LOCUS       NM_144632               3588 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens transmembrane protein 182 (TMEM182), transcript
            variant 1, mRNA.
ACCESSION   NM_144632
VERSION     NM_144632.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3588)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 3588)
  AUTHORS   Ma,M., Lee,J.H. and Kim,M.
  TITLE     Identification of a TMEM182 rs141764639 polymorphism associated
            with central obesity by regulating tumor necrosis factor-alpha in a
            Korean population
  JOURNAL   J Diabetes Complications 34 (12), 107732 (2020)
   PUBMED   32938560
  REMARK    GeneRIF: Identification of a TMEM182 rs141764639 polymorphism
            associated with central obesity by regulating tumor necrosis
            factor-alpha in a Korean population.
REFERENCE   3  (bases 1 to 3588)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 3588)
  AUTHORS   Hsing,E.W., Shiah,S.G., Peng,H.Y., Chen,Y.W., Chuu,C.P.,
            Hsiao,J.R., Lyu,P.C. and Chang,J.Y.
  TITLE     TNF-alpha-induced miR-450a mediates TMEM182 expression to promote
            oral squamous cell carcinoma motility
  JOURNAL   PLoS One 14 (3), e0213463 (2019)
   PUBMED   30893332
  REMARK    GeneRIF: Tumor necrosis factor alpha (TNF-alpha)-mediated
            expression of TMEM182 was regulated by miR-450a induction in oral
            squamous cell carcinoma. MiR-450a-reduced cellular adhesion was
            abolished by TMEM182 restoration.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3588)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   6  (bases 1 to 3588)
  AUTHORS   Kim,Y.K., Kim,Y., Hwang,M.Y., Shimokawa,K., Won,S., Kato,N.,
            Tabara,Y., Yokota,M., Han,B.G., Lee,J.H. and Kim,B.J.
  TITLE     Identification of a genetic variant at 2q12.1 associated with blood
            pressure in East Asians by genome-wide scan including
            gene-environment interactions
  JOURNAL   BMC Med Genet 15, 65 (2014)
   PUBMED   24903457
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 3588)
  AUTHORS   Lauc,G., Huffman,J.E., Pucic,M., Zgaga,L., Adamczyk,B., Muzinic,A.,
            Novokmet,M., Polasek,O., Gornik,O., Kristic,J., Keser,T.,
            Vitart,V., Scheijen,B., Uh,H.W., Molokhia,M., Patrick,A.L.,
            McKeigue,P., Kolcic,I., Lukic,I.K., Swann,O., van Leeuwen,F.N.,
            Ruhaak,L.R., Houwing-Duistermaat,J.J., Slagboom,P.E., Beekman,M.,
            de Craen,A.J., Deelder,A.M., Zeng,Q., Wang,W., Hastie,N.D.,
            Gyllensten,U., Wilson,J.F., Wuhrer,M., Wright,A.F., Rudd,P.M.,
            Hayward,C., Aulchenko,Y., Campbell,H. and Rudan,I.
  TITLE     Loci associated with N-glycosylation of human immunoglobulin G show
            pleiotropy with autoimmune diseases and haematological cancers
  JOURNAL   PLoS Genet 9 (1), e1003225 (2013)
   PUBMED   23382691
REFERENCE   8  (bases 1 to 3588)
  AUTHORS   Wu,Y. and Smas,C.M.
  TITLE     Expression and regulation of transcript for the novel transmembrane
            protein Tmem182 in the adipocyte and muscle lineage
  JOURNAL   BMC Res Notes 1, 85 (2008)
   PUBMED   18803820
  REMARK    Publication Status: Online-Only
REFERENCE   9  (bases 1 to 3588)
  AUTHORS   Clark,H.F., Gurney,A.L., Abaya,E., Baker,K., Baldwin,D., Brush,J.,
            Chen,J., Chow,B., Chui,C., Crowley,C., Currell,B., Deuel,B.,
            Dowd,P., Eaton,D., Foster,J., Grimaldi,C., Gu,Q., Hass,P.E.,
            Heldens,S., Huang,A., Kim,H.S., Klimowski,L., Jin,Y., Johnson,S.,
            Lee,J., Lewis,L., Liao,D., Mark,M., Robbie,E., Sanchez,C.,
            Schoenfeld,J., Seshagiri,S., Simmons,L., Singh,J., Smith,V.,
            Stinson,J., Vagts,A., Vandlen,R., Watanabe,C., Wieand,D., Woods,K.,
            Xie,M.H., Yansura,D., Yi,S., Yu,G., Yuan,J., Zhang,M., Zhang,Z.,
            Goddard,A., Wood,W.I., Godowski,P. and Gray,A.
  TITLE     The secreted protein discovery initiative (SPDI), a large-scale
            effort to identify novel human secreted and transmembrane proteins:
            a bioinformatics assessment
  JOURNAL   Genome Res 13 (10), 2265-2270 (2003)
   PUBMED   12975309
  REMARK    Erratum:[Genome Res. 2003 Dec;13(12):2759]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC007251.4.
            
            On Nov 23, 2018 this sequence version replaced NM_144632.4.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript was available
            for the full length of the gene. The extent of this transcript is
            supported by transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: CR936735.1, AK129862.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2142680, SAMEA2142853
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000412401.3/ ENSP00000394178.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-319               AC007251.4         31956-32274
            320-419             AC007251.4         32512-32611
            420-518             AC007251.4         34254-34352
            519-656             AC007251.4         67788-67925
            657-3588            AC007251.4         84673-87604
FEATURES             Location/Qualifiers
     source          1..3588
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q12.1"
     gene            1..3588
                     /gene="TMEM182"
                     /note="transmembrane protein 182"
                     /db_xref="GeneID:130827"
                     /db_xref="HGNC:HGNC:26391"
     exon            1..319
                     /gene="TMEM182"
                     /inference="alignment:Splign:2.1.0"
     CDS             188..877
                     /gene="TMEM182"
                     /note="isoform a precursor is encoded by transcript
                     variant 1"
                     /codon_start=1
                     /product="transmembrane protein 182 isoform a precursor"
                     /protein_id="NP_653233.5"
                     /db_xref="CCDS:CCDS2064.1"
                     /db_xref="GeneID:130827"
                     /db_xref="HGNC:HGNC:26391"
                     /translation="MRLNIAIFFGALFGALGVLLFLVAFGSDYWLLATEVGRCSGEKN
                     IENVTFHHEGFFWRCWFNGIVEENDSNIWKFWYTNQPPSKNCTHAYLSPYPFMRGEHN
                     STSYDSAVIYRGFWAVLMLLGVVAVVIASFLIICAAPFASHFLYKAGGGSYIAAGILF
                     SLVVMLYVIWVQAVADMESYRNMKMKDCLDFTPSVLYGWSFFLAPAGIFFSLLAGLLF
                     LVVGWHIQIHH"
     exon            320..419
                     /gene="TMEM182"
                     /inference="alignment:Splign:2.1.0"
     exon            420..518
                     /gene="TMEM182"
                     /inference="alignment:Splign:2.1.0"
     exon            519..656
                     /gene="TMEM182"
                     /inference="alignment:Splign:2.1.0"
     exon            657..3588
                     /gene="TMEM182"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3285..3290
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TMEM182"
                     /note="hexamer: AATAAA"
     polyA_site      3329
                     /gene="TMEM182"
                     /note="major polyA site"
     regulatory      3554..3559
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TMEM182"
                     /note="hexamer: ATTAAA"
     regulatory      3566..3571
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TMEM182"
                     /note="hexamer: TATAAA"
     polyA_site      3575
                     /gene="TMEM182"
                     /note="major polyA site"
     polyA_site      3588
                     /gene="TMEM182"
ORIGIN      
        1 gaatctgccg gtggggcgtg agcgagaagc caccaaaaca tgagctagga cagccttctc
       61 aagaagattc tgccaactca aaaatattat tctttttttt ttttttttgc tgttgtttct
      121 gagaaactag gtgtcttacc attttaaaat ttcatatttt atttaaaagg aaaccagtga
      181 attgaaaatg agactaaata tcgctatctt ctttggagct ctctttggtg ctttgggggt
      241 gttactcttt ttggtggctt ttggatcgga ttattggctt cttgcaactg aagtggggag
      301 atgttcaggt gaaaagaata tagagaacgt cacttttcac catgaagggt tcttctggag
      361 gtgttggttt aatgggattg tggaagagaa tgactccaat atttggaagt tctggtacac
      421 caatcagcca ccgtccaaga actgcacaca tgcttacctg tctccgtacc ccttcatgag
      481 aggcgagcac aactcgacct cctatgactc tgcagttatt taccgtggtt tctgggcagt
      541 cctgatgctc ctgggggtag ttgctgtagt catcgcaagc tttttgatca tctgtgcagc
      601 ccccttcgcc agccattttc tctacaaagc tgggggaggc tcatatattg ctgcaggcat
      661 cctattttca ttggtggtga tgctgtatgt catctgggtc caggcagtgg ctgacatgga
      721 aagctaccga aacatgaaaa tgaaggactg cctggatttc accccttctg ttctgtatgg
      781 ctggtcattt ttcctggccc cagctgggat atttttttct ttgctagctg gattactatt
      841 tctggttgtt ggatggcata ttcagataca tcactaaatc aactgttgcc acaagtattt
      901 tcttgagaga ttttaaaaca aggaatactt tttttccatt ttgtttcatt gatcccagca
      961 taaagttagt agatataact ttttagttgc tattcaaatt aatcatttta ctaaaatttt
     1021 cttcagtaag aaggtcctag aatctctcca gacaccagca agcctctatc ttgtctaagt
     1081 gctgtcaagg acctagttct ttagggaata ggtaaacagg tctccctttc attgaacatg
     1141 ttagagttca tgcaggtcgc aaaggcctga taatagctta ataccatgac atggggaaaa
     1201 tctcgataga tttggcttaa agtctccttg gcattcactt ctgctaatta aaaaaaatcc
     1261 ttgaagaata attaagaatg ggcaaggttg tcagagaatt tattttgttt cttgcccaca
     1321 cagataatat ccacatacac attcactggc tcttgtgagc aaatgaattt aaaaatagac
     1381 agcagttgtt ctaattagtg ggagccatgt actcaccagt taaaatgggc cacaacaaac
     1441 aagactgaga gcatgtactt atcttgcttt ttcaccaaca gtggtttggt tacctagttt
     1501 tattcactta attgtgcatg cttacataaa ctttaaacta catttaaaac tagcaaatct
     1561 gcataccaaa ttatgtataa cgtagattga atttttatga acttaaagtg agttaattgt
     1621 ataatgtaat attgtttaaa atatgtaaaa accaagcatt tccgcttggt ccataattct
     1681 atttgatatt ttaaaattct catttaaaaa ttatattgct atcattcagc atgtgaaaat
     1741 ttattgataa aatgtgattt taatattttt tagatataaa ctttcaacgt acttccatat
     1801 gaggattata atagccctgc tttattaaag accataaaat attaactttc cccaagatgt
     1861 tatgggttcc agttcttctg atcatttgat tcctttaatt actgtccctc aatttcttca
     1921 tctttacaat agatatatta acatttacag atcgactatt tcctttaacc tcctagaaga
     1981 aagtttttgt ggggaaagat gattctgtat tattcagtag catagacatt ttgcatatca
     2041 aagatgttca tttggcacta atgttgattg aaatcaaatc catctgagat gcctagctcg
     2101 tatttgcatt ctggaagcct ccatcgcagg ggagctcggc agggtatgtg agctttgttg
     2161 gaggtgcggt gtttcattct gcagctgttg tgaggacaga gaggcatggc ccacaggcaa
     2221 aaaaagtcac cacccagaag atgctctggg atagaggaac tgctcctttt catcagctct
     2281 tccaatgccg tgggagaggt gatcccagtc ttctctgtac atcttgtgct tttccattaa
     2341 gacttgttcc agtgggaagg agctttggaa aaattgcaaa ggtctgaatc ttcagggcat
     2401 tttcatgaca ggacttgcca ataataataa taataataat aataataata ataataaagc
     2461 tccagaggcc taactggttt ctcaagtcat ttcagtgata tcattgaaac gtttttgtgg
     2521 tacttccctt tgtctttcac tgtttcattt ttatattgct tcatttactt ctttgctttt
     2581 ggctttgtta ttagaaaaaa taattatgag gtctgttgtg catgttgact gtgatattaa
     2641 gttatggcat gccattaagt tttccagacg atgttggatg tatctgatta gttcatgtca
     2701 tctgtaaata caattctttt ttgtagtact ttggaatgga gcctttttct ggtgtactgt
     2761 atgccattta agtttcacat acaagctgct ttcggcaaag gcttgaatat ttataaattt
     2821 cagatggtta tcctcacttt atagtacact taagtggcta ccatatattt tttatatgac
     2881 aattggctga atagctgatg tgtatgacac ttttacacag atttgcactt tggaactatt
     2941 ttatagttgt aatgcatcaa tcaaatacat ttcaagcaca tttcttgatc aatttaccag
     3001 caaccctctg aaggaatgaa ggagagttgt gattgctatg tcaatgagtg aaatatactt
     3061 aaaaatggca gagttatata gtacattatt gtagcaacct tatatctgat ttgagatact
     3121 gtgttgccaa atgtccatgt tatgtttatt tctctattgg ttgtatttat taatttttag
     3181 aagcctttaa actgtgttag aatctttttg aaaaatgttg attttgcatc ataaagtttc
     3241 aatttatcaa ggatatcttt tcagttacac ttttagaaag agtgaataaa aagggcagtg
     3301 agttatgctc ttggacttgg tgaaagctat catctctcca tattgtattt gttcagctgg
     3361 tttaattcac tcaggtggat gattgcacat acattggaat tggctggaga gactacacag
     3421 agaagtttaa tgatcgtgta caatttgagg gttgatggta gggctttcta aaaaaagtaa
     3481 tatcaagtgt gttgttagta ttcatttagt catttttatt actaatctat aaatatattt
     3541 attaaatttg aagattaaat ggaattataa aggaatatat tggaggaa
//
