LOCUS       NM_001101312            1115 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens transmembrane protein 176B (TMEM176B), transcript
            variant 3, mRNA.
ACCESSION   NM_001101312
VERSION     NM_001101312.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1115)
  AUTHORS   Cambui,R.A.G., Fernandes,F.P., Leal,V.N.C., Reis,E.C., de
            Lima,D.S., do Espirito Santo,G.F., Elias,R.M. and Pontillo,A.
  TITLE     The Ala134Thr variant in TMEM176B exerts a beneficial role in
            colorectal cancer prognosis by increasing NLRP3 inflammasome
            activation
  JOURNAL   J Cancer Res Clin Oncol 149 (7), 3729-3738 (2023)
   PUBMED   35980484
  REMARK    GeneRIF: The Ala134Thr variant in TMEM176B exerts a beneficial role
            in colorectal cancer prognosis by increasing NLRP3 inflammasome
            activation.
REFERENCE   2  (bases 1 to 1115)
  AUTHORS   Hill,M., Russo,S., Olivera,D., Malcuori,M., Galliussi,G. and
            Segovia,M.
  TITLE     The intracellular cation channel TMEM176B as a dual immunoregulator
  JOURNAL   Front Cell Dev Biol 10, 1038429 (2022)
   PUBMED   36340035
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1115)
  AUTHORS   Kang,C., Rostoker,R., Ben-Shumel,S., Rashed,R., Duty,J.A.,
            Demircioglu,D., Antoniou,I.M., Isakov,L., Shen-Orr,Z.,
            Bravo-Cordero,J.J., Kase,N., Cuajungco,M.P., Moran,T.M., LeRoith,D.
            and Gallagher,E.J.
  TITLE     TMEM176B Regulates AKT/mTOR Signaling and Tumor Growth in
            Triple-Negative Breast Cancer
  JOURNAL   Cells 10 (12), 3430 (2021)
   PUBMED   34943938
  REMARK    GeneRIF: TMEM176B Regulates AKT/mTOR Signaling and Tumor Growth in
            Triple-Negative Breast Cancer.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1115)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   5  (bases 1 to 1115)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   6  (bases 1 to 1115)
  AUTHORS   Drujont,L., Lemoine,A., Moreau,A., Bienvenu,G., Lancien,M.,
            Cens,T., Guillot,F., Beriou,G., Bouchet-Delbos,L., Fehling,H.J.,
            Chiffoleau,E., Nicot,A.B., Charnet,P., Martin,J.C., Josien,R.,
            Cuturi,M.C. and Louvet,C.
  TITLE     RORgammat+ cells selectively express redundant cation channels
            linked to the Golgi apparatus
  JOURNAL   Sci Rep 6, 23682 (2016)
   PUBMED   27009467
  REMARK    GeneRIF: Study characterized Tmem176a and b expression in RORgamma
            t+ lymphocytes at transcriptional and protein levels and present
            evidence that both genes exert a redundant ion channel function
            related to a colocalisation in close proximity to the Golgi
            apparatus.
            Publication Status: Online-Only
REFERENCE   7  (bases 1 to 1115)
  AUTHORS   Cuajungco,M.P., Podevin,W., Valluri,V.K., Bui,Q., Nguyen,V.H. and
            Taylor,K.
  TITLE     Abnormal accumulation of human transmembrane (TMEM)-176A and 176B
            proteins is associated with cancer pathology
  JOURNAL   Acta Histochem 114 (7), 705-712 (2012)
   PUBMED   22244448
  REMARK    GeneRIF: human TMEM176A and 176B protein levels are significantly
            elevated in lymphoma, but not in normal tissues
REFERENCE   8  (bases 1 to 1115)
  AUTHORS   Louvet,C., Chiffoleau,E., Heslan,M., Tesson,L., Heslan,J.M.,
            Brion,R., Beriou,G., Guillonneau,C., Khalife,J., Anegon,I. and
            Cuturi,M.C.
  TITLE     Identification of a new member of the CD20/FcepsilonRIbeta family
            overexpressed in tolerated allografts
  JOURNAL   Am J Transplant 5 (9), 2143-2153 (2005)
   PUBMED   16095493
REFERENCE   9  (bases 1 to 1115)
  AUTHORS   Nakajima,H., Takenaka,M., Kaimori,J.Y., Nagasawa,Y., Kosugi,A.,
            Kawamoto,S., Imai,E., Hori,M. and Okubo,K.
  TITLE     Gene expression profile of renal proximal tubules regulated by
            proteinuria
  JOURNAL   Kidney Int 61 (5), 1577-1587 (2002)
   PUBMED   11967007
REFERENCE   10 (bases 1 to 1115)
  AUTHORS   Lurton,J., Rose,T.M., Raghu,G. and Narayanan,A.S.
  TITLE     Isolation of a gene product expressed by a subpopulation of human
            lung fibroblasts by differential display
  JOURNAL   Am J Respir Cell Mol Biol 20 (2), 327-331 (1999)
   PUBMED   9922225
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BI761752.1, AK000841.1, BC091471.1 and AK129525.1.
            
            On Nov 22, 2018 this sequence version replaced NM_001101312.1.
            
            Transcript Variant: This variant (3) differs in the 5' UTR compared
            to variant 1. Variants 1-4 encode the same isoform (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC091471.1, AK000841.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMN04284274
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000326442.10/ ENSP00000318409.5
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-33                BI761752.1         170-202
            34-351              AK000841.1         34-351
            352-887             BC091471.1         352-887
            888-1114            AK129525.1         782-1008
            1115-1115           AK000841.1         1115-1115
FEATURES             Location/Qualifiers
     source          1..1115
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q36.1"
     gene            1..1115
                     /gene="TMEM176B"
                     /gene_synonym="LR8; MS4B2"
                     /note="transmembrane protein 176B"
                     /db_xref="GeneID:28959"
                     /db_xref="HGNC:HGNC:29596"
                     /db_xref="MIM:610385"
     exon            1..67
                     /gene="TMEM176B"
                     /gene_synonym="LR8; MS4B2"
                     /inference="alignment:Splign:2.1.0"
     exon            68..276
                     /gene="TMEM176B"
                     /gene_synonym="LR8; MS4B2"
                     /inference="alignment:Splign:2.1.0"
     CDS             73..885
                     /gene="TMEM176B"
                     /gene_synonym="LR8; MS4B2"
                     /note="isoform a is encoded by transcript variant 3;
                     LR8-like protein"
                     /codon_start=1
                     /product="transmembrane protein 176B isoform a"
                     /protein_id="NP_001094782.1"
                     /db_xref="CCDS:CCDS5908.1"
                     /db_xref="GeneID:28959"
                     /db_xref="HGNC:HGNC:29596"
                     /db_xref="MIM:610385"
                     /translation="MTQNTVIVNGVAMASRPSQPTHVNVHIHQESALTQLLKAGGSLK
                     KFLFHPGDTVPSTARIGYEQLALGVTQILLGVVSCVLGVCLSLGPWTVLSASGCAFWA
                     GSVVIAAGAGAIVHEKHPGKLAGYISSLLTLAGFATAMAAVVLCVNSFIWQTEPFLYI
                     DTVCDRSDPVFPTTGYRWMRRSQENQWQKEECRAYMQMLRKLFTAIRALFLAVCVLKV
                     IVSLVSLGVGLRNLCGQSSQPLNEEGSEKRLLGENSVPPSPSREQTSTAIVL"
     exon            277..387
                     /gene="TMEM176B"
                     /gene_synonym="LR8; MS4B2"
                     /inference="alignment:Splign:2.1.0"
     exon            388..444
                     /gene="TMEM176B"
                     /gene_synonym="LR8; MS4B2"
                     /inference="alignment:Splign:2.1.0"
     exon            445..672
                     /gene="TMEM176B"
                     /gene_synonym="LR8; MS4B2"
                     /inference="alignment:Splign:2.1.0"
     exon            673..792
                     /gene="TMEM176B"
                     /gene_synonym="LR8; MS4B2"
                     /inference="alignment:Splign:2.1.0"
     exon            793..1115
                     /gene="TMEM176B"
                     /gene_synonym="LR8; MS4B2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1095..1100
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TMEM176B"
                     /gene_synonym="LR8; MS4B2"
                     /note="hexamer: AATAAA"
     polyA_site      1115
                     /gene="TMEM176B"
                     /gene_synonym="LR8; MS4B2"
                     /note="major polyA site"
ORIGIN      
        1 gtcgctcccc tgctcggggt cagctagtgt ccgctctgct cggccgcggg ctcccggagg
       61 actgcaggca ggatgacgca aaacacggtg attgtgaatg gagttgctat ggcctctagg
      121 ccatcccagc ccacccacgt caacgtccac atccaccagg agtcagcttt gacacaactg
      181 ctgaaagctg gaggttctct gaagaagttt ctttttcacc ctggggacac tgtgccttcc
      241 acagccagga ttggttatga gcagctggct ctaggggtga ctcagatatt gctgggggtt
      301 gtgagttgtg ttcttggagt gtgtctcagc ttggggccct ggactgtgct gagtgcctca
      361 ggctgtgcct tctgggcggg gtctgtggtg atcgcagcag gagctggggc cattgtccat
      421 gagaagcacc cgggcaaact tgctggctat atatccagcc tgctcaccct ggcaggcttt
      481 gctacagcta tggctgctgt tgtcctctgc gtgaatagct tcatctggca aactgaaccc
      541 tttttataca tcgacactgt gtgtgatcgc tcagaccctg tcttccctac cactgggtac
      601 agatggatgc ggcgaagtca agagaaccaa tggcagaagg aggagtgtag agcttacatg
      661 cagatgctga ggaagttgtt cacagcaatc cgtgccctgt tcctggctgt ctgtgtcttg
      721 aaggtcattg tgtccttggt ttccttggga gtaggtcttc gaaacttgtg tggccagagc
      781 tcccagcccc tgaatgagga aggatcagag aagaggctac tgggggagaa ttcagtgccc
      841 ccttcgccct ctagggagca gacctccact gccattgtcc tgtgagctgc caaagacccc
      901 acggggtgcc cgcatgtccc tgtctagggc agcccagggc ccccactcct ggctcctcac
      961 acttgcctcc cctatggccg ctctccagac cctcctcctt tcttctcccc acatccgcac
     1021 ctgctgttcc cactctgggg ttctcaagtc catgaacaga tattgttgca ttttccacaa
     1081 tgctgattaa acataataaa caatccagaa aagca
//
