LOCUS       NM_001286389            3348 bp    mRNA    linear   PRI 09-FEB-2025
DEFINITION  Homo sapiens transmembrane protein 179 (TMEM179), transcript
            variant 1, mRNA.
ACCESSION   NM_001286389 XM_005267633
VERSION     NM_001286389.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3348)
  AUTHORS   He,Z., Zhang,Y., Zhang,H., Zhou,C., Ma,Q., Deng,P., Lu,M., Mou,Z.,
            Lin,M., Yang,L., Li,Y., Yue,Y., Pi,H., Lu,Y., He,M., Zhang,L.,
            Chen,C., Zhou,Z. and Yu,Z.
  TITLE     NAC antagonizes arsenic-induced neurotoxicity through TMEM179 by
            inhibiting oxidative stress in Oli-neu cells
  JOURNAL   Ecotoxicol Environ Saf 223, 112554 (2021)
   PUBMED   34332247
REFERENCE   2  (bases 1 to 3348)
  AUTHORS   Heilig,R., Eckenberg,R., Petit,J.L., Fonknechten,N., Da Silva,C.,
            Cattolico,L., Levy,M., Barbe,V., de Berardinis,V., Ureta-Vidal,A.,
            Pelletier,E., Vico,V., Anthouard,V., Rowen,L., Madan,A., Qin,S.,
            Sun,H., Du,H., Pepin,K., Artiguenave,F., Robert,C., Cruaud,C.,
            Bruls,T., Jaillon,O., Friedlander,L., Samson,G., Brottier,P.,
            Cure,S., Segurens,B., Aniere,F., Samain,S., Crespeau,H., Abbasi,N.,
            Aiach,N., Boscus,D., Dickhoff,R., Dors,M., Dubois,I., Friedman,C.,
            Gouyvenoux,M., James,R., Madan,A., Mairey-Estrada,B., Mangenot,S.,
            Martins,N., Menard,M., Oztas,S., Ratcliffe,A., Shaffer,T.,
            Trask,B., Vacherie,B., Bellemere,C., Belser,C., Besnard-Gonnet,M.,
            Bartol-Mavel,D., Boutard,M., Briez-Silla,S., Combette,S.,
            Dufosse-Laurent,V., Ferron,C., Lechaplais,C., Louesse,C.,
            Muselet,D., Magdelenat,G., Pateau,E., Petit,E.,
            Sirvain-Trukniewicz,P., Trybou,A., Vega-Czarny,N., Bataille,E.,
            Bluet,E., Bordelais,I., Dubois,M., Dumont,C., Guerin,T.,
            Haffray,S., Hammadi,R., Muanga,J., Pellouin,V., Robert,D.,
            Wunderle,E., Gauguet,G., Roy,A., Sainte-Marthe,L., Verdier,J.,
            Verdier-Discala,C., Hillier,L., Fulton,L., McPherson,J.,
            Matsuda,F., Wilson,R., Scarpelli,C., Gyapay,G., Wincker,P.,
            Saurin,W., Quetier,F., Waterston,R., Hood,L. and Weissenbach,J.
  TITLE     The DNA sequence and analysis of human chromosome 14
  JOURNAL   Nature 421 (6923), 601-607 (2003)
   PUBMED   12508121
  REMARK    Erratum:[Nature. 2023 Aug;620(7973):E17. doi:
            10.1038/s41586-023-06403-y.. PMID: 37491470]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BX927359.1, AK124477.1 and AW026835.1.
            
            On Nov 23, 2018 this sequence version replaced NM_001286389.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.549334.1,
                                           SRR3476690.28785.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2142586, SAMEA2145544
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000556573.6/ ENSP00000450958.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-12                BX927359.1         155522-155533       c
            13-137              AK124477.1         1-125
            138-633             AW026835.1         1-496
            634-3348            BX927359.1         141625-144339       c
FEATURES             Location/Qualifiers
     source          1..3348
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q32.33"
     gene            1..3348
                     /gene="TMEM179"
                     /gene_synonym="C14orf90; TMEM179A"
                     /note="transmembrane protein 179"
                     /db_xref="GeneID:388021"
                     /db_xref="HGNC:HGNC:20137"
     exon            1..336
                     /gene="TMEM179"
                     /gene_synonym="C14orf90; TMEM179A"
                     /inference="alignment:Splign:2.1.0"
     CDS             32..733
                     /gene="TMEM179"
                     /gene_synonym="C14orf90; TMEM179A"
                     /note="isoform 1 is encoded by transcript variant 1;
                     transmembrane protein 179A"
                     /codon_start=1
                     /product="transmembrane protein 179 isoform 1"
                     /protein_id="NP_001273318.1"
                     /db_xref="CCDS:CCDS66723.1"
                     /db_xref="GeneID:388021"
                     /db_xref="HGNC:HGNC:20137"
                     /translation="MALNNFLFAQCACYFLAFLFSFVVVVPLSENGHDFRGRCLLFTE
                     GMWLSANLTVQERERFTVQEWGPPAACRFSLLASLLSLLLAAAHAWRTLFFLCKGHEG
                     SFFSAFLNLLVSAFVVFLVFIASTIVSVGFTMWCDTITEKGTVPHSCEELQDIDLELG
                     VDNSAFYDQFAIAQFGLWASWLAWLAITTLAFLKVYHNYRQEDLLDSLIHEKELLLAR
                     PSPRTSFQEEKSAVI"
     exon            337..474
                     /gene="TMEM179"
                     /gene_synonym="C14orf90; TMEM179A"
                     /inference="alignment:Splign:2.1.0"
     exon            475..553
                     /gene="TMEM179"
                     /gene_synonym="C14orf90; TMEM179A"
                     /inference="alignment:Splign:2.1.0"
     exon            554..3348
                     /gene="TMEM179"
                     /gene_synonym="C14orf90; TMEM179A"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3329..3334
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TMEM179"
                     /gene_synonym="C14orf90; TMEM179A"
                     /note="hexamer: AGTAAA"
     polyA_site      3348
                     /gene="TMEM179"
                     /gene_synonym="C14orf90; TMEM179A"
                     /note="major polyA site"
ORIGIN      
        1 cttcccgccg ccgctctcgc ccgggccggc catggcgctc aacaatttcc ttttcgctca
       61 gtgcgcctgc tacttcttgg ccttcctgtt cagcttcgtg gtggtggtcc cgctgtccga
      121 gaacggccac gacttccgcg gccgctgcct gctcttcacc gagggcatgt ggctgagcgc
      181 caacctcacg gtgcaggagc gcgagcgctt cacggtgcag gagtggggcc cgccggccgc
      241 ctgccgcttc agcctgctcg ccagcctcct gtctctgctg ctggccgccg cgcacgcctg
      301 gcgcacgctc ttcttcctct gcaagggaca cgagggctcc ttcttctccg ccttcctgaa
      361 cctcctggtc agcgccttcg tggtcttcct ggtcttcatt gccagcacca tcgtgagcgt
      421 gggcttcacc atgtggtgcg acaccatcac cgagaagggc accgtacccc acagctgtga
      481 agagctccag gacatcgact tggagctggg cgtggacaac tccgccttct acgatcagtt
      541 tgcaattgcc cagtttggcc tctgggcctc atggctggcc tggctggcca tcaccacgct
      601 ggccttcctg aaggtctacc acaactaccg tcaggaggac ctgctggaca gcctgatcca
      661 cgagaaggag ctgctgctgg cccggccgtc cccacgcacc tccttccaag aggagaagag
      721 cgctgtcatt taggcacagt gcaggcaggg ggagctggcc ccgacctccc tgctgcgctc
      781 gggggcacgg gcctgcctgg ggaagcagct ggggggctct gcctgggccc tggccacatg
      841 cagccctgcg tgtgtcccct cgacgccacg tgtagtgagg tgagcgcccc agtgcccacc
      901 tgtgagcctg gcagtggact gggtgggtgc cggctccctg atgaggatgg tgcagagaga
      961 ctatgggtgt ggggcggggg cggggggcac ctccaggcct cgcacagggc cccttggctg
     1021 tcccagtagg acctgactgg ccagcctatg tggagggcgt ccagcttgtc tcccccaacc
     1081 ctggccggat gctgtctcca tgccagctgg cccaggggtg gccagatgtc acttagccct
     1141 gaacgaattc tgcatgaatt ctgccatcca ggcagaggct gcgtgtgggg aggagctcac
     1201 ggcaccttcc agcctctggc cccaggttgg ccccctcccc agctgagtcc ccctcctggg
     1261 tgggtgccat aggcctggga gaccctgtgg ccgggctcag ggaggcttct gaggcctgtg
     1321 agttcacctc actgtgtgtg ggtcctgtct gtgcttggct gagggtcagg gaagtggtaa
     1381 tctgggctcc acagaatcgg gggcatcatc tggttgggga tttcgggggc acacgtacca
     1441 catagaggac tgggccagga gccatggcag gggtctgtgt gtgggtgagt atgggaggat
     1501 gtgattgtga gtgcctttgt gcatgggagg gtgtgattgt gtatatgagt gcatgagagg
     1561 atgtgactga gtgtgcatgt gtgggtgtga cagtgcaggt gtgactgcat gtgaaggtgt
     1621 cactgagtgt gcacgagagg gtgtgactgc atgtgagagt gtgtgactgc atgggaggat
     1681 atgagtgtgc atgagtgtgc atgtgagggt gtgactgagt gcatgagagt gtgactgcct
     1741 gtgagtgaat gtgtgactgc atgtgcgagt gactgcctgg gaggatgtga ttgtgcatga
     1801 gtgtgcatgt gggtgtgact gcatgtgagg gtgtgactgt tgtgcgtgtg aaggcttgat
     1861 tgtgagtgtg cctgggagga tgtgagtgtg agggtgtgac tccctgtgac atgagtgtgc
     1921 atgcatgtga gtgtgaggaa gagtgtgtag gtgtgagtgt ctaggcaggt gtgtctgcag
     1981 tgtgtgcagc atgtgcgtaa gtgcatgtga atgtgcgtgt gttgcatgtg agcatgtgca
     2041 cgcctgtgcg tgtgagcatt gtgtgcgtga tgggagccgt gggtgctgtg tggacagccc
     2101 ctctgcccct cccatgggct cccacgccca gcatccacct gagagaggag ggagctgcct
     2161 tcccattctg cagagtctgt gtgctgaggc cccgcagaag caagtggagg agctgggatg
     2221 tgaacctggg accccggcgt agggggctgc ttggctgtgg accctgcccc tcaggaaagc
     2281 ccagggtcca cctccagagg actcgttctg gggcgggggc ggaggcgggg ggcctcccca
     2341 cccggggctc gatgaggggc tgtccgtttc ttggctcgag tgctgccaag tgctccctgc
     2401 tgctgcgccc accttcccgg ggagaggcga gcccctggct ccctgagttc atgacccacc
     2461 ctgtccacca tcagcagctg gcttgtgtct ctgggtggct gggcaccagc ctcctggagg
     2521 ccacgtgcct gggtccacat ggagggtcct ggtgggggca tcatcctggg tcccgggagt
     2581 gaggctggca ggtgcccatc gggggtgtca agtccagggg gatcgaggct ctggaagctc
     2641 aagggggctc tggccttggg gaccagctga gtttccagct ggcagccagg tcctcgaggg
     2701 aaggggtttg gacagaatcc gaggccccct aagctgatgg ggtcccctgt ctccccttcc
     2761 agccctgacc cactggacat ggggactctt tccagtccgg agagctcctt gtctgtgtcc
     2821 ccagcagaag gtggggtggc tcctgcctca ccctctgccc agccctgatc caggccacag
     2881 ccatctaggg ccctgaagga ggggcaggag gcaggggtgg cttctggaac ctgaggcttg
     2941 gccccggttg ggtctgttct tgggggctgc actgctggat cccaggagca ggtgtggaac
     3001 agccccatgg ccagggtgat ggaaatcctc ggctgcatgc agacatagac ccaccctgga
     3061 ctgggctgtc tccggagccc agacacatcg ccctgggaag gggcagctgg gcctgcagtg
     3121 tgctgggcag gggctggcgg ccctggtcgt gggctctcca gggtccctca ggggattggg
     3181 cctctcccca ggcaggaagg tgggaagtgc aggcatgacc cggggttcct gaggctggtc
     3241 caccaagttg cttctgagac gccttcgctt ctgtcctggc tggctgttaa tgatatccct
     3301 gttctaattc cactctggct aaactgaaag taaagatcct taagctta
//
