LOCUS       NM_001376850            5127 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens transmembrane protein 181 (TMEM181), transcript
            variant 3, mRNA.
ACCESSION   NM_001376850
VERSION     NM_001376850.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5127)
  AUTHORS   Zhang,J., Yang,X., Zhu,S., Dai,Z.M. and Zhu,X.J.
  TITLE     TMEM181: a key mediator of cytolethal distending toxin required for
            Wnt signaling activity
  JOURNAL   J Genet Genomics 50 (1), 54-57 (2023)
   PUBMED   35577237
REFERENCE   2  (bases 1 to 5127)
  AUTHORS   Hoel,C.M., Zhang,L. and Brohawn,S.G.
  TITLE     Structure of the GOLD-domain seven-transmembrane helix protein
            family member TMEM87A
  JOURNAL   Elife 11, e81704 (2022)
   PUBMED   36373655
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5127)
  AUTHORS   Carette,J.E., Guimaraes,C.P., Varadarajan,M., Park,A.S.,
            Wuethrich,I., Godarova,A., Kotecki,M., Cochran,B.H., Spooner,E.,
            Ploegh,H.L. and Brummelkamp,T.R.
  TITLE     Haploid genetic screens in human cells identify host factors used
            by pathogens
  JOURNAL   Science 326 (5957), 1231-1235 (2009)
   PUBMED   19965467
REFERENCE   4  (bases 1 to 5127)
  AUTHORS   Wollscheid,B., Bausch-Fluck,D., Henderson,C., O'Brien,R., Bibel,M.,
            Schiess,R., Aebersold,R. and Watts,J.D.
  TITLE     Mass-spectrometric identification and relative quantification of
            N-linked cell surface glycoproteins
  JOURNAL   Nat Biotechnol 27 (4), 378-386 (2009)
   PUBMED   19349973
  REMARK    Erratum:[Nat Biotechnol. 2009 Sep;27(9):864]
REFERENCE   5  (bases 1 to 5127)
  AUTHORS   Girard,A., Sachidanandam,R., Hannon,G.J. and Carmell,M.A.
  TITLE     A germline-specific class of small RNAs binds mammalian Piwi
            proteins
  JOURNAL   Nature 442 (7099), 199-202 (2006)
   PUBMED   16751776
REFERENCE   6  (bases 1 to 5127)
  AUTHORS   Wistrand,M., Kall,L. and Sonnhammer,E.L.
  TITLE     A general model of G protein-coupled receptor sequences and its
            application to detect remote homologs
  JOURNAL   Protein Sci 15 (3), 509-521 (2006)
   PUBMED   16452613
REFERENCE   7  (bases 1 to 5127)
  AUTHORS   Cheng,J., Kapranov,P., Drenkow,J., Dike,S., Brubaker,S., Patel,S.,
            Long,J., Stern,D., Tammana,H., Helt,G., Sementchenko,V.,
            Piccolboni,A., Bekiranov,S., Bailey,D.K., Ganesh,M., Ghosh,S.,
            Bell,I., Gerhard,D.S. and Gingeras,T.R.
  TITLE     Transcriptional maps of 10 human chromosomes at 5-nucleotide
            resolution
  JOURNAL   Science 308 (5725), 1149-1154 (2005)
   PUBMED   15790807
REFERENCE   8  (bases 1 to 5127)
  AUTHORS   Mungall,A.J., Palmer,S.A., Sims,S.K., Edwards,C.A., Ashurst,J.L.,
            Wilming,L., Jones,M.C., Horton,R., Hunt,S.E., Scott,C.E.,
            Gilbert,J.G., Clamp,M.E., Bethel,G., Milne,S., Ainscough,R.,
            Almeida,J.P., Ambrose,K.D., Andrews,T.D., Ashwell,R.I.,
            Babbage,A.K., Bagguley,C.L., Bailey,J., Banerjee,R., Barker,D.J.,
            Barlow,K.F., Bates,K., Beare,D.M., Beasley,H., Beasley,O.,
            Bird,C.P., Blakey,S., Bray-Allen,S., Brook,J., Brown,A.J.,
            Brown,J.Y., Burford,D.C., Burrill,W., Burton,J., Carder,C.,
            Carter,N.P., Chapman,J.C., Clark,S.Y., Clark,G., Clee,C.M.,
            Clegg,S., Cobley,V., Collier,R.E., Collins,J.E., Colman,L.K.,
            Corby,N.R., Coville,G.J., Culley,K.M., Dhami,P., Davies,J.,
            Dunn,M., Earthrowl,M.E., Ellington,A.E., Evans,K.A., Faulkner,L.,
            Francis,M.D., Frankish,A., Frankland,J., French,L., Garner,P.,
            Garnett,J., Ghori,M.J., Gilby,L.M., Gillson,C.J., Glithero,R.J.,
            Grafham,D.V., Grant,M., Gribble,S., Griffiths,C., Griffiths,M.,
            Hall,R., Halls,K.S., Hammond,S., Harley,J.L., Hart,E.A.,
            Heath,P.D., Heathcott,R., Holmes,S.J., Howden,P.J., Howe,K.L.,
            Howell,G.R., Huckle,E., Humphray,S.J., Humphries,M.D., Hunt,A.R.,
            Johnson,C.M., Joy,A.A., Kay,M., Keenan,S.J., Kimberley,A.M.,
            King,A., Laird,G.K., Langford,C., Lawlor,S., Leongamornlert,D.A.,
            Leversha,M., Lloyd,C.R., Lloyd,D.M., Loveland,J.E., Lovell,J.,
            Martin,S., Mashreghi-Mohammadi,M., Maslen,G.L., Matthews,L.,
            McCann,O.T., McLaren,S.J., McLay,K., McMurray,A., Moore,M.J.,
            Mullikin,J.C., Niblett,D., Nickerson,T., Novik,K.L., Oliver,K.,
            Overton-Larty,E.K., Parker,A., Patel,R., Pearce,A.V., Peck,A.I.,
            Phillimore,B., Phillips,S., Plumb,R.W., Porter,K.M., Ramsey,Y.,
            Ranby,S.A., Rice,C.M., Ross,M.T., Searle,S.M., Sehra,H.K.,
            Sheridan,E., Skuce,C.D., Smith,S., Smith,M., Spraggon,L.,
            Squares,S.L., Steward,C.A., Sycamore,N., Tamlyn-Hall,G., Tester,J.,
            Theaker,A.J., Thomas,D.W., Thorpe,A., Tracey,A., Tromans,A.,
            Tubby,B., Wall,M., Wallis,J.M., West,A.P., White,S.S.,
            Whitehead,S.L., Whittaker,H., Wild,A., Willey,D.J., Wilmer,T.E.,
            Wood,J.M., Wray,P.W., Wyatt,J.C., Young,L., Younger,R.M.,
            Bentley,D.R., Coulson,A., Durbin,R., Hubbard,T., Sulston,J.E.,
            Dunham,I., Rogers,J. and Beck,S.
  TITLE     The DNA sequence and analysis of human chromosome 6
  JOURNAL   Nature 425 (6960), 805-811 (2003)
   PUBMED   14574404
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL591025.8.
            
            Summary: The TMEM181 gene encodes a putative G protein-coupled
            receptor expressed on the cell surface (Carette et al., 2009
            [PubMed 19965467]; Wollscheid et al., 2009 [PubMed
            19349973]).[supplied by OMIM, Jan 2010].
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA1968832,
                              SAMEA1968968 [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-142               AL591025.8         35811-35952
            143-246             AL591025.8         49140-49243
            247-302             AL591025.8         56660-56715
            303-393             AL591025.8         59674-59764
            394-515             AL591025.8         61024-61145
            516-650             AL591025.8         65368-65502
            651-731             AL591025.8         80987-81067
            732-831             AL591025.8         82964-83063
            832-962             AL591025.8         84053-84183
            963-1054            AL591025.8         84379-84470
            1055-1112           AL591025.8         99270-99327
            1113-1215           AL591025.8         100824-100926
            1216-1267           AL591025.8         101423-101474
            1268-1350           AL591025.8         104128-104210
            1351-1440           AL591025.8         105450-105539
            1441-1507           AL591025.8         107043-107109
            1508-5127           AL591025.8         107530-111149
FEATURES             Location/Qualifiers
     source          1..5127
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6q25.3"
     gene            1..5127
                     /gene="TMEM181"
                     /gene_synonym="GPR178; KIAA1423"
                     /note="transmembrane protein 181"
                     /db_xref="GeneID:57583"
                     /db_xref="HGNC:HGNC:20958"
                     /db_xref="MIM:613209"
     exon            1..142
                     /gene="TMEM181"
                     /gene_synonym="GPR178; KIAA1423"
                     /inference="alignment:Splign:2.1.0"
     CDS             135..1586
                     /gene="TMEM181"
                     /gene_synonym="GPR178; KIAA1423"
                     /note="isoform 3 is encoded by transcript variant 3; G
                     protein-coupled receptor 178"
                     /codon_start=1
                     /product="transmembrane protein 181 isoform 3"
                     /protein_id="NP_001363779.1"
                     /db_xref="GeneID:57583"
                     /db_xref="HGNC:HGNC:20958"
                     /db_xref="MIM:613209"
                     /translation="MEPLAPMRLYTLSKRHFVLVFVVFFICFGLTIFVGIRGPKVIQT
                     SAANFSLNNSKKLKPIQILSNPLSTYNQQLWLTCVVELDQSKETSIKTSFPMTVKVDG
                     VAQDGTTMYIHNKVHNRTRTLTCAGANLSVYLQKCAEIIVAHLGYLNYTQYTVIVGFE
                     HLKLPIKGMNFTWKTYNPAFSRLEIWFRFFFVVLTFIVTCLFAHSLRKFSMRDWGIEQ
                     KWMSVLLPLLLLYNDPFFPLSFLVNSWLPGMLDDLFQSMFLCALLLFWLCVYHGIRVQ
                     GERKCLTFYLPKFFIVGLLWLASVTLGIWQTVNELHDPMYQYRVDTGNFQGMKVFFMV
                     VAAVYILYLLFLIVRACSELRHMPYVDLRLKFLTALTFVVLVISIAILYLRFGAQVLQ
                     DNFVAELSTHYQNSAEFLSFYGLLNFYLYTLAFVYSPSKNALYESQLKDNPAFSMLND
                     SDDDVIYGSDYEEMPLQNGQAIRAKYKEESDSD"
     exon            143..246
                     /gene="TMEM181"
                     /gene_synonym="GPR178; KIAA1423"
                     /inference="alignment:Splign:2.1.0"
     exon            247..302
                     /gene="TMEM181"
                     /gene_synonym="GPR178; KIAA1423"
                     /inference="alignment:Splign:2.1.0"
     exon            303..393
                     /gene="TMEM181"
                     /gene_synonym="GPR178; KIAA1423"
                     /inference="alignment:Splign:2.1.0"
     exon            394..515
                     /gene="TMEM181"
                     /gene_synonym="GPR178; KIAA1423"
                     /inference="alignment:Splign:2.1.0"
     exon            516..650
                     /gene="TMEM181"
                     /gene_synonym="GPR178; KIAA1423"
                     /inference="alignment:Splign:2.1.0"
     exon            651..731
                     /gene="TMEM181"
                     /gene_synonym="GPR178; KIAA1423"
                     /inference="alignment:Splign:2.1.0"
     exon            732..831
                     /gene="TMEM181"
                     /gene_synonym="GPR178; KIAA1423"
                     /inference="alignment:Splign:2.1.0"
     exon            832..962
                     /gene="TMEM181"
                     /gene_synonym="GPR178; KIAA1423"
                     /inference="alignment:Splign:2.1.0"
     exon            963..1054
                     /gene="TMEM181"
                     /gene_synonym="GPR178; KIAA1423"
                     /inference="alignment:Splign:2.1.0"
     exon            1055..1112
                     /gene="TMEM181"
                     /gene_synonym="GPR178; KIAA1423"
                     /inference="alignment:Splign:2.1.0"
     exon            1113..1215
                     /gene="TMEM181"
                     /gene_synonym="GPR178; KIAA1423"
                     /inference="alignment:Splign:2.1.0"
     exon            1216..1267
                     /gene="TMEM181"
                     /gene_synonym="GPR178; KIAA1423"
                     /inference="alignment:Splign:2.1.0"
     exon            1268..1350
                     /gene="TMEM181"
                     /gene_synonym="GPR178; KIAA1423"
                     /inference="alignment:Splign:2.1.0"
     exon            1351..1440
                     /gene="TMEM181"
                     /gene_synonym="GPR178; KIAA1423"
                     /inference="alignment:Splign:2.1.0"
     exon            1441..1507
                     /gene="TMEM181"
                     /gene_synonym="GPR178; KIAA1423"
                     /inference="alignment:Splign:2.1.0"
     exon            1508..5127
                     /gene="TMEM181"
                     /gene_synonym="GPR178; KIAA1423"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5109..5114
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TMEM181"
                     /gene_synonym="GPR178; KIAA1423"
                     /note="hexamer: AATAAA"
     polyA_site      5127
                     /gene="TMEM181"
                     /gene_synonym="GPR178; KIAA1423"
                     /note="major polyA site"
ORIGIN      
        1 gagttttccg cggccggccg ctgctcagcc gctgtcgctc cggctccggc tgcggctgcc
       61 gctgccgagg ctgctgcgcg gcgcctggcg ggctcgggac gcgcgggccg gggccgaggg
      121 ctctgggcgc cgagatggag ccgctggcgc ccatgcggct ctacacgctc tccaagcgcc
      181 actttgtcct cgtgtttgtc gtcttcttca tctgctttgg cctgaccatc ttcgttggga
      241 tcagaggacc taaagtgatc cagacttctg cggctaattt ttcactaaat aatagcaaaa
      301 agctaaagcc aattcaaata ctttcaaatc cactgtctac atacaatcag caactatggc
      361 tgacatgtgt tgttgagttg gatcaatcaa aagaaacttc tattaagaca agctttccca
      421 tgactgttaa agtcgatggt gtagctcaag atggaaccac gatgtacatt cataacaaag
      481 ttcacaaccg gacaaggacc ctcacatgtg caggggcaaa tctttctgtg tatttgcaga
      541 aatgtgcgga gattattgtg gctcaccttg gctacctgaa ctacactcag tatacagtga
      601 tagtgggatt tgaacacctg aagctcccca tcaagggaat gaacttcaca tggaagactt
      661 ataaccctgc cttctcccgg ttggaaatct ggttccggtt tttctttgtg gtgctcacct
      721 tcatcgtcac ttgcctgttt gcgcattccc tccggaaatt ttccatgaga gactggggca
      781 tcgagcagaa gtggatgtct gttctcctgc ctctgctgct actttacaat gatccgttct
      841 tccccctctc cttcctggtc aacagctggc tcccagggat gctggatgac ctctttcagt
      901 ccatgttcct gtgcgccctg ctgctcttct ggctgtgcgt gtaccacggg attcgtgtcc
      961 agggagaaag aaagtgttta actttctatt tgcctaaatt cttcattgtt ggactattgt
     1021 ggttggcttc tgttacgcta ggaatatggc aaacagttaa cgaattacat gatccaatgt
     1081 accagtatcg agttgatacc ggaaattttc agggaatgaa ggtcttcttc atggtggtgg
     1141 cagcggtgta cattctgtac ctcttgttct tgatagtgcg ggcgtgttcc gagctacgtc
     1201 acatgcctta tgtggatctc aggttgaaat ttttgactgc attgactttc gtagtacttg
     1261 tcattagcat cgccatcctt tatttgagat ttggggcgca agtactacaa gacaattttg
     1321 tagcagagct gtcaactcac taccagaatt cagccgagtt cttatctttc tatggcctgt
     1381 tgaacttcta tctctacacc ttggcctttg tatattctcc atcgaagaat gccctctatg
     1441 agtcccagct gaaagacaat cctgccttct ccatgctgaa tgactcggat gatgatgtga
     1501 tttatgggag tgactatgag gaaatgccgc tgcagaacgg ccaggccatc cgggccaagt
     1561 acaaggagga gtcagatagt gactgagccc cggccagccc agcgaggcga caagatgcct
     1621 ggatgctttc cccggtgacc gtctgctgac cttcccctgt tatattcaga tttttcttac
     1681 aagcagagat ttcctgttca tttgtttaca tattttttta aaggaaaacc aaaactgagg
     1741 gtaaatttaa atgtttagcc aaatttattg tcatggtggc tacgagaaga ggcattgata
     1801 acaagtttca acagccaaat ccttttttac agagatttca gatgagcgtg ttttcagtga
     1861 tgaggaaatt tcacgttttt agtacagtga attatgtact tttttttcct gtaatcattc
     1921 actgattcca agttcacggg cagcctgtga ctaggtcctc agcgtgacag catcaccctc
     1981 tttcttccct tttccatggt actgttttgt gaccctttaa actcaaaggg aagccttatc
     2041 tgtggctgct tcagggcagt ccttcctcgt tgagtggcca gtgccctggg taaccaggtg
     2101 gctgaagtga ttggtcagtt atgtggactg cgttttgtgc agtgtgtgag ttatgactca
     2161 tcgggaatgg gagatgctgg ggttccaacc cttcacgtca ccaaagggga agtaatagtg
     2221 tggagttctg aggagggttt gataagttga ataaggaaag gctaagataa tttacaggtt
     2281 accaactcat gtggggaagg tcttactgcc atggtgcttt tcaggggcct gtgtgtacac
     2341 acatgattaa atggatttgc ctgtgggagg tatgggcagg agaggaaccc ttaccattcc
     2401 agtaaatagc agtttctgca attctgttga atatgaaatg ccatagagct ttatttattt
     2461 atgtaagtaa aagctaaatg aggggccagg tgcagtggct cacatctgta atctcaacac
     2521 tttgggaggc caaggtggga ggatcacttg agcccaggag tttgagacca gcctgggcaa
     2581 cacagggaga ccccgtctct ataaaacatt tagaaagttg gctgggcatg ctggggcatg
     2641 cccatagtcc cagctactca ggaggctgag gtgggaggat tgcttgagcc ctggaggtca
     2701 aggctgcagt gagccatgat tgcaccactg cactccagcc tgggtgtcag agcgagaacc
     2761 cgtgtcataa ataaataaag ctacatgaaa gattgataga atattttaga ttatttattg
     2821 gccaaaagtt tttaaaactc atatttggaa gcaaaatgaa aagcaagtaa aatgttttaa
     2881 atggttcatg gaaaacgtat ttgggtagaa ggcaactcgt gcttccggaa ggggttccct
     2941 gtcctccatg tgtccacatg gcggtcaggt agggacgacc tgttctgtaa agtccttggc
     3001 actgctgaat ctgtggcatc atagaaggcc ctggagcttc cccgttcctt tcagtcaggg
     3061 actccatata gagtctcatg tggacgtctc ccgtgctttc ctcttgacct ctacagtcac
     3121 acttctgtta acatctggta actgtgggca acctgactga tgccgtcttg gcaattgagg
     3181 tccagaagat gatagttccg caacgcaagc agtacctact ttttttcttc atctatgcat
     3241 tgactctcag attaccatgc agagcttcac gttatcatcc acgttaagta gtgctaggta
     3301 ggaccttaga gatgttcatg agaaactatt tgttatgact ttcctttgta tctttccttt
     3361 taatttaaac tttaatgata atgtactttt aatatggatt ctattcacat ttgttttaaa
     3421 aaccttgtaa atatgaatgt ttaagacaac ttactgcaag ggtaattcaa gtttacatga
     3481 tttttaaatt tgcaatgatg ttttttttat tctgtgtatt gaaaaaaatt ttctgttacc
     3541 aaattttaca acttctaata agactactat aactttatgt aaactgatga agatgtgctg
     3601 attaacatat tctgtgatat ggtttacaac ttttaatcat aattgtccat gattttggaa
     3661 tgctgttatt tatcagtaaa tgtaaaatat ttgaggcatt tagccataca cacactagaa
     3721 ctttttaaaa ctttgtccta tagtgtaatt ataaactgat gactattatc ttcatacatt
     3781 gagtcttcat gcatcaatga aatgaaaaat ataggattat ttatttactt tttgtaacta
     3841 agtgggaaat aagaaaaaaa gttagaaagt acttaagggg aaaatcgttc ttactaagtc
     3901 atgtattttc aacttgtctt ccctggtata tcataaatac cgacatatta cataccccat
     3961 gtaaaatttt gcttaaactc tctagcactt ggcatgtaga atatgtacca taggtatcag
     4021 gttaaaacac taaagtctgc cagaaacttt tgacagtagc aagaaaattg ttgaagaaaa
     4081 aataaattat ttactgaggg tagttatgtt aaagttttgc gaacttaaag ggctgacttt
     4141 agttccttca tggtaatggc ttgagtaaca tcatctttgg gattttttaa atactggtcc
     4201 agtctaggag aacctggaag atgaccagag gtatttcagt ttccctaggg agagcttcgt
     4261 tatccatgtg gatgataagt ctgcttgatt tattattaaa tcattatagc agtgaagtgg
     4321 tgccattttc tctctcttaa gccccatttg aaaggctaga gaaggggata tatatactat
     4381 gttcaaggtt tgtaaggttg ttaatgtaca taattgcaga ttgcaataaa agcttagata
     4441 cattttgtaa acccaaccca ctaaatgagc aggttacaag acaaatgtca ccagcctcaa
     4501 gtattttatg aactatttac tgagggtagt tatgttaaat agattataat gtggtaaatt
     4561 atttcctgaa tcctttatca caggaaaaac acagaccctc ataaaaggga taattaaaac
     4621 ggatgtgtct gaacatttag tgaagatgag acttaaaaca tgaaagtgta tttgtgtatt
     4681 ttgagggttt tagaaaccgg ttgccttaga ggttagactt ttgaagaaaa aaaaaaaaag
     4741 atacagatct tttcccctgg ccaaagggaa gttgtattag tctgtgacat cttgtgatgc
     4801 tgtttatctt ggtttgacat tggagatacg ctagtaactg tgataccata ctataaaaca
     4861 gaagaatttt ctgctactaa aaactgcctt tttacaaaat gactgtaaat atttgtaaaa
     4921 taaaataaca ctaaacttta agcccaaaag gagagataga gccatgtgtt cagttgtgga
     4981 cctgtccgtg gggcacagtg ccaccccatc acagtgttgc tgtcatcagg caaaagtgaa
     5041 tgtttgttta tggcaaattc gtcttttgcg aatggcttaa ttctgacact acctttctgg
     5101 gaaatgttaa taaattttta atattca
//
