LOCUS       NM_199337               1043 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens transmembrane protein 179B (TMEM179B), transcript
            variant 1, mRNA.
ACCESSION   NM_199337 XM_350833
VERSION     NM_199337.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1043)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 1043)
  AUTHORS   Gonzalez,P., Epstein,D.L. and Borras,T.
  TITLE     Characterization of gene expression in human trabecular meshwork
            using single-pass sequencing of 1060 clones
  JOURNAL   Invest Ophthalmol Vis Sci 41 (12), 3678-3693 (2000)
   PUBMED   11053263
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BE439533.1, BC051355.1 and BM684628.1.
            
            On Nov 22, 2018 this sequence version replaced NM_199337.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189652.208974.1,
                                           SRR5189655.191679.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000333449.9/ ENSP00000333697.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-25                BE439533.1         2-26
            26-889              BC051355.1         1-864
            890-1043            BM684628.1         18-171              c
FEATURES             Location/Qualifiers
     source          1..1043
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q12.3"
     gene            1..1043
                     /gene="TMEM179B"
                     /note="transmembrane protein 179B"
                     /db_xref="GeneID:374395"
                     /db_xref="HGNC:HGNC:33744"
     exon            1..126
                     /gene="TMEM179B"
                     /inference="alignment:Splign:2.1.0"
     CDS             31..690
                     /gene="TMEM179B"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1"
                     /codon_start=1
                     /product="transmembrane protein 179B isoform 1 precursor"
                     /protein_id="NP_955369.1"
                     /db_xref="CCDS:CCDS8036.1"
                     /db_xref="GeneID:374395"
                     /db_xref="HGNC:HGNC:33744"
                     /translation="MALSWLQRVELALFAAAFLCGAVAAAAMTRTQGSFSGRCPLYGV
                     ATLNGSSLALSRPSAPSLCYFVAGASGLLALYCLLLLLFWIYSSCIEDSHRGAIGLRI
                     ALAISAIAVFLVLVSACILRFGTRSLCNSIISLNTTISCSEAQKIPWTPPGTALQFYS
                     NLHNAETSSWVNLVLWCVVLVLQVVQWKSEATPYRPLERGDPEWSSETDALVGSRLSH
                     S"
     exon            127..314
                     /gene="TMEM179B"
                     /inference="alignment:Splign:2.1.0"
     exon            315..449
                     /gene="TMEM179B"
                     /inference="alignment:Splign:2.1.0"
     exon            450..528
                     /gene="TMEM179B"
                     /inference="alignment:Splign:2.1.0"
     exon            529..1043
                     /gene="TMEM179B"
                     /inference="alignment:Splign:2.1.0"
     regulatory      867..872
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TMEM179B"
                     /note="hexamer: ATTATA"
     polyA_site      889
                     /gene="TMEM179B"
                     /note="major polyA site"
     regulatory      1019..1024
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TMEM179B"
                     /note="hexamer: AATGAA"
     polyA_site      1043
                     /gene="TMEM179B"
ORIGIN      
        1 gcagcggcgc ttcctggtgg tcagggcgcc atggcgctgt cctggctgca gcgcgtcgag
       61 cttgcgctct ttgctgccgc cttcctgtgc ggggccgtgg cggccgcggc gatgactcgg
      121 acccagggct ccttcagtgg tagatgtccc ctgtatggtg tggccaccct gaatggctcc
      181 tccctggcct tatcccgtcc ctcagcacca tccctgtgct actttgtagc tggggcctct
      241 ggcctcttgg ccctctactg cctcctgctt ttgctcttct ggatctacag cagctgcatc
      301 gaggactccc acagaggtgc tatagggctg cgcattgcac tggccatctc agctatagcc
      361 gtcttcctgg tcttggtgtc tgcctgtatc cttcgatttg gcaccaggtc tctctgcaac
      421 tccatcatct ccttgaacac tacaattagc tgttctgaag cccagaaaat tccatggaca
      481 ccccctggaa ctgctctgca gttttactcc aacctacaca atgctgaaac ctcttcttgg
      541 gtgaatttgg tattgtggtg tgtggtcttg gtgctccagg tcgtgcagtg gaagtctgaa
      601 gccaccccat accggcctct ggagaggggt gaccctgagt ggagctctga gacagatgct
      661 ctcgttgggt cacgcctttc ccattcctga agaataagcg gagtgcttcc tgcagccgaa
      721 gactccatgc ccaagtgcct gtaatccccc ccctcaaggc cctgtttatg ttgggagtct
      781 tagttttcct ttcgttgggg ggtggggggg aaacataatg acaggccccc ctccacctct
      841 tcctgcagct gtttttgtac caaaatatta tattactgtc ttcatcttag tagtgagttt
      901 ttgatgttaa agtacaacta gataggagga aggagtgaag gctaagcaga catggactga
      961 aacttagagg tactgttagg cagctgccct agggatgact gctcctttat ttgttgttaa
     1021 tgaatcttga cctccttgtg tga
//
