LOCUS       NM_001376854            5022 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens transmembrane protein 181 (TMEM181), transcript
            variant 5, mRNA.
ACCESSION   NM_001376854
VERSION     NM_001376854.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5022)
  AUTHORS   Zhang,J., Yang,X., Zhu,S., Dai,Z.M. and Zhu,X.J.
  TITLE     TMEM181: a key mediator of cytolethal distending toxin required for
            Wnt signaling activity
  JOURNAL   J Genet Genomics 50 (1), 54-57 (2023)
   PUBMED   35577237
REFERENCE   2  (bases 1 to 5022)
  AUTHORS   Hoel,C.M., Zhang,L. and Brohawn,S.G.
  TITLE     Structure of the GOLD-domain seven-transmembrane helix protein
            family member TMEM87A
  JOURNAL   Elife 11, e81704 (2022)
   PUBMED   36373655
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5022)
  AUTHORS   Carette,J.E., Guimaraes,C.P., Varadarajan,M., Park,A.S.,
            Wuethrich,I., Godarova,A., Kotecki,M., Cochran,B.H., Spooner,E.,
            Ploegh,H.L. and Brummelkamp,T.R.
  TITLE     Haploid genetic screens in human cells identify host factors used
            by pathogens
  JOURNAL   Science 326 (5957), 1231-1235 (2009)
   PUBMED   19965467
REFERENCE   4  (bases 1 to 5022)
  AUTHORS   Wollscheid,B., Bausch-Fluck,D., Henderson,C., O'Brien,R., Bibel,M.,
            Schiess,R., Aebersold,R. and Watts,J.D.
  TITLE     Mass-spectrometric identification and relative quantification of
            N-linked cell surface glycoproteins
  JOURNAL   Nat Biotechnol 27 (4), 378-386 (2009)
   PUBMED   19349973
  REMARK    Erratum:[Nat Biotechnol. 2009 Sep;27(9):864]
REFERENCE   5  (bases 1 to 5022)
  AUTHORS   Girard,A., Sachidanandam,R., Hannon,G.J. and Carmell,M.A.
  TITLE     A germline-specific class of small RNAs binds mammalian Piwi
            proteins
  JOURNAL   Nature 442 (7099), 199-202 (2006)
   PUBMED   16751776
REFERENCE   6  (bases 1 to 5022)
  AUTHORS   Wistrand,M., Kall,L. and Sonnhammer,E.L.
  TITLE     A general model of G protein-coupled receptor sequences and its
            application to detect remote homologs
  JOURNAL   Protein Sci 15 (3), 509-521 (2006)
   PUBMED   16452613
REFERENCE   7  (bases 1 to 5022)
  AUTHORS   Cheng,J., Kapranov,P., Drenkow,J., Dike,S., Brubaker,S., Patel,S.,
            Long,J., Stern,D., Tammana,H., Helt,G., Sementchenko,V.,
            Piccolboni,A., Bekiranov,S., Bailey,D.K., Ganesh,M., Ghosh,S.,
            Bell,I., Gerhard,D.S. and Gingeras,T.R.
  TITLE     Transcriptional maps of 10 human chromosomes at 5-nucleotide
            resolution
  JOURNAL   Science 308 (5725), 1149-1154 (2005)
   PUBMED   15790807
REFERENCE   8  (bases 1 to 5022)
  AUTHORS   Mungall,A.J., Palmer,S.A., Sims,S.K., Edwards,C.A., Ashurst,J.L.,
            Wilming,L., Jones,M.C., Horton,R., Hunt,S.E., Scott,C.E.,
            Gilbert,J.G., Clamp,M.E., Bethel,G., Milne,S., Ainscough,R.,
            Almeida,J.P., Ambrose,K.D., Andrews,T.D., Ashwell,R.I.,
            Babbage,A.K., Bagguley,C.L., Bailey,J., Banerjee,R., Barker,D.J.,
            Barlow,K.F., Bates,K., Beare,D.M., Beasley,H., Beasley,O.,
            Bird,C.P., Blakey,S., Bray-Allen,S., Brook,J., Brown,A.J.,
            Brown,J.Y., Burford,D.C., Burrill,W., Burton,J., Carder,C.,
            Carter,N.P., Chapman,J.C., Clark,S.Y., Clark,G., Clee,C.M.,
            Clegg,S., Cobley,V., Collier,R.E., Collins,J.E., Colman,L.K.,
            Corby,N.R., Coville,G.J., Culley,K.M., Dhami,P., Davies,J.,
            Dunn,M., Earthrowl,M.E., Ellington,A.E., Evans,K.A., Faulkner,L.,
            Francis,M.D., Frankish,A., Frankland,J., French,L., Garner,P.,
            Garnett,J., Ghori,M.J., Gilby,L.M., Gillson,C.J., Glithero,R.J.,
            Grafham,D.V., Grant,M., Gribble,S., Griffiths,C., Griffiths,M.,
            Hall,R., Halls,K.S., Hammond,S., Harley,J.L., Hart,E.A.,
            Heath,P.D., Heathcott,R., Holmes,S.J., Howden,P.J., Howe,K.L.,
            Howell,G.R., Huckle,E., Humphray,S.J., Humphries,M.D., Hunt,A.R.,
            Johnson,C.M., Joy,A.A., Kay,M., Keenan,S.J., Kimberley,A.M.,
            King,A., Laird,G.K., Langford,C., Lawlor,S., Leongamornlert,D.A.,
            Leversha,M., Lloyd,C.R., Lloyd,D.M., Loveland,J.E., Lovell,J.,
            Martin,S., Mashreghi-Mohammadi,M., Maslen,G.L., Matthews,L.,
            McCann,O.T., McLaren,S.J., McLay,K., McMurray,A., Moore,M.J.,
            Mullikin,J.C., Niblett,D., Nickerson,T., Novik,K.L., Oliver,K.,
            Overton-Larty,E.K., Parker,A., Patel,R., Pearce,A.V., Peck,A.I.,
            Phillimore,B., Phillips,S., Plumb,R.W., Porter,K.M., Ramsey,Y.,
            Ranby,S.A., Rice,C.M., Ross,M.T., Searle,S.M., Sehra,H.K.,
            Sheridan,E., Skuce,C.D., Smith,S., Smith,M., Spraggon,L.,
            Squares,S.L., Steward,C.A., Sycamore,N., Tamlyn-Hall,G., Tester,J.,
            Theaker,A.J., Thomas,D.W., Thorpe,A., Tracey,A., Tromans,A.,
            Tubby,B., Wall,M., Wallis,J.M., West,A.P., White,S.S.,
            Whitehead,S.L., Whittaker,H., Wild,A., Willey,D.J., Wilmer,T.E.,
            Wood,J.M., Wray,P.W., Wyatt,J.C., Young,L., Younger,R.M.,
            Bentley,D.R., Coulson,A., Durbin,R., Hubbard,T., Sulston,J.E.,
            Dunham,I., Rogers,J. and Beck,S.
  TITLE     The DNA sequence and analysis of human chromosome 6
  JOURNAL   Nature 425 (6960), 805-811 (2003)
   PUBMED   14574404
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL591025.8.
            
            Summary: The TMEM181 gene encodes a putative G protein-coupled
            receptor expressed on the cell surface (Carette et al., 2009
            [PubMed 19965467]; Wollscheid et al., 2009 [PubMed
            19349973]).[supplied by OMIM, Jan 2010].
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA1968968,
                              SAMEA2142348 [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-142               AL591025.8         35811-35952
            143-246             AL591025.8         49140-49243
            247-302             AL591025.8         56660-56715
            303-393             AL591025.8         59674-59764
            394-515             AL591025.8         61024-61145
            516-626             AL591025.8         65392-65502
            627-726             AL591025.8         82964-83063
            727-857             AL591025.8         84053-84183
            858-949             AL591025.8         84379-84470
            950-1007            AL591025.8         99270-99327
            1008-1110           AL591025.8         100824-100926
            1111-1162           AL591025.8         101423-101474
            1163-1245           AL591025.8         104128-104210
            1246-1335           AL591025.8         105450-105539
            1336-1402           AL591025.8         107043-107109
            1403-5022           AL591025.8         107530-111149
FEATURES             Location/Qualifiers
     source          1..5022
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6q25.3"
     gene            1..5022
                     /gene="TMEM181"
                     /gene_synonym="GPR178; KIAA1423"
                     /note="transmembrane protein 181"
                     /db_xref="GeneID:57583"
                     /db_xref="HGNC:HGNC:20958"
                     /db_xref="MIM:613209"
     exon            1..142
                     /gene="TMEM181"
                     /gene_synonym="GPR178; KIAA1423"
                     /inference="alignment:Splign:2.1.0"
     CDS             135..1481
                     /gene="TMEM181"
                     /gene_synonym="GPR178; KIAA1423"
                     /note="isoform 5 is encoded by transcript variant 5; G
                     protein-coupled receptor 178"
                     /codon_start=1
                     /product="transmembrane protein 181 isoform 5"
                     /protein_id="NP_001363783.1"
                     /db_xref="GeneID:57583"
                     /db_xref="HGNC:HGNC:20958"
                     /db_xref="MIM:613209"
                     /translation="MEPLAPMRLYTLSKRHFVLVFVVFFICFGLTIFVGIRGPKVIQT
                     SAANFSLNNSKKLKPIQILSNPLSTYNQQLWLTCVVELDQSKETSIKTSFPMTVKVDG
                     VAQDGTTMYIHNKVHNRTRTLTCAGKCAEIIVAHLGYLNYTQYTVIVGFEHLKLPIKG
                     MNFTCLFAHSLRKFSMRDWGIEQKWMSVLLPLLLLYNDPFFPLSFLVNSWLPGMLDDL
                     FQSMFLCALLLFWLCVYHGIRVQGERKCLTFYLPKFFIVGLLWLASVTLGIWQTVNEL
                     HDPMYQYRVDTGNFQGMKVFFMVVAAVYILYLLFLIVRACSELRHMPYVDLRLKFLTA
                     LTFVVLVISIAILYLRFGAQVLQDNFVAELSTHYQNSAEFLSFYGLLNFYLYTLAFVY
                     SPSKNALYESQLKDNPAFSMLNDSDDDVIYGSDYEEMPLQNGQAIRAKYKEESDSD"
     exon            143..246
                     /gene="TMEM181"
                     /gene_synonym="GPR178; KIAA1423"
                     /inference="alignment:Splign:2.1.0"
     exon            247..302
                     /gene="TMEM181"
                     /gene_synonym="GPR178; KIAA1423"
                     /inference="alignment:Splign:2.1.0"
     exon            303..393
                     /gene="TMEM181"
                     /gene_synonym="GPR178; KIAA1423"
                     /inference="alignment:Splign:2.1.0"
     exon            394..515
                     /gene="TMEM181"
                     /gene_synonym="GPR178; KIAA1423"
                     /inference="alignment:Splign:2.1.0"
     exon            516..626
                     /gene="TMEM181"
                     /gene_synonym="GPR178; KIAA1423"
                     /inference="alignment:Splign:2.1.0"
     exon            627..726
                     /gene="TMEM181"
                     /gene_synonym="GPR178; KIAA1423"
                     /inference="alignment:Splign:2.1.0"
     exon            727..857
                     /gene="TMEM181"
                     /gene_synonym="GPR178; KIAA1423"
                     /inference="alignment:Splign:2.1.0"
     exon            858..949
                     /gene="TMEM181"
                     /gene_synonym="GPR178; KIAA1423"
                     /inference="alignment:Splign:2.1.0"
     exon            950..1007
                     /gene="TMEM181"
                     /gene_synonym="GPR178; KIAA1423"
                     /inference="alignment:Splign:2.1.0"
     exon            1008..1110
                     /gene="TMEM181"
                     /gene_synonym="GPR178; KIAA1423"
                     /inference="alignment:Splign:2.1.0"
     exon            1111..1162
                     /gene="TMEM181"
                     /gene_synonym="GPR178; KIAA1423"
                     /inference="alignment:Splign:2.1.0"
     exon            1163..1245
                     /gene="TMEM181"
                     /gene_synonym="GPR178; KIAA1423"
                     /inference="alignment:Splign:2.1.0"
     exon            1246..1335
                     /gene="TMEM181"
                     /gene_synonym="GPR178; KIAA1423"
                     /inference="alignment:Splign:2.1.0"
     exon            1336..1402
                     /gene="TMEM181"
                     /gene_synonym="GPR178; KIAA1423"
                     /inference="alignment:Splign:2.1.0"
     exon            1403..5022
                     /gene="TMEM181"
                     /gene_synonym="GPR178; KIAA1423"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5004..5009
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TMEM181"
                     /gene_synonym="GPR178; KIAA1423"
                     /note="hexamer: AATAAA"
     polyA_site      5022
                     /gene="TMEM181"
                     /gene_synonym="GPR178; KIAA1423"
                     /note="major polyA site"
ORIGIN      
        1 gagttttccg cggccggccg ctgctcagcc gctgtcgctc cggctccggc tgcggctgcc
       61 gctgccgagg ctgctgcgcg gcgcctggcg ggctcgggac gcgcgggccg gggccgaggg
      121 ctctgggcgc cgagatggag ccgctggcgc ccatgcggct ctacacgctc tccaagcgcc
      181 actttgtcct cgtgtttgtc gtcttcttca tctgctttgg cctgaccatc ttcgttggga
      241 tcagaggacc taaagtgatc cagacttctg cggctaattt ttcactaaat aatagcaaaa
      301 agctaaagcc aattcaaata ctttcaaatc cactgtctac atacaatcag caactatggc
      361 tgacatgtgt tgttgagttg gatcaatcaa aagaaacttc tattaagaca agctttccca
      421 tgactgttaa agtcgatggt gtagctcaag atggaaccac gatgtacatt cataacaaag
      481 ttcacaaccg gacaaggacc ctcacatgtg cagggaaatg tgcggagatt attgtggctc
      541 accttggcta cctgaactac actcagtata cagtgatagt gggatttgaa cacctgaagc
      601 tccccatcaa gggaatgaac ttcacatgcc tgtttgcgca ttccctccgg aaattttcca
      661 tgagagactg gggcatcgag cagaagtgga tgtctgttct cctgcctctg ctgctacttt
      721 acaatgatcc gttcttcccc ctctccttcc tggtcaacag ctggctccca gggatgctgg
      781 atgacctctt tcagtccatg ttcctgtgcg ccctgctgct cttctggctg tgcgtgtacc
      841 acgggattcg tgtccaggga gaaagaaagt gtttaacttt ctatttgcct aaattcttca
      901 ttgttggact attgtggttg gcttctgtta cgctaggaat atggcaaaca gttaacgaat
      961 tacatgatcc aatgtaccag tatcgagttg ataccggaaa ttttcaggga atgaaggtct
     1021 tcttcatggt ggtggcagcg gtgtacattc tgtacctctt gttcttgata gtgcgggcgt
     1081 gttccgagct acgtcacatg ccttatgtgg atctcaggtt gaaatttttg actgcattga
     1141 ctttcgtagt acttgtcatt agcatcgcca tcctttattt gagatttggg gcgcaagtac
     1201 tacaagacaa ttttgtagca gagctgtcaa ctcactacca gaattcagcc gagttcttat
     1261 ctttctatgg cctgttgaac ttctatctct acaccttggc ctttgtatat tctccatcga
     1321 agaatgccct ctatgagtcc cagctgaaag acaatcctgc cttctccatg ctgaatgact
     1381 cggatgatga tgtgatttat gggagtgact atgaggaaat gccgctgcag aacggccagg
     1441 ccatccgggc caagtacaag gaggagtcag atagtgactg agccccggcc agcccagcga
     1501 ggcgacaaga tgcctggatg ctttccccgg tgaccgtctg ctgaccttcc cctgttatat
     1561 tcagattttt cttacaagca gagatttcct gttcatttgt ttacatattt ttttaaagga
     1621 aaaccaaaac tgagggtaaa tttaaatgtt tagccaaatt tattgtcatg gtggctacga
     1681 gaagaggcat tgataacaag tttcaacagc caaatccttt tttacagaga tttcagatga
     1741 gcgtgttttc agtgatgagg aaatttcacg tttttagtac agtgaattat gtactttttt
     1801 ttcctgtaat cattcactga ttccaagttc acgggcagcc tgtgactagg tcctcagcgt
     1861 gacagcatca ccctctttct tcccttttcc atggtactgt tttgtgaccc tttaaactca
     1921 aagggaagcc ttatctgtgg ctgcttcagg gcagtccttc ctcgttgagt ggccagtgcc
     1981 ctgggtaacc aggtggctga agtgattggt cagttatgtg gactgcgttt tgtgcagtgt
     2041 gtgagttatg actcatcggg aatgggagat gctggggttc caacccttca cgtcaccaaa
     2101 ggggaagtaa tagtgtggag ttctgaggag ggtttgataa gttgaataag gaaaggctaa
     2161 gataatttac aggttaccaa ctcatgtggg gaaggtctta ctgccatggt gcttttcagg
     2221 ggcctgtgtg tacacacatg attaaatgga tttgcctgtg ggaggtatgg gcaggagagg
     2281 aacccttacc attccagtaa atagcagttt ctgcaattct gttgaatatg aaatgccata
     2341 gagctttatt tatttatgta agtaaaagct aaatgagggg ccaggtgcag tggctcacat
     2401 ctgtaatctc aacactttgg gaggccaagg tgggaggatc acttgagccc aggagtttga
     2461 gaccagcctg ggcaacacag ggagaccccg tctctataaa acatttagaa agttggctgg
     2521 gcatgctggg gcatgcccat agtcccagct actcaggagg ctgaggtggg aggattgctt
     2581 gagccctgga ggtcaaggct gcagtgagcc atgattgcac cactgcactc cagcctgggt
     2641 gtcagagcga gaacccgtgt cataaataaa taaagctaca tgaaagattg atagaatatt
     2701 ttagattatt tattggccaa aagtttttaa aactcatatt tggaagcaaa atgaaaagca
     2761 agtaaaatgt tttaaatggt tcatggaaaa cgtatttggg tagaaggcaa ctcgtgcttc
     2821 cggaaggggt tccctgtcct ccatgtgtcc acatggcggt caggtaggga cgacctgttc
     2881 tgtaaagtcc ttggcactgc tgaatctgtg gcatcataga aggccctgga gcttccccgt
     2941 tcctttcagt cagggactcc atatagagtc tcatgtggac gtctcccgtg ctttcctctt
     3001 gacctctaca gtcacacttc tgttaacatc tggtaactgt gggcaacctg actgatgccg
     3061 tcttggcaat tgaggtccag aagatgatag ttccgcaacg caagcagtac ctactttttt
     3121 tcttcatcta tgcattgact ctcagattac catgcagagc ttcacgttat catccacgtt
     3181 aagtagtgct aggtaggacc ttagagatgt tcatgagaaa ctatttgtta tgactttcct
     3241 ttgtatcttt ccttttaatt taaactttaa tgataatgta cttttaatat ggattctatt
     3301 cacatttgtt ttaaaaacct tgtaaatatg aatgtttaag acaacttact gcaagggtaa
     3361 ttcaagttta catgattttt aaatttgcaa tgatgttttt tttattctgt gtattgaaaa
     3421 aaattttctg ttaccaaatt ttacaacttc taataagact actataactt tatgtaaact
     3481 gatgaagatg tgctgattaa catattctgt gatatggttt acaactttta atcataattg
     3541 tccatgattt tggaatgctg ttatttatca gtaaatgtaa aatatttgag gcatttagcc
     3601 atacacacac tagaactttt taaaactttg tcctatagtg taattataaa ctgatgacta
     3661 ttatcttcat acattgagtc ttcatgcatc aatgaaatga aaaatatagg attatttatt
     3721 tactttttgt aactaagtgg gaaataagaa aaaaagttag aaagtactta aggggaaaat
     3781 cgttcttact aagtcatgta ttttcaactt gtcttccctg gtatatcata aataccgaca
     3841 tattacatac cccatgtaaa attttgctta aactctctag cacttggcat gtagaatatg
     3901 taccataggt atcaggttaa aacactaaag tctgccagaa acttttgaca gtagcaagaa
     3961 aattgttgaa gaaaaaataa attatttact gagggtagtt atgttaaagt tttgcgaact
     4021 taaagggctg actttagttc cttcatggta atggcttgag taacatcatc tttgggattt
     4081 tttaaatact ggtccagtct aggagaacct ggaagatgac cagaggtatt tcagtttccc
     4141 tagggagagc ttcgttatcc atgtggatga taagtctgct tgatttatta ttaaatcatt
     4201 atagcagtga agtggtgcca ttttctctct cttaagcccc atttgaaagg ctagagaagg
     4261 ggatatatat actatgttca aggtttgtaa ggttgttaat gtacataatt gcagattgca
     4321 ataaaagctt agatacattt tgtaaaccca acccactaaa tgagcaggtt acaagacaaa
     4381 tgtcaccagc ctcaagtatt ttatgaacta tttactgagg gtagttatgt taaatagatt
     4441 ataatgtggt aaattatttc ctgaatcctt tatcacagga aaaacacaga ccctcataaa
     4501 agggataatt aaaacggatg tgtctgaaca tttagtgaag atgagactta aaacatgaaa
     4561 gtgtatttgt gtattttgag ggttttagaa accggttgcc ttagaggtta gacttttgaa
     4621 gaaaaaaaaa aaaagataca gatcttttcc cctggccaaa gggaagttgt attagtctgt
     4681 gacatcttgt gatgctgttt atcttggttt gacattggag atacgctagt aactgtgata
     4741 ccatactata aaacagaaga attttctgct actaaaaact gcctttttac aaaatgactg
     4801 taaatatttg taaaataaaa taacactaaa ctttaagccc aaaaggagag atagagccat
     4861 gtgttcagtt gtggacctgt ccgtggggca cagtgccacc ccatcacagt gttgctgtca
     4921 tcaggcaaaa gtgaatgttt gtttatggca aattcgtctt ttgcgaatgg cttaattctg
     4981 acactacctt tctgggaaat gttaataaat ttttaatatt ca
//
