LOCUS       NM_153217               1761 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens transmembrane protein 174 (TMEM174), mRNA.
ACCESSION   NM_153217
VERSION     NM_153217.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1761)
  AUTHORS   Sasaki,S., Shiozaki,Y., Hanazaki,A., Koike,M., Tanifuji,K., Uga,M.,
            Kawahara,K., Kaneko,I., Kawamoto,Y., Wiriyasermkul,P., Hasegawa,T.,
            Amizuka,N., Miyamoto,K.I., Nagamori,S., Kanai,Y. and Segawa,H.
  TITLE     Tmem174, a regulator of phosphate transporter prevents
            hyperphosphatemia
  JOURNAL   Sci Rep 12 (1), 6353 (2022)
   PUBMED   35428804
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1761)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   3  (bases 1 to 1761)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 1761)
  AUTHORS   Okada,Y., Sim,X., Go,M.J., Wu,J.Y., Gu,D., Takeuchi,F.,
            Takahashi,A., Maeda,S., Tsunoda,T., Chen,P., Lim,S.C., Wong,T.Y.,
            Liu,J., Young,T.L., Aung,T., Seielstad,M., Teo,Y.Y., Kim,Y.J.,
            Lee,J.Y., Han,B.G., Kang,D., Chen,C.H., Tsai,F.J., Chang,L.C.,
            Fann,S.J., Mei,H., Rao,D.C., Hixson,J.E., Chen,S., Katsuya,T.,
            Isono,M., Ogihara,T., Chambers,J.C., Zhang,W., Kooner,J.S.,
            Albrecht,E., Yamamoto,K., Kubo,M., Nakamura,Y., Kamatani,N.,
            Kato,N., He,J., Chen,Y.T., Cho,Y.S., Tai,E.S. and Tanaka,T.
  CONSRTM   KidneyGen Consortium; CKDGen Consortium; GUGC consortium
  TITLE     Meta-analysis identifies multiple loci associated with kidney
            function-related traits in east Asian populations
  JOURNAL   Nat Genet 44 (8), 904-909 (2012)
   PUBMED   22797727
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1761)
  AUTHORS   Wang,P., Sun,B., Hao,D., Zhang,X., Shi,T. and Ma,D.
  TITLE     Human TMEM174 that is highly expressed in kidney tissue activates
            AP-1 and promotes cell proliferation
  JOURNAL   Biochem Biophys Res Commun 394 (4), 993-999 (2010)
   PUBMED   20331980
  REMARK    GeneRIF: these results suggest the potential role of TMEM174 in
            renal development and physiological function.
            Erratum:[Biochem Biophys Res Commun. 2011 Jan 7;404(1):580]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC116345.2 and AK315460.1.
            
            On Nov 22, 2018 this sequence version replaced NM_153217.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BG434015.1, AK315460.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1970526, SAMEA2142348
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000296776.6/ ENSP00000296776.5
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3                 AC116345.2         75565-75567
            4-783               AK315460.1         1-780
            784-1761            AC116345.2         76538-77515
FEATURES             Location/Qualifiers
     source          1..1761
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q13.2"
     gene            1..1761
                     /gene="TMEM174"
                     /note="transmembrane protein 174"
                     /db_xref="GeneID:134288"
                     /db_xref="HGNC:HGNC:28187"
                     /db_xref="MIM:614909"
     exon            1..677
                     /gene="TMEM174"
                     /inference="alignment:Splign:2.1.0"
     CDS             52..783
                     /gene="TMEM174"
                     /codon_start=1
                     /product="transmembrane protein 174"
                     /protein_id="NP_694949.1"
                     /db_xref="CCDS:CCDS4018.1"
                     /db_xref="GeneID:134288"
                     /db_xref="HGNC:HGNC:28187"
                     /db_xref="MIM:614909"
                     /translation="MEQGSGRLEDFPVNVFSVTPYTPSTADIQVSDDDKAGATLLFSG
                     IFLGLVGITFTVMGWIKYQGVSHFEWTQLLGPVLLSVGVTFILIAVCKFKMLSCQLCK
                     ESEERVPDSEQTPGGPSFVFTGINQPITFHGATVVQYIPPPYGSPEPMGINTSYLQSV
                     VSPCGLITSGGAAAAMSSPPQYYTIYPQDNSAFVVDEGCLSFTDGGNHRPNPDVDQLE
                     ETQLEEEACACFSPPPYEEIYSLPR"
     exon            678..1761
                     /gene="TMEM174"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1366..1371
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TMEM174"
                     /note="hexamer: AATAAA"
     polyA_site      1391
                     /gene="TMEM174"
                     /note="major polyA site"
     regulatory      1737..1742
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TMEM174"
                     /note="hexamer: ATTAAA"
     polyA_site      1761
                     /gene="TMEM174"
ORIGIN      
        1 gttctcacaa tcctctccac tctaagaagc agggtgagcc cacaaggagc aatggagcag
       61 ggcagcggcc gcttggagga cttccctgtc aatgtgttct ccgtcactcc ttacacaccc
      121 agcaccgctg acatccaggt gtccgatgat gacaaggcgg gggccacctt gctcttctca
      181 ggcatctttc tgggactggt ggggatcaca ttcactgtca tgggctggat caaataccaa
      241 ggtgtctccc actttgaatg gacccagctc cttgggcccg tcctgctgtc agttggggtg
      301 acattcatcc tgattgctgt gtgcaagttc aaaatgctct cctgccagtt gtgcaaagaa
      361 agtgaggaaa gggtcccgga ctcggaacag acaccaggag gaccatcatt tgttttcact
      421 ggcatcaacc aacccatcac cttccatggg gccactgtgg tgcagtacat ccctcctcct
      481 tatggttctc cagagcctat ggggataaat accagctacc tgcagtctgt ggtgagcccc
      541 tgcggcctca taacctctgg aggggcagca gccgccatgt caagtcctcc tcaatactac
      601 accatctacc ctcaagataa ctctgcattt gtggttgatg agggctgcct ttctttcacg
      661 gacggtggaa atcacaggcc caatcctgat gttgaccagc tagaagagac acagctggaa
      721 gaggaggcct gtgcctgctt ctctcctccc ccttatgaag aaatatactc tctccctcgc
      781 tagaggctat tctgatataa taacacaatg ctcagctcag ggagcaagtg tttccgtcat
      841 tgttacctga caaccgtggt gttctatgtt gtaaccttca gaagttacag cagcgcccag
      901 gcagcctgac agagatcatt caagggggga aaggggaagt gggaggtgca atttctcaga
      961 ttggtaaaaa ttaggctggg ctggggaaat tctcctccgg aacagtttca aattccctcg
     1021 ggtaagaaat ctcctgtata aggttcagga gcaggaattt cactttttca tccaccaccc
     1081 tcccccttct ctgtaggaag gcattggtgg ctcaatttta accccagcag ccaatggaaa
     1141 aatcacgact tctgagactt tgggagtttc cacagaggtg agagtcgggt gggaaggaag
     1201 cagggaagag aaagcaggcc cagctggaga tttcctggtg gctgtccttg gccccaaagc
     1261 agactcacta atcccaaaca actcagctgc catctggcct ctctgaggac tctgggtacc
     1321 ttaaagacta taaaacaaaa caaaacaaaa acatcaaacc aatgaaataa aataaatcat
     1381 gtctcctgct agaatagtat tggatacctg actaaattac acaaaataga ccataatagg
     1441 atagcgctgt gaatacatcc ttcccgatca ctgagtcaca gtgacccttg gctgctgctg
     1501 ttctcttctg caaggttgaa gcttgacgtg tgatgaacat gggtgggctc ttggtccacc
     1561 ccaggctggg gcctgcgcca agcatgaact agctgggacc agtggctgac agaacacagg
     1621 acttccctaa gtacccgtag gtctgtggag caagacagag cagagttgcc atgtcaacac
     1681 atggggaatg atatgataga aacaatcttt atgactaaaa gaaactcatc ttcttcatta
     1741 aaaaaacttt ggtgtcctta a
//
