LOCUS       NP_001363781             475 aa            linear   PRI 29-APR-2025
DEFINITION  transmembrane protein 181 isoform 4 [Homo sapiens].
ACCESSION   NP_001363781 XP_005267131
VERSION     NP_001363781.1
DBSOURCE    REFSEQ: accession NM_001376852.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 475)
  AUTHORS   Zhang,J., Yang,X., Zhu,S., Dai,Z.M. and Zhu,X.J.
  TITLE     TMEM181: a key mediator of cytolethal distending toxin required for
            Wnt signaling activity
  JOURNAL   J Genet Genomics 50 (1), 54-57 (2023)
   PUBMED   35577237
REFERENCE   2  (residues 1 to 475)
  AUTHORS   Hoel,C.M., Zhang,L. and Brohawn,S.G.
  TITLE     Structure of the GOLD-domain seven-transmembrane helix protein
            family member TMEM87A
  JOURNAL   Elife 11, e81704 (2022)
   PUBMED   36373655
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 475)
  AUTHORS   Carette,J.E., Guimaraes,C.P., Varadarajan,M., Park,A.S.,
            Wuethrich,I., Godarova,A., Kotecki,M., Cochran,B.H., Spooner,E.,
            Ploegh,H.L. and Brummelkamp,T.R.
  TITLE     Haploid genetic screens in human cells identify host factors used
            by pathogens
  JOURNAL   Science 326 (5957), 1231-1235 (2009)
   PUBMED   19965467
REFERENCE   4  (residues 1 to 475)
  AUTHORS   Wollscheid,B., Bausch-Fluck,D., Henderson,C., O'Brien,R., Bibel,M.,
            Schiess,R., Aebersold,R. and Watts,J.D.
  TITLE     Mass-spectrometric identification and relative quantification of
            N-linked cell surface glycoproteins
  JOURNAL   Nat Biotechnol 27 (4), 378-386 (2009)
   PUBMED   19349973
  REMARK    Erratum:[Nat Biotechnol. 2009 Sep;27(9):864]
REFERENCE   5  (residues 1 to 475)
  AUTHORS   Girard,A., Sachidanandam,R., Hannon,G.J. and Carmell,M.A.
  TITLE     A germline-specific class of small RNAs binds mammalian Piwi
            proteins
  JOURNAL   Nature 442 (7099), 199-202 (2006)
   PUBMED   16751776
REFERENCE   6  (residues 1 to 475)
  AUTHORS   Wistrand,M., Kall,L. and Sonnhammer,E.L.
  TITLE     A general model of G protein-coupled receptor sequences and its
            application to detect remote homologs
  JOURNAL   Protein Sci 15 (3), 509-521 (2006)
   PUBMED   16452613
REFERENCE   7  (residues 1 to 475)
  AUTHORS   Cheng,J., Kapranov,P., Drenkow,J., Dike,S., Brubaker,S., Patel,S.,
            Long,J., Stern,D., Tammana,H., Helt,G., Sementchenko,V.,
            Piccolboni,A., Bekiranov,S., Bailey,D.K., Ganesh,M., Ghosh,S.,
            Bell,I., Gerhard,D.S. and Gingeras,T.R.
  TITLE     Transcriptional maps of 10 human chromosomes at 5-nucleotide
            resolution
  JOURNAL   Science 308 (5725), 1149-1154 (2005)
   PUBMED   15790807
REFERENCE   8  (residues 1 to 475)
  AUTHORS   Mungall,A.J., Palmer,S.A., Sims,S.K., Edwards,C.A., Ashurst,J.L.,
            Wilming,L., Jones,M.C., Horton,R., Hunt,S.E., Scott,C.E.,
            Gilbert,J.G., Clamp,M.E., Bethel,G., Milne,S., Ainscough,R.,
            Almeida,J.P., Ambrose,K.D., Andrews,T.D., Ashwell,R.I.,
            Babbage,A.K., Bagguley,C.L., Bailey,J., Banerjee,R., Barker,D.J.,
            Barlow,K.F., Bates,K., Beare,D.M., Beasley,H., Beasley,O.,
            Bird,C.P., Blakey,S., Bray-Allen,S., Brook,J., Brown,A.J.,
            Brown,J.Y., Burford,D.C., Burrill,W., Burton,J., Carder,C.,
            Carter,N.P., Chapman,J.C., Clark,S.Y., Clark,G., Clee,C.M.,
            Clegg,S., Cobley,V., Collier,R.E., Collins,J.E., Colman,L.K.,
            Corby,N.R., Coville,G.J., Culley,K.M., Dhami,P., Davies,J.,
            Dunn,M., Earthrowl,M.E., Ellington,A.E., Evans,K.A., Faulkner,L.,
            Francis,M.D., Frankish,A., Frankland,J., French,L., Garner,P.,
            Garnett,J., Ghori,M.J., Gilby,L.M., Gillson,C.J., Glithero,R.J.,
            Grafham,D.V., Grant,M., Gribble,S., Griffiths,C., Griffiths,M.,
            Hall,R., Halls,K.S., Hammond,S., Harley,J.L., Hart,E.A.,
            Heath,P.D., Heathcott,R., Holmes,S.J., Howden,P.J., Howe,K.L.,
            Howell,G.R., Huckle,E., Humphray,S.J., Humphries,M.D., Hunt,A.R.,
            Johnson,C.M., Joy,A.A., Kay,M., Keenan,S.J., Kimberley,A.M.,
            King,A., Laird,G.K., Langford,C., Lawlor,S., Leongamornlert,D.A.,
            Leversha,M., Lloyd,C.R., Lloyd,D.M., Loveland,J.E., Lovell,J.,
            Martin,S., Mashreghi-Mohammadi,M., Maslen,G.L., Matthews,L.,
            McCann,O.T., McLaren,S.J., McLay,K., McMurray,A., Moore,M.J.,
            Mullikin,J.C., Niblett,D., Nickerson,T., Novik,K.L., Oliver,K.,
            Overton-Larty,E.K., Parker,A., Patel,R., Pearce,A.V., Peck,A.I.,
            Phillimore,B., Phillips,S., Plumb,R.W., Porter,K.M., Ramsey,Y.,
            Ranby,S.A., Rice,C.M., Ross,M.T., Searle,S.M., Sehra,H.K.,
            Sheridan,E., Skuce,C.D., Smith,S., Smith,M., Spraggon,L.,
            Squares,S.L., Steward,C.A., Sycamore,N., Tamlyn-Hall,G., Tester,J.,
            Theaker,A.J., Thomas,D.W., Thorpe,A., Tracey,A., Tromans,A.,
            Tubby,B., Wall,M., Wallis,J.M., West,A.P., White,S.S.,
            Whitehead,S.L., Whittaker,H., Wild,A., Willey,D.J., Wilmer,T.E.,
            Wood,J.M., Wray,P.W., Wyatt,J.C., Young,L., Younger,R.M.,
            Bentley,D.R., Coulson,A., Durbin,R., Hubbard,T., Sulston,J.E.,
            Dunham,I., Rogers,J. and Beck,S.
  TITLE     The DNA sequence and analysis of human chromosome 6
  JOURNAL   Nature 425 (6960), 805-811 (2003)
   PUBMED   14574404
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL591025.8.
            
            On Nov 20, 2019 this sequence version replaced XP_005267131.1.
            
            Summary: The TMEM181 gene encodes a putative G protein-coupled
            receptor expressed on the cell surface (Carette et al., 2009
            [PubMed 19965467]; Wollscheid et al., 2009 [PubMed
            19349973]).[supplied by OMIM, Jan 2010].
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA1965299,
                              SAMEA1966682 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000684151.1/ ENSP00000507085.1
            RefSeq Select criteria :: based on manual assertion, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..475
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6q25.3"
     Protein         1..475
                     /product="transmembrane protein 181 isoform 4"
                     /note="G protein-coupled receptor 178"
                     /calculated_mol_wt=54884
     Site            16..36
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9P2C4.3)"
     Region          128..423
                     /region_name="MIG-14_Wnt-bd"
                     /note="Wnt-binding factor required for Wnt secretion;
                     pfam06664"
                     /db_xref="CDD:461980"
     Site            131..151
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9P2C4.3)"
     Site            175..195
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9P2C4.3)"
     Site            214..234
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9P2C4.3)"
     Site            245..265
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9P2C4.3)"
     Site            276..296
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9P2C4.3)"
     Site            320..340
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9P2C4.3)"
     Site            356..376
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9P2C4.3)"
     Site            401..421
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9P2C4.3)"
     Site            443
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:17081983,
                     ECO:0007744|PubMed:18691976, ECO:0007744|PubMed:20068231;
                     propagated from UniProtKB/Swiss-Prot (Q9P2C4.3)"
     CDS             1..475
                     /gene="TMEM181"
                     /gene_synonym="GPR178; KIAA1423"
                     /coded_by="NM_001376852.1:135..1562"
                     /note="isoform 4 is encoded by transcript variant 4"
                     /db_xref="CCDS:CCDS94026.1"
                     /db_xref="GeneID:57583"
                     /db_xref="HGNC:HGNC:20958"
                     /db_xref="MIM:613209"
ORIGIN      
        1 meplapmrly tlskrhfvlv fvvfficfgl tifvgirgpk viqtsaanfs lnnskklkpi
       61 qilsnplsty nqqlwltcvv eldqsketsi ktsfpmtvkv dgvaqdgttm yihnkvhnrt
      121 rtltcagkca eiivahlgyl nytqytvivg fehlklpikg mnftwktynp afsrleiwfr
      181 fffvvltfiv tclfahslrk fsmrdwgieq kwmsvllpll llyndpffpl sflvnswlpg
      241 mlddlfqsmf lcalllfwlc vyhgirvqge rkcltfylpk ffivgllwla svtlgiwqtv
      301 nelhdpmyqy rvdtgnfqgm kvffmvvaav yilyllfliv racselrhmp yvdlrlkflt
      361 altfvvlvis iailylrfga qvlqdnfvae lsthyqnsae flsfygllnf ylytlafvys
      421 psknalyesq lkdnpafsml ndsdddviyg sdyeemplqn gqairakyke esdsd
//
