LOCUS       NM_030577               1363 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens transmembrane protein 177 (TMEM177), transcript
            variant 2, mRNA.
ACCESSION   NM_030577
VERSION     NM_030577.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1363)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   2  (bases 1 to 1363)
  AUTHORS   Lorenzi,I., Oeljeklaus,S., Aich,A., Ronsor,C., Callegari,S.,
            Dudek,J., Warscheid,B., Dennerlein,S. and Rehling,P.
  TITLE     The mitochondrial TMEM177 associates with COX20 during COX2
            biogenesis
  JOURNAL   Biochim Biophys Acta Mol Cell Res 1865 (2), 323-333 (2018)
   PUBMED   29154948
  REMARK    GeneRIF: data shows that by unbalancing the amount of TMEM177,
            newly synthesized COX2 accumulates in a COX20-associated state.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC069154.5.
            
            On Nov 23, 2018 this sequence version replaced NM_030577.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC004404.1, SRR3476690.284893.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000272521.7/ ENSP00000272521.6
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-76                AC069154.5         82753-82828
            77-1363             AC069154.5         84384-85670
FEATURES             Location/Qualifiers
     source          1..1363
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q14.2"
     gene            1..1363
                     /gene="TMEM177"
                     /note="transmembrane protein 177"
                     /db_xref="GeneID:80775"
                     /db_xref="HGNC:HGNC:28143"
                     /db_xref="MIM:620752"
     exon            1..76
                     /gene="TMEM177"
                     /inference="alignment:Splign:2.1.0"
     exon            77..1363
                     /gene="TMEM177"
                     /inference="alignment:Splign:2.1.0"
     CDS             99..1034
                     /gene="TMEM177"
                     /codon_start=1
                     /product="transmembrane protein 177"
                     /protein_id="NP_085054.2"
                     /db_xref="CCDS:CCDS2128.1"
                     /db_xref="GeneID:80775"
                     /db_xref="HGNC:HGNC:28143"
                     /db_xref="MIM:620752"
                     /translation="MAGPLWRTAAFVQRHRTGLLVGSCAGLFGVPISYHLFPDPVVQW
                     LYQYWPQGQPAPLPPQLQSLFQEVLQDIGVPSGHCYKPFTTFTFQPVSAGFPRLPAGA
                     VVGIPASFLGDLVINTNHPVVIHGHTVDWRSPAGARLRASLTLSREAQKFALAREVVY
                     LESSTTAVHALLAPACLAGTWALGVGAKYTLGLHAGPMNLRAAFSLVAAVAGFVAYAF
                     SQDSLTHAVESWLDRRTASLSAAYACGGVEFYEKLLSGNLALRSLLGKDGEKLYTPSG
                     NIVPRHLFRIKHLPYTTRRDSVLQMWRGMLNPGRS"
     regulatory      1343..1348
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TMEM177"
                     /note="hexamer: AATAAA"
     polyA_site      1363
                     /gene="TMEM177"
                     /note="major polyA site"
ORIGIN      
        1 gtaggcgttc cgagcggcgg cggaggtgag cgcacggacg agcgggaggg acccttctcc
       61 ggcctgatgc gacccgattg tccgcagtga ctacactcat ggcaggtccc ctgtggcgga
      121 ccgcagcatt tgtgcagaga cacaggacag gcctcttggt gggttcctgt gcaggcctgt
      181 ttggagttcc aatctcgtac cacctcttcc cggatcccgt ggtccaatgg ctctaccagt
      241 actggcctca gggccagcca gctccgctcc ctccacagct gcagagcctc ttccaagagg
      301 tgctacagga cataggtgtt ccttcaggcc attgctacaa gcccttcacc accttcacct
      361 tccaacctgt gagtgcaggc ttcccaagac tccctgctgg ggctgtggtg ggcatccctg
      421 ccagtttctt gggagaccta gtgatcaaca ctaaccatcc cgtggtcata catgggcata
      481 cagtggactg gcggagccca gcaggcgccc ggctgagagc ttccctgacc ttgtcccgtg
      541 aagcccagaa gttcgccttg gccagggaag tggtgtacct ggaaagcagt accactgccg
      601 tgcacgccct gctggcccca gcttgcctgg cagggacctg ggcactgggc gtgggtgcca
      661 agtacaccct ggggctccat gcaggcccca tgaatttacg ggctgccttc agcttggtgg
      721 cagcagtggc aggctttgtg gcctacgcct tctcccagga ttctctcact catgccgtgg
      781 agtcctggct ggaccgccgc acggcctccc tctctgcagc ctatgcctgt ggtggagtgg
      841 agttctatga gaagcttctg tcgggcaacc tggccctgcg cagtctcttg ggcaaagacg
      901 gggagaagct gtatacaccc agcgggaaca tcgtccccag acacttgttc cgaatcaaac
      961 atttacccta caccacccgc cgggactctg tgctgcagat gtggaggggg atgctcaatc
     1021 cgggccgctc ctgatgggct catcacaagg acacttccag cttgtgcaga caccaccctg
     1081 ccattgagtc tggagggccc tgttggagcc tttggaccta tagctcacgg ccagaaaaat
     1141 cactggcttt ggaattaaat agcttagatt gtactataac cactacttat gaactcaggg
     1201 actatgaggg actattcagg ggctatgaat ctgagccttt gtttcttgaa ctgtaaagtg
     1261 gagatgatgt aaaccgcctt gcaagattgt agagttgggt aaggtcatga acataagggc
     1321 ctggcacaaa gggtgcactg taaataaaca gacatccctc ctt
//
