LOCUS       NM_173490               1244 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens transmembrane protein 171 (TMEM171), transcript
            variant 1, mRNA.
ACCESSION   NM_173490
VERSION     NM_173490.8
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1244)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   2  (bases 1 to 1244)
  AUTHORS   Kottgen,A., Albrecht,E., Teumer,A., Vitart,V., Krumsiek,J.,
            Hundertmark,C., Pistis,G., Ruggiero,D., O'Seaghdha,C.M., Haller,T.,
            Yang,Q., Tanaka,T., Johnson,A.D., Kutalik,Z., Smith,A.V., Shi,J.,
            Struchalin,M., Middelberg,R.P., Brown,M.J., Gaffo,A.L., Pirastu,N.,
            Li,G., Hayward,C., Zemunik,T., Huffman,J., Yengo,L., Zhao,J.H.,
            Demirkan,A., Feitosa,M.F., Liu,X., Malerba,G., Lopez,L.M., van der
            Harst,P., Li,X., Kleber,M.E., Hicks,A.A., Nolte,I.M., Johansson,A.,
            Murgia,F., Wild,S.H., Bakker,S.J., Peden,J.F., Dehghan,A.,
            Steri,M., Tenesa,A., Lagou,V., Salo,P., Mangino,M., Rose,L.M.,
            Lehtimaki,T., Woodward,O.M., Okada,Y., Tin,A., Muller,C.,
            Oldmeadow,C., Putku,M., Czamara,D., Kraft,P., Frogheri,L.,
            Thun,G.A., Grotevendt,A., Gislason,G.K., Harris,T.B., Launer,L.J.,
            McArdle,P., Shuldiner,A.R., Boerwinkle,E., Coresh,J., Schmidt,H.,
            Schallert,M., Martin,N.G., Montgomery,G.W., Kubo,M., Nakamura,Y.,
            Tanaka,T., Munroe,P.B., Samani,N.J., Jacobs,D.R. Jr., Liu,K.,
            D'Adamo,P., Ulivi,S., Rotter,J.I., Psaty,B.M., Vollenweider,P.,
            Waeber,G., Campbell,S., Devuyst,O., Navarro,P., Kolcic,I.,
            Hastie,N., Balkau,B., Froguel,P., Esko,T., Salumets,A., Khaw,K.T.,
            Langenberg,C., Wareham,N.J., Isaacs,A., Kraja,A., Zhang,Q.,
            Wild,P.S., Scott,R.J., Holliday,E.G., Org,E., Viigimaa,M.,
            Bandinelli,S., Metter,J.E., Lupo,A., Trabetti,E., Sorice,R.,
            Doring,A., Lattka,E., Strauch,K., Theis,F., Waldenberger,M.,
            Wichmann,H.E., Davies,G., Gow,A.J., Bruinenberg,M., Stolk,R.P.,
            Kooner,J.S., Zhang,W., Winkelmann,B.R., Boehm,B.O., Lucae,S.,
            Penninx,B.W., Smit,J.H., Curhan,G., Mudgal,P., Plenge,R.M.,
            Portas,L., Persico,I., Kirin,M., Wilson,J.F., Mateo Leach,I., van
            Gilst,W.H., Goel,A., Ongen,H., Hofman,A., Rivadeneira,F.,
            Uitterlinden,A.G., Imboden,M., von Eckardstein,A., Cucca,F.,
            Nagaraja,R., Piras,M.G., Nauck,M., Schurmann,C., Budde,K.,
            Ernst,F., Farrington,S.M., Theodoratou,E., Prokopenko,I.,
            Stumvoll,M., Jula,A., Perola,M., Salomaa,V., Shin,S.Y.,
            Spector,T.D., Sala,C., Ridker,P.M., Kahonen,M., Viikari,J.,
            Hengstenberg,C., Nelson,C.P., Meschia,J.F., Nalls,M.A., Sharma,P.,
            Singleton,A.B., Kamatani,N., Zeller,T., Burnier,M., Attia,J.,
            Laan,M., Klopp,N., Hillege,H.L., Kloiber,S., Choi,H., Pirastu,M.,
            Tore,S., Probst-Hensch,N.M., Volzke,H., Gudnason,V., Parsa,A.,
            Schmidt,R., Whitfield,J.B., Fornage,M., Gasparini,P.,
            Siscovick,D.S., Polasek,O., Campbell,H., Rudan,I., Bouatia-Naji,N.,
            Metspalu,A., Loos,R.J., van Duijn,C.M., Borecki,I.B., Ferrucci,L.,
            Gambaro,G., Deary,I.J., Wolffenbuttel,B.H., Chambers,J.C., Marz,W.,
            Pramstaller,P.P., Snieder,H., Gyllensten,U., Wright,A.F., Navis,G.,
            Watkins,H., Witteman,J.C., Sanna,S., Schipf,S., Dunlop,M.G.,
            Tonjes,A., Ripatti,S., Soranzo,N., Toniolo,D., Chasman,D.I.,
            Raitakari,O., Kao,W.H., Ciullo,M., Fox,C.S., Caulfield,M.,
            Bochud,M. and Gieger,C.
  CONSRTM   LifeLines Cohort Study; CARDIoGRAM Consortium; DIAGRAM Consortium;
            ICBP Consortium; MAGIC Consortium
  TITLE     Genome-wide association analyses identify 18 new loci associated
            with serum urate concentrations
  JOURNAL   Nat Genet 45 (2), 145-154 (2013)
   PUBMED   23263486
REFERENCE   3  (bases 1 to 1244)
  AUTHORS   Okada,Y., Sim,X., Go,M.J., Wu,J.Y., Gu,D., Takeuchi,F.,
            Takahashi,A., Maeda,S., Tsunoda,T., Chen,P., Lim,S.C., Wong,T.Y.,
            Liu,J., Young,T.L., Aung,T., Seielstad,M., Teo,Y.Y., Kim,Y.J.,
            Lee,J.Y., Han,B.G., Kang,D., Chen,C.H., Tsai,F.J., Chang,L.C.,
            Fann,S.J., Mei,H., Rao,D.C., Hixson,J.E., Chen,S., Katsuya,T.,
            Isono,M., Ogihara,T., Chambers,J.C., Zhang,W., Kooner,J.S.,
            Albrecht,E., Yamamoto,K., Kubo,M., Nakamura,Y., Kamatani,N.,
            Kato,N., He,J., Chen,Y.T., Cho,Y.S., Tai,E.S. and Tanaka,T.
  CONSRTM   KidneyGen Consortium; CKDGen Consortium; GUGC consortium
  TITLE     Meta-analysis identifies multiple loci associated with kidney
            function-related traits in east Asian populations
  JOURNAL   Nat Genet 44 (8), 904-909 (2012)
   PUBMED   22797727
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1244)
  AUTHORS   Takeda,S., Kadowaki,S., Haga,T., Takaesu,H. and Mitaku,S.
  TITLE     Identification of G protein-coupled receptor genes from the human
            genome sequence
  JOURNAL   FEBS Lett 520 (1-3), 97-101 (2002)
   PUBMED   12044878
  REMARK    Erratum:[FEBS Lett 2002 Jul 17;523(1-3):257]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC018083.1, AC116345.2 and KF457920.1.
            
            On Nov 23, 2018 this sequence version replaced NM_173490.7.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC018083.1, ERR1172418.1874.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000454765.7/ ENSP00000415030.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-256               BC018083.1         1-256
            257-272             AC116345.2         25812-25827
            273-400             KF457920.1         1-128
            401-1244            BC018083.1         401-1244
FEATURES             Location/Qualifiers
     source          1..1244
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q13.2"
     gene            1..1244
                     /gene="TMEM171"
                     /gene_synonym="PRP2"
                     /note="transmembrane protein 171"
                     /db_xref="GeneID:134285"
                     /db_xref="HGNC:HGNC:27031"
     exon            1..122
                     /gene="TMEM171"
                     /gene_synonym="PRP2"
                     /inference="alignment:Splign:2.1.0"
     exon            123..830
                     /gene="TMEM171"
                     /gene_synonym="PRP2"
                     /inference="alignment:Splign:2.1.0"
     CDS             191..1165
                     /gene="TMEM171"
                     /gene_synonym="PRP2"
                     /note="isoform 1 is encoded by transcript variant 1;
                     proline-rich protein PRP2"
                     /codon_start=1
                     /product="transmembrane protein 171 isoform 1"
                     /protein_id="NP_775761.4"
                     /db_xref="CCDS:CCDS4017.1"
                     /db_xref="GeneID:134285"
                     /db_xref="HGNC:HGNC:27031"
                     /translation="MSPAAAAEPDGDQQDRHVSKLIFCFFVFGAVLLCVGVLLSIFGF
                     QACQYKPLPDCPMVLKVAGPACAVVGLGAVILARSRAQLQLRAGLQRGQQMDPDRAFI
                     CGESRQFAQCLIFGFLFLTSGMLISVLGIWVPGCGSNWAQEPLNETDTGDSEPRMCGF
                     LSLQIMGPLIVLVGLCFFVVAHVKKRNTLNAGQDASEREEGQIQIMEPVQVTVGDSVI
                     IFPPPPPPYFPESSASAVAESPGTNSLLPNENPPSYYSIFNYGRTPTSEGAASERDCE
                     SIYTISGTNSSSEASHTPHLPSELPPRYEEKENAAATFLPLSSEPSPP"
     exon            831..972
                     /gene="TMEM171"
                     /gene_synonym="PRP2"
                     /inference="alignment:Splign:2.1.0"
     exon            973..1244
                     /gene="TMEM171"
                     /gene_synonym="PRP2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1226..1231
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TMEM171"
                     /gene_synonym="PRP2"
                     /note="hexamer: AATAAA"
     polyA_site      1244
                     /gene="TMEM171"
                     /gene_synonym="PRP2"
                     /note="major polyA site"
ORIGIN      
        1 aggacgcgcg gtgggtaggg tgcagggcgg ccggcgcagc cgaggccgcg tgcggaggcg
       61 gacgccgcgc ccagccagtg cccacagcag cgcggtcagc caggcgccgg acccagcttc
      121 agagctgctg aaatcttgga gggaagaaaa cacatcccac cctgcctccg ggaaggggcc
      181 tctcctggac atgtctcctg cagctgctgc tgagccagat ggggaccagc aggacagaca
      241 cgtcagcaaa ctcatcttct gcttctttgt cttcggcgcc gtcttgttgt gtgtgggagt
      301 cctgctctcc atctttgggt tccaggcatg ccaatataag cccctcccag actgccccat
      361 ggtgctcaag gtggcggggc ctgcatgtgc cgtggttggg cttggggctg tgatcctggc
      421 ccgctcccgg gcgcaacttc agctccgtgc agggctgcag agaggtcagc agatggaccc
      481 cgaccgagcc ttcatctgtg gagagagccg ccagtttgcc cagtgcctta tctttgggtt
      541 tctgttcttg acaagcggca tgctcatcag cgtcctgggc atttgggtcc ctggatgtgg
      601 ctccaactgg gcgcaggaac cgctaaacga gacagacact ggcgactcag agccccggat
      661 gtgtgggttc ctttctctgc agatcatggg gcccttgatt gtgcttgtgg gattgtgttt
      721 cttcgtggtt gcccatgtta agaagagaaa cacgctgaat gctggccagg atgcctctga
      781 gagagaagag ggacagatcc agattatgga gcctgtccag gtcactgtag gtgactcggt
      841 aataatattt ccaccccctc caccacctta ctttcctgaa tcttcagctt ctgcggtcgc
      901 tgagagtcct ggaactaaca gtctgcttcc gaatgaaaac cccccttcat attacagtat
      961 tttcaactat ggcaggaccc caacttcaga gggtgcagcc tctgaaagag actgtgaatc
     1021 tatatatacc atttctggga cgaattcatc ttctgaggcc tcacacactc cacatcttcc
     1081 atctgaattg cctcctagat atgaagaaaa agaaaatgct gcagctacat tcttgcctct
     1141 atcttctgag ccttccccac cgtaaactat ggactctagt tcagttttat atgcaatgga
     1201 tcactatttt atttaatttt ttttaaataa aaaatacaat agca
//
