LOCUS       NM_001322955            3020 bp    mRNA    linear   PRI 10-JUN-2024
DEFINITION  Homo sapiens transmembrane protein 183A (TMEM183A), transcript
            variant 2, mRNA.
ACCESSION   NM_001322955
VERSION     NM_001322955.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3020)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 3020)
  AUTHORS   Hubel,P., Urban,C., Bergant,V., Schneider,W.M., Knauer,B.,
            Stukalov,A., Scaturro,P., Mann,A., Brunotte,L., Hoffmann,H.H.,
            Schoggins,J.W., Schwemmle,M., Mann,M., Rice,C.M. and Pichlmair,A.
  TITLE     A protein-interaction network of interferon-stimulated genes
            extends the innate immune system landscape
  JOURNAL   Nat Immunol 20 (4), 493-502 (2019)
   PUBMED   30833792
REFERENCE   3  (bases 1 to 3020)
  AUTHORS   Ehret,G.B., O'Connor,A.A., Weder,A., Cooper,R.S. and Chakravarti,A.
  TITLE     Follow-up of a major linkage peak on chromosome 1 reveals
            suggestive QTLs associated with essential hypertension: GenNet
            study
  JOURNAL   Eur J Hum Genet 17 (12), 1650-1657 (2009)
   PUBMED   19536175
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   4  (bases 1 to 3020)
  AUTHORS   Davidsson,J., Andersson,A., Paulsson,K., Heidenblad,M.,
            Isaksson,M., Borg,A., Heldrup,J., Behrendtz,M., Panagopoulos,I.,
            Fioretos,T. and Johansson,B.
  TITLE     Tiling resolution array comparative genomic hybridization,
            expression and methylation analyses of dup(1q) in Burkitt lymphomas
            and pediatric high hyperdiploid acute lymphoblastic leukemias
            reveal clustered near-centromeric breakpoints and overexpression of
            genes in 1q22-32.3
  JOURNAL   Hum Mol Genet 16 (18), 2215-2225 (2007)
   PUBMED   17613536
  REMARK    GeneRIF: B4GALT3, DAP3, RGS16, TMEM183A and UCK2--were
            significantly overexpressed in dup(1q)-positive ALLs compared with
            high hyperdiploid ALLs without dup(1q).
REFERENCE   5  (bases 1 to 3020)
  AUTHORS   Yu,H., Jiang,H., Zhou,Q., Yang,J., Cun,Y., Su,B., Xiao,C. and
            Wang,W.
  TITLE     Origination and evolution of a human-specific transmembrane protein
            gene, c1orf37-dup
  JOURNAL   Hum Mol Genet 15 (11), 1870-1875 (2006)
   PUBMED   16644869
  REMARK    GeneRIF: c1orf37-dup encodes a novel transmembrane protein in
            humans which potentially endows new properties to cell surface
            interactions
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC096632.3.
            
            On Aug 14, 2020 this sequence version replaced NM_001322955.1.
            
            Transcript Variant: This variant (2) encodes isoform 2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660807.42630.1 [ECO:0000332]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-201               AC096632.3         116528-116728
            202-291             AC096632.3         116928-117017
            292-459             AC096632.3         117797-117964
            460-616             AC096632.3         124046-124202
            617-797             AC096632.3         125114-125294
            798-878             AC096632.3         127635-127715
            879-1026            AC096632.3         129955-130102
            1027-3020           AC096632.3         132009-134002
FEATURES             Location/Qualifiers
     source          1..3020
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q32.1"
     gene            1..3020
                     /gene="TMEM183A"
                     /gene_synonym="C1orf37"
                     /note="transmembrane protein 183A"
                     /db_xref="GeneID:92703"
                     /db_xref="HGNC:HGNC:20173"
     exon            1..201
                     /gene="TMEM183A"
                     /gene_synonym="C1orf37"
                     /inference="alignment:Splign:2.1.0"
     CDS             93..1121
                     /gene="TMEM183A"
                     /gene_synonym="C1orf37"
                     /note="isoform 2 is encoded by transcript variant 2"
                     /codon_start=1
                     /product="transmembrane protein 183A isoform 2"
                     /protein_id="NP_001309884.1"
                     /db_xref="GeneID:92703"
                     /db_xref="HGNC:HGNC:20173"
                     /translation="MARGPGPLGRPRPDTVAMPKRGKRLKFRAHDACSGRVTVADYAN
                     SDPAVVRSGRVKKAVANAVQQEVKSLCGLEASQVPAEEALSGAGEPCDIIDSSDEMDA
                     QEESIHERTVSRKKKSKRHKELDGAGGEEYPMDIWLLLASYIRPEDIVNFSLICKNAW
                     TVTCTAAFWTRLYRRHYTLDASLPLRLRPESMEKLRCLRACVIRSLYHMYEPFAARIS
                     KNPAIPESTPSTLKNSKCLLFWCRKIVGNRQEPMWEFNFKFKKQVKEQVYRRIAASRS
                     VRRCSYQSRPGLLPTAGHHPQFHLYSDCHGNDIYSVYYQCEHGHAASSSETGVPRFPC
                     PWWSETAQ"
     exon            202..291
                     /gene="TMEM183A"
                     /gene_synonym="C1orf37"
                     /inference="alignment:Splign:2.1.0"
     exon            292..459
                     /gene="TMEM183A"
                     /gene_synonym="C1orf37"
                     /inference="alignment:Splign:2.1.0"
     exon            460..616
                     /gene="TMEM183A"
                     /gene_synonym="C1orf37"
                     /inference="alignment:Splign:2.1.0"
     exon            617..797
                     /gene="TMEM183A"
                     /gene_synonym="C1orf37"
                     /inference="alignment:Splign:2.1.0"
     exon            798..878
                     /gene="TMEM183A"
                     /gene_synonym="C1orf37"
                     /inference="alignment:Splign:2.1.0"
     exon            879..1026
                     /gene="TMEM183A"
                     /gene_synonym="C1orf37"
                     /inference="alignment:Splign:2.1.0"
     exon            1027..3020
                     /gene="TMEM183A"
                     /gene_synonym="C1orf37"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2997..3002
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TMEM183A"
                     /gene_synonym="C1orf37"
                     /note="hexamer: AATAAA"
     polyA_site      3020
                     /gene="TMEM183A"
                     /gene_synonym="C1orf37"
                     /note="major polyA site"
ORIGIN      
        1 ctcgcgagag ttagcggcct ccggtgtggg atggccgcgg agccgggcgg agctggcttg
       61 cggctcccgg ggccggctct ccggccggag acatggcccg ggggcccggc ccgctaggca
      121 ggcctcgccc cgatacggtc gccatgccca agagaggaaa gcgactcaag ttccgggccc
      181 acgacgcctg ctccggccga gtgaccgtgg cggattacgc caactcggat ccggcggtcg
      241 tgaggtctgg acgagtcaag aaagccgtag ccaacgctgt tcagcaggaa gtaaaatctc
      301 tttgtggctt ggaagcctct caggttcctg cagaggaagc tctttctggg gctggtgagc
      361 cctgtgacat catcgacagc agtgatgaga tggatgccca ggaggaaagc atccatgaga
      421 gaactgtctc cagaaaaaag aaaagcaaga gacacaaaga actggacggg gctggaggag
      481 aagagtatcc catggatatt tggctattgc tggcctccta tatccgtcct gaggacattg
      541 tgaatttttc cctgatttgt aagaatgcct ggactgtcac ttgcactgct gccttttgga
      601 ccaggttgta ccgaaggcac tacacgctgg atgcttccct gcctttgcgt ctgcgaccag
      661 agtcaatgga gaagctgcgc tgtctccggg cttgtgtgat ccgatctctg taccatatgt
      721 atgagccatt tgctgctcga atctccaaga atccagccat tccagaaagc acccccagca
      781 cattaaagaa ttccaaatgc ttacttttct ggtgcagaaa gattgttggg aacagacagg
      841 aaccaatgtg ggaattcaac ttcaagttca aaaaacaggt taaagagcaa gtgtacagga
      901 ggattgcagc ctcccgttca gtacgaagat gttcatacca atccagacca ggactgctgc
      961 ctactgcagg tcaccaccct caatttcatc tttattccga ttgtcatggg aatgatattt
     1021 actctgttta ctatcaatgt gagcacggac atgcggcatc atcgagtgag actggtgttc
     1081 caagattccc ctgtccatgg tggtcggaaa ctgcgcagtg aacagggtgt gcaagtcatc
     1141 ctggacccag tgcacagcgt tcggctcttt gactggtggc atcctcagta cccattctcc
     1201 ctgagagcgt agttactgct tcccatccct tgggggcagc ctcgagtgta gtccattagt
     1261 aatcagattc cagtttggac agggtggctg gattgtatat ctcgttagta atgtacatgc
     1321 tcttcaggtt ctagggctcc tgttagggga gggagaaatg ttgaatcaag agggaaaaca
     1381 actactatga tttataaaca tattttaatg taaaaatttg catttaaaag gagtggccct
     1441 gttttctgtg ttaaaacccc atttggtgct attgagtttg ttctttattc ttttatccca
     1501 gtgaaaattg ttgatcttgc tgtagggaaa aattaaactc tttgaatctc caaacaagga
     1561 agtttcagca ttcccttatg gatcagagga accttagagg cctgaaattg ttgcttccag
     1621 tttagctgcc cctcaaattc aagtgaatat tttcccttct ccctttaccc ttctccagaa
     1681 ataaagcagg tgacagggtt ttcagaatct taccatattg acttgtgtat cttttttaaa
     1741 aaataatttg tgatatttat tgcatacatt ttcttttggc agttttggat tttaggtatt
     1801 tttttgcatg aggctgataa tggtgatgat gactttatac ccttggtact atactaggaa
     1861 ctttacatag tatctctact tctcacagtc ttgcaaagta ggtgatatta ttcccatttt
     1921 atagttgaga aaacggaatt agtgactgta cctataacac cagtaaatgc agagccaaga
     1981 ttctgaccca ggtctttttg ttgtaccata agtttaaaag atgagtctca tttttcttgt
     2041 ggtagatggt ggtaaaaagg agtaggcaga gtgtacatag ataaaaaaaa gtaaaagggt
     2101 aagtaaaaaa ttgattgtgg tatatgttat tctaatcagc caaaaaagtt tagaagattg
     2161 atgaaatgat cttttaaata tgtatttctg aataaaatgt aaaaccaaga aagttatttc
     2221 aggaaggata gtgacccttt ccttgaactg ttagaagggc atttattagg ctaaaacgtc
     2281 attaacaaaa tgcattgcat gttgaaacca gcctcttgaa ccataagcac ttagcgactt
     2341 tgctctgccc tgtactgtgc tgcttctgct gtcatcctgt gtgcctacag aagcctggtc
     2401 ttccgtccat gcagaaatgc ttatgtcctc ctgttgttta gatgactcct attgttcagg
     2461 tgtactctga gaagagaatc acgtttttct gttttgctaa ggagaaaacc ttgctgcttg
     2521 tctctcctcc caccctccac catccaaaat taaccagtga gctggatatt acctggatat
     2581 tgccaggagg tgggcattaa gacagtattc tttaaaagtg aaaatcttgt gaggcaaact
     2641 gctaaattca catttttgtt tttttttttt taccatcttc cctaggaata ttcctagaaa
     2701 gcatctgctt aattttgctg ctaacagcta accttatccc acgttgaggg tggtattaaa
     2761 actgttcaca cagagtgagc ctgggtcagt caaaaacaga atttgggcat ttgagtgata
     2821 acagacaacc taaggacaat gagcactttg cagatctcta caattaaaag ttgcctcttt
     2881 gaggcaggag gggagaagca cagtccctgc caggttgcct gaactaaaga tgccatggag
     2941 caggagtgtc ttggtgcatt gttccccgct taggagtacc tttaaaaagg gggtgaaata
     3001 aatttggctt aataattgta
//
