LOCUS       NM_001376852            5103 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens transmembrane protein 181 (TMEM181), transcript
            variant 4, mRNA.
ACCESSION   NM_001376852 XM_005267074
VERSION     NM_001376852.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5103)
  AUTHORS   Zhang,J., Yang,X., Zhu,S., Dai,Z.M. and Zhu,X.J.
  TITLE     TMEM181: a key mediator of cytolethal distending toxin required for
            Wnt signaling activity
  JOURNAL   J Genet Genomics 50 (1), 54-57 (2023)
   PUBMED   35577237
REFERENCE   2  (bases 1 to 5103)
  AUTHORS   Hoel,C.M., Zhang,L. and Brohawn,S.G.
  TITLE     Structure of the GOLD-domain seven-transmembrane helix protein
            family member TMEM87A
  JOURNAL   Elife 11, e81704 (2022)
   PUBMED   36373655
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5103)
  AUTHORS   Carette,J.E., Guimaraes,C.P., Varadarajan,M., Park,A.S.,
            Wuethrich,I., Godarova,A., Kotecki,M., Cochran,B.H., Spooner,E.,
            Ploegh,H.L. and Brummelkamp,T.R.
  TITLE     Haploid genetic screens in human cells identify host factors used
            by pathogens
  JOURNAL   Science 326 (5957), 1231-1235 (2009)
   PUBMED   19965467
REFERENCE   4  (bases 1 to 5103)
  AUTHORS   Wollscheid,B., Bausch-Fluck,D., Henderson,C., O'Brien,R., Bibel,M.,
            Schiess,R., Aebersold,R. and Watts,J.D.
  TITLE     Mass-spectrometric identification and relative quantification of
            N-linked cell surface glycoproteins
  JOURNAL   Nat Biotechnol 27 (4), 378-386 (2009)
   PUBMED   19349973
  REMARK    Erratum:[Nat Biotechnol. 2009 Sep;27(9):864]
REFERENCE   5  (bases 1 to 5103)
  AUTHORS   Girard,A., Sachidanandam,R., Hannon,G.J. and Carmell,M.A.
  TITLE     A germline-specific class of small RNAs binds mammalian Piwi
            proteins
  JOURNAL   Nature 442 (7099), 199-202 (2006)
   PUBMED   16751776
REFERENCE   6  (bases 1 to 5103)
  AUTHORS   Wistrand,M., Kall,L. and Sonnhammer,E.L.
  TITLE     A general model of G protein-coupled receptor sequences and its
            application to detect remote homologs
  JOURNAL   Protein Sci 15 (3), 509-521 (2006)
   PUBMED   16452613
REFERENCE   7  (bases 1 to 5103)
  AUTHORS   Cheng,J., Kapranov,P., Drenkow,J., Dike,S., Brubaker,S., Patel,S.,
            Long,J., Stern,D., Tammana,H., Helt,G., Sementchenko,V.,
            Piccolboni,A., Bekiranov,S., Bailey,D.K., Ganesh,M., Ghosh,S.,
            Bell,I., Gerhard,D.S. and Gingeras,T.R.
  TITLE     Transcriptional maps of 10 human chromosomes at 5-nucleotide
            resolution
  JOURNAL   Science 308 (5725), 1149-1154 (2005)
   PUBMED   15790807
REFERENCE   8  (bases 1 to 5103)
  AUTHORS   Mungall,A.J., Palmer,S.A., Sims,S.K., Edwards,C.A., Ashurst,J.L.,
            Wilming,L., Jones,M.C., Horton,R., Hunt,S.E., Scott,C.E.,
            Gilbert,J.G., Clamp,M.E., Bethel,G., Milne,S., Ainscough,R.,
            Almeida,J.P., Ambrose,K.D., Andrews,T.D., Ashwell,R.I.,
            Babbage,A.K., Bagguley,C.L., Bailey,J., Banerjee,R., Barker,D.J.,
            Barlow,K.F., Bates,K., Beare,D.M., Beasley,H., Beasley,O.,
            Bird,C.P., Blakey,S., Bray-Allen,S., Brook,J., Brown,A.J.,
            Brown,J.Y., Burford,D.C., Burrill,W., Burton,J., Carder,C.,
            Carter,N.P., Chapman,J.C., Clark,S.Y., Clark,G., Clee,C.M.,
            Clegg,S., Cobley,V., Collier,R.E., Collins,J.E., Colman,L.K.,
            Corby,N.R., Coville,G.J., Culley,K.M., Dhami,P., Davies,J.,
            Dunn,M., Earthrowl,M.E., Ellington,A.E., Evans,K.A., Faulkner,L.,
            Francis,M.D., Frankish,A., Frankland,J., French,L., Garner,P.,
            Garnett,J., Ghori,M.J., Gilby,L.M., Gillson,C.J., Glithero,R.J.,
            Grafham,D.V., Grant,M., Gribble,S., Griffiths,C., Griffiths,M.,
            Hall,R., Halls,K.S., Hammond,S., Harley,J.L., Hart,E.A.,
            Heath,P.D., Heathcott,R., Holmes,S.J., Howden,P.J., Howe,K.L.,
            Howell,G.R., Huckle,E., Humphray,S.J., Humphries,M.D., Hunt,A.R.,
            Johnson,C.M., Joy,A.A., Kay,M., Keenan,S.J., Kimberley,A.M.,
            King,A., Laird,G.K., Langford,C., Lawlor,S., Leongamornlert,D.A.,
            Leversha,M., Lloyd,C.R., Lloyd,D.M., Loveland,J.E., Lovell,J.,
            Martin,S., Mashreghi-Mohammadi,M., Maslen,G.L., Matthews,L.,
            McCann,O.T., McLaren,S.J., McLay,K., McMurray,A., Moore,M.J.,
            Mullikin,J.C., Niblett,D., Nickerson,T., Novik,K.L., Oliver,K.,
            Overton-Larty,E.K., Parker,A., Patel,R., Pearce,A.V., Peck,A.I.,
            Phillimore,B., Phillips,S., Plumb,R.W., Porter,K.M., Ramsey,Y.,
            Ranby,S.A., Rice,C.M., Ross,M.T., Searle,S.M., Sehra,H.K.,
            Sheridan,E., Skuce,C.D., Smith,S., Smith,M., Spraggon,L.,
            Squares,S.L., Steward,C.A., Sycamore,N., Tamlyn-Hall,G., Tester,J.,
            Theaker,A.J., Thomas,D.W., Thorpe,A., Tracey,A., Tromans,A.,
            Tubby,B., Wall,M., Wallis,J.M., West,A.P., White,S.S.,
            Whitehead,S.L., Whittaker,H., Wild,A., Willey,D.J., Wilmer,T.E.,
            Wood,J.M., Wray,P.W., Wyatt,J.C., Young,L., Younger,R.M.,
            Bentley,D.R., Coulson,A., Durbin,R., Hubbard,T., Sulston,J.E.,
            Dunham,I., Rogers,J. and Beck,S.
  TITLE     The DNA sequence and analysis of human chromosome 6
  JOURNAL   Nature 425 (6960), 805-811 (2003)
   PUBMED   14574404
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL591025.8.
            
            On Nov 20, 2019 this sequence version replaced XM_005267074.4.
            
            Summary: The TMEM181 gene encodes a putative G protein-coupled
            receptor expressed on the cell surface (Carette et al., 2009
            [PubMed 19965467]; Wollscheid et al., 2009 [PubMed
            19349973]).[supplied by OMIM, Jan 2010].
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA1965299,
                              SAMEA1966682 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000684151.1/ ENSP00000507085.1
            RefSeq Select criteria :: based on manual assertion, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-142               AL591025.8         35811-35952
            143-246             AL591025.8         49140-49243
            247-302             AL591025.8         56660-56715
            303-393             AL591025.8         59674-59764
            394-515             AL591025.8         61024-61145
            516-626             AL591025.8         65392-65502
            627-707             AL591025.8         80987-81067
            708-807             AL591025.8         82964-83063
            808-938             AL591025.8         84053-84183
            939-1030            AL591025.8         84379-84470
            1031-1088           AL591025.8         99270-99327
            1089-1191           AL591025.8         100824-100926
            1192-1243           AL591025.8         101423-101474
            1244-1326           AL591025.8         104128-104210
            1327-1416           AL591025.8         105450-105539
            1417-1483           AL591025.8         107043-107109
            1484-5103           AL591025.8         107530-111149
FEATURES             Location/Qualifiers
     source          1..5103
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6q25.3"
     gene            1..5103
                     /gene="TMEM181"
                     /gene_synonym="GPR178; KIAA1423"
                     /note="transmembrane protein 181"
                     /db_xref="GeneID:57583"
                     /db_xref="HGNC:HGNC:20958"
                     /db_xref="MIM:613209"
     exon            1..142
                     /gene="TMEM181"
                     /gene_synonym="GPR178; KIAA1423"
                     /inference="alignment:Splign:2.1.0"
     CDS             135..1562
                     /gene="TMEM181"
                     /gene_synonym="GPR178; KIAA1423"
                     /note="isoform 4 is encoded by transcript variant 4; G
                     protein-coupled receptor 178"
                     /codon_start=1
                     /product="transmembrane protein 181 isoform 4"
                     /protein_id="NP_001363781.1"
                     /db_xref="CCDS:CCDS94026.1"
                     /db_xref="GeneID:57583"
                     /db_xref="HGNC:HGNC:20958"
                     /db_xref="MIM:613209"
                     /translation="MEPLAPMRLYTLSKRHFVLVFVVFFICFGLTIFVGIRGPKVIQT
                     SAANFSLNNSKKLKPIQILSNPLSTYNQQLWLTCVVELDQSKETSIKTSFPMTVKVDG
                     VAQDGTTMYIHNKVHNRTRTLTCAGKCAEIIVAHLGYLNYTQYTVIVGFEHLKLPIKG
                     MNFTWKTYNPAFSRLEIWFRFFFVVLTFIVTCLFAHSLRKFSMRDWGIEQKWMSVLLP
                     LLLLYNDPFFPLSFLVNSWLPGMLDDLFQSMFLCALLLFWLCVYHGIRVQGERKCLTF
                     YLPKFFIVGLLWLASVTLGIWQTVNELHDPMYQYRVDTGNFQGMKVFFMVVAAVYILY
                     LLFLIVRACSELRHMPYVDLRLKFLTALTFVVLVISIAILYLRFGAQVLQDNFVAELS
                     THYQNSAEFLSFYGLLNFYLYTLAFVYSPSKNALYESQLKDNPAFSMLNDSDDDVIYG
                     SDYEEMPLQNGQAIRAKYKEESDSD"
     exon            143..246
                     /gene="TMEM181"
                     /gene_synonym="GPR178; KIAA1423"
                     /inference="alignment:Splign:2.1.0"
     exon            247..302
                     /gene="TMEM181"
                     /gene_synonym="GPR178; KIAA1423"
                     /inference="alignment:Splign:2.1.0"
     exon            303..393
                     /gene="TMEM181"
                     /gene_synonym="GPR178; KIAA1423"
                     /inference="alignment:Splign:2.1.0"
     exon            394..515
                     /gene="TMEM181"
                     /gene_synonym="GPR178; KIAA1423"
                     /inference="alignment:Splign:2.1.0"
     exon            516..626
                     /gene="TMEM181"
                     /gene_synonym="GPR178; KIAA1423"
                     /inference="alignment:Splign:2.1.0"
     exon            627..707
                     /gene="TMEM181"
                     /gene_synonym="GPR178; KIAA1423"
                     /inference="alignment:Splign:2.1.0"
     exon            708..807
                     /gene="TMEM181"
                     /gene_synonym="GPR178; KIAA1423"
                     /inference="alignment:Splign:2.1.0"
     exon            808..938
                     /gene="TMEM181"
                     /gene_synonym="GPR178; KIAA1423"
                     /inference="alignment:Splign:2.1.0"
     exon            939..1030
                     /gene="TMEM181"
                     /gene_synonym="GPR178; KIAA1423"
                     /inference="alignment:Splign:2.1.0"
     exon            1031..1088
                     /gene="TMEM181"
                     /gene_synonym="GPR178; KIAA1423"
                     /inference="alignment:Splign:2.1.0"
     exon            1089..1191
                     /gene="TMEM181"
                     /gene_synonym="GPR178; KIAA1423"
                     /inference="alignment:Splign:2.1.0"
     exon            1192..1243
                     /gene="TMEM181"
                     /gene_synonym="GPR178; KIAA1423"
                     /inference="alignment:Splign:2.1.0"
     exon            1244..1326
                     /gene="TMEM181"
                     /gene_synonym="GPR178; KIAA1423"
                     /inference="alignment:Splign:2.1.0"
     exon            1327..1416
                     /gene="TMEM181"
                     /gene_synonym="GPR178; KIAA1423"
                     /inference="alignment:Splign:2.1.0"
     exon            1417..1483
                     /gene="TMEM181"
                     /gene_synonym="GPR178; KIAA1423"
                     /inference="alignment:Splign:2.1.0"
     exon            1484..5103
                     /gene="TMEM181"
                     /gene_synonym="GPR178; KIAA1423"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5085..5090
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TMEM181"
                     /gene_synonym="GPR178; KIAA1423"
                     /note="hexamer: AATAAA"
     polyA_site      5103
                     /gene="TMEM181"
                     /gene_synonym="GPR178; KIAA1423"
                     /note="major polyA site"
ORIGIN      
        1 gagttttccg cggccggccg ctgctcagcc gctgtcgctc cggctccggc tgcggctgcc
       61 gctgccgagg ctgctgcgcg gcgcctggcg ggctcgggac gcgcgggccg gggccgaggg
      121 ctctgggcgc cgagatggag ccgctggcgc ccatgcggct ctacacgctc tccaagcgcc
      181 actttgtcct cgtgtttgtc gtcttcttca tctgctttgg cctgaccatc ttcgttggga
      241 tcagaggacc taaagtgatc cagacttctg cggctaattt ttcactaaat aatagcaaaa
      301 agctaaagcc aattcaaata ctttcaaatc cactgtctac atacaatcag caactatggc
      361 tgacatgtgt tgttgagttg gatcaatcaa aagaaacttc tattaagaca agctttccca
      421 tgactgttaa agtcgatggt gtagctcaag atggaaccac gatgtacatt cataacaaag
      481 ttcacaaccg gacaaggacc ctcacatgtg cagggaaatg tgcggagatt attgtggctc
      541 accttggcta cctgaactac actcagtata cagtgatagt gggatttgaa cacctgaagc
      601 tccccatcaa gggaatgaac ttcacatgga agacttataa ccctgccttc tcccggttgg
      661 aaatctggtt ccggtttttc tttgtggtgc tcaccttcat cgtcacttgc ctgtttgcgc
      721 attccctccg gaaattttcc atgagagact ggggcatcga gcagaagtgg atgtctgttc
      781 tcctgcctct gctgctactt tacaatgatc cgttcttccc cctctccttc ctggtcaaca
      841 gctggctccc agggatgctg gatgacctct ttcagtccat gttcctgtgc gccctgctgc
      901 tcttctggct gtgcgtgtac cacgggattc gtgtccaggg agaaagaaag tgtttaactt
      961 tctatttgcc taaattcttc attgttggac tattgtggtt ggcttctgtt acgctaggaa
     1021 tatggcaaac agttaacgaa ttacatgatc caatgtacca gtatcgagtt gataccggaa
     1081 attttcaggg aatgaaggtc ttcttcatgg tggtggcagc ggtgtacatt ctgtacctct
     1141 tgttcttgat agtgcgggcg tgttccgagc tacgtcacat gccttatgtg gatctcaggt
     1201 tgaaattttt gactgcattg actttcgtag tacttgtcat tagcatcgcc atcctttatt
     1261 tgagatttgg ggcgcaagta ctacaagaca attttgtagc agagctgtca actcactacc
     1321 agaattcagc cgagttctta tctttctatg gcctgttgaa cttctatctc tacaccttgg
     1381 cctttgtata ttctccatcg aagaatgccc tctatgagtc ccagctgaaa gacaatcctg
     1441 ccttctccat gctgaatgac tcggatgatg atgtgattta tgggagtgac tatgaggaaa
     1501 tgccgctgca gaacggccag gccatccggg ccaagtacaa ggaggagtca gatagtgact
     1561 gagccccggc cagcccagcg aggcgacaag atgcctggat gctttccccg gtgaccgtct
     1621 gctgaccttc ccctgttata ttcagatttt tcttacaagc agagatttcc tgttcatttg
     1681 tttacatatt tttttaaagg aaaaccaaaa ctgagggtaa atttaaatgt ttagccaaat
     1741 ttattgtcat ggtggctacg agaagaggca ttgataacaa gtttcaacag ccaaatcctt
     1801 ttttacagag atttcagatg agcgtgtttt cagtgatgag gaaatttcac gtttttagta
     1861 cagtgaatta tgtacttttt tttcctgtaa tcattcactg attccaagtt cacgggcagc
     1921 ctgtgactag gtcctcagcg tgacagcatc accctctttc ttcccttttc catggtactg
     1981 ttttgtgacc ctttaaactc aaagggaagc cttatctgtg gctgcttcag ggcagtcctt
     2041 cctcgttgag tggccagtgc cctgggtaac caggtggctg aagtgattgg tcagttatgt
     2101 ggactgcgtt ttgtgcagtg tgtgagttat gactcatcgg gaatgggaga tgctggggtt
     2161 ccaacccttc acgtcaccaa aggggaagta atagtgtgga gttctgagga gggtttgata
     2221 agttgaataa ggaaaggcta agataattta caggttacca actcatgtgg ggaaggtctt
     2281 actgccatgg tgcttttcag gggcctgtgt gtacacacat gattaaatgg atttgcctgt
     2341 gggaggtatg ggcaggagag gaacccttac cattccagta aatagcagtt tctgcaattc
     2401 tgttgaatat gaaatgccat agagctttat ttatttatgt aagtaaaagc taaatgaggg
     2461 gccaggtgca gtggctcaca tctgtaatct caacactttg ggaggccaag gtgggaggat
     2521 cacttgagcc caggagtttg agaccagcct gggcaacaca gggagacccc gtctctataa
     2581 aacatttaga aagttggctg ggcatgctgg ggcatgccca tagtcccagc tactcaggag
     2641 gctgaggtgg gaggattgct tgagccctgg aggtcaaggc tgcagtgagc catgattgca
     2701 ccactgcact ccagcctggg tgtcagagcg agaacccgtg tcataaataa ataaagctac
     2761 atgaaagatt gatagaatat tttagattat ttattggcca aaagttttta aaactcatat
     2821 ttggaagcaa aatgaaaagc aagtaaaatg ttttaaatgg ttcatggaaa acgtatttgg
     2881 gtagaaggca actcgtgctt ccggaagggg ttccctgtcc tccatgtgtc cacatggcgg
     2941 tcaggtaggg acgacctgtt ctgtaaagtc cttggcactg ctgaatctgt ggcatcatag
     3001 aaggccctgg agcttccccg ttcctttcag tcagggactc catatagagt ctcatgtgga
     3061 cgtctcccgt gctttcctct tgacctctac agtcacactt ctgttaacat ctggtaactg
     3121 tgggcaacct gactgatgcc gtcttggcaa ttgaggtcca gaagatgata gttccgcaac
     3181 gcaagcagta cctacttttt ttcttcatct atgcattgac tctcagatta ccatgcagag
     3241 cttcacgtta tcatccacgt taagtagtgc taggtaggac cttagagatg ttcatgagaa
     3301 actatttgtt atgactttcc tttgtatctt tccttttaat ttaaacttta atgataatgt
     3361 acttttaata tggattctat tcacatttgt tttaaaaacc ttgtaaatat gaatgtttaa
     3421 gacaacttac tgcaagggta attcaagttt acatgatttt taaatttgca atgatgtttt
     3481 ttttattctg tgtattgaaa aaaattttct gttaccaaat tttacaactt ctaataagac
     3541 tactataact ttatgtaaac tgatgaagat gtgctgatta acatattctg tgatatggtt
     3601 tacaactttt aatcataatt gtccatgatt ttggaatgct gttatttatc agtaaatgta
     3661 aaatatttga ggcatttagc catacacaca ctagaacttt ttaaaacttt gtcctatagt
     3721 gtaattataa actgatgact attatcttca tacattgagt cttcatgcat caatgaaatg
     3781 aaaaatatag gattatttat ttactttttg taactaagtg ggaaataaga aaaaaagtta
     3841 gaaagtactt aaggggaaaa tcgttcttac taagtcatgt attttcaact tgtcttccct
     3901 ggtatatcat aaataccgac atattacata ccccatgtaa aattttgctt aaactctcta
     3961 gcacttggca tgtagaatat gtaccatagg tatcaggtta aaacactaaa gtctgccaga
     4021 aacttttgac agtagcaaga aaattgttga agaaaaaata aattatttac tgagggtagt
     4081 tatgttaaag ttttgcgaac ttaaagggct gactttagtt ccttcatggt aatggcttga
     4141 gtaacatcat ctttgggatt ttttaaatac tggtccagtc taggagaacc tggaagatga
     4201 ccagaggtat ttcagtttcc ctagggagag cttcgttatc catgtggatg ataagtctgc
     4261 ttgatttatt attaaatcat tatagcagtg aagtggtgcc attttctctc tcttaagccc
     4321 catttgaaag gctagagaag gggatatata tactatgttc aaggtttgta aggttgttaa
     4381 tgtacataat tgcagattgc aataaaagct tagatacatt ttgtaaaccc aacccactaa
     4441 atgagcaggt tacaagacaa atgtcaccag cctcaagtat tttatgaact atttactgag
     4501 ggtagttatg ttaaatagat tataatgtgg taaattattt cctgaatcct ttatcacagg
     4561 aaaaacacag accctcataa aagggataat taaaacggat gtgtctgaac atttagtgaa
     4621 gatgagactt aaaacatgaa agtgtatttg tgtattttga gggttttaga aaccggttgc
     4681 cttagaggtt agacttttga agaaaaaaaa aaaaagatac agatcttttc ccctggccaa
     4741 agggaagttg tattagtctg tgacatcttg tgatgctgtt tatcttggtt tgacattgga
     4801 gatacgctag taactgtgat accatactat aaaacagaag aattttctgc tactaaaaac
     4861 tgccttttta caaaatgact gtaaatattt gtaaaataaa ataacactaa actttaagcc
     4921 caaaaggaga gatagagcca tgtgttcagt tgtggacctg tccgtggggc acagtgccac
     4981 cccatcacag tgttgctgtc atcaggcaaa agtgaatgtt tgtttatggc aaattcgtct
     5041 tttgcgaatg gcttaattct gacactacct ttctgggaaa tgttaataaa tttttaatat
     5101 tca
//
