LOCUS       NM_152834               6187 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens transmembrane protein 18 (TMEM18), transcript variant
            1, mRNA.
ACCESSION   NM_152834
VERSION     NM_152834.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6187)
  AUTHORS   Chermon,D. and Birk,R.
  TITLE     Drinking Habits and Physical Activity Interact and Attenuate
            Obesity Predisposition of TMEM18 Polymorphisms Carriers
  JOURNAL   Nutrients 15 (2), 266 (2023)
   PUBMED   36678137
  REMARK    GeneRIF: Drinking Habits and Physical Activity Interact and
            Attenuate Obesity Predisposition of TMEM18 Polymorphisms Carriers.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6187)
  AUTHORS   Landgraf,K., Kloting,N., Gericke,M., Maixner,N., Guiu-Jurado,E.,
            Scholz,M., Witte,A.V., Beyer,F., Schwartze,J.T., Lacher,M.,
            Villringer,A., Kovacs,P., Rudich,A., Bluher,M., Kiess,W. and
            Korner,A.
  TITLE     The Obesity-Susceptibility Gene TMEM18 Promotes Adipogenesis
            through Activation of PPARG
  JOURNAL   Cell Rep 33 (3), 108295 (2020)
   PUBMED   33086065
  REMARK    GeneRIF: The Obesity-Susceptibility Gene TMEM18 Promotes
            Adipogenesis through Activation of PPARG.
REFERENCE   3  (bases 1 to 6187)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 6187)
  AUTHORS   Rana,S. and Sultana,A.
  TITLE     Association of the Variant rs7561317 Downstream of the TMEM18 Gene
            with Overweight/Obesity and Related Anthropometric Traits in a
            Sample of Pakistani Population
  JOURNAL   Biochem Genet 58 (2), 257-278 (2020)
   PUBMED   31628562
  REMARK    GeneRIF: Association of the Variant rs7561317 Downstream of the
            TMEM18 Gene with Overweight/Obesity and Related Anthropometric
            Traits in a Sample of Pakistani Population.
REFERENCE   5  (bases 1 to 6187)
  AUTHORS   Kang,J., Guan,R.C., Zhao,Y. and Chen,Y.
  TITLE     Obesity-related loci in TMEM18, CDKAL1 and FAIM2 are associated
            with obesity and type 2 diabetes in Chinese Han patients
  JOURNAL   BMC Med Genet 21 (1), 65 (2020)
   PUBMED   32228543
  REMARK    GeneRIF: Loci near TMEM18 (rs6548238), CDKAL1 (rs7754840), and
            FAIM2 (rs7138803) may be associated with obesity-related
            indicators, and loci near TMEM18 (rs6548238) and FAIM2 (rs7138803)
            may increase susceptibility of concurrent type 2 diabetes
            associated with obesity.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 6187)
  AUTHORS   Trynka,G., Zhernakova,A., Romanos,J., Franke,L., Hunt,K.A.,
            Turner,G., Bruinenberg,M., Heap,G.A., Platteel,M., Ryan,A.W., de
            Kovel,C., Holmes,G.K., Howdle,P.D., Walters,J.R., Sanders,D.S.,
            Mulder,C.J., Mearin,M.L., Verbeek,W.H., Trimble,V., Stevens,F.M.,
            Kelleher,D., Barisani,D., Bardella,M.T., McManus,R., van Heel,D.A.
            and Wijmenga,C.
  TITLE     Coeliac disease-associated risk variants in TNFAIP3 and REL
            implicate altered NF-kappaB signalling
  JOURNAL   Gut 58 (8), 1078-1083 (2009)
   PUBMED   19240061
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   7  (bases 1 to 6187)
  AUTHORS   Renstrom,F., Payne,F., Nordstrom,A., Brito,E.C., Rolandsson,O.,
            Hallmans,G., Barroso,I., Nordstrom,P. and Franks,P.W.
  CONSRTM   GIANT Consortium
  TITLE     Replication and extension of genome-wide association study results
            for obesity in 4923 adults from northern Sweden
  JOURNAL   Hum Mol Genet 18 (8), 1489-1496 (2009)
   PUBMED   19164386
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   8  (bases 1 to 6187)
  AUTHORS   Willer,C.J., Speliotes,E.K., Loos,R.J., Li,S., Lindgren,C.M.,
            Heid,I.M., Berndt,S.I., Elliott,A.L., Jackson,A.U., Lamina,C.,
            Lettre,G., Lim,N., Lyon,H.N., McCarroll,S.A., Papadakis,K., Qi,L.,
            Randall,J.C., Roccasecca,R.M., Sanna,S., Scheet,P., Weedon,M.N.,
            Wheeler,E., Zhao,J.H., Jacobs,L.C., Prokopenko,I., Soranzo,N.,
            Tanaka,T., Timpson,N.J., Almgren,P., Bennett,A., Bergman,R.N.,
            Bingham,S.A., Bonnycastle,L.L., Brown,M., Burtt,N.P., Chines,P.,
            Coin,L., Collins,F.S., Connell,J.M., Cooper,C., Smith,G.D.,
            Dennison,E.M., Deodhar,P., Elliott,P., Erdos,M.R., Estrada,K.,
            Evans,D.M., Gianniny,L., Gieger,C., Gillson,C.J., Guiducci,C.,
            Hackett,R., Hadley,D., Hall,A.S., Havulinna,A.S., Hebebrand,J.,
            Hofman,A., Isomaa,B., Jacobs,K.B., Johnson,T., Jousilahti,P.,
            Jovanovic,Z., Khaw,K.T., Kraft,P., Kuokkanen,M., Kuusisto,J.,
            Laitinen,J., Lakatta,E.G., Luan,J., Luben,R.N., Mangino,M.,
            McArdle,W.L., Meitinger,T., Mulas,A., Munroe,P.B., Narisu,N.,
            Ness,A.R., Northstone,K., O'Rahilly,S., Purmann,C., Rees,M.G.,
            Ridderstrale,M., Ring,S.M., Rivadeneira,F., Ruokonen,A.,
            Sandhu,M.S., Saramies,J., Scott,L.J., Scuteri,A., Silander,K.,
            Sims,M.A., Song,K., Stephens,J., Stevens,S., Stringham,H.M.,
            Tung,Y.C., Valle,T.T., Van Duijn,C.M., Vimaleswaran,K.S.,
            Vollenweider,P., Waeber,G., Wallace,C., Watanabe,R.M.,
            Waterworth,D.M., Watkins,N., Witteman,J.C., Zeggini,E., Zhai,G.,
            Zillikens,M.C., Altshuler,D., Caulfield,M.J., Chanock,S.J.,
            Farooqi,I.S., Ferrucci,L., Guralnik,J.M., Hattersley,A.T., Hu,F.B.,
            Jarvelin,M.R., Laakso,M., Mooser,V., Ong,K.K., Ouwehand,W.H.,
            Salomaa,V., Samani,N.J., Spector,T.D., Tuomi,T., Tuomilehto,J.,
            Uda,M., Uitterlinden,A.G., Wareham,N.J., Deloukas,P.,
            Frayling,T.M., Groop,L.C., Hayes,R.B., Hunter,D.J., Mohlke,K.L.,
            Peltonen,L., Schlessinger,D., Strachan,D.P., Wichmann,H.E.,
            McCarthy,M.I., Boehnke,M., Barroso,I., Abecasis,G.R. and
            Hirschhorn,J.N.
  CONSRTM   Wellcome Trust Case Control Consortium; Genetic Investigation of
            ANthropometric Traits Consortium
  TITLE     Six new loci associated with body mass index highlight a neuronal
            influence on body weight regulation
  JOURNAL   Nat Genet 41 (1), 25-34 (2009)
   PUBMED   19079261
  REMARK    GeneRIF: Observational study, meta-analysis, and genome-wide
            association study of gene-disease association. (HuGE Navigator)
REFERENCE   9  (bases 1 to 6187)
  AUTHORS   Thorleifsson,G., Walters,G.B., Gudbjartsson,D.F.,
            Steinthorsdottir,V., Sulem,P., Helgadottir,A., Styrkarsdottir,U.,
            Gretarsdottir,S., Thorlacius,S., Jonsdottir,I., Jonsdottir,T.,
            Olafsdottir,E.J., Olafsdottir,G.H., Jonsson,T., Jonsson,F.,
            Borch-Johnsen,K., Hansen,T., Andersen,G., Jorgensen,T.,
            Lauritzen,T., Aben,K.K., Verbeek,A.L., Roeleveld,N., Kampman,E.,
            Yanek,L.R., Becker,L.C., Tryggvadottir,L., Rafnar,T., Becker,D.M.,
            Gulcher,J., Kiemeney,L.A., Pedersen,O., Kong,A.,
            Thorsteinsdottir,U. and Stefansson,K.
  TITLE     Genome-wide association yields new sequence variants at seven loci
            that associate with measures of obesity
  JOURNAL   Nat Genet 41 (1), 18-24 (2009)
   PUBMED   19079260
REFERENCE   10 (bases 1 to 6187)
  AUTHORS   Jurvansuu,J., Zhao,Y., Leung,D.S., Boulaire,J., Yu,Y.H., Ahmed,S.
            and Wang,S.
  TITLE     Transmembrane protein 18 enhances the tropism of neural stem cells
            for glioma cells
  JOURNAL   Cancer Res 68 (12), 4614-4622 (2008)
   PUBMED   18559506
  REMARK    GeneRIF: Overexpression of TMEM18 is associated with glioma
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL137269.1, CK826537.1, DN601654.1, FN163096.1, AC092159.4 and
            AI272939.1.
            
            On Nov 23, 2018 this sequence version replaced NM_152834.3.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BM762047.1, SRR1803612.15009.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000281017.8/ ENSP00000281017.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2091              AL137269.1         34-2124
            2092-2510           CK826537.1         134-552
            2511-2889           DN601654.1         285-663
            2890-2890           FN163096.1         33-33
            2891-3039           DN601654.1         665-813
            3040-6177           AC092159.4         15126-18263         c
            6178-6187           AI272939.1         30-39               c
FEATURES             Location/Qualifiers
     source          1..6187
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2p25.3"
     gene            1..6187
                     /gene="TMEM18"
                     /gene_synonym="lncND"
                     /note="transmembrane protein 18"
                     /db_xref="GeneID:129787"
                     /db_xref="HGNC:HGNC:25257"
                     /db_xref="MIM:613220"
     exon            1..118
                     /gene="TMEM18"
                     /gene_synonym="lncND"
                     /inference="alignment:Splign:2.1.0"
     CDS             62..484
                     /gene="TMEM18"
                     /gene_synonym="lncND"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /codon_start=1
                     /product="transmembrane protein 18 isoform 1"
                     /protein_id="NP_690047.2"
                     /db_xref="CCDS:CCDS33141.1"
                     /db_xref="GeneID:129787"
                     /db_xref="HGNC:HGNC:25257"
                     /db_xref="MIM:613220"
                     /translation="MPSAFSVSSFPVSIPAVLTQTDWTEPWLMGLATFHALCVLLTCL
                     SSRSYRLQIGHFLCLVILVYCAEYINEAAAMNWRLFSKYQYFDSRGMFISIVFSAPLL
                     VNAMIIVVMWVWKTLNVMTDLKNAQERRKEKKRRRKED"
     exon            119..239
                     /gene="TMEM18"
                     /gene_synonym="lncND"
                     /inference="alignment:Splign:2.1.0"
     exon            240..294
                     /gene="TMEM18"
                     /gene_synonym="lncND"
                     /inference="alignment:Splign:2.1.0"
     exon            295..388
                     /gene="TMEM18"
                     /gene_synonym="lncND"
                     /inference="alignment:Splign:2.1.0"
     exon            389..6187
                     /gene="TMEM18"
                     /gene_synonym="lncND"
                     /inference="alignment:Splign:2.1.0"
     regulatory      835..840
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TMEM18"
                     /gene_synonym="lncND"
                     /note="hexamer: AATAAA"
     polyA_site      854
                     /gene="TMEM18"
                     /gene_synonym="lncND"
                     /note="major polyA site"
     regulatory      2067..2072
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TMEM18"
                     /gene_synonym="lncND"
                     /note="hexamer: ATTAAA"
     polyA_site      2091
                     /gene="TMEM18"
                     /gene_synonym="lncND"
                     /note="major polyA site"
     regulatory      6151..6156
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TMEM18"
                     /gene_synonym="lncND"
                     /note="hexamer: AATAAA"
     polyA_site      6187
                     /gene="TMEM18"
                     /gene_synonym="lncND"
ORIGIN      
        1 ctctgtggat tctggccagg ccgggttcgg cggttgctgt gagagcgggc ttcccaacac
       61 catgccgtcc gccttctctg tcagctcttt ccccgtcagc atcccagccg tgctcacgca
      121 gacggactgg actgagccct ggctcatggg gctggccacc ttccacgcgc tctgcgtgct
      181 cctcacctgc ttgtcctccc gaagctacag actacagatc gggcactttc tgtgtctagt
      241 catcttagtc tactgtgctg aatacatcaa tgaggcggct gcgatgaact ggagattatt
      301 ttcgaaatac cagtatttcg actccagggg gatgttcatt tctatagtat tttcagcccc
      361 actgctggtg aatgccatga tcattgtggt tatgtgggta tggaagactt tgaatgtgat
      421 gactgacctg aagaatgcac aagagagaag aaaggaaaag aaaaggagaa ggaaagaaga
      481 ctgaggggca gcagctgctt ggagtttgcg tccttcccgt ccacccagtg cagctcccag
      541 tgctgcagtg tgcgtggcgt gggcatcctt ccagctgact catggtttga aaaaccgttg
      601 ttttatttaa atatccacag tggtagggca cacactgaag ttggcttttc agccagcact
      661 gaatgtatcc atcaggacat gcgtcttcag gtgcctgatc tttgtagtca ggctgtggga
      721 acggtctctg cagagcttca taactgggaa tttgatttga agaagtccat gtcatatgtg
      781 taactagtac taattataaa tataaaatac acaatataaa atatgaaact caataataaa
      841 cagtgccacc tgtacatggg caccatgccc tcctcctcgt gctgtgtttt ctagtgcatg
      901 ccacagttcg cagtagaggg tgttttcacc ttccaagaca tggggcaaag tttggagaca
      961 cctggttgtc actggagggg gtggtgctcc tggcttctcc tgtggagccc ggggtgatgc
     1021 ataaaatcct gtgtgcctgg gtcagccgca tcacagacaa tgacttgaca tgaaatgtca
     1081 gctgtgctgg ggcagagaga ccttggaagg aagctcttgg aaaatacgtt gtatctcagt
     1141 ttgatgaacc aattcacaag aggctaggcc ctctctagca aagttatggg ctgctttact
     1201 gaaaacagaa tggaagccct gaagtcaaca ctccatggag aagcgtgtct ttcctaatgt
     1261 cctggtgttc tgttgattta ggtgcttggg aacacaatgc tcccagttct gttaggacag
     1321 gcatactgtt actttgcaat atccacttta taaaatagct cctgcccagt ggctcttggt
     1381 tcctgtcaaa tgtggacctg tagtttaaga atgacaggtg gttagagacc cagatattta
     1441 aaaataggtg ttcaataagg gaatactgat tgtgcattgt atctggatag catgcctaat
     1501 tgtgcatttc tgaaagttac caattcaaaa tgtaattgga acagttatct ttgattagac
     1561 aagcctggga agagaatgtt gaggtgcaga gctcaccagc caagttcatg cccctctcgg
     1621 gcctttgtgg ctgagaagtg ggacagaaag atgattaagg taatgtgtcc tccctgtagc
     1681 attgtccagg gccgttgtgt agatatttga cttcactgac agaaaagaaa ccagggagtt
     1741 tgtagagact gtgcattttt agtataacat tttcaccatc tgatatggtt tggctttgtg
     1801 tccccaccca aattgcatct caaattgtaa tccccatgtg tcaagggagg gacctgatgg
     1861 gaggtgatgg gatcatgggg gtggtttccc ctatgttgtt atcataatag agagggagtt
     1921 ctcacaagat ctgctggttt taaagacagc agtttcccct gctgtcactg tctctctcct
     1981 gctgccttgt gaagaaggtg cttgtttctc cctctgccat gattgtaagt ttcccgaggc
     2041 ctccccggcc atgtggaact gagtcaatta aacttcttgt ttataaagta atccaggtct
     2101 caggtagtat ctttatagca gtgtgagaac agactaatta aacatctata tgttatttgg
     2161 acttaatatg gggccgtgtg attgaatctc agtttgcctg tgataaagta gtgtaacagt
     2221 attgctagct ttgcatgaat ttgatgctga tgacatgtca gtgtgaaacc atgacgtgtg
     2281 gtctttgatt ttcattctgc atgtgtgtgt ctgtgttttg gaacagttat attttggttt
     2341 tgtaaaaaca accttcactt tatttttaac tgtgtagtaa gtttatattc aatgccttaa
     2401 agtgcattgt taacaattgt cttgatatgt tgtcctcatt ttagggaaag tcatagaagc
     2461 caaaatgatc agcagttgag taatttacga aagcacaggt gcaatcccac tttaaagcac
     2521 tgggggttgc acagagcaca ctggtttcag gctccataaa tgtggatgac tcactggaga
     2581 gcttcatctg tttaagtaga acaaatgttt ttactctact gataaagtac aggaaaggag
     2641 gtttgggatc aaaattattt ttcacattcc aaacctgtga caccttacgt ttatcgattg
     2701 ctatgcaata aaatacatct ttaataatat gtagtatttt tttttgtttt tttcaaaaaa
     2761 atggtatttg ttttgcacct tactgtaact ggaaacagga gcacctggaa cttagctcca
     2821 cctttggctg gcaggtccct ttgctgcagc atctggtgct gagttttaac aaacaaatgc
     2881 aattgtgtcc ttgccagtag aagaaagtct acttgcacag ataatgtata tcaaatcaga
     2941 aagcaatatg caacctgaat ggctagcttc tgtgagaagt aaagtggcaa ggaaatgtta
     3001 acatgttctt gccctttaca aaataataaa tgttaaaaaa aaaaaaaaag ggctgggggt
     3061 ggaattcagg gtaaggagct tcagtggcgc gaagttgagt gggatgctta aagacagacg
     3121 agaattgccg tcagagatat accggtcagg cccaagcatc ttttccctgg aaaagaactt
     3181 caggcttcct tgtctggatt tcagtggagc acccttcttc tttcaccaag ttaaccagaa
     3241 catgttttca gtgcagcctt cccctcttta ctgaagcccc tcttgctggt cgactacacc
     3301 agcaagtcgg tcctggggag gacggggctg ggctccacat gcagagttct cggaggcagg
     3361 aagggagcga gccagggcag agaagagcac ccagggggtg gcgctgccca gtcccaggat
     3421 ggtgcgaaga tgtctccaag ccctggttgc tgcacaggga aggcaggatg gggcggcgag
     3481 gcccacgcag gctgtgggtg ccatgcgttg gtggcagctt gttccgagtg gggctggaac
     3541 agttgacagc aagcatcctc atcggcctgg taagctttct agctcctctt cctccgatgt
     3601 tccagtttca cagcggcctg tacagttaga tctttcctcg ctttggggga aggtgtagct
     3661 attatagtct ccgaatcatg ctgtcattag aaattgcaca agacctatgc caggggaggc
     3721 gctgactggc acaggccctg aaaggaacct gaggacagag aaggagctcc ctgcagcctt
     3781 caggcagcca agcagaggcc taagtccaag catgtggcca tagggtctgc tctgtaagcc
     3841 tcagggctac tgccttctgc tccagtcctg ggccaaaaca cccttcagca gctcctgctc
     3901 catctgagcg agctggatgt cagcctccat gggccctgtt gtgcatgggg ttgatgcttc
     3961 atctgagtga gctgggcatc tgcctccatg ggtcctgttg tgtgtagggt tgatgctcca
     4021 tctcagtgag ctgagcatct gcatctcggg gttctgttgt acatggggtt aatactccat
     4081 ccgagtgagc tgggcatccg catctctggg ttttgtgtgc gtggggttaa cactccatct
     4141 gagtgagctg ggtgactgcc tccatgagtc ctgttgtgtg tggggttgat gctccatctg
     4201 agtgagtggg gcatctgcat ctctgtgtcc tgttgtgtgt ggggttgatg ctgcatctga
     4261 gtgagtgggg catctgcatc tctgggtcct gttgtgtgtg gggttgatgc tccatctgag
     4321 tgagtggggc atctgcatct ctgggtcctg ttgtatgtag ggttgattct ctatctgagt
     4381 gagtggggca tctgcatctc tgggttctgt tgtatgtggg gttgttgctc tgagtgagtg
     4441 gtgcatctgc atctctgggt tctattttat gtggggttga ttctctgagt gagtggggca
     4501 tctgcatctc tgggttctag tttatgtggg gttgattctc tgtctgagtg agtggggtgt
     4561 ttgcatctct gggtcctgtt gtatgtggag ttgattctct atctgagtga gtggagcatc
     4621 tgcatctctg ggtcctgttg tatgtggggt tgattatctg agtgaatggg gcatctgcat
     4681 ctctgggttc tagtttatgt ggggttgatt ctctatctga gtgagtggtg catctgcatc
     4741 tctgggttct attttatgtg gggttgattc tctatctgag tgagtggggt gtctgcatct
     4801 ctggatcctg ttgtatatgg ggttgattct ctatcggagt gagtggggca tctgcatctc
     4861 tgggttctgt tgtatgtggg agtgatgctc catctgagct gggcgtctgc atctctgggt
     4921 ttatggatcc ctaagcccaa ctcactcaca gcttggccct ccatgtgctg gtctttcctc
     4981 tgccttaccc atgtttggtt atttcttata taacattgga tatctttgga acaggagaaa
     5041 attgttaagt gtcaatttgc tgcccctttt ttctgtaagt ctatcttcta taaagtaatg
     5101 tagtccctat tatcatgatg ctatttcact atataacatt attttcaatg cctgcatagt
     5161 aaacacattg taggggtata ggctgaattt acgtaaccag ttactgatat tagagatgca
     5221 gagtttttct aattgtttta ctgacaacag caacacagaa atctccaacc tcacatgcct
     5281 acatttccac tattgacttg gaataaattc ttacaagtga aatttagtca acatatataa
     5341 cttttatgtg acagttggta aatgttgcta aatcaatttt cagaaagcat atgccaatat
     5401 tggttgtaca tatttcctga aatccttgtc tgcactaagt agcaacgtaa aaaaagaaac
     5461 ttttctgagt aataggtgaa agttttatct cactgtttta acttgtactt ctgtggttac
     5521 ctgtgaggtt taacgctttt caaatgattg ttggtgtttt gcattttttt agtgaataat
     5581 ctgttcgtat tcttctttgt tttgcaatat gggctttaaa aaacctattt ctaattttat
     5641 gtgttaaaat tggtaacaca tatagggcag aaatatgtgt tactagtctg tagtttggct
     5701 ttggcttgtg ttgaaaaggt tttagaaagt caaacagttt tttgctttat gtatcatcag
     5761 gaactgtgaa gagctgaggt tccacctcct cccaagctga caagtgaccc tcggagaaga
     5821 accgtgaaaa cctcacaaca gtgaagttag tttaaacaag ttacaacgac aaacacattg
     5881 tgccatcctt atgatttcac ctgttactta gttcacactg atgggtggct ggtgtttaaa
     5941 tgctttccaa gttcatttca tttattatac aaatgcctgt gaaataccca ggcagcatca
     6001 ttgcttcctt ctctagcctc caaaccgaat atccttttgc tcaagcatcc aggtaaaaaa
     6061 agggggacct taggaattgt gaatttgaag ccagaagcca tggtttacct aggaatggat
     6121 ttacttgcca agaactgtga cacctttata aataaagtta ctcatgttgg cttttttgct
     6181 ctttaaa
//
