LOCUS       NM_152390               1664 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens transmembrane protein 178A (TMEM178A), transcript
            variant 1, mRNA.
ACCESSION   NM_152390
VERSION     NM_152390.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1664)
  AUTHORS   Decker,C.E., Yang,Z., Rimer,R., Park-Min,K.H., Macaubas,C.,
            Mellins,E.D., Novack,D.V. and Faccio,R.
  TITLE     Tmem178 acts in a novel negative feedback loop targeting NFATc1 to
            regulate bone mass
  JOURNAL   Proc Natl Acad Sci U S A 112 (51), 15654-15659 (2015)
   PUBMED   26644563
  REMARK    GeneRIF: Tmem178 localizes to the ER membrane and regulates
            RANKL-induced Ca(2+) fluxes, thus controlling NFATc1 induction
REFERENCE   2  (bases 1 to 1664)
  AUTHORS   Comuzzie,A.G., Cole,S.A., Laston,S.L., Voruganti,V.S., Haack,K.,
            Gibbs,R.A. and Butte,N.F.
  TITLE     Novel genetic loci identified for the pathophysiology of childhood
            obesity in the Hispanic population
  JOURNAL   PLoS One 7 (12), e51954 (2012)
   PUBMED   23251661
REFERENCE   3  (bases 1 to 1664)
  AUTHORS   Clark,H.F., Gurney,A.L., Abaya,E., Baker,K., Baldwin,D., Brush,J.,
            Chen,J., Chow,B., Chui,C., Crowley,C., Currell,B., Deuel,B.,
            Dowd,P., Eaton,D., Foster,J., Grimaldi,C., Gu,Q., Hass,P.E.,
            Heldens,S., Huang,A., Kim,H.S., Klimowski,L., Jin,Y., Johnson,S.,
            Lee,J., Lewis,L., Liao,D., Mark,M., Robbie,E., Sanchez,C.,
            Schoenfeld,J., Seshagiri,S., Simmons,L., Singh,J., Smith,V.,
            Stinson,J., Vagts,A., Vandlen,R., Watanabe,C., Wieand,D., Woods,K.,
            Xie,M.H., Yansura,D., Yi,S., Yu,G., Yuan,J., Zhang,M., Zhang,Z.,
            Goddard,A., Wood,W.I., Godowski,P. and Gray,A.
  TITLE     The secreted protein discovery initiative (SPDI), a large-scale
            effort to identify novel human secreted and transmembrane proteins:
            a bioinformatics assessment
  JOURNAL   Genome Res 13 (10), 2265-2270 (2003)
   PUBMED   12975309
  REMARK    Erratum:[Genome Res. 2003 Dec;13(12):2759]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DN993805.1, BC029530.1 and AC007246.3.
            
            On Nov 23, 2018 this sequence version replaced NM_152390.2.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC029530.1, AK075440.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA1968832
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000281961.3/ ENSP00000281961.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-36                DN993805.1         29-64
            37-376              BC029530.1         4-343
            377-377             AC007246.3         93957-93957         c
            378-1664            BC029530.1         345-1631
FEATURES             Location/Qualifiers
     source          1..1664
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2p22.1"
     gene            1..1664
                     /gene="TMEM178A"
                     /gene_synonym="TMEM178"
                     /note="transmembrane protein 178A"
                     /db_xref="GeneID:130733"
                     /db_xref="HGNC:HGNC:28517"
     exon            1..458
                     /gene="TMEM178A"
                     /gene_synonym="TMEM178"
                     /inference="alignment:Splign:2.1.0"
     CDS             59..952
                     /gene="TMEM178A"
                     /gene_synonym="TMEM178"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; transmembrane protein 178"
                     /codon_start=1
                     /product="transmembrane protein 178A isoform 1 precursor"
                     /protein_id="NP_689603.2"
                     /db_xref="CCDS:CCDS1804.1"
                     /db_xref="GeneID:130733"
                     /db_xref="HGNC:HGNC:28517"
                     /translation="MEPRALVTALSLGLSLCSLGLLVTAIFTDHWYETDPRRHKESCE
                     RSRAGADPPDQKNRLMPLSHLPLRDSPPLGRRLLPGGPGRADPESWRSLLGLGGLDAE
                     CGRPLFATYSGLWRKCYFLGIDRDIDTLILKGIAQRCTAIKYHFSQPIRLRNIPFNLT
                     KTIQQDEWHLLHLRRITAGFLGMAVAVLLCGCIVATVSFFWEESLTQHVAGLLFLMTG
                     IFCTISLCTYAASISYDLNRLPKLIYSLPADVEHGYSWSIFCAWCSLGFIVAAGGLCI
                     AYPFISRTKIAQLKSGRDSTV"
     exon            459..572
                     /gene="TMEM178A"
                     /gene_synonym="TMEM178"
                     /inference="alignment:Splign:2.1.0"
     exon            573..710
                     /gene="TMEM178A"
                     /gene_synonym="TMEM178"
                     /inference="alignment:Splign:2.1.0"
     exon            711..1664
                     /gene="TMEM178A"
                     /gene_synonym="TMEM178"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1641..1646
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TMEM178A"
                     /gene_synonym="TMEM178"
                     /note="hexamer: ATTAAA"
     polyA_site      1664
                     /gene="TMEM178A"
                     /gene_synonym="TMEM178"
                     /note="major polyA site"
ORIGIN      
        1 gcattgtgtc tggcggcggc gcgcgagccc accggcggct gcggcggggc gggaagccat
       61 ggagccgcgg gcgctcgtca cggcgctcag cctcggcctc agcctgtgct ccctggggct
      121 gctcgtcacg gccatcttca ccgaccactg gtacgagacc gacccccggc gccacaagga
      181 gagctgcgag cgcagccgcg cgggcgccga ccccccggac cagaagaacc gcctgatgcc
      241 gctgtcgcac ctgccgctgc gggactcgcc cccgctgggg cgccggctgc tcccgggcgg
      301 cccggggcgc gccgaccccg agtcctggcg ctcgctcctg gggctcggcg ggctggacgc
      361 cgagtgcggc cggcccctct tcgccaccta ctcgggcctc tggaggaagt gctacttcct
      421 gggcatcgac cgggacatcg acaccctcat cctgaaaggt attgcgcagc gatgcacggc
      481 catcaagtac cacttttctc agcccatccg cttgcgaaac attcctttta atttaaccaa
      541 gaccatacag caagatgagt ggcacctgct tcatttaaga agaatcactg ctggcttcct
      601 cggcatggcc gtagccgtcc ttctctgcgg ctgcattgtg gccacagtca gtttcttctg
      661 ggaggagagc ttgacccagc acgtggctgg actcctgttc ctcatgacag ggatattttg
      721 caccatttcc ctctgtactt atgccgccag tatctcgtat gatttgaacc ggctcccaaa
      781 gctaatttat agcctgcctg ctgatgtgga acatggttac agctggtcca tcttttgcgc
      841 ctggtgcagt ttaggcttta ttgtggcagc tggaggtctc tgcatcgctt atccgtttat
      901 tagccggacc aagattgcac agctaaagtc tggcagagac tccacggtat gactgtcctc
      961 actgggcctg tccacagtgc gagcgactcc tgaggggaac agcgcggagt tcaggagtcc
     1021 aagcacaaag cggtctttta cattccaacc tgttgcctgc cagccctttc tggattactg
     1081 atagaaaatc atgcaaaacc tcccaacctt tctaaggaca agactactgt ggattcaagt
     1141 gctttaatga ctatttatgc gttgactgtg agaataggga gcagtgccat gggacatttc
     1201 taggtgtaga gaaagaagaa actgcaatgg aaaaatttgt atgatttcca tttatttcag
     1261 aaagtttgta tgtaacaatt acccgagagt catttctact tgcaaaagga ttcgtaacaa
     1321 agcgagtata attttcttgt cattgtatca tgcttgttaa attttaatgc agcatcttca
     1381 gaacttgtcc tgatggtgtc ttattgtgtc agcaccaaat atttgtgcat tatttgtgga
     1441 cgttccttgt cacaggaaga ttcttcttct gttgccttat tgtttttttt tttttaagtc
     1501 tcttctctgt ctttgtactg gaatcgaaat cataagataa acagatcaaa cgtgcttaag
     1561 agctaactcg tgacactatg cagtattgtt tgaagacctg ttgttcaacc tctgtctctt
     1621 tatgttaact ggatttctgc attaaatgac tgcccccttg ttaa
//
