LOCUS       NM_001195278           10726 bp    mRNA    linear   PRI 09-FEB-2025
DEFINITION  Homo sapiens transmembrane protein 178B (TMEM178B), mRNA.
ACCESSION   NM_001195278 XM_001714428 XM_001716072 XM_001716337 XM_001716921
            XM_001723883 XM_001724518 XM_002344396 XM_002344427
VERSION     NM_001195278.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 10726)
  AUTHORS   Khanna,K., Yan,H., Mehra,M., Rohatgi,N., Mbalaviele,G.,
            Mellins,E.D. and Faccio,R.
  TITLE     Tmem178 Negatively Regulates IL-1beta Production Through Inhibition
            of the NLRP3 Inflammasome
  JOURNAL   Arthritis Rheumatol 76 (1), 107-118 (2024)
   PUBMED   37534578
  REMARK    GeneRIF: Tmem178 Negatively Regulates IL-1beta Production Through
            Inhibition of the NLRP3 Inflammasome.
REFERENCE   2  (bases 1 to 10726)
  AUTHORS   Yang,Z., Yan,H., Dai,W., Jing,J., Yang,Y., Mahajan,S., Zhou,Y.,
            Li,W., Macaubas,C., Mellins,E.D., Shih,C.C., Fitzpatrick,J.A.J. and
            Faccio,R.
  TITLE     Tmem178 negatively regulates store-operated calcium entry in
            myeloid cells via association with STIM1
  JOURNAL   J Autoimmun 101, 94-108 (2019)
   PUBMED   31018906
  REMARK    GeneRIF: Tmem178 modulates the rate-limiting step of STIM1 puncta
            formation and therefore controls SOCE in inflammatory conditions.
REFERENCE   3  (bases 1 to 10726)
  AUTHORS   Kim,H.S., Jung,M., Kang,H.N., Kim,H., Park,C.W., Kim,S.M.,
            Shin,S.J., Kim,S.H., Kim,S.G., Kim,E.K., Yun,M.R., Zheng,Z.,
            Chung,K.Y., Greenbowe,J., Ali,S.M., Kim,T.M. and Cho,B.C.
  TITLE     Oncogenic BRAF fusions in mucosal melanomas activate the MAPK
            pathway and are sensitive to MEK/PI3K inhibition or MEK/CDK4/6
            inhibition
  JOURNAL   Oncogene 36 (23), 3334-3345 (2017)
   PUBMED   28092667
REFERENCE   4  (bases 1 to 10726)
  AUTHORS   Zeng,Z., Feingold,E., Wang,X., Weeks,D.E., Lee,M., Cuenco,D.T.,
            Broffitt,B., Weyant,R.J., Crout,R., McNeil,D.W., Levy,S.M.,
            Marazita,M.L. and Shaffer,J.R.
  TITLE     Genome-wide association study of primary dentition pit-and-fissure
            and smooth surface caries
  JOURNAL   Caries Res 48 (4), 330-338 (2014)
   PUBMED   24556642
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC006362.2, AC006396.1, AC005692.1 and AC073878.7.
            
            On Nov 23, 2018 this sequence version replaced NM_001195278.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence because no single transcript was available for the
            full length of the gene. The genomic coordinates used for the
            transcript record were based on transcript and protein alignments.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA1965299,
                              SAMEA1968540 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000565468.6/ ENSP00000456594.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-629               AC006362.2         28133-28761
            630-743             AC006396.1         37437-37550
            744-881             AC005692.1         43863-44000
            882-10726           AC073878.7         14455-24299
FEATURES             Location/Qualifiers
     source          1..10726
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q34"
     gene            1..10726
                     /gene="TMEM178B"
                     /note="transmembrane protein 178B"
                     /db_xref="GeneID:100507421"
                     /db_xref="HGNC:HGNC:44112"
     exon            1..629
                     /gene="TMEM178B"
                     /inference="alignment:Splign:2.1.0"
     CDS             248..1132
                     /gene="TMEM178B"
                     /codon_start=1
                     /product="transmembrane protein 178B precursor"
                     /protein_id="NP_001182207.1"
                     /db_xref="CCDS:CCDS59086.1"
                     /db_xref="GeneID:100507421"
                     /db_xref="HGNC:HGNC:44112"
                     /translation="MAAGRLLLYTGLSLALCALGMLAVAICSDHWYETDARKHRDRCK
                     AFNTRRVDPGFIYNNNNNLPLRASRSRLDRWEGKLLRARNRRQLFAMSPADECSRQYN
                     STNMGLWRKCHRQGFDPEIAALIRKGEIERCTYIKYHYSSATIPRNLTFNITKTIRQD
                     EWHALHLRRMTAGFMGMAVAIILFGWIIGVLGCCWDRGLMQYVAGLLFLMGGTFCIIS
                     LCTCVAGINFELSRYPRYLYGLPDDISHGYGWSMFCAWGGLGLTLISGFFCTLAPSVQ
                     PVPRTNYPKSRPENGTVC"
     exon            630..743
                     /gene="TMEM178B"
                     /inference="alignment:Splign:2.1.0"
     exon            744..881
                     /gene="TMEM178B"
                     /inference="alignment:Splign:2.1.0"
     exon            882..10726
                     /gene="TMEM178B"
                     /inference="alignment:Splign:2.1.0"
     regulatory      10685..10690
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TMEM178B"
                     /note="hexamer: ATTAAA"
     regulatory      10697..10702
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TMEM178B"
                     /note="hexamer: AATAAA"
     polyA_site      10705
                     /gene="TMEM178B"
                     /note="major polyA site"
     polyA_site      10726
                     /gene="TMEM178B"
                     /note="major polyA site"
ORIGIN      
        1 acctgcctca gaggatgccc aggagcccgc gggagcctct ccggatcaga actttttagg
       61 ccgcccgccc ccatccccgc agtccccggg ccgtgctccg gtaggcgggg gccgaggggg
      121 cgccgcggcg cgagtccctc tcctgccccc tcccccagct cggccgcccg ccgctttgtt
      181 ccgggtgcgg cgagggaagg cgaggctgcg gcggatcatg cccatggtgt agccgccaag
      241 cggaggcatg gctgccggaa ggttactgct ctacactggc ctctcgctag cgctctgcgc
      301 cctcggcatg ctggccgtgg ccatctgctc ggaccactgg tacgagacgg acgccaggaa
      361 gcacagggac aggtgcaagg ccttcaacac ccgccgggtc gaccccggct tcatttacaa
      421 caataacaac aacttgccgc tccgggcgag ccgctcgcgc ctggaccgct gggagggcaa
      481 actcctccgg gcccggaatc gccggcagct gttcgccatg agccccgcgg acgagtgcag
      541 ccggcagtac aactccacca acatgggcct ctggaggaag tgccaccggc agggcttcga
      601 ccccgagatc gccgccctca ttcggaaagg agaaattgag cgatgtacgt acatcaaata
      661 ccactactcc tcagcaacca tccccaggaa cctcactttc aatatcacga agaccatccg
      721 tcaggatgag tggcatgccc tacacctgcg cagaatgacg gctggcttca tgggcatggc
      781 ggtggccatc atcctctttg gctggatcat cggcgtgctg ggctgctgct gggaccgagg
      841 ccttatgcag tacgtggcag ggctgctctt cctcatggga ggaaccttct gcatcatttc
      901 actgtgcacc tgtgtggccg ggatcaactt tgagctgtca cgctacccac gctacctgta
      961 cggactccct gatgacatca gccatggcta tggctggtcc atgttctgtg catggggggg
     1021 cctgggcctc acactcatct cgggattctt ctgtacctta gccccttctg ttcaacctgt
     1081 cccgaggacc aactacccta aatccagacc cgagaatggg acagtgtgct aaaaaacaaa
     1141 cccatacata catatatata tataaatata tatatataat atacatatat aaaacaaaac
     1201 aaaactaaat caagacgatg ccagtgccaa ggtagagttg agttggctca ggcacctgca
     1261 tctcgccgga ctttgtgttg cctcatctct gagatgggga aagtttttcc atcctgtggc
     1321 tcttccatca gttcttgact tttggcttca tggtctcttg aagacagagc aaacaccacc
     1381 acttgcgacc gcgtcttgat ccccatcact ggcgaggatg gggtggtgaa gggacagtgg
     1441 aaggggtctg aggcagcaca gatgtagaga aggaagtgcc acccactggg tcaacgggag
     1501 aggacgccac ccctaaccag tcatatcaca gggtaacaaa gccctcagtt cctagaatgt
     1561 aaccaaatta ttgaggccat tttcagaatc acttcttctc ctgctcttcc tgttcggact
     1621 tccttcccag cccaccagca acacacaagg agtggaagag aaaacaaact gagaaggacg
     1681 ttttctcttt gctgccaaac ttttggacca tgtttcatag gtgggaaggg aagagaacat
     1741 gctgagaggc aagatctgca tcaatgaaag gacgcttcgg tggatgctca gacaacccag
     1801 tcttaccttc cagctgcctt acacccagtg aaacaagagg ccaccctgtc cccagccgca
     1861 cctgcactcc ctgggcagac tggagccttg gagtcatgct gtgatgtgtg tgtgtgggtg
     1921 tgcgtgcatg tgtactttgg gcggtttcct ttttttcttt tctacctttt aaatggaaat
     1981 actgcattat gactgttgtc tctcttatca ctgtagtggt ttcatggccc cagatagagg
     2041 cccagagacc tagaaattgt catgagggac aggcctataa gggtgccaat tctgcagcta
     2101 cagatccctg gagtggtgtg tgtgtgcgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg
     2161 tgtggtggat gtttcttgag cgtggggttt tattgtttgt gttgtgtttt tttaaattgt
     2221 ttctggtata gctgaaattt ccagagggca gaaccaagaa caaagccact gggccagagg
     2281 acccccgtgg ttctccacat tacagctctg ggactctgca cgatttagtc ctctaatttt
     2341 ggaagttcaa gacacagctg ggcacataag ccatgagaga agagggggaa cacacagttc
     2401 aggagagaga agaaatgttg ctctggttgc tgttgtacaa gaacataaac caacaagacc
     2461 ttcactcccc attatagaag ctgtcctttg tcactggaca tctccccttt ccctaggggt
     2521 gacctctgta caaacgaaag gaagtgggtc acatgcagag agagcacctc catttcccat
     2581 gggctcaagt ttgtatgata ttgtgtaaat taatgcagaa ctcttgactc tttccatcct
     2641 cttcctttcc ctcttgatat tcaaggccat gaatcccaaa ataacagtct tagtggctag
     2701 cacccaaaca gaggtggaat aaatccaccc cagtgtctcg ggctcatttg agcaaattag
     2761 cactgcaggt gctggcaagc aaagtcagcc agagagttgt gaacgctgta ggggtgggag
     2821 tctgctggag tgggctggag ccgctcacag tcatctcagt gagcctgctg gtgcccagca
     2881 gccctgggga ggccaggtga gaatccctga gctggtgtag ccatggtcaa ctgtgtagca
     2941 gagaatcccc ttgtttcata aacaaatatg ctttgggagc tttgccaggc actcagcagc
     3001 ctttcttcca ctgctgtgta atctgtttca tttacacgtc ttccaaccca tcttcctacc
     3061 actctcctcc ttttctcacc tactaaccac ttaccttctc tctcttctat cttccaccct
     3121 catctgctcc tttgaactgc gtgtatgtaa ttcatatctg gatatgatat gacatctgat
     3181 gtgcatgaat ggggttgaat gtggatctct ctgtatgtgt atctctctgg tgcattttgt
     3241 gtacgtttgt gtcagtacac acctgcacac aggtgtgggt gccctactca agacttcctt
     3301 accggggact ctggtcagct tctgcaaaag gtctcatgtg tgagttccct gtgtgtgggt
     3361 gtgctgggcg atagggtaag gtgtgcaacg ggaaaagttg ttagcttcca gttggggttc
     3421 taaggattat ttttaaaaca aaggatttat tctatgagaa gggaaataat tttcaggaaa
     3481 acccagtttt tcaattgggc attttatttc taattttctt tgaaaagtta gatttctccc
     3541 ttaaggggaa gggcatactt gggcttaagg aaaagtgaag aaaagtatct cagattgaga
     3601 ggccttttgt cttccttcca agcgtcctga aggggctctg ccgaggaagg gacagacagg
     3661 ttcacaagca tccatttggg ggagagggct tgtctatgac cacactgaaa ttccagcttt
     3721 tttccagttg caggagagag gggaaaaatt ctaaatgggg aaatttgcta tgaaccattt
     3781 aaactttttg taagtaatca tgtttgagga tgctggctca cagacctatc attatttata
     3841 tcctcttttt aaaaaaaaat cccatacttt caatgaatag attatctgct ctatccaatt
     3901 attgtctttg tgacagacat ttagcaaagc ttactgcatc cctttgaaac cttgagagtt
     3961 cctgaaatgt tagaaagctc ccaggaaaga cgtaaacaac ctgggctcaa ctcaccagcc
     4021 cagagcaggg gctttgagtg acttctttga tagcaggacc agataaatac gaacacactt
     4081 tgggatctga tcctgctggg aagcaaaaga cgcccagcca catgaccagg atagaggccc
     4141 ctttcagacg gcaagtcctg gccaatggga ggacttctca ggtgaccttg atccctctag
     4201 cataagggct tgaccacaga ttaaaacatg tgactccaac cagttacgga agctttctgg
     4261 ctgtgaggta gctgagggag atgaggagga ggaagagagg agccttgact tgtgaggctc
     4321 tgtaggtcag actctgctaa ctccaaatca aagtggaacc caaccttatg agggcattta
     4381 gggtcaatga cctcactaaa gtcaccagcc gcaaccccag gtcaagttca aacttcttac
     4441 tggcatatga acatgtatgt gctttgagct ccatgcaagt caaccttgag cctggggccc
     4501 attgcaactt ttatttcctt ccctactcta ctaccttgag attcaggaaa gtgaggtatt
     4561 ctacctagag agaggtccca tatctttttc tccttatttt gggagttacg gtttcttctt
     4621 ctgtttccgt ttcctctctc tctactcact cctactttct cctgcatcaa ctttggtcaa
     4681 ttaacataga caagtgattc atctgtagag aggctcctag actccaagca gcccccttcc
     4741 ttgttcattg tggctgtagg ttttataagg aggtctgtgg ctccctggca tcaaaatatg
     4801 aaaaataaaa tctgtgcctg ttccagcttc aatcctcctc caagccttag cttttcaaca
     4861 accctaccct ttcaacttca gggatcatgg agtcacagag actggacaac tcctccaaat
     4921 ctagacaaag actttcttaa gcgccctgag cccaggtgca tatcttccca tcagggatga
     4981 gtggtcccac ctagcaatgc ttgcctctcc tgtgacaaga gggtaggata tcctaggact
     5041 ctgagactgg gccctatatc tcaatattca tccacactca tgataagatg ccggaaatga
     5101 atgcactgtg tgtagctgtc ttgatttagt gggaggatgt gctgcttagg tctccaaaga
     5161 tgcccacctg ggtcaaattc agaataatga actcaggtac atcacccaga ggcatttaga
     5221 atggactctc tcttcacctg gattatgtgc tgagtgttaa gtgatttttc aaatatctgg
     5281 gggaaggagt gggaagagat acactctggt catcctttgg tgtggtttgt gggggatact
     5341 tggttgattc ttgtagttaa agtgaagttg cttttctgaa aatgttccct gtcttcaggg
     5401 gacttaccca tcccagggga cacatccatc ccaggggaca cagccagccc tttccaggga
     5461 aatacgatgt ttctgagtga gaggtgattt cagtgcagat aggaagagct ggtgcacacc
     5521 agcagggttg ccttccatgc catcttccag ctggtgtggg atagactaag ggggcagatt
     5581 tttaagaacc ccaccagagt tgacatacac acgtgattct cgtgtctgtc tctcaaagct
     5641 ctcaatgtct ggggctgtgt ttgccctctt ttcattgatg ctgccatgat gcaaaatgtt
     5701 tcttaaacat tattcctggt tcttagaata tgtgattact gagtattgga tttctttcct
     5761 gaataataac tgctcattgt agaaaataag aaaaataaaa tacaaaaaag actacaagat
     5821 ttttcataat ccagtcactc tgaggcatct accgcgggcc caatccaaat ggtcatgacc
     5881 tcaaaacttc cccaatgagt gcttgtctct gggttggcag ctggggccat gtgagcagtg
     5941 tacaccacag aaccgcactg gtctgcgttg agttgaccct gtgttcctgg cagcaagagt
     6001 gcagggccct gagcccccag agatagcaaa gaggcctaaa agtttaatgc cagaccttag
     6061 gggcaggatg gagcagggct aaaagatgtc tctttgggcc tgtctgcctg ctttccttcc
     6121 ttccttttct ttcctttttt tttttggtca gttgccatct caatctaatc atagatgtaa
     6181 gaatgcggaa gccagagtaa ctcactcatt aagctacact tgtgtaacag ttactgtaaa
     6241 tttcactaca gctctgcact gaaatgattt gtgactctgg gcactgtgtc ttctccatac
     6301 ttgaacttcc tcatctacaa aatgaggata agtgataaca ccttacctca tggtatatta
     6361 agggtgacaa agaaattgca aagtgatttg caaacatgaa gtgtcatatg agttatgtat
     6421 gttctaatta tccctcagaa gaccccccgc tggaatggaa ttctcacatc aagtgtctgt
     6481 gcctcgctgc tgaaggataa cccagagtgc aaggtcatct ttgttgctga acagggctgg
     6541 acctgtcgca cttaagcaca cttaaaggat tctattcttc attcaggtcc cccagagaaa
     6601 ttggctcctt atttttcttt acctattcct agacttcctt ttgtctagag ccagttttgc
     6661 aaagggcact tttatccatc tcagttattc ccagaggtga cagaatgagt aaaccatatg
     6721 gggcaaatag catatatgag ctaaaccagt taactgttaa ccaaggcaca tggtcaatgc
     6781 cttagtattt ttttttttaa ttctcctaac gttatttcta gctgtacatt cccaaaagga
     6841 atgggtggaa gcaaatcaga ttctgaaagg tttcaatgat ctttcaagtt taggatgaga
     6901 ccaagtctca aggagctggg atcttctttc tcttgtcagt tgctgaagcc agtagcttcg
     6961 tcaaaaacat atgaattcat ataaggaagc cctttagatg gtacattcac taagacgtgt
     7021 ctgggtgtga tcctgtttgg gaaaaacaga atcctaggtt ctaaacaaga aaagaacgcc
     7081 cttcccaaag ggtccgcaca ctttctgctt tgcagcggat caagtgtcct tgtgagggtg
     7141 agacttcctt caagggaagg gaagccattg ctctctctgt agatagagcc cagctggtaa
     7201 cgggggagcc acccaactgc aggggggtgt atgttcaggt gtgaaaaaca gaaaactggg
     7261 tctgaacatg aagagttgca cagcagtagt tcgaagaagc tggcatctct ttggcaaaca
     7321 ccaacctcag caaatgcaac tcctacactt cattcccaag gaccaggtgt tgctccttaa
     7381 ggaactctgt atccctctct cctctccaga accccattcc tcccactggc tgagcttttc
     7441 ctttcctttc cgggtcaccc atagaccctc tccgtctgta ccagtgcgtc tgtgttgtga
     7501 gcgtgacgaa gcctttcctg tgaagagctt tcatgaactc attctcatac tccttcccca
     7561 tttccaccca tggtgtgact gttttgctat tcaagactat ctgtaaaaat gtacaaataa
     7621 aagtgaaaac tgaaaataaa ggggagggag attgagatta aacaaatgca atgatgtagc
     7681 ccttagtttt ctgaggactt ctgtggacgg ccctaaaatc ctgagttagg gtgggatatg
     7741 aagggaggga taccattgac acaggaggtt tttttctggt tgtttctctc acagtcatca
     7801 gtgtctgctt agaactctct gttctaaagg tttttccctg taaagtagaa tgcacttccc
     7861 ccaaaataaa agtaaatcag caatgtttga agggtcatgg caagggtcat gacaaagacc
     7921 tgactctggg gtggcatgag tggccctgtc accggctcac tcagggcctt gggggagtct
     7981 cattacctca ccttgtctcc acgtcttctc agccaaatgg ggatcagggg cttccagggc
     8041 tctgggggtg cgcagtcccc ttgtgtattt tgctgctatt tctagagaga ctttgagccc
     8101 ttgctagtgc gtgcttactg catggaggta aattaggaga tgttttctct ctgctactcc
     8161 tggcctctgc tttcgcccct cagaaagtga ccttgagcta gcagccagtt tgcactcaga
     8221 gtccagagcc ttctatctac cgtttcattc tcagattcct tttcccaccc actttgacga
     8281 tctcatttta ctatcagtct ctactgactg agctttgctg cactgggctg gggtaggaga
     8341 aagagcatcc aaggagatga tgtgtgaatt gctttgtaat ttatgactca ccatataaat
     8401 gtggcttgca gtgtcagaag cagggagtct ggccaagggt tgctaccaaa taagactgaa
     8461 gatggtggag gcagtggtgg cgtggaggca gtaggcagaa gatgtgggtt gggagcagag
     8521 gtaagatgaa cggagctttg ggaaggacag atggcagaag caccagaaaa tcctcagcaa
     8581 ggcagcagag aaggatcctc aaagcagtaa ccctgaagta ataggaagta ggaaagagga
     8641 gcagggatta ggtaaatctg cagcataaac agctgtctcc ctgcaggact gagaagacca
     8701 gctgccccag agaggggagg cacgtcgagc ttggccagtg acccaaccca tgattagagg
     8761 caccttcaat cccaactttc ctctcctctg ctgggtcaca gtgatggaac cagcttcagg
     8821 aaggtagtat agaccagcgt catccaatgg aaccatgatc caagccacat atgcaattta
     8881 aaatattcta gtagccacat tttttaaagt ccaaagaaac agctaaaatc agtgaaatta
     8941 atttttagac tacattttaa cctaacatgt caaaaatagt atcacttcag catggaatca
     9001 atataaaaat tactgggata ttttacattc ttttttccaa atgaagtctt caaaatccaa
     9061 tgtgattttc ctcttagaaa acatctcagt ctggcccagc cctatttcca gtgttcaata
     9121 gccacacctg actactggtt gctgtatagg acagcacgga cttaggttct tcattaggag
     9181 actgatgggg ggggtccttc ctggtgggtc actcactgcc atagctcttg tcatagctga
     9241 tgaaggcagg agtgagtctt attatgttgg cctagagtag aaagcacaga gctatgtcga
     9301 ggctgctgtc tcagcctctg gaagttctgc ttcacctgct tagtaagagg agatgaccac
     9361 tcctgtggac tgcatgtccc atctgccccc agagggtgtc ggcgctgccc cagtcatgtc
     9421 ccttatgacc tgtccaagtc ctagaggcca aagcaggtca tattcttcag ctgcaggaat
     9481 gtcagctact gcctcccacc ccttaacctg atccccttat catatagtgg ggaaggggca
     9541 ggcaggcctt ctctctgtca agaacaaaga tctctacaac atttcgtcac ctgggccagt
     9601 cacctgctaa tatcatctca ccaatatttg gagctgtttt ctgaatccct taattttctt
     9661 aaatatttat cttaaagtca aatgctataa aggagatacc ctgggaaggg cagtggccac
     9721 aggcagactg ggtctcctag gaggtggtgg tgttggtgac aagttctact tggactggga
     9781 ctcaacccac cattgcctac ctctcttccc tgcctggaga ccttccttag gattgaagaa
     9841 acctcttttg tttgtgaaaa agataggtat cgagatctta atggagagaa cagaataaaa
     9901 tgcaaggagc caacccctgg gtattctcaa agcatttcaa cggtcagtat aacaaggttt
     9961 gattgattta aaatataaca ttctgagccc tgtgttactg agcaaaaatg agctgatttg
    10021 gtgagtatgt tttatatatg gtcattagac agggaccata actgacaaaa ctctcaaacg
    10081 cctggagtgt ttatggccca ccagattatt gctcagtcaa tataaattta tttaccttta
    10141 ttttaatttg catagtgctt tctgattggt cagacaagga gtggtgtgta ctgcaggatt
    10201 ctaacaatgc ctctgccctt ggaggcagca attcctgtgg ttattggtgc taaaataaga
    10261 taaaatatta tgttaatttg ttctgatatg atgtgaataa atgtgttgtt taatcttaac
    10321 aagaatgcta catcttatca gatctattgt actgtctgtt ccttctcata attaattaat
    10381 tacaggaaag gcgattcaaa ccagatcttg aaactattgt gatgttctga gaggtaaatt
    10441 taacagggaa gtgggagggg ggatgaaaag ggaaattgcc aggttcctgt gactttgaaa
    10501 ggactgagga agcagagagc atttggggac ttcactgaaa ctgactgcat cttgcaattt
    10561 tctttttcga attggcagaa atattgtatt tccattgatt gaagaaaaac aagtgtctgg
    10621 taattaatta aatgacttgt tcatggaaaa aataaataat ctgtcagttg tggaatgtaa
    10681 actgattaaa caattaaata aagaagatta tgttgtgtgt tttaaa
//
