTRLYRRHYTLDASLPLRLRPESMEKLRCLRACVIRSLYHMYEPFAARIS
                     KNPAIPESTPSTLKNSKCLLFWCRKIVGNRQEPMWEFNFKFKKQSPRLKSKCTGGLQP
                     PVQYEDVHTNPDQDCCLLQVTTLNFIFIPIVMGMIFTLFTINVSTDMRHHRVRLVFQD
                     SPVHGGRKLRSEQGVQVILDPVHSVRLFDWWHPQYPFSLRA"
     exon            202..291
                     /gene="TMEM183A"
                     /gene_synonym="C1orf37"
                     /inference="alignment:Splign:2.1.0"
     exon            292..459
                     /gene="TMEM183A"
                     /gene_synonym="C1orf37"
                     /inference="alignment:Splign:2.1.0"
     exon            460..616
                     /gene="TMEM183A"
                     /gene_synonym="C1orf37"
                     /inference="alignment:Splign:2.1.0"
     exon            617..797
                     /gene="TMEM183A"
                     /gene_synonym="C1orf37"
                     /inference="alignment:Splign:2.1.0"
     exon            798..878
                     /gene="TMEM183A"
                     /gene_synonym="C1orf37"
                     /inference="alignment:Splign:2.1.0"
     exon            879..1034
                     /gene="TMEM183A"
                     /gene_synonym="C1orf37"
                     /inference="alignment:Splign:2.1.0"
     exon            1035..3028
                     /gene="TMEM183A"
                     /gene_synonym="C1orf37"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3005..3010
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TMEM183A"
                     /gene_synonym="C1orf37"
                     /note="hexamer: AATAAA"
     polyA_site      3028
                     /gene="TMEM183A"
                     /gene_synonym="C1orf37"
                     /note="major polyA site"
ORIGIN      
        1 ctcgcgagag ttagcggcct ccggtgtggg atggccgcgg agccgggcgg agctggcttg
       61 cggctcccgg ggccggctct ccggccggag acatggcccg ggggcccggc ccgctaggca
      121 ggcctcgccc cgatacggtc gccatgccca agagaggaaa gcgactcaag ttccgggccc
      181 acgacgcctg ctccggccga gtgaccgtgg cggattacgc caactcggat ccggcggtcg
      241 tgaggtctgg acgagtcaag aaagccgtag ccaacgctgt tcagcaggaa gtaaaatctc
      301 tttgtggctt ggaagcctct caggttcctg cagaggaagc tctttctggg gctggtgagc
      361 cctgtgacat catcgacagc agtgatgaga tggatgccca ggaggaaagc atccatgaga
      421 gaactgtctc cagaaaaaag aaaagcaaga gacacaaaga actggacggg gctggaggag
      481 aagagtatcc catggatatt tggctattgc tggcctccta tatccgtcct gaggacattg
      541 tgaatttttc cctgatttgt aagaatgcct ggactgtcac ttgcactgct gccttttgga
      601 ccaggttgta ccgaaggcac tacacgctgg atgcttccct gcctttgcgt ctgcgaccag
      661 agtcaatgga gaagctgcgc tgtctccggg cttgtgtgat ccgatctctg taccatatgt
      721 atgagccatt tgctgctcga atctccaaga atccagccat tccagaaagc acccccagca
      781 cattaaagaa ttccaaatgc ttacttttct ggtgcagaaa gattgttggg aacagacagg
      841 aaccaatgtg ggaattcaac ttcaagttca aaaaacagtc ccctaggtta aagagcaagt
      901 gtacaggagg attgcagcct cccgttcagt acgaagatgt tcataccaat ccagaccagg
      961 actgctgcct actgcaggtc accaccctca atttcatctt tattccgatt gtcatgggaa
     1021 tgatatttac tctgtttact atcaatgtga gcacggacat gcggcatcat cgagtgagac
     1081 tggtgttcca agattcccct gtccatggtg gtcggaaact gcgcagtgaa cagggtgtgc
     1141 aagtcatcct ggacccagtg cacagcgttc ggctctttga ctggtggcat cctcagtacc
     1201 cattctccct gagagcgtag ttactgcttc ccatcccttg ggggcagcct cgagtgtagt
     1261 ccattagtaa tcagattcca gtttggacag ggtggctgga ttgtatatct cgttagtaat
     1321 gtacatgctc ttcaggttct agggctcctg ttaggggagg gagaaatgtt gaatcaagag
     1381 ggaaaacaac tactatgatt tataaacata ttttaatgta aaaatttgca tttaaaagga
     1441 gtggccctgt tttctgtgtt aaaaccccat ttggtgctat tgagtttgtt ctttattctt
     1501 ttatcccagt gaaaattgtt gatcttgctg tagggaaaaa ttaaactctt tgaatctcca
     1561 aacaaggaag tttcagcatt cccttatgga tcagaggaac cttagaggcc tgaaattgtt
     1621 gcttccagtt tagctgcccc tcaaattcaa gtgaatattt tcccttctcc ctttaccctt
     1681 ctccagaaat aaagcaggtg acagggtttt cagaatctta ccatattgac ttgtgtatct
     1741 tttttaaaaa ataatttgtg atatttattg catacatttt cttttggcag ttttggattt
     1801 taggtatttt tttgcatgag gctgataatg gtgatgatga ctttataccc ttggtactat
     1861 actaggaact ttacatagta tctctacttc tcacagtctt gcaaagtagg tgatattatt
     1921 cccattttat agttgagaaa acggaattag tgactgtacc tataacacca gtaaatgcag
     1981 agccaagatt ctgacccagg tctttttgtt gtaccataag tttaaaagat gagtctcatt
     2041 tttcttgtgg tagatggtgg taaaaaggag taggcagagt gtacatagat aaaaaaaagt
     2101 aaaagggtaa gtaaaaaatt gattgtggta tatgttattc taatcagcca aaaaagttta
     2161 gaagattgat gaaatgatct tttaaatatg tatttctgaa taaaatgtaa aaccaagaaa
     2221 gttatttcag gaaggatagt gaccctttcc ttgaactgtt agaagggcat ttattaggct
     2281 aaaacgtcat taacaaaatg cattgcatgt tgaaaccagc ctcttgaacc ataagcactt
     2341 agcgactttg ctctgccctg tactgtgctg cttctgctgt catcctgtgt gcctacagaa
     2401 gcctggtctt ccgtccatgc agaaatgctt atgtcctcct gttgtttaga tgactcctat
     2461 tgttcaggtg tactctgaga agagaatcac gtttttctgt tttgctaagg agaaaacctt
     2521 gctgcttgtc tctcctccca ccctccacca tccaaaatta accagtgagc tggatattac
     2581 ctggatattg ccaggaggtg ggcattaaga cagtattctt taaaagtgaa aatcttgtga
     2641 ggcaaactgc taaattcaca tttttgtttt ttttttttta ccatcttccc taggaatatt
     2701 cctagaaagc atctgcttaa ttttgctgct aacagctaac cttatcccac gttgagggtg
     2761 gtattaaaac tgttcacaca gagtgagcct gggtcagtca aaaacagaat ttgggcattt
     2821 gagtgataac agacaaccta aggacaatga gcactttgca gatctctaca attaaaagtt
     2881 gcctctttga ggcaggaggg gagaagcaca gtccctgcca ggttgcctga actaaagatg
     2941 ccatggagca ggagtgtctt ggtgcattgt tccccgctta ggagtacctt taaaaagggg
     3001 gtgaaataaa tttggcttaa taattgta
//
